GREMLIN Database
MCH - Methenyltetrahydromethanopterin cyclohydrolase
UniProt: Q9HPD7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (306)
Sequences: 228 (155)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_S129_D4.7350.99
53_A181_A4.1510.99
134_A158_V4.1450.99
187_A236_L3.6430.97
108_G264_V3.5420.96
102_D134_A3.2260.93
104_Y107_L3.2190.93
256_Y300_R3.2080.93
233_R283_Q2.9470.89
54_E59_G2.7880.86
25_G42_H2.7760.86
92_A104_Y2.6810.84
40_V143_L2.6600.84
40_V167_T2.5600.81
200_D240_E2.4530.78
55_L166_P2.4500.78
242_F287_D2.4270.77
112_A136_L2.3580.75
214_A221_I2.2620.72
283_Q295_A2.2440.71
221_I270_D2.2080.70
18_F21_E2.1880.69
4_L129_D2.1460.68
191_L201_V2.1120.66
98_E107_L2.0630.65
190_R228_L2.0200.63
92_A99_L1.9690.61
7_M10_E1.9580.60
118_T155_R1.9450.60
18_F51_L1.9330.59
153_A158_V1.9240.59
170_T249_V1.8990.58
38_F166_P1.8910.58
137_T174_A1.7870.53
134_A176_S1.7330.51
240_E287_D1.7320.51
5_N193_E1.7270.50
242_F292_P1.7120.50
158_V163_V1.6930.49
106_A138_L1.6890.49
24_I51_L1.6630.48
52_L174_A1.6500.47
136_L165_L1.6310.46
4_L221_I1.6280.46
108_G216_D1.6220.46
12_A55_L1.6220.46
34_T164_F1.5910.45
140_S167_T1.5700.44
166_P201_V1.5700.44
52_L166_P1.5670.44
227_A308_F1.5650.44
45_G83_D1.5350.42
51_L196_Y1.5340.42
94_K189_F1.5280.42
91_G206_G1.5100.41
107_L303_V1.5070.41
8_A207_C1.4970.41
149_A165_L1.4930.40
225_N260_F1.4920.40
214_A229_A1.4790.40
139_E279_F1.4620.39
196_Y240_E1.4280.38
179_A208_A1.4280.38
153_A285_T1.4100.37
90_L187_A1.3980.37
200_D206_G1.3900.36
35_V143_L1.3900.36
231_G252_A1.3870.36
112_A221_I1.3680.35
83_D191_L1.3680.35
16_L34_T1.3650.35
41_E210_V1.3560.35
22_L51_L1.3560.35
102_D147_A1.3560.35
105_E272_G1.3560.35
208_A264_V1.3480.35
83_D308_F1.3440.34
31_T146_T1.3300.34
12_A129_D1.3300.34
136_L183_T1.3250.34
101_V147_A1.3110.33
30_D68_D1.3110.33
12_A104_Y1.2940.33
57_T228_L1.2900.32
160_E163_V1.2850.32
14_E51_L1.2820.32
148_A151_E1.2660.31
62_T263_V1.2520.31
124_A192_Y1.2510.31
82_C206_G1.2440.31
181_A306_D1.2390.30
104_Y302_D1.2310.30
11_L201_V1.2290.30
169_R178_S1.2270.30
212_P308_F1.2170.30
87_V234_V1.2170.30
90_L236_L1.2160.30
52_L137_T1.2090.29
122_F127_Y1.2080.29
94_K121_E1.2070.29
204_A249_V1.2030.29
208_A227_A1.1950.29
119_E223_R1.1930.29
95_A225_N1.1880.29
174_A189_F1.1830.28
11_L15_A1.1770.28
12_A47_E1.1770.28
31_T150_S1.1760.28
24_I52_L1.1700.28
20_E161_E1.1690.28
171_A215_G1.1620.28
268_D273_D1.1570.28
134_A163_V1.1500.27
