GREMLIN Database
Q9HPD8 - Phytoene dehydrogenase
UniProt: Q9HPD8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 512 (446)
Sequences: 14703 (11743)
Seq/√Len: 556.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_S31_D4.3551.00
10_A291_A4.1131.00
33_T264_R3.8001.00
256_A261_V3.7931.00
8_S292_D3.6481.00
37_K268_P3.6451.00
41_I265_T3.4631.00
271_A282_D3.3841.00
21_T295_V3.2971.00
84_G242_E3.1981.00
35_V289_V3.1581.00
296_S303_T2.9431.00
10_A35_V2.9141.00
41_I253_T2.9061.00
39_D266_G2.8401.00
10_A289_V2.7741.00
409_V412_S2.7521.00
14_A41_I2.7071.00
500_G504_A2.6541.00
273_K282_D2.6491.00
282_D288_A2.6331.00
10_A281_L2.6031.00
246_G250_D2.6001.00
31_D262_E2.5771.00
267_H283_T2.5341.00
273_K280_K2.5161.00
270_S284_E2.4961.00
12_I296_S2.4341.00
268_P284_E2.4171.00
247_G250_D2.3981.00
35_V264_R2.3211.00
283_T289_V2.3121.00
443_E446_D2.2451.00
253_T257_R2.2291.00
422_A430_R2.2111.00
297_D483_T2.2041.00
24_Y501_E2.2041.00
9_V30_A2.2041.00
253_T263_F2.2001.00
264_R267_H2.1711.00
280_K288_A2.1701.00
49_E54_R2.0931.00
189_G197_Q2.0631.00
16_F493_V2.0481.00
8_S33_T2.0451.00
293_V481_Y2.0401.00
264_R287_D2.0381.00
12_I298_A2.0061.00
35_V291_A1.9911.00
337_E432_R1.9861.00
40_Q46_S1.9771.00
28_A508_L1.9631.00
192_Q196_E1.9621.00
47_T54_R1.9571.00
415_D419_D1.9481.00
251_G254_A1.9001.00
86_T242_E1.8991.00
17_G297_D1.8641.00
24_Y27_D1.8561.00
20_S497_L1.8541.00
295_V507_V1.8421.00
280_K290_L1.8411.00
130_K145_D1.8331.00
270_S282_D1.8191.00
23_C255_L1.8151.00
7_T33_T1.7991.00
449_N453_G1.7791.00
24_Y505_N1.7661.00
450_S453_G1.7581.00
196_E205_Q1.7511.00
264_R289_V1.7361.00
390_H434_V1.7281.00
30_A508_L1.7151.00
337_E434_V1.7101.00
9_V293_V1.7001.00
27_D74_S1.6961.00
422_A428_D1.6951.00
411_E415_D1.6871.00
190_S193_D1.6751.00
146_D150_Q1.6511.00
414_R436_E1.6381.00
267_H285_P1.6211.00
33_T262_E1.5801.00
22_A34_V1.5771.00
273_K288_A1.5731.00
483_T503_T1.5281.00
125_D128_Q1.5261.00
298_A303_T1.5201.00
272_I279_F1.5201.00
271_A309_P1.5151.00
35_V269_V1.5001.00
73_A78_H1.4941.00
41_I249_V1.4941.00
337_E390_H1.4871.00
269_V281_L1.4801.00
45_A249_V1.4601.00
338_G432_R1.4461.00
443_E447_R1.4451.00
279_F294_V1.4351.00
453_G456_L1.4271.00
14_A34_V1.4221.00
53_F335_G1.4201.00
70_E501_E1.4171.00
256_A263_F1.4161.00
250_D254_A1.4121.00
23_C27_D1.4081.00
11_V22_A1.4021.00
33_T291_A1.4001.00
254_A257_R1.3941.00
245_M493_V1.3921.00
8_S30_A1.3891.00
70_E74_S1.3881.00
69_E73_A1.3821.00
313_R316_D1.3801.00
34_V263_F1.3781.00
10_A33_T1.3771.00
348_L351_P1.3721.00
18_G297_D1.3611.00
283_T287_D1.3571.00
142_D146_D1.3541.00
33_T289_V1.3521.00
293_V507_V1.3481.00
41_I263_F1.3391.00
279_F479_G1.3391.00
257_R262_E1.3361.00
9_V25_L1.3221.00
17_G499_S1.3041.00
432_R435_V1.3001.00
415_D430_R1.2961.00
143_V146_D1.2891.00
267_H287_D1.2871.00
481_Y503_T1.2731.00
