GREMLIN Database
RL6 - 50S ribosomal protein L6
UniProt: Q9HPB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (169)
Sequences: 3825 (2216)
Seq/√Len: 170.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_H79_E3.0791.00
71_A75_H2.9401.00
119_I125_V2.5671.00
24_E29_S2.5491.00
42_S51_A2.4371.00
126_V135_S2.3861.00
82_E135_S2.3541.00
102_E118_Q2.2341.00
102_E116_R2.1731.00
84_K165_D2.1371.00
13_T24_E2.0411.00
144_Q148_D2.0361.00
50_V70_V2.0291.00
109_L152_L2.0191.00
54_V59_T1.9521.00
163_F169_I1.9331.00
134_L142_V1.8851.00
35_W38_D1.8721.00
22_T29_S1.8641.00
32_R140_E1.8431.00
88_H163_F1.8281.00
117_T145_T1.7741.00
20_D31_T1.7411.00
38_D59_T1.7321.00
98_V127_V1.7291.00
136_G142_V1.7281.00
117_T152_L1.6851.00
124_D135_S1.6731.00
84_K133_T1.6561.00
84_K131_E1.6221.00
52_S63_V1.5991.00
32_R73_M1.5721.00
138_S141_D1.5651.00
20_D33_R1.5581.00
86_E166_G1.5221.00
105_I109_L1.5191.00
16_V21_L1.4921.00
40_D51_A1.4811.00
98_V119_I1.4751.00
104_V116_R1.4751.00
43_V48_V1.4681.00
7_E47_A1.4651.00
22_T31_T1.4571.00
99_E104_V1.4261.00
99_E102_E1.4091.00
101_E121_G1.3961.00
109_L162_V1.3911.00
25_G28_G1.3831.00
8_I14_A1.3821.00
131_E165_D1.3591.00
173_P176_G1.3561.00
122_D141_D1.3481.00
40_D53_E1.3431.00
128_D133_T1.3401.00
8_I43_V1.3191.00
32_R69_H1.3001.00
115_R152_L1.2971.00
117_T148_D1.2961.00
16_V43_V1.2901.00
65_T69_H1.2631.00
21_L70_V1.2581.00
79_E82_E1.2451.00
123_T145_T1.2051.00
27_E137_P1.1811.00
101_E118_Q1.1801.00
52_S60_D1.1801.00
125_V145_T1.1781.00
62_T66_F1.1771.00
34_L41_V1.1651.00
111_E115_R1.1561.00
87_V96_V1.1331.00
86_E165_D1.1281.00
23_V73_M1.1201.00
58_K61_S1.1191.00
7_E46_D1.1121.00
150_E155_V1.1111.00
65_T68_S1.1071.00
42_S49_V1.0991.00
151_Q154_R1.0841.00
15_E22_T1.0641.00
125_V134_L1.0591.00
105_I152_L1.0570.99
56_D59_T1.0330.99
39_V53_E1.0300.99
145_T149_I1.0290.99
140_E144_Q1.0210.99
97_D104_V1.0210.99
128_D131_E1.0190.99
27_E135_S1.0170.99
126_V133_T1.0150.99
104_V114_A1.0150.99
103_V125_V1.0120.99
96_V105_I1.0080.99
67_E71_A1.0070.99
163_F171_E1.0030.99
150_E167_V1.0020.99
53_E59_T0.9970.99
82_E133_T0.9960.99
48_V70_V0.9840.99
18_H33_R0.9810.99
19_L33_R0.9710.99
86_E131_E0.9710.99
119_I145_T0.9680.99
155_V160_T0.9660.99
52_S55_D0.9640.99
17_D20_D0.9640.99
88_H169_I0.9540.99
13_T29_S0.9490.99
35_W62_T0.9380.99
98_V125_V0.9350.99
14_A48_V0.9320.99
111_E152_L0.9300.99
97_D106_Q0.9300.99
96_V132_V0.9200.99
102_E119_I0.9140.99
28_G77_V0.9130.99
106_Q114_A0.9110.98
103_V149_I0.9060.98
141_D145_T0.9030.98
38_D54_V0.8980.98
119_I134_L0.8980.98
99_E116_R0.8950.98
39_V59_T0.8920.98
117_T125_V0.8820.98
156_T169_I0.8800.98
134_L149_I0.8760.98
86_E163_F0.8740.98
25_G77_V0.8690.98
32_R66_F0.8690.98
123_T136_G0.8580.98
61_S68_S0.8560.98
157_D171_E0.8530.98
121_G141_D0.8510.98
30_V73_M0.8510.98
