GREMLIN Database
LYEL - Lycopene elongase
UniProt: Q9HPD9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (259)
Sequences: 9085 (6499)
Seq/√Len: 403.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_R83_G3.7851.00
61_V83_G3.7191.00
54_Y94_G3.1821.00
82_G85_A3.1241.00
201_D205_A3.1021.00
84_A88_V3.0491.00
61_V87_A2.9891.00
231_A234_V2.7811.00
4_Y80_Y2.5961.00
101_A104_L2.4431.00
25_V41_V2.3301.00
183_I187_R2.3101.00
71_P74_D2.2811.00
184_E187_R2.1441.00
57_G93_C2.1341.00
65_D69_T2.0951.00
249_A253_Y2.0941.00
202_R205_A2.0741.00
237_F241_R2.0201.00
97_L101_A2.0151.00
106_A110_P1.9861.00
105_P108_A1.9671.00
66_V191_I1.9511.00
62_F124_A1.9401.00
14_W49_L1.9181.00
91_A95_V1.9171.00
256_V260_V1.8921.00
108_A152_A1.8451.00
205_A209_G1.8291.00
251_W255_A1.8181.00
43_L100_V1.7951.00
198_L202_R1.7341.00
236_V240_R1.7121.00
187_R196_T1.7021.00
232_Y236_V1.6441.00
183_I200_A1.6291.00
88_V92_V1.6101.00
87_A91_A1.6051.00
65_D68_E1.5951.00
99_F103_P1.5781.00
5_L85_A1.5771.00
22_L45_S1.5751.00
83_G87_A1.5711.00
250_Y253_Y1.5521.00
224_R231_A1.5501.00
100_V104_L1.5311.00
254_P258_T1.5301.00
37_S40_A1.5211.00
195_A203_A1.5131.00
51_A97_L1.5101.00
81_R86_V1.5091.00
16_Y174_M1.4991.00
57_G89_I1.4731.00
61_V86_V1.4671.00
133_P197_A1.4661.00
257_N261_G1.4431.00
234_V238_G1.4341.00
246_V249_A1.4281.00
215_A232_Y1.4061.00
227_L267_G1.4061.00
43_L103_P1.4051.00
234_V237_F1.3921.00
66_V69_T1.3641.00
58_I90_V1.3571.00
50_P96_F1.3541.00
53_I93_C1.3241.00
212_L216_A1.3221.00
183_I196_T1.3161.00
250_Y254_P1.3121.00
200_A204_L1.2951.00
102_A109_W1.2881.00
9_S53_I1.2871.00
202_R206_Y1.2811.00
247_G250_Y1.2771.00
24_G28_G1.2731.00
21_V48_L1.2731.00
50_P93_C1.2711.00
230_L234_V1.2681.00
129_F139_S1.2671.00
228_L232_Y1.2531.00
129_F132_T1.2501.00
236_V239_I1.2461.00
239_I243_Q1.2401.00
94_G116_F1.2391.00
192_Q197_A1.2331.00
233_P237_F1.2201.00
151_Y155_S1.2201.00
247_G251_W1.2101.00
68_E77_E1.2051.00
248_R252_W1.2041.00
110_P114_A1.2001.00
227_L231_A1.1911.00
238_G242_L1.1861.00
57_G90_V1.1851.00
224_R232_Y1.1771.00
156_G160_P1.1731.00
251_W254_P1.1641.00
161_L165_A1.1531.00
253_Y257_N1.1511.00
252_W255_A1.1501.00
239_I242_L1.1491.00
84_A87_A1.1481.00
5_L89_I1.1471.00
76_R86_V1.1401.00
136_D193_T1.1331.00
50_P97_L1.1281.00
240_R243_Q1.1261.00
254_P257_N1.1151.00
61_V90_V1.1101.00
225_F229_L1.1091.00
102_A106_A1.1081.00
98_G101_A1.1051.00
252_W256_V1.1041.00
130_K191_I1.1021.00
89_I93_C1.0991.00
257_N260_V1.0881.00
166_G217_V1.0811.00
42_V46_Y1.0811.00
90_V94_G1.0771.00
253_Y260_V1.0761.00
113_A117_V1.0711.00
176_T206_Y1.0701.00
8_L57_G1.0681.00
63_D131_T1.0681.00
201_D204_L1.0671.00
233_P236_V1.0631.00
64_R68_E1.0581.00
9_S93_C1.0571.00
241_R245_A1.0551.00
67_D71_P1.0541.00
182_D186_D1.0501.00