291_A294_V1.2691.00
192_Q220_D1.2611.00
336_V418_L1.2511.00
26_A261_V1.2471.00
147_Y150_Q1.2461.00
44_R485_A1.2401.00
442_S445_A1.2271.00
127_E130_K1.2211.00
67_V501_E1.2171.00
503_T506_N1.2161.00
334_L418_L1.2061.00
408_A412_S1.2011.00
123_T128_Q1.2011.00
502_V506_N1.1981.00
274_G279_F1.1941.00
23_C252_I1.1931.00
412_S415_D1.1931.00
299_D302_H1.1891.00
35_V283_T1.1891.00
457_G460_H1.1881.00
298_A307_L1.1761.00
7_T292_D1.1701.00
414_R418_L1.1691.00
444_F447_R1.1581.00
49_E52_G1.1561.00
24_Y74_S1.1561.00
257_R260_G1.1451.00
250_D253_T1.1431.00
50_R437_E1.1431.00
302_H306_A1.1371.00
300_Y486_N1.1371.00
26_A32_V1.1351.00
25_L504_A1.1321.00
420_D424_N1.1311.00
49_E246_G1.1261.00
35_V267_H1.1221.00
481_Y507_V1.1201.00
11_V32_V1.1111.00
267_H289_V1.1101.00
428_D431_D1.1101.00
477_L480_L1.1101.00
418_L422_A1.1051.00
372_A377_V1.1021.00
272_I294_V1.0981.00
347_T351_P1.0981.00
123_T132_V1.0981.00
177_K181_Y1.0971.00
241_P248_V1.0941.00
275_R290_L1.0931.00
487_T502_V1.0931.00
419_D430_R1.0901.00
374_Y378_P1.0891.00
189_G193_D1.0881.00
17_G483_T1.0841.00
180_E183_R1.0821.00
48_L57_M1.0781.00
396_L399_V1.0691.00
416_L419_D1.0631.00
278_G290_L1.0591.00
453_G458_L1.0541.00
317_A321_D1.0541.00
243_G247_G1.0451.00
220_D223_P1.0441.00
414_R417_V1.0401.00
481_Y506_N1.0401.00
16_F45_A1.0381.00
405_D408_A1.0341.00
53_F387_P1.0341.00
501_E505_N1.0321.00
370_D424_N1.0301.00
487_T499_S1.0291.00
272_I281_L1.0291.00
23_C74_S1.0191.00
24_Y500_G1.0081.00
247_G251_G1.0021.00
433_I436_E1.0011.00
100_E203_K1.0001.00
457_G461_T0.9971.00
253_T265_T0.9971.00
466_A469_R0.9951.00
440_S443_E0.9951.00
274_G479_G0.9941.00
26_A256_A0.9931.00
293_V479_G0.9871.00
461_T464_Q0.9871.00
318_D321_D0.9861.00
7_T31_D0.9831.00
24_Y28_A0.9821.00
371_P377_V0.9811.00
201_H205_Q0.9801.00
181_Y184_G0.9791.00
146_D149_A0.9771.00
372_A375_L0.9771.00
8_S289_V0.9721.00
458_L461_T0.9681.00
152_K156_E0.9671.00
23_C256_A0.9641.00
14_A265_T0.9601.00
309_P312_K0.9601.00
149_A153_E0.9571.00
128_Q131_Q0.9571.00
153_E156_E0.9561.00
456_L460_H0.9551.00
255_L258_E0.9511.00
397_V417_V0.9501.00
374_Y377_V0.9481.00
84_G87_R0.9461.00
70_E73_A0.9451.00
228_L232_V0.9421.00
377_V380_K0.9381.00
196_E201_H0.9341.00
257_R261_V0.9331.00
202_P206_Q0.9321.00
442_S446_D0.9301.00
484_G499_S0.9301.00
156_E159_M0.9301.00
394_F398_P0.9291.00
144_L147_Y0.9291.00
95_F100_E0.9281.00
30_A33_T0.9281.00
67_V70_E0.9231.00
182_A185_L0.9211.00
131_Q134_D0.9211.00
347_T350_L0.9201.00
412_S416_L0.9161.00
226_Y229_M0.9151.00
142_D147_Y0.9101.00
97_K100_E0.9091.00
269_V283_T0.9081.00
309_P313_R0.9081.00
169_R172_D0.9061.00
272_I296_S0.9051.00
47_T246_G0.9011.00
296_S480_L0.8991.00
217_G223_P0.8981.00
346_H351_P0.8971.00
194_H198_Y0.8971.00
270_S283_T0.8971.00
228_L234_F0.8931.00
241_P247_G0.8881.00
