GREMLIN Database
RS4E - 30S ribosomal protein S4e
UniProt: Q9HPC2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (223)
Sequences: 454 (297)
Seq/√Len: 19.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_V206_V4.6331.00
68_N117_K4.1671.00
86_A93_Y4.0111.00
42_V106_L3.8561.00
134_L164_I3.4421.00
60_I65_V3.4401.00
65_V87_F3.4381.00
66_L88_P3.3991.00
119_N157_V3.2671.00
116_S156_V2.9400.99
121_V149_Y2.9160.99
96_V106_L2.7270.98
152_G217_A2.6820.98
28_G74_D2.6300.98
92_E108_E2.5550.98
123_D135_N2.4550.97
63_D73_G2.4420.97
176_V190_I2.2660.95
64_G89_D2.2170.94
91_D175_L2.1660.94
54_S58_Y2.0210.91
140_S162_N1.9200.89
166_A225_E1.9020.88
9_S26_K1.8820.88
57_Q75_V1.8510.87
158_D161_T1.8490.87
117_K140_S1.7430.83
174_A222_V1.7220.83
5_Q27_A1.7040.82
23_F58_Y1.6750.81
97_F107_T1.6650.80
52_D60_I1.6420.79
29_A139_G1.5960.77
49_Y92_E1.5620.76
31_P78_P1.4900.72
68_N160_D1.4820.72
68_N138_D1.4570.71
50_V59_A1.4560.71
26_K29_A1.4440.70
82_F140_S1.3920.67
68_N82_F1.3920.67
174_A226_N1.3840.67
44_R68_N1.3740.66
115_G160_D1.3730.66
194_N203_T1.3690.66
117_K138_D1.3560.65
164_I167_H1.3470.64
180_A221_V1.3450.64
216_I219_Y1.3120.62
130_G133_Q1.3110.62
5_Q14_W1.2990.61
199_S206_V1.2930.61
153_D167_H1.2850.61
168_F222_V1.2830.60
79_I96_V1.2820.60
187_I223_I1.2790.60
53_T128_S1.2730.60
196_Q216_I1.2720.60
68_N140_S1.2550.59
8_L129_G1.2510.58
71_S206_V1.2400.58
5_Q23_F1.2280.57
5_Q9_S1.2250.57
121_V143_A1.2040.55
158_D165_V1.2040.55
60_I75_V1.1990.55
55_E80_G1.1860.54
79_I87_F1.1750.54
93_Y114_A1.1750.54
5_Q10_V1.1590.53
23_F126_T1.1490.52
58_Y126_T1.1480.52
56_A60_I1.1470.52
20_T57_Q1.1370.51
186_D208_D1.1280.51
215_T219_Y1.1230.50
112_D128_S1.1190.50
54_S125_T1.1110.49
52_D182_Q1.1070.49
204_V215_T1.1070.49
99_D102_G1.1040.49
25_A40_V1.1040.49
169_Q173_G1.1030.49
194_N205_R1.0920.48
159_T203_T1.0910.48
15_P46_V1.0880.48
131_R211_G1.0840.48
66_L71_S1.0840.48
57_Q119_N1.0820.48
132_T178_A1.0800.47
135_N141_N1.0730.47
49_Y145_D1.0720.47
81_M154_S1.0670.47
125_T135_N1.0620.46
174_A184_A1.0610.46
176_V184_A1.0600.46
23_F120_K1.0590.46
91_D195_V1.0530.46
41_V56_A1.0480.45
174_A190_I1.0440.45
94_Y142_L1.0430.45
125_T133_Q1.0390.45
82_F117_K1.0300.44
159_T165_V1.0260.44
133_Q139_G1.0250.44
174_A205_R1.0150.43
3_N18_R0.9970.42
147_D186_D0.9920.42
165_V168_F0.9890.42
11_P14_W0.9890.42
144_L147_D0.9840.41
109_I113_A0.9810.41
120_K187_I0.9760.41