249_A252_W1.0481.00
254_P261_G1.0371.00
180_I203_A1.0191.00
121_E139_S1.0151.00
65_D70_N1.0071.00
250_Y257_N1.0061.00
194_T198_L0.9991.00
180_I202_R0.9981.00
55_L119_A0.9951.00
107_E111_Y0.9941.00
246_V250_Y0.9931.00
264_F267_G0.9841.00
238_G241_R0.9811.00
261_G265_T0.9811.00
142_L164_V0.9791.00
107_E152_A0.9711.00
260_V264_F0.9621.00
69_T189_A0.9621.00
118_L142_L0.9611.00
7_V80_Y0.9591.00
232_Y235_L0.9591.00
183_I195_A0.9571.00
98_G102_A0.9551.00
205_A208_A0.9541.00
256_V259_L0.9531.00
173_G210_I0.9481.00
120_T124_A0.9451.00
107_E110_P0.9441.00
152_A160_P0.9441.00
225_F232_Y0.9431.00
70_N185_P0.9431.00
156_G161_L0.9431.00
143_Y147_A0.9411.00
169_L210_I0.9371.00
39_P43_L0.9321.00
66_V131_T0.9311.00
179_A195_A0.9311.00
165_A169_L0.9281.00
250_Y255_A0.9261.00
228_L231_A0.9201.00
81_R89_I0.9131.00
69_T72_K0.9111.00
18_A22_L0.9081.00
157_T160_P0.9041.00
258_T262_M0.8921.00
6_F9_S0.8911.00
255_A259_L0.8891.00
43_L104_L0.8821.00
184_E188_A0.8771.00
64_R76_R0.8771.00
8_L86_V0.8771.00
259_L263_V0.8761.00
27_Y151_Y0.8741.00
21_V44_F0.8731.00
38_A42_V0.8721.00
77_E86_V0.8671.00
236_V243_Q0.8661.00
97_L104_L0.8651.00
115_W145_L0.8591.00
121_E129_F0.8571.00
143_Y146_P0.8541.00
26_S265_T0.8531.00
39_P42_V0.8521.00
67_D72_K0.8511.00
85_A89_I0.8431.00
144_V168_W0.8411.00
256_V261_G0.8401.00
117_V120_T0.8311.00
148_A160_P0.8311.00
232_Y239_I0.8291.00
148_A164_V0.8251.00
101_A112_L0.8241.00
212_L240_R0.8231.00
259_L262_M0.8231.00
63_D66_V0.8211.00
232_Y243_Q0.8181.00
213_L217_V0.8181.00
19_G261_G0.8171.00
51_A112_L0.8161.00
237_F240_R0.8111.00
18_A45_S0.8061.00
23_V163_A0.8041.00
208_A212_L0.7981.00
204_L208_A0.7971.00
226_G230_L0.7971.00
217_V221_V0.7901.00
144_V171_A0.7901.00
123_S131_T0.7851.00
46_Y100_V0.7841.00
240_R244_V0.7831.00
234_V241_R0.7801.00
133_P139_S0.7791.00
16_Y20_P0.7791.00
235_L243_Q0.7791.00
165_A217_V0.7771.00
218_F221_V0.7721.00
77_E80_Y0.7721.00
6_F11_P0.7691.00
222_D225_F0.7681.00
260_V265_T0.7651.00
36_F41_V0.7631.00
258_T261_G0.7621.00
85_A88_V0.7601.00
224_R228_L0.7591.00
214_S218_F0.7561.00
246_V254_P0.7551.00
108_A149_A0.7551.00
180_I200_A0.7541.00
9_S57_G0.7531.00
129_F133_P0.7501.00
63_D123_S0.7491.00
15_L258_T0.7451.00
57_G81_R0.7441.00
22_L265_T0.7441.00
257_N264_F0.7371.00
229_L232_Y0.7341.00
58_I120_T0.7341.00
112_L149_A0.7261.00
229_L233_P0.7241.00
47_F100_V0.7241.00
17_L52_N0.7231.00
75_G79_R0.7201.00
66_V72_K0.7171.00
241_R244_V0.7151.00
53_I89_I0.7151.00
25_V44_F0.7131.00
76_R81_R0.7121.00
198_L206_Y0.7101.00
26_S269_L0.7091.00
242_L245_A0.7091.00
70_N74_D0.7031.00
67_D70_N0.7001.00
172_M210_I0.6961.00
66_V70_N0.6961.00
144_V167_G0.6931.00
206_Y209_G0.6921.00
5_L9_S0.6901.00
65_D71_P0.6891.00
7_V12_R0.6881.00
257_N265_T0.6881.00
57_G86_V0.6821.00
46_Y50_P0.6810.99
