GREMLIN Database
SECY - Protein translocase subunit SecY
UniProt: Q9HPB1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 491 (401)
Sequences: 3159 (1672)
Seq/√Len: 83.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
375_I437_G5.4041.00
43_L74_L5.3761.00
36_V172_M5.2031.00
415_G419_K5.1421.00
88_L111_Y4.5411.00
397_A418_E4.3031.00
31_Y35_G3.9771.00
383_I430_V3.6501.00
32_W36_V3.5261.00
152_F156_V3.4541.00
422_E426_P3.3791.00
96_L111_Y3.3681.00
99_L114_L3.0891.00
39_L168_L3.0631.00
105_P108_Q2.9881.00
135_N155_E2.9781.00
379_A437_G2.9571.00
63_R69_G2.8541.00
88_L118_L2.7741.00
335_G339_Y2.7621.00
336_L339_Y2.7531.00
120_G167_I2.7341.00
271_L283_F2.7291.00
95_N98_G2.7041.00
124_V163_A2.6031.00
168_L172_M2.5901.00
127_G163_A2.5881.00
273_H405_M2.4651.00
97_L101_T2.4591.00
375_I379_A2.4431.00
285_V425_I2.4291.00
336_L340_L2.4291.00
398_R402_N2.4091.00
24_V28_R2.4031.00
46_V73_V2.3261.00
295_M440_A2.3091.00
219_D222_V2.2891.00
395_A399_Q2.2391.00
265_V287_L2.2381.00
153_G157_L2.2301.00
88_L96_L2.1801.00
167_I170_L2.1621.00
33_T187_L2.1511.00
37_L191_A2.1511.00
37_L187_L2.1401.00
98_G102_D2.0891.00
110_I113_G2.0801.00
382_A436_V2.0671.00
40_Y192_G2.0651.00
398_R401_Q2.0421.00
258_V438_L2.0411.00
269_I424_Y2.0381.00
269_I407_I2.0091.00
221_I245_G1.9771.00
423_R427_Q1.9701.00
48_L158_I1.9571.00
124_V159_F1.9481.00
30_M34_G1.9061.00
246_I250_L1.8871.00
376_I380_I1.8861.00
434_A438_L1.8831.00
39_L172_M1.8811.00
116_K174_E1.7711.00
301_L377_G1.7271.00
29_K474_E1.7181.00
394_D418_E1.7091.00
369_I372_S1.6681.00
382_A433_G1.6491.00
56_N60_G1.6221.00
289_Y425_I1.5971.00
337_F340_L1.5901.00
263_E286_K1.5861.00
364_L368_A1.5641.00
147_M150_G1.5591.00
263_E435_L1.5551.00
152_F155_E1.5551.00
383_I426_P1.5531.00
413_N417_I1.5351.00
95_N99_L1.5200.99
124_V127_G1.5170.99
391_M396_T1.5130.99
393_P422_E1.5090.99
368_A372_S1.5070.99
122_M483_M1.5070.99
264_S465_Y1.4870.99
92_G100_D1.4800.99
121_V125_L1.4690.99
123_V163_A1.4670.99
25_P28_R1.4670.99
333_T337_F1.4570.99
218_F222_V1.4550.99
123_V166_G1.4400.99
78_I185_I1.4350.99
251_T255_I1.4340.99
312_L315_T1.4180.99
88_L114_L1.4140.99
38_V42_F1.4130.99
36_V168_L1.4130.99
181_V471_I1.3970.99
369_I373_F1.3940.99
166_G169_L1.3880.99
35_G38_V1.3860.99
170_L185_I1.3770.99
306_Q309_G1.3620.99
119_V170_L1.3350.99
416_V419_K1.3280.99
435_L458_L1.3270.99
333_T336_L1.3200.99
32_W179_W1.3190.99
334_G338_Y1.3170.99
33_T180_G1.3150.99
119_V166_G1.3090.98
154_V158_I1.3050.98
371_L441_V1.2920.98
339_Y369_I1.2920.98
92_G111_Y1.2820.98
421_M425_I1.2800.98
304_N308_L1.2790.98
218_F221_I1.2560.98
283_F479_M1.2470.98
63_R196_S1.2430.98
262_A265_V1.2380.98
292_V453_S1.2370.98
136_F139_P1.2300.98
116_K170_L1.2300.98
269_I421_M1.2290.98
139_P142_Q1.2130.97
155_E159_F1.2110.97
387_E422_E1.2070.97
396_T421_M1.2020.97
456_G460_T1.1910.97
243_Q247_L1.1880.97
379_A434_A1.1800.97