347_T352_S0.8861.00
93_R121_D0.8861.00
219_P222_T0.8831.00
149_A152_K0.8831.00
414_R438_R0.8831.00
336_V433_I0.8831.00
459_A464_Q0.8811.00
346_H350_L0.8761.00
230_S234_F0.8761.00
38_T46_S0.8731.00
318_D322_A0.8711.00
332_L438_R0.8671.00
226_Y230_S0.8671.00
275_R278_G0.8671.00
8_S290_L0.8651.00
20_S500_G0.8611.00
273_K310_A0.8601.00
231_H234_F0.8591.00
373_Y376_C0.8581.00
218_S221_T0.8571.00
346_H349_V0.8551.00
465_T469_R0.8531.00
456_L459_A0.8511.00
373_Y378_P0.8501.00
268_P306_A0.8491.00
143_V147_Y0.8491.00
29_G32_V0.8491.00
249_V253_T0.8461.00
7_T10_A0.8461.00
72_F77_S0.8421.00
75_F252_I0.8421.00
410_R440_S0.8421.00
419_D424_N0.8391.00
254_A258_E0.8381.00
271_A310_A0.8381.00
96_F99_N0.8361.00
283_T286_G0.8351.00
17_G496_C0.8351.00
453_G459_A0.8341.00
145_D150_Q0.8321.00
419_D422_A0.8301.00
21_T500_G0.8301.00
153_E157_V0.8291.00
145_D149_A0.8291.00
371_P374_Y0.8271.00
142_D145_D0.8271.00
77_S258_E0.8241.00
280_K283_T0.8231.00
128_Q132_V0.8181.00
20_S252_I0.8161.00
371_P378_P0.8121.00
373_Y377_V0.8091.00
205_Q209_Q0.8041.00
152_K155_Y0.8041.00
53_F390_H0.8031.00
71_F75_F0.8031.00
235_G239_Y0.8011.00
415_D436_E0.8001.00
53_F434_V0.7991.00
130_K134_D0.7971.00
449_N452_Q0.7941.00
334_L395_A0.7931.00
453_G460_H0.7931.00
226_Y231_H0.7921.00
474_S506_N0.7921.00
140_A143_V0.7921.00
218_S223_P0.7911.00
335_G435_V0.7911.00
217_G222_T0.7901.00
496_C500_G0.7891.00
73_A76_D0.7881.00
31_D292_D0.7871.00
141_G145_D0.7821.00
411_E414_R0.7811.00
155_Y158_G0.7801.00
33_T292_D0.7781.00
34_V256_A0.7781.00
36_E265_T0.7781.00
394_F397_V0.7751.00
144_L150_Q0.7741.00
178_L181_Y0.7741.00
68_F497_L0.7721.00
143_V150_Q0.7711.00
467_L470_P0.7691.00
270_S273_K0.7671.00
391_S394_F0.7671.00
44_R58_G0.7661.00
27_D255_L0.7641.00
22_A256_A0.7631.00
129_V132_V0.7631.00
85_L88_L0.7621.00
347_T353_D0.7611.00
134_D139_G0.7611.00
227_N230_S0.7611.00
145_D148_L0.7581.00
351_P354_W0.7571.00
335_G434_V0.7561.00
201_H204_L0.7551.00
19_L34_V0.7551.00
19_L256_A0.7541.00
11_V18_G0.7541.00
157_V160_E0.7541.00
278_G478_D0.7531.00
180_E184_G0.7511.00
30_A292_D0.7491.00
345_H351_P0.7471.00
171_R174_M0.7471.00
455_A459_A0.7461.00
372_A378_P0.7451.00
16_F496_C0.7431.00
8_S291_A0.7391.00
295_V481_Y0.7381.00
179_A182_A0.7371.00
20_S24_Y0.7371.00
45_A59_P0.7361.00
498_I502_V0.7341.00
420_D425_T0.7331.00
189_G194_H0.7321.00
275_R280_K0.7291.00
444_F449_N0.7281.00
72_F241_P0.7271.00
504_A507_V0.7251.00
349_V352_S0.7231.00
56_D245_M0.7231.00
223_P227_N0.7221.00
28_A505_N0.7221.00
16_F249_V0.7211.00
26_A262_E0.7201.00
23_C75_F0.7201.00
503_T507_V0.7151.00
148_L152_K0.7121.00
16_F497_L0.7111.00
410_R414_R0.7091.00
147_Y151_A0.7091.00
181_Y185_L0.7081.00
199_F208_M0.7071.00
35_V281_L0.7061.00
230_S233_D0.7051.00
294_V479_G0.7041.00
144_L149_A0.7021.00
421_I429_L0.7021.00
371_P375_L0.7021.00