63_V78_V1.1480.27
144_P209_P1.1450.27
12_A107_L1.1440.27
183_T252_A1.1420.27
40_V60_L1.1410.27
62_T152_V1.1390.27
33_T153_A1.1170.26
250_S259_P1.1130.26
251_S299_V1.1080.26
189_F278_V1.1070.26
59_G90_L1.1040.26
58_A61_A1.1040.26
112_A286_V1.1000.26
86_A198_P1.0950.25
28_E66_R1.0930.25
223_R231_G1.0910.25
19_T114_A1.0870.25
229_A292_P1.0820.25
9_L13_D1.0810.25
98_E104_Y1.0760.25
114_A129_D1.0730.25
59_G127_Y1.0720.25
167_T184_V1.0710.25
144_P175_G1.0710.25
118_T156_A1.0600.24
170_T224_T1.0530.24
124_A137_T1.0450.24
102_D156_A1.0450.24
50_L65_T1.0430.24
178_S225_N1.0430.24
240_E289_V1.0430.24
119_E227_A1.0410.24
52_L168_Y1.0380.24
88_A230_H1.0350.24
187_A202_L1.0240.23
158_V283_Q1.0200.23
280_G308_F1.0170.23
83_D128_V1.0150.23
4_L194_L1.0090.23
211_A284_L1.0090.23
184_V204_A1.0090.23
49_G95_A1.0060.23
121_E125_I0.9880.22
167_T171_A0.9870.22
31_T160_E0.9810.22
106_A292_P0.9780.22
14_E18_F0.9770.22
99_L286_V0.9760.22
116_V274_V0.9750.22
12_A16_L0.9750.22
178_S190_R0.9730.22
13_D36_I0.9730.22
131_F165_L0.9700.22
258_D266_T0.9700.22
3_S114_A0.9690.22
224_T264_V0.9680.22
169_R255_R0.9670.22
220_A291_G0.9670.22
167_T229_A0.9620.21
173_V177_V0.9590.21
148_A163_V0.9560.21
108_G224_T0.9540.21
168_Y229_A0.9520.21
230_H251_S0.9520.21
125_I184_V0.9510.21
181_A292_P0.9470.21
107_L186_L0.9380.21
45_G65_T0.9300.20
191_L306_D0.9300.20
141_T168_Y0.9260.20
40_V168_Y0.9250.20
253_A296_F0.9240.20
136_L248_V0.9230.20
94_K137_T0.9160.20
274_V290_G0.9140.20
250_S281_P0.9100.20
86_A94_K0.9070.20
154_A303_V0.9060.20
140_S168_Y0.9010.20
224_T279_F0.9000.20
215_G300_R0.8970.20
158_V212_P0.8950.19
29_L33_T0.8920.19
222_G256_Y0.8900.19
13_D45_G0.8870.19
45_G147_A0.8860.19
175_G209_P0.8850.19
91_G162_S0.8830.19
190_R280_G0.8790.19
89_M275_D0.8740.19
191_L308_F0.8700.19
141_T284_L0.8680.19
168_Y186_L0.8670.19
180_A211_A0.8670.19
11_L192_Y0.8630.19
89_M178_S0.8630.19
166_P290_G0.8600.19
200_D238_V0.8560.18
36_I132_E0.8560.18
8_A243_D0.8540.18
181_A304_L0.8540.18
100_A261_A0.8530.18
10_E13_D0.8530.18
95_A109_S0.8510.18
24_I239_A0.8510.18
8_A220_A0.8460.18
140_S176_S0.8430.18
247_A302_D0.8420.18
137_T192_Y0.8370.18
99_L160_E0.8330.18
100_A131_F0.8330.18
115_L134_A0.8320.18
139_E281_P0.8310.18
256_Y273_D0.8290.18
156_A269_W0.8280.18
242_F290_G0.8240.18
171_A202_L0.8230.18
236_L278_V0.8230.18
246_D302_D0.8220.18
16_L36_I0.8170.17
16_L126_D0.8130.17
20_E31_T0.8090.17
94_K174_A0.8050.17
22_L47_E0.8050.17