8_L178_A0.9730.41
128_S189_E0.9710.41
158_D163_E0.9660.40
184_A211_G0.9650.40
30_G121_V0.9610.40
23_F225_E0.9610.40
173_G204_V0.9580.40
155_V159_T0.9500.39
20_T128_S0.9490.39
121_V158_D0.9470.39
39_L78_P0.9430.39
114_A156_V0.9360.38
69_G159_T0.9340.38
43_L65_V0.9330.38
40_V53_T0.9310.38
115_G174_A0.9300.38
39_L79_I0.9250.38
53_T76_N0.9240.38
156_V219_Y0.9220.38
20_T36_G0.9120.37
210_N220_V0.9120.37
58_Y87_F0.9070.37
83_D95_R0.8990.36
23_F42_V0.8940.36
49_Y90_R0.8930.36
24_T78_P0.8870.35
22_T29_A0.8860.35
171_E206_V0.8820.35
6_K198_G0.8820.35
26_K178_A0.8800.35
206_V220_V0.8730.35
204_V220_V0.8700.34
196_Q200_A0.8690.34
181_G185_G0.8690.34
103_R118_L0.8680.34
117_K160_D0.8660.34
32_H68_N0.8650.34
128_S160_D0.8620.34
133_Q149_Y0.8620.34
208_D213_F0.8600.34
95_R143_A0.8590.34
30_G188_G0.8530.33
139_G176_V0.8530.33
102_G213_F0.8460.33
176_V189_E0.8410.33
92_E107_T0.8370.33
85_L92_E0.8350.32
7_R95_R0.8320.32
89_D115_G0.8280.32
139_G157_V0.8200.32
99_D213_F0.8200.32
85_L115_G0.8190.32
20_T41_V0.8190.32
45_D68_N0.8150.31
90_R128_S0.8080.31
66_L220_V0.8040.31
60_I133_Q0.8020.31
93_Y168_F0.8010.31
5_Q16_V0.8000.30
102_G198_G0.7950.30
23_F202_N0.7940.30
10_V155_V0.7880.30
37_V103_R0.7860.30
165_V193_I0.7750.29
118_L154_S0.7730.29
114_A178_A0.7680.29
23_F190_I0.7650.29
43_L60_I0.7650.29
74_D160_D0.7620.28
125_T128_S0.7610.28
7_R14_W0.7610.28
186_D198_G0.7600.28
195_V202_N0.7600.28
4_H8_L0.7590.28
3_N14_W0.7590.28
124_K133_Q0.7590.28
29_A77_R0.7570.28
16_V50_V0.7570.28
99_D118_L0.7560.28
85_L97_F0.7530.28
134_L155_V0.7520.28
119_N155_V0.7520.28
49_Y94_Y0.7430.27
18_R137_H0.7400.27
6_K153_D0.7370.27
114_A128_S0.7360.27
86_A159_T0.7310.27
191_A212_G0.7240.26
156_V184_A0.7200.26
61_N160_D0.7190.26
12_K152_G0.7180.26
183_H195_V0.7160.26
15_P34_E0.7160.26
90_R147_D0.7160.26
7_R30_G0.7160.26
4_H9_S0.7150.26
134_L174_A0.7140.26
63_D95_R0.7100.26
15_P26_K0.7100.26
183_H202_N0.7100.26
177_T196_Q0.7080.26
43_L76_N0.7080.26
3_N25_A0.7020.25
28_G150_A0.7010.25
157_V189_E0.7010.25
61_N76_N0.6990.25
27_A36_G0.6970.25
85_L123_D0.6940.25
48_E65_V0.6920.25
23_F184_A0.6890.25
147_D208_D0.6890.25
39_L149_Y0.6860.25
178_A213_F0.6830.24
24_T81_M0.6830.24
136_F144_L0.6800.24
82_F137_H0.6760.24
68_N72_V0.6720.24
189_E218_E0.6710.24
95_R140_S0.6700.24
58_Y211_G0.6690.24
72_V85_L0.6630.24
91_D111_A0.6630.24
11_P31_P0.6630.24
9_S130_G0.6620.23