298_A302_H0.7021.00
382_D385_V0.7011.00
10_A294_V0.7001.00
178_L182_A0.6991.00
451_H454_T0.6991.00
168_P172_D0.6991.00
274_G477_L0.6981.00
251_G255_L0.6941.00
96_F100_E0.6931.00
200_D204_L0.6931.00
441_V444_F0.6921.00
177_K180_E0.6891.00
202_P205_Q0.6891.00
422_A431_D0.6881.00
150_Q153_E0.6881.00
222_T227_N0.6871.00
335_G390_H0.6861.00
169_R174_M0.6861.00
127_E131_Q0.6851.00
300_Y304_E0.6851.00
192_Q209_Q0.6781.00
170_V174_M0.6781.00
460_H463_R0.6761.00
217_G221_T0.6761.00
12_I269_V0.6761.00
227_N231_H0.6751.00
336_V340_V0.6731.00
134_D141_G0.6711.00
483_T500_G0.6701.00
150_Q154_N0.6681.00
40_Q246_G0.6671.00
220_D224_A0.6671.00
7_T30_A0.6661.00
418_L436_E0.6641.00
21_T503_T0.6631.00
122_V125_D0.6611.00
209_Q219_P0.6601.00
464_Q469_R0.6581.00
50_R435_V0.6581.00
320_W323_R0.6571.00
125_D129_V0.6561.00
16_F252_I0.6551.00
235_G238_V0.6531.00
415_D418_L0.6531.00
179_A183_R0.6521.00
16_F20_S0.6521.00
93_R97_K0.6521.00
392_N396_L0.6521.00
83_Y86_T0.6511.00
169_R173_W0.6511.00
22_A261_V0.6501.00
270_S285_P0.6471.00
67_V498_I0.6451.00
45_A493_V0.6441.00
463_R466_A0.6441.00
30_A293_V0.6421.00
452_Q455_A0.6421.00
330_F438_R0.6391.00
20_S71_F0.6381.00
122_V129_V0.6381.00
453_G457_G0.6381.00
86_T89_D0.6371.00
227_N232_V0.6371.00
300_Y320_W0.6361.00
67_V497_L0.6351.00
371_P376_C0.6321.00
387_P390_H0.6311.00
121_D124_P0.6301.00
295_V503_T0.6291.00
119_T122_V0.6281.00
226_Y233_D0.6271.00
428_D432_R0.6261.00
120_I125_D0.6261.00
229_M232_V0.6251.00
395_A421_I0.6251.00
193_D196_E0.6251.00
59_P493_V0.6231.00
452_Q456_L0.6231.00
34_V41_I0.6231.00
217_G220_D0.6231.00
375_L378_P0.6231.00
296_S482_F0.6221.00
299_D486_N0.6201.00
170_V173_W0.6201.00
146_D152_K0.6181.00
56_D61_W0.6181.00
11_V295_V0.6171.00
206_Q210_Y0.6171.00
152_K157_V0.6171.00
72_F75_F0.6171.00
236_L239_Y0.6161.00
274_G277_G0.6151.00
436_E439_F0.6151.00
195_V205_Q0.6141.00
349_V353_D0.6131.00
59_P245_M0.6111.00
442_S447_R0.6101.00
177_K183_R0.6101.00
345_H348_L0.6081.00
431_D434_V0.6071.00
502_V505_N0.6071.00
348_L353_D0.6071.00
68_F494_P0.6061.00
299_D451_H0.6061.00
418_L430_R0.6051.00
227_N233_D0.6051.00
336_V341_E0.6011.00
278_G292_D0.6011.00
346_H352_S0.6011.00
71_F74_S0.5991.00
191_M227_N0.5981.00
123_T130_K0.5981.00
455_A458_L0.5981.00
416_L420_D0.5971.00
228_L231_H0.5961.00
281_L294_V0.5961.00
504_A508_L0.5951.00
226_Y234_F0.5951.00
60_S394_F0.5941.00
439_F443_E0.5931.00
244_G247_G0.5931.00
371_P420_D0.5891.00
195_V209_Q0.5891.00
121_D125_D0.5861.00
386_A390_H0.5861.00
143_V151_A0.5861.00
394_F399_V0.5851.00
214_F217_G0.5851.00
464_Q468_F0.5841.00
178_L185_L0.5841.00
345_H349_V0.5831.00
93_R100_E0.5831.00
454_T459_A0.5831.00
216_G224_A0.5821.00
346_H353_D0.5821.00
345_H350_L0.5801.00
227_N234_F0.5801.00
47_T244_G0.5780.99
493_V497_L0.5770.99
370_D420_D0.5750.99