144_Q151_Q0.8330.97
27_E80_G0.8320.97
39_V50_V0.8180.97
101_E124_D0.8170.97
10_D46_D0.8080.97
58_K62_T0.8060.97
111_E153_T0.7990.97
27_E124_D0.7930.96
39_V62_T0.7920.96
92_F153_T0.7900.96
83_Y166_G0.7840.96
120_R141_D0.7830.96
38_D53_E0.7780.96
109_L113_A0.7780.96
122_D136_G0.7780.96
163_F166_G0.7750.96
38_D58_K0.7730.96
23_V78_S0.7620.96
150_E164_Q0.7460.95
60_D63_V0.7450.95
28_G137_P0.7420.95
35_W58_K0.7410.95
34_L70_V0.7350.95
44_E49_V0.7320.94
61_S65_T0.7280.94
30_V137_P0.7190.94
146_A164_Q0.7180.94
88_H166_G0.7160.94
63_V176_G0.7160.94
44_E47_A0.7150.94
15_E24_E0.7150.94
85_L132_V0.7140.94
8_I48_V0.7130.94
145_T148_D0.6960.93
4_V67_E0.6950.93
50_V66_F0.6920.93
12_V78_S0.6890.92
95_Q129_D0.6820.92
6_I74_F0.6810.92
35_W39_V0.6750.92
35_W66_F0.6750.92
17_D22_T0.6710.91
77_V137_P0.6700.91
87_V109_L0.6660.91
57_A61_S0.6650.91
14_A23_V0.6620.91
98_V126_V0.6470.90
5_E47_A0.6460.90
95_Q106_Q0.6450.90
41_V50_V0.6420.90
123_T134_L0.6420.90
141_D148_D0.6380.89
96_V127_V0.6340.89
11_D26_P0.6330.89
13_T43_V0.6300.89
5_E67_E0.6260.88
67_E74_F0.6260.88
156_T171_E0.6260.88
103_V132_V0.6240.88
84_K128_D0.6160.88
68_S72_N0.6120.87
55_D63_V0.6100.87
115_R162_V0.6080.87
111_E154_R0.6030.86
8_I11_D0.6010.86
164_Q167_V0.5930.86
12_V77_V0.5890.85
85_L134_L0.5850.85
159_D171_E0.5840.85
5_E49_V0.5830.85
62_T65_T0.5750.84
89_Y161_R0.5740.84
6_I71_A0.5730.84
16_V48_V0.5710.83
148_D152_L0.5700.83
145_T152_L0.5680.83
9_P12_V0.5660.83
88_H130_E0.5650.83
23_V32_R0.5650.83
83_Y164_Q0.5630.82
155_V169_I0.5610.82
142_V146_A0.5600.82
65_T176_G0.5590.82
3_R60_D0.5570.82
153_T162_V0.5570.82
19_L40_D0.5560.82
119_I123_T0.5550.82
71_A79_E0.5510.81
19_L53_E0.5450.80
55_D58_K0.5430.80
156_T173_P0.5410.80
97_D132_V0.5410.80
82_E165_D0.5400.80
85_L146_A0.5400.80
123_T141_D0.5370.79
16_V41_V0.5370.79
30_V77_V0.5360.79
68_S71_A0.5330.79
144_Q147_A0.5300.79
8_I74_F0.5290.78
148_D151_Q0.5290.78
17_D33_R0.5240.78
103_V127_V0.5220.78
83_Y168_Y0.5210.77
30_V138_S0.5210.77
6_I67_E0.5200.77
81_W142_V0.5160.77
33_R73_M0.5160.77
171_E174_A0.5160.77
63_V174_A0.5140.76
21_L43_V0.5090.76
39_V52_S0.5090.76
156_T159_D0.5090.76
26_P78_S0.5080.76
23_V30_V0.5050.75
119_I142_V0.5040.75
91_H161_R0.5030.75
55_D60_D0.5030.75
97_D100_G0.5000.74
163_F168_Y0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vq8E 1 0.9663 100 0.078 Contact Map
3j21F 1 1 100 0.092 Contact Map
3bboI 1 0.9719 100 0.105 Contact Map
1nkwE 1 0.9663 100 0.108 Contact Map
2zjrE 1 0.9494 100 0.112 Contact Map
4rb6H 1 0.9551 100 0.112 Contact Map
1rl6A 1 0.9101 100 0.117 Contact Map
4tp9G 1 0.9663 100 0.118 Contact Map
1vw4F 1 0.927 100 0.139 Contact Map
4ujqK 1 1 100 0.145 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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