GREMLIN Database
RS8 - 30S ribosomal protein S8
UniProt: Q9HPB9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 130 (127)
Sequences: 2873 (1326)
Seq/√Len: 117.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_H119_A3.7911.00
42_Y49_G3.5181.00
12_S15_D3.1851.00
39_E43_D2.7391.00
36_S39_E2.7361.00
26_T62_E2.6641.00
115_E119_A2.6381.00
43_D115_E2.5931.00
10_A38_L2.5181.00
77_P130_Y2.3931.00
113_H117_R2.2301.00
18_E73_G2.2171.00
7_L37_V2.1851.00
11_L127_A2.0451.00
53_V62_E1.9991.00
9_D13_G1.9741.00
38_L63_V1.8941.00
35_G52_F1.8661.00
47_I50_F1.8131.00
6_P34_V1.7981.00
24_T62_E1.7981.00
26_T60_R1.7711.00
17_A25_H1.6531.00
10_A27_V1.6121.00
54_D59_G1.5931.00
94_L113_H1.5281.00
42_Y47_I1.5201.00
33_M126_I1.4991.00
115_E118_E1.4411.00
102_L128_Y1.4351.00
30_A35_G1.4261.00
40_V110_I1.4241.00
41_F129_V1.4241.00
5_D80_S1.3961.00
39_E50_F1.3401.00
31_S34_V1.3251.00
79_Y128_Y1.3181.00
51_E62_E1.3151.00
37_V110_I1.3071.00
7_L33_M1.2911.00
27_V61_F1.2911.00
90_E94_L1.2730.99
68_A72_C1.2380.99
68_A73_G1.2060.99
24_T64_E1.1780.99
30_A52_F1.1430.99
35_G61_F1.1340.99
21_G71_E1.1310.99
57_K60_R1.0830.98
30_A59_G1.0810.98
86_F128_Y1.0780.98
108_H121_I1.0780.98
51_E64_E1.0690.98
35_G39_E1.0680.98
55_N59_G1.0680.98
77_P128_Y1.0670.98
54_D57_K1.0650.98
10_A34_V1.0620.98
90_E104_V1.0550.98
95_P128_Y1.0420.98
42_Y50_F1.0360.98
39_E42_Y1.0230.98
95_P102_L1.0070.97
18_E130_Y1.0060.97
94_L125_V0.9930.97
52_F59_G0.9930.97
27_V63_V0.9920.97
29_P34_V0.9860.97
46_Y101_S0.9840.97
33_M110_I0.9800.97
94_L104_V0.9690.97
103_V127_A0.9320.96
6_P31_S0.9250.96
96_A113_H0.9160.95
80_S87_E0.8930.95
48_D64_E0.8920.95
35_G59_G0.8730.94
17_A20_V0.8700.94
87_E124_Q0.8580.93
18_E68_A0.8560.93
26_T53_V0.8550.93
105_T124_Q0.8530.93
81_V88_Q0.8440.93
111_M119_A0.8440.93
7_L130_Y0.8380.93
53_V60_R0.8380.93
10_A37_V0.8210.92
55_N58_A0.7990.91
102_L113_H0.7930.90
21_G73_G0.7920.90
98_D113_H0.7890.90
55_N60_R0.7860.90
111_M115_E0.7860.90
125_V128_Y0.7840.90
54_D58_A0.7790.90
45_G66_K0.7780.90
90_E93_Y0.7700.89
49_G64_E0.7680.89
11_L15_D0.7630.89
86_F90_E0.7620.89
32_N35_G0.7620.89
108_H111_M0.7620.89
53_V57_K0.7550.88
90_E125_V0.7370.87
82_G89_W0.7340.87
111_M121_I0.7300.86
8_S34_V0.7230.86
18_E78_R0.7210.86
13_G17_A0.7120.85
85_G89_W0.7120.85
44_R115_E0.7060.85
67_G73_G0.6970.84
4_N8_S0.6970.84
82_G124_Q0.6860.83
110_I126_I0.6810.82
43_D111_M0.6800.82
35_G42_Y0.6700.81
24_T48_D0.6630.81
68_A71_E0.6610.80
41_F103_V0.6570.80
92_R107_S0.6490.79
90_E130_Y0.6480.79
24_T51_E0.6440.79
106_T111_M0.6440.79
32_N59_G0.6430.79
14_I78_R0.6390.78
14_I63_V0.6350.78
72_C76_N0.6330.78
82_G87_E0.6320.77
23_L48_D0.6310.77
44_R112_S0.6290.77
40_V101_S0.6280.77
56_G59_G0.6240.77
40_V127_A0.6230.76
37_V127_A0.6210.76
35_G50_F0.6170.76
68_A76_N0.6160.76
111_M116_A0.6140.75
38_L61_F0.6130.75
46_Y99_Y0.6120.75
66_K75_V0.6120.75
81_V128_Y0.6120.75
101_S129_V0.6070.75
85_G124_Q0.6060.74
8_S12_S0.6050.74
96_A117_R0.5970.73
86_F114_Y0.5920.73
43_D118_E0.5900.72
77_P86_F0.5840.72
27_V34_V0.5830.72
82_G85_G0.5810.71
91_K107_S0.5770.71
37_V103_V0.5770.71
40_V103_V0.5750.71
13_G22_H0.5750.71
23_L68_A0.5710.70
90_E102_L0.5670.69
36_S51_E0.5660.69
48_D62_E0.5630.69
14_I75_V0.5620.69
41_F101_S0.5610.69
23_L118_E0.5610.69
38_L52_F0.5580.68
106_T109_G0.5580.68
33_M38_L0.5540.68
22_H68_A0.5500.67
105_T110_I0.5480.67
104_V125_V0.5440.66
10_A63_V0.5420.66
91_K121_I0.5390.66
83_A124_Q0.5370.65
50_F63_V0.5350.65
52_F61_F0.5340.65
107_S121_I0.5310.64
101_S126_I0.5290.64
2_T127_A0.5270.64
4_N34_V0.5230.63
40_V112_S0.5220.63
41_F87_E0.5220.63
18_E74_P0.5210.63
22_H25_H0.5200.63
77_P127_A0.5190.63
43_D56_G0.5170.62
4_N13_G0.5150.62
2_T120_G0.5110.62
102_L125_V0.5110.62
95_P100_G0.5070.61
84_D124_Q0.5070.61
45_G49_G0.5020.60
20_V38_L0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pdbA 1 0.9692 100 0.078 Contact Map
4rb5H 1 0.9769 100 0.097 Contact Map
3rf2A 1 0.9692 100 0.11 Contact Map
3bbnH 1 0.9846 100 0.113 Contact Map
1seiA 2 0.9769 100 0.12 Contact Map
1s03H 1 0.9538 100 0.143 Contact Map
1i6uA 1 0.9923 100 0.165 Contact Map
4bpeH 1 0.9923 100 0.174 Contact Map
4ujpX 1 0.9923 100 0.199 Contact Map
3qd7X 1 0.5077 45.9 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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