489_P492_G0.5730.99
55_F333_Y0.5730.99
48_L437_E0.5720.99
278_G479_G0.5690.99
147_Y155_Y0.5680.99
214_F219_P0.5670.99
120_I123_T0.5670.99
145_D152_K0.5660.99
47_T56_D0.5660.99
45_A245_M0.5650.99
70_E76_D0.5640.99
229_M233_D0.5630.99
191_M195_V0.5630.99
455_A460_H0.5630.99
430_R433_I0.5620.99
418_L433_I0.5610.99
346_H354_W0.5610.99
143_V148_L0.5600.99
120_I124_P0.5600.99
293_V296_S0.5570.99
295_V483_T0.5570.99
390_H394_F0.5560.99
393_L397_V0.5560.99
348_L352_S0.5550.99
205_Q210_Y0.5540.99
334_L414_R0.5520.99
451_H456_L0.5520.99
449_N455_A0.5520.99
174_M177_K0.5520.99
441_V446_D0.5510.99
56_D59_P0.5490.99
393_L398_P0.5490.99
402_G405_D0.5480.99
410_R413_Y0.5480.99
395_A399_V0.5480.99
55_F392_N0.5470.99
224_A227_N0.5450.99
194_H224_A0.5450.99
451_H455_A0.5440.99
11_V34_V0.5430.99
250_D257_R0.5430.99
411_E436_E0.5430.99
465_T468_F0.5430.99
129_V133_F0.5420.99
121_D128_Q0.5420.99
281_L284_E0.5410.99
466_A470_P0.5400.99
154_N157_V0.5390.99
253_T261_V0.5380.99
374_Y379_S0.5370.99
247_G254_A0.5370.99
465_T470_P0.5370.99
379_S391_S0.5360.99
450_S454_T0.5360.99
473_R476_A0.5360.99
213_V217_G0.5330.99
370_D377_V0.5330.99
70_E75_F0.5310.99
14_A253_T0.5310.99
475_T478_D0.5300.99
475_T482_F0.5300.99
88_L91_H0.5280.99
9_V507_V0.5280.99
450_S456_L0.5280.99
59_P63_L0.5270.99
67_V71_F0.5270.99
93_R96_F0.5270.99
69_E72_F0.5260.99
301_A325_Y0.5250.99
406_T410_R0.5230.99
371_P379_S0.5220.99
72_F76_D0.5220.99
87_R90_P0.5220.99
85_L89_D0.5220.99
39_D265_T0.5220.99
126_R130_K0.5220.99
127_E145_D0.5200.99
50_R335_G0.5200.99
413_Y416_L0.5190.99
262_E265_T0.5190.99
306_A309_P0.5180.99
208_M211_T0.5180.99
178_L183_R0.5170.99
14_A19_L0.5170.99
488_T502_V0.5160.99
330_F397_V0.5160.99
121_D130_K0.5160.99
150_Q198_Y0.5150.99
68_F72_F0.5130.99
313_R317_A0.5120.99
142_D149_A0.5120.99
26_A257_R0.5120.99
408_A413_Y0.5120.99
391_S398_P0.5110.99
431_D435_V0.5110.99
451_H458_L0.5110.99
344_A349_V0.5110.99
215_L227_N0.5090.99
240_Y245_M0.5070.99
19_L249_V0.5070.99
67_V494_P0.5070.99
168_P171_R0.5060.99
241_P245_M0.5060.99
51_D435_V0.5040.99
348_L354_W0.5040.99
216_G219_P0.5030.99
220_D225_L0.5030.99
435_V438_R0.5030.99
195_V199_F0.5030.99
124_P127_E0.5030.99
146_D154_N0.5020.99
338_G391_S0.5020.99
24_Y71_F0.5010.99
271_A308_L0.5010.99
336_V393_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dgkA 1 0.7793 100 0.337 Contact Map
4repA 1 0.9414 100 0.373 Contact Map
4i59A 1 0.8379 100 0.413 Contact Map
2yg5A 2 0.8418 100 0.416 Contact Map
1s3eA 2 0.8477 100 0.439 Contact Map
2ivdA 1 0.8164 100 0.446 Contact Map
3i6dA 1 0.7988 100 0.449 Contact Map
1sezA 3 0.8242 100 0.457 Contact Map
2vvmA 2 0.8398 100 0.461 Contact Map
1b37A 4 0.8281 100 0.465 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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