112_A134_A0.8040.17
173_V263_V0.8020.17
152_V165_L0.8020.17
172_S175_G0.7990.17
10_E22_L0.7940.17
50_L54_E0.7920.17
17_E280_G0.7910.17
57_T116_V0.7900.17
35_V78_V0.7880.17
78_V200_D0.7870.17
4_L127_Y0.7870.17
107_L168_Y0.7870.17
158_V285_T0.7860.17
40_V229_A0.7860.17
146_T265_G0.7840.17
45_G273_D0.7840.17
81_A246_D0.7820.17
56_Q106_A0.7820.17
45_G153_A0.7800.17
130_A146_T0.7780.17
183_T248_V0.7780.17
137_T189_F0.7770.16
143_L167_T0.7750.16
132_E266_T0.7740.16
193_E267_D0.7730.16
184_V228_L0.7720.16
43_D128_V0.7720.16
87_V211_A0.7690.16
198_P229_A0.7670.16
99_L186_L0.7660.16
35_V142_G0.7630.16
267_D280_G0.7620.16
178_S249_V0.7590.16
101_V230_H0.7540.16
53_A201_V0.7540.16
20_E42_H0.7490.16
52_L58_A0.7480.16
192_Y278_V0.7470.16
202_L288_V0.7470.16
16_L161_E0.7460.16
92_A160_E0.7410.16
11_L181_A0.7400.16
183_T232_G0.7390.16
9_L265_G0.7370.16
298_T301_E0.7360.16
19_T26_A0.7360.16
36_I299_V0.7320.15
267_D278_V0.7270.15
252_A286_V0.7250.15
27_F35_V0.7240.15
82_C184_V0.7230.15
54_E203_S0.7230.15
204_A254_A0.7220.15
214_A303_V0.7220.15
248_V286_V0.7220.15
102_D307_G0.7210.15
146_T230_H0.7210.15
56_Q178_S0.7170.15
175_G279_F0.7160.15
83_D203_S0.7120.15
152_V163_V0.7100.15
106_A296_F0.7080.15
125_I177_V0.7070.15
280_G287_D0.7060.15
46_L91_G0.7060.15
166_P174_A0.7040.15
5_N20_E0.7020.15
219_T302_D0.7000.15
91_G245_F0.6980.15
215_G219_T0.6980.15
80_V89_M0.6960.15
59_G220_A0.6950.15
112_A165_L0.6950.15
88_A132_E0.6950.15
16_L47_E0.6930.15
99_L138_L0.6910.15
10_E52_L0.6910.15
17_E262_E0.6910.15
119_E187_A0.6900.15
216_D219_T0.6860.14
165_L294_H0.6860.14
245_F286_V0.6850.14
4_L117_A0.6840.14
134_A146_T0.6830.14
254_A290_G0.6820.14
265_G269_W0.6810.14
29_L35_V0.6810.14
210_V248_V0.6810.14
152_V302_D0.6810.14
15_A168_Y0.6790.14
109_S144_P0.6750.14
150_S156_A0.6730.14
46_L237_T0.6720.14
33_T157_G0.6710.14
187_A207_C0.6710.14
112_A129_D0.6700.14
231_G305_A0.6690.14
151_E155_R0.6690.14
35_V41_E0.6660.14
141_T265_G0.6640.14
34_T240_E0.6610.14
17_E23_D0.6610.14
85_P93_Q0.6580.14
227_A231_G0.6580.14
157_G290_G0.6580.14
119_E231_G0.6570.14
33_T91_G0.6560.14
23_D125_I0.6540.14
277_G280_G0.6530.14
120_G231_G0.6490.14
195_G237_T0.6470.14
107_L235_H0.6460.14
129_D186_L0.6440.14
158_V193_E0.6430.14
57_T117_A0.6410.13
58_A294_H0.6370.13
230_H263_V0.6360.13
118_T141_T0.6350.13
149_A163_V0.6330.13
158_V308_F0.6310.13
179_A190_R0.6300.13
33_T87_V0.6260.13
224_T278_V0.6230.13
26_A135_V0.6220.13
