GREMLIN Database
RL2 - 50S ribosomal protein L2
UniProt: Q9HPD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (227)
Sequences: 2553 (1012)
Seq/√Len: 67.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_G59_V3.3281.00
115_D118_K3.2381.00
37_D154_R3.2001.00
44_I60_A3.0471.00
137_T151_P2.8621.00
129_L137_T2.7721.00
17_F189_R2.7391.00
120_A127_A2.6121.00
108_N117_G2.4471.00
104_V157_I2.4471.00
106_V129_L2.4431.00
106_V139_V2.4421.00
98_A152_D2.4201.00
185_T189_R2.3701.00
73_E163_G2.3601.00
207_R210_P2.3041.00
231_S234_T2.2961.00
109_V127_A2.2491.00
22_H182_A2.2431.00
206_G210_P2.2341.00
53_S165_R2.0911.00
8_Q14_T2.0531.00
222_P226_V2.0461.00
139_V149_L2.0451.00
206_G212_R1.9791.00
170_F176_K1.9441.00
159_V163_G1.9331.00
94_T154_R1.9031.00
59_V81_I1.9021.00
75_V81_I1.9021.00
207_R212_R1.8911.00
208_Q212_R1.8701.00
76_G79_D1.8591.00
138_I146_T1.8081.00
193_V209_H1.8001.00
35_D63_D1.7661.00
18_R185_T1.7601.00
43_V75_V1.7431.00
210_P214_K1.7331.00
70_L117_G1.7141.00
210_P224_R1.6820.99
135_D150_S1.6790.99
212_R216_V1.6510.99
34_E67_R1.6430.99
100_I157_I1.6250.99
170_F183_R1.6200.99
60_A66_Q1.6190.99
57_A71_A1.6100.99
96_P99_E1.6070.99
40_A80_T1.5960.99
55_P161_A1.5630.99
202_F216_V1.5610.99
217_S221_A1.5510.99
73_E159_V1.5500.99
79_D90_E1.5420.99
110_E116_G1.5210.99
109_V139_V1.5150.99
131_T138_I1.4990.99
35_D65_D1.4850.99
72_S75_V1.4840.99
84_G87_A1.4770.99
223_G226_V1.4680.99
119_F149_L1.4600.98
38_V86_S1.4540.98
42_E60_A1.4520.98
176_K183_R1.4520.98
230_A236_R1.4490.98
15_S189_R1.4460.98
54_A160_V1.4330.98
193_V210_P1.3950.98
37_D84_G1.3940.98
132_H151_P1.3930.98
4_R18_R1.3930.98
44_I66_Q1.3910.98
221_A226_V1.3830.98
136_A150_S1.3670.98
111_S119_F1.3360.97
95_L100_I1.3240.97
37_D83_I1.3180.97
40_A62_E1.3040.97
38_V84_G1.2930.97
233_R236_R1.2850.96
73_E161_A1.2810.96
42_E80_T1.2770.96
43_V59_V1.2750.96
98_A151_P1.2640.96
87_A95_L1.2240.95
193_V208_Q1.2190.95
190_V194_A1.2060.95
105_P126_N1.1960.95
138_I148_R1.1930.95
231_S236_R1.1810.94
209_H224_R1.1770.94
113_P150_S1.1680.94
232_K236_R1.1560.94
72_S107_C1.1510.94
196_N199_D1.1320.93
17_F185_T1.1270.93
232_K235_G1.1230.93
164_G167_E1.0960.92
94_T156_T1.0830.91
202_F210_P1.0830.91
231_S235_G1.0770.91
57_A75_V1.0720.91
86_S99_E1.0660.91
119_F141_L1.0620.91
176_K185_T1.0550.90
24_Y51_A1.0530.90
111_S149_L1.0460.90
70_L160_V1.0440.90
135_D151_P1.0420.90
112_H115_D1.0400.90
100_I155_A1.0380.89
13_G17_F1.0240.89