41_V204_V0.6620.23
26_K202_N0.6560.23
30_G153_D0.6560.23
23_F156_V0.6560.23
96_V175_L0.6550.23
77_R87_F0.6540.23
67_V121_V0.6530.23
157_V162_N0.6530.23
29_A184_A0.6520.23
120_K182_Q0.6490.23
82_F120_K0.6470.23
37_V51_D0.6370.22
30_G138_D0.6360.22
191_A207_D0.6360.22
117_K137_H0.6350.22
106_L146_E0.6330.22
156_V165_V0.6310.22
176_V199_S0.6270.22
120_K223_I0.6240.22
126_T204_V0.6220.22
174_A225_E0.6170.21
6_K102_G0.6170.21
69_G142_L0.6160.21
28_G217_A0.6150.21
96_V115_G0.6130.21
183_H186_D0.6130.21
39_L215_T0.6020.21
103_R143_A0.6020.21
85_L112_D0.6010.21
35_S161_T0.5960.21
123_D141_N0.5950.20
46_V87_F0.5920.20
60_I129_G0.5920.20
166_A220_V0.5900.20
132_T144_L0.5860.20
48_E142_L0.5850.20
8_L57_Q0.5850.20
36_G96_V0.5810.20
21_E24_T0.5790.20
13_S82_F0.5790.20
82_F221_V0.5790.20
176_V197_P0.5760.20
18_R46_V0.5750.20
6_K14_W0.5750.20
23_F68_N0.5730.20
136_F149_Y0.5730.20
144_L149_Y0.5730.20
57_Q151_G0.5710.20
85_L176_V0.5700.19
132_T147_D0.5670.19
13_S170_Y0.5650.19
23_F197_P0.5640.19
122_T205_R0.5630.19
80_G83_D0.5620.19
21_E72_V0.5610.19
124_K160_D0.5610.19
34_E74_D0.5570.19
74_D215_T0.5560.19
29_A41_V0.5560.19
118_L221_V0.5530.19
30_G80_G0.5530.19
118_L158_D0.5510.19
155_V225_E0.5490.19
53_T93_Y0.5470.19
135_N151_G0.5460.19
112_D165_V0.5440.18
78_P188_G0.5420.18
188_G206_V0.5410.18
6_K13_S0.5330.18
13_S219_Y0.5290.18
70_D140_S0.5280.18
156_V223_I0.5280.18
67_V168_F0.5270.18
29_A137_H0.5250.18
67_V79_I0.5240.18
119_N176_V0.5230.18
25_A76_N0.5230.18
42_V61_N0.5230.18
171_E225_E0.5210.18
91_D130_G0.5200.18
7_R153_D0.5180.17
129_G134_L0.5170.17
117_K173_G0.5170.17
44_R82_F0.5130.17
9_S74_D0.5130.17
218_E225_E0.5120.17
102_G202_N0.5120.17
56_A140_S0.5120.17
54_S68_N0.5090.17
49_Y70_D0.5080.17
106_L211_G0.5070.17
82_F168_F0.5050.17
50_V68_N0.5030.17
67_V140_S0.5030.17
57_Q149_Y0.5020.17
169_Q179_V0.5010.17
184_A191_A0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zey1 1 0.9657 100 0.051 Contact Map
4ujpF 1 0.9957 100 0.059 Contact Map
3j60E 1 0.8155 100 0.06 Contact Map
3j7aF 1 0.9957 100 0.061 Contact Map
4bpeW 1 0.9957 100 0.064 Contact Map
3j20E 1 1 100 0.205 Contact Map
3kbgA 2 0.8197 100 0.395 Contact Map
2cqjA 1 0.2961 96.5 0.928 Contact Map
1p9kA 1 0.3305 95.7 0.932 Contact Map
1jilA 2 0.0987 90.4 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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