83_D248_V0.6210.13
236_L240_E0.6160.13
43_D146_T0.6140.13
23_D200_D0.6140.13
67_V79_E0.6120.13
15_A298_T0.6100.13
156_A288_V0.6100.13
42_H84_Q0.6060.13
190_R249_V0.6060.13
48_A113_R0.6050.13
24_I68_D0.6040.13
70_V245_F0.6030.13
165_L198_P0.6020.13
220_A223_R0.6010.13
142_G258_D0.5970.13
123_Q162_S0.5960.13
15_A24_I0.5950.13
92_A249_V0.5940.13
202_L296_F0.5940.13
22_L211_A0.5890.12
16_L26_A0.5880.12
115_L232_G0.5850.12
56_Q224_T0.5820.12
248_V293_T0.5800.12
121_E189_F0.5790.12
15_A115_L0.5770.12
105_E190_R0.5750.12
158_V208_A0.5750.12
93_Q144_P0.5750.12
114_A299_V0.5710.12
81_A84_Q0.5660.12
184_V294_H0.5660.12
45_G308_F0.5640.12
16_L21_E0.5640.12
46_L78_V0.5610.12
165_L229_A0.5600.12
95_A190_R0.5590.12
86_A189_F0.5580.12
231_G241_D0.5580.12
257_D278_V0.5570.12
8_A100_A0.5570.12
28_E34_T0.5560.12
106_A168_Y0.5550.12
47_E81_A0.5550.12
109_S190_R0.5540.12
33_T120_G0.5540.12
95_A260_F0.5520.12
46_L50_L0.5520.12
58_A243_D0.5510.12
23_D134_A0.5510.12
99_L107_L0.5500.12
138_L249_V0.5490.12
89_M189_F0.5480.12
181_A300_R0.5460.12
116_V210_V0.5440.12
181_A231_G0.5430.12
20_E210_V0.5430.12
211_A292_P0.5420.12
23_D158_V0.5360.12
178_S222_G0.5350.11
254_A287_D0.5340.11
24_I103_D0.5300.11
107_L119_E0.5290.11
177_V274_V0.5290.11
103_D148_A0.5270.11
47_E197_D0.5270.11
124_A275_D0.5240.11
112_A264_V0.5230.11
108_G170_T0.5230.11
89_M280_G0.5220.11
220_A283_Q0.5210.11
123_Q247_A0.5200.11
16_L84_Q0.5180.11
213_V245_F0.5180.11
229_A269_W0.5170.11
174_A261_A0.5170.11
121_E228_L0.5160.11
53_A306_D0.5160.11
74_T198_P0.5150.11
17_E84_Q0.5130.11
38_F99_L0.5130.11
204_A298_T0.5130.11
85_P144_P0.5130.11
184_V203_S0.5130.11
34_T76_P0.5120.11
142_G230_H0.5110.11
171_A217_E0.5110.11
234_V304_L0.5110.11
174_A178_S0.5110.11
180_A210_V0.5100.11
222_G226_D0.5090.11
94_K119_E0.5070.11
23_D157_G0.5070.11
107_L138_L0.5060.11
101_V217_E0.5050.11
24_I142_G0.5040.11
129_D221_I0.5030.11
4_L288_V0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qlmA 3 0.9968 100 0.022 Contact Map
4gvqA 3 1 100 0.026 Contact Map
4fioA 3 0.9968 100 0.026 Contact Map
3hwcA 4 0.4116 21.1 0.979 Contact Map
4jutA 4 0.1801 19.3 0.979 Contact Map
3l1eA 2 0.1736 17.3 0.98 Contact Map
3bg3A 4 0.8907 14.9 0.98 Contact Map
2l8nA 1 0.1511 12.4 0.981 Contact Map
3x17B 1 0.3344 12.1 0.981 Contact Map
1nt2A 2 0.5627 9.9 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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