61_V76_R0.6800.99
184_E200_A0.6760.99
130_K136_D0.6720.99
87_A90_V0.6720.99
259_L264_F0.6710.99
66_V189_A0.6710.99
246_V252_W0.6680.99
219_A223_V0.6600.99
81_R85_A0.6590.99
143_Y150_A0.6580.99
247_G253_Y0.6480.99
180_I204_L0.6480.99
54_Y93_C0.6460.99
52_N56_Y0.6450.99
76_R79_R0.6430.99
24_G151_Y0.6420.99
95_V99_F0.6400.99
179_A193_T0.6390.99
186_D193_T0.6380.99
248_R251_W0.6380.99
157_T161_L0.6360.99
253_Y261_G0.6340.99
106_A109_W0.6330.99
249_A254_P0.6330.99
25_V28_G0.6330.99
206_Y210_I0.6320.99
96_F100_V0.6270.99
143_Y151_Y0.6270.99
54_Y120_T0.6250.99
53_I57_G0.6240.99
199_G203_A0.6240.99
22_L41_V0.6210.99
59_N123_S0.6200.99
167_G171_A0.6180.99
136_D140_N0.6170.99
134_V197_A0.6150.99
136_D179_A0.6120.99
135_L141_G0.6120.99
97_L103_P0.6110.99
88_V91_A0.6090.99
23_V167_G0.6090.99
234_V243_Q0.6080.99
70_N73_K0.6020.99
248_R255_A0.6000.99
62_F123_S0.5990.99
79_R85_A0.5980.99
28_G154_V0.5980.99
98_G109_W0.5980.99
250_Y261_G0.5980.99
33_G36_F0.5970.99
251_W258_T0.5930.99
173_G211_W0.5920.99
215_A218_F0.5880.99
86_V90_V0.5880.99
135_L139_S0.5880.99
235_L238_G0.5870.99
231_A235_L0.5850.98
246_V251_W0.5840.98
47_F101_A0.5840.98
210_I213_L0.5820.98
235_L239_I0.5820.98
63_D191_I0.5800.98
226_G229_L0.5750.98
180_I195_A0.5750.98
25_V36_F0.5740.98
257_N262_M0.5730.98
225_F234_V0.5710.98
255_A258_T0.5700.98
229_L236_V0.5680.98
178_S181_P0.5680.98
224_R238_G0.5640.98
144_V151_Y0.5630.98
204_L207_C0.5610.98
247_G258_T0.5600.98
149_A164_V0.5600.98
28_G151_Y0.5590.98
97_L102_A0.5580.98
253_Y259_L0.5580.98
13_F181_P0.5580.98
143_Y171_A0.5560.98
239_I244_V0.5550.98
7_V75_G0.5540.98
175_H179_A0.5540.98
137_S175_H0.5500.98
224_R235_L0.5420.98
140_N145_L0.5410.97
61_V64_R0.5380.97
261_G264_F0.5350.97
135_L138_L0.5310.97
25_V155_S0.5300.97
134_V192_Q0.5300.97
6_F89_I0.5260.97
111_Y152_A0.5250.97
117_V121_E0.5240.97
110_P113_A0.5240.97
24_G150_A0.5200.97
262_M265_T0.5190.97
231_A260_V0.5170.97
45_S49_L0.5170.97
246_V255_A0.5170.97
207_C211_W0.5160.97
60_D63_D0.5150.97
150_A154_V0.5130.97
219_A222_D0.5110.96
254_P265_T0.5070.96
246_V253_Y0.5070.96
174_M178_S0.5070.96
13_F52_N0.5050.96
97_L112_L0.5050.96
40_A154_V0.5050.96
92_V96_F0.5040.96
111_Y148_A0.5030.96
147_A150_A0.5030.96
159_P162_L0.5020.96
249_A257_N0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.9236 100 0.27 Contact Map
4tq3A 1 0.9673 100 0.315 Contact Map
2xq2A 2 0.8073 13.8 0.947 Contact Map
2onkC 2 0.24 10.8 0.949 Contact Map
3d31C 2 0.2291 5.8 0.955 Contact Map
3dh4A 3 0.7564 5.7 0.955 Contact Map
1qleC 1 0.5491 4.8 0.957 Contact Map
1v54C 1 0.5418 3.7 0.959 Contact Map
4px7A 1 0.6327 3 0.961 Contact Map
4llsA 2 0.8073 2.9 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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