18_R189_R1.0170.89
132_H137_T1.0120.88
45_D77_V1.0040.88
45_D57_A1.0020.88
42_E62_E0.9980.88
16_T195_M0.9970.88
189_R202_F0.9920.87
5_I18_R0.9900.87
29_S56_V0.9870.87
202_F223_G0.9860.87
214_K224_R0.9810.87
193_V214_K0.9600.85
100_I129_L0.9590.85
175_N183_R0.9480.85
217_S224_R0.9440.84
70_L108_N0.9310.84
58_R68_L0.9250.83
15_S18_R0.8980.81
170_F175_N0.8970.81
230_A233_R0.8940.81
53_S71_A0.8910.81
17_F190_V0.8880.81
45_D58_R0.8850.80
168_K175_N0.8730.80
39_L62_E0.8700.79
221_A224_R0.8690.79
9_R14_T0.8600.79
86_S95_L0.8410.77
39_L65_D0.8380.77
46_V55_P0.8330.76
217_S223_G0.8330.76
216_V222_P0.8290.76
225_K228_D0.8240.75
85_I99_E0.8230.75
83_I94_T0.8200.75
193_V212_R0.8180.75
40_A82_E0.8060.74
107_C156_T0.7970.73
192_G202_F0.7930.73
209_H214_K0.7920.73
82_E88_T0.7890.72
218_R230_A0.7880.72
191_R194_A0.7820.72
35_D39_L0.7800.71
21_S24_Y0.7760.71
109_V120_A0.7760.71
44_I59_V0.7730.71
206_G209_H0.7680.70
27_E30_H0.7650.70
41_G61_F0.7650.70
197_A206_G0.7630.70
69_V72_S0.7620.70
75_V107_C0.7560.69
46_V56_V0.7550.69
128_D140_E0.7480.68
198_V224_R0.7480.68
108_N156_T0.7470.68
45_D161_A0.7470.68
19_A24_Y0.7450.68
49_D52_R0.7420.68
8_Q12_R0.7420.68
7_G13_G0.7410.67
59_V67_R0.7390.67
193_V216_V0.7370.67
45_D66_Q0.7360.67
85_I98_A0.7350.67
129_L151_P0.7340.67
217_S222_P0.7280.66
210_P223_G0.7190.65
220_A224_R0.7190.65
209_H212_R0.7180.65
74_G144_G0.7130.64
202_F209_H0.7130.64
17_F195_M0.7120.64
50_P121_R0.7120.64
9_R13_G0.7120.64
110_E114_G0.7120.64
29_S45_D0.7110.64
47_E68_L0.7090.64
8_Q13_G0.7080.64
46_V57_A0.7070.64
202_F224_R0.7000.63
120_A139_V0.7000.63
17_F186_K0.7000.63
45_D55_P0.6990.63
120_A142_P0.6970.63
84_G154_R0.6950.63
26_A51_A0.6940.62
75_V91_E0.6930.62
216_V223_G0.6900.62
195_M199_D0.6870.62
3_R18_R0.6860.62
41_G81_I0.6770.60
102_E227_G0.6740.60
107_C160_V0.6730.60
33_T107_C0.6720.60
89_I95_L0.6690.60
212_R224_R0.6670.59
120_A125_V0.6670.59
39_L61_F0.6650.59
41_G67_R0.6630.59
230_A234_T0.6620.59
205_G209_H0.6610.59
106_V127_A0.6600.59
9_R12_R0.6570.58
198_V214_K0.6570.58
102_E132_H0.6540.58
38_V82_E0.6520.58
129_L132_H0.6510.58
89_I157_I0.6510.58
202_F217_S0.6500.57
97_L139_V0.6490.57
62_E80_T0.6490.57
55_P142_P0.6490.57
73_E167_E0.6470.57
13_G16_T0.6470.57
208_Q224_R0.6430.57
214_K223_G0.6430.57
83_I154_R0.6420.56
64_D116_G0.6400.56
126_N159_V0.6380.56
59_V161_A0.6280.55
197_A216_V0.6250.54
102_E131_T0.6250.54
69_V107_C0.6230.54
35_D61_F0.6220.54
14_T17_F0.6210.54
55_P73_E0.6180.54
97_L149_L0.6130.53
208_Q214_K0.6120.53
9_R15_S0.6110.53
71_A161_A0.6100.53
10_R13_G0.6070.52
85_I95_L0.6070.52
85_I96_P0.6060.52
193_V207_R0.6060.52
127_A139_V0.6050.52
105_P159_V0.6040.52
202_F215_S0.6000.52
98_A137_T0.5980.51
163_G166_T0.5980.51
88_T166_T0.5970.51
122_A125_V0.5960.51
30_H33_T0.5900.50
29_S134_R0.5890.50
171_V175_N0.5880.50
106_V109_V0.5860.50
105_P128_D0.5860.50
131_T134_R0.5820.49
87_A99_E0.5820.49
193_V205_G0.5800.49
226_V231_S0.5790.49
88_T154_R0.5780.49
84_G95_L0.5770.49
131_T142_P0.5750.49
161_A166_T0.5740.48
10_R14_T0.5730.48
47_E56_V0.5710.48
17_F218_R0.5710.48
15_S190_V0.5700.48
53_S168_K0.5700.48
33_T94_T0.5690.48
111_S153_C0.5680.48
27_E50_P0.5660.47
58_R66_Q0.5650.47
46_V66_Q0.5650.47
77_V130_V0.5640.47
177_H186_K0.5620.47
189_R218_R0.5620.47
206_G211_G0.5610.47
55_P164_G0.5610.47
111_S139_V0.5590.47
170_F194_A0.5560.46
20_P23_R0.5560.46
123_G165_R0.5550.46
13_G20_P0.5530.46
218_R223_G0.5520.46
53_S161_A0.5510.46
16_T20_P0.5490.45
15_S55_P0.5480.45
85_I154_R0.5470.45
34_E65_D0.5470.45
45_D142_P0.5450.45
96_P152_D0.5440.45
198_V210_P0.5440.45
13_G189_R0.5430.45
104_V128_D0.5410.45
126_N163_G0.5400.44
123_G171_V0.5390.44
39_L82_E0.5360.44
7_G20_P0.5350.44
110_E153_C0.5340.44
4_R24_Y0.5330.44
35_D67_R0.5320.43
70_L107_C0.5300.43
5_I15_S0.5280.43
55_P168_K0.5280.43
133_E144_G0.5260.43
38_V85_I0.5250.43
45_D56_V0.5250.43
194_A216_V0.5250.43
13_G190_V0.5240.43
4_R15_S0.5230.42
137_T149_L0.5220.42
26_A29_S0.5220.42
193_V224_R0.5200.42
175_N182_A0.5190.42
97_L129_L0.5180.42
226_V234_T0.5180.42
136_A148_R0.5160.42
142_P167_E0.5130.41
97_L105_P0.5120.41
62_E67_R0.5110.41
8_Q21_S0.5110.41
45_D59_V0.5100.41
18_R21_S0.5080.41
4_R102_E0.5070.41
193_V206_G0.5040.40
194_A205_G0.5030.40
225_K229_I0.5030.40
127_A141_L0.5020.40
119_F127_A0.5020.40
14_T113_P0.5020.40
205_G208_Q0.5010.40
165_R168_K0.5000.40
38_V61_F0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j3wC 1 0.975 100 0.046 Contact Map
4tp9C 1 0.0083 100 0.053 Contact Map
4rb6D 1 0.9708 100 0.057 Contact Map
3bboE 1 0.975 100 0.062 Contact Map
1vw3B 1 0.9708 100 0.063 Contact Map
3j21B 1 0.9792 100 0.083 Contact Map
1vq8A 1 0.9708 100 0.089 Contact Map
4ujqD 1 0.9875 100 0.12 Contact Map
3zf7e 1 0.7333 100 0.122 Contact Map
1vx7D 1 0.9833 100 0.122 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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