29_K287_L1.1730.97
40_Y44_T1.1690.97
255_I259_V1.1650.97
79_G83_T1.1610.97
335_G338_Y1.1560.97
20_P30_M1.1500.97
63_R66_L1.1450.96
391_M421_M1.1300.96
262_A435_L1.1150.96
292_V455_T1.1150.96
307_F311_I1.1150.96
186_G463_I1.1120.96
74_L169_L1.1070.96
147_M151_A1.1030.96
264_S469_E1.1030.96
131_V158_I1.0970.95
196_S199_G1.0910.95
219_D223_G1.0900.95
128_A159_F1.0890.95
412_K417_I1.0880.95
258_V262_A1.0850.95
467_L471_I1.0830.95
133_L137_L1.0820.95
334_G339_Y1.0790.95
15_P18_E1.0780.95
69_G72_T1.0740.95
169_L188_F1.0730.95
190_V464_T1.0730.95
27_R31_Y1.0690.95
124_V156_V1.0660.95
18_E22_G1.0650.95
16_A94_A1.0650.95
127_G159_F1.0650.95
261_Y265_V1.0630.95
154_V157_L1.0550.94
312_L316_L1.0490.94
150_G154_V1.0380.94
336_L342_P1.0340.94
23_H475_Q1.0310.94
466_K470_E1.0300.94
306_Q310_Q1.0260.93
201_L204_W1.0220.93
379_A433_G1.0170.93
302_Q441_V1.0160.93
392_G395_A1.0140.93
40_Y172_M1.0130.93
19_R479_M1.0090.93
293_L388_T1.0090.93
28_R31_Y1.0040.93
333_T342_P1.0000.93
48_L131_V0.9970.92
151_A154_V0.9960.92
220_I225_V0.9890.92
48_L71_G0.9830.92
433_G437_G0.9830.92
122_M300_A0.9820.92
156_V160_A0.9760.92
295_M454_G0.9720.92
299_R374_M0.9710.91
268_E282_R0.9590.91
84_A118_L0.9490.91
372_S376_I0.9480.90
313_N316_L0.9370.90
118_L185_I0.9350.90
290_A386_V0.9340.90
193_V292_V0.9330.90
445_M449_I0.9310.90
199_G203_F0.9300.90
254_F257_V0.9250.89
50_G154_V0.9200.89
283_F421_M0.9150.89
17_V21_E0.9090.89
333_T339_Y0.9080.88
181_V467_L0.9030.88
105_P109_A0.8960.88
472_A478_E0.8890.87
76_L166_G0.8880.87
44_T72_T0.8870.87
272_S473_E0.8840.87
40_Y72_T0.8830.87
174_E275_R0.8790.87
401_Q404_G0.8770.87
260_V435_L0.8730.86
364_L369_I0.8720.86
38_V221_I0.8690.86
133_L138_Q0.8690.86
188_F307_F0.8680.86
197_L201_L0.8670.86
242_M246_I0.8660.86
285_V428_V0.8620.86
147_M154_V0.8610.86
97_L100_D0.8590.86
136_F373_F0.8580.85
85_S455_T0.8450.85
467_L470_E0.8450.85
114_L118_L0.8420.84
20_P471_I0.8400.84
79_G386_V0.8400.84
78_I167_I0.8380.84
173_D185_I0.8380.84
292_V296_I0.8370.84
159_F163_A0.8320.84
415_G418_E0.8310.84
335_G342_P0.8270.83
203_F219_D0.8270.83
24_V478_E0.8260.83
437_G441_V0.8260.83
77_G118_L0.8240.83
309_G312_L0.8220.83
128_A162_I0.8180.83
244_A248_G0.8180.83
374_M441_V0.8180.83
406_Q412_K0.8160.83
163_A425_I0.8160.83
313_N317_A0.8130.82
410_F420_V0.8120.82
375_I441_V0.8120.82
338_Y342_P0.8120.82
400_I405_M0.8090.82
191_A194_S0.8090.82
113_G117_F0.8080.82
250_L254_F0.8070.82
248_G252_T0.8030.81
76_L396_T0.7980.81
303_A307_F0.7970.81
370_D375_I0.7940.81
45_N63_R0.7930.81
26_F181_V0.7860.80
295_M436_V0.7860.80
370_D387_E0.7830.80
262_A431_I0.7830.80
375_I434_A0.7820.80
399_Q403_S0.7790.80
291_S458_L0.7790.80
87_V122_M0.7780.79
109_A275_R0.7780.79
472_A482_M0.7760.79
335_G340_L0.7760.79
142_Q147_M0.7740.79
96_L99_L0.7700.79
191_A388_T0.7680.79
249_L253_L0.7660.78
200_G204_W0.7650.78
247_L250_L0.7640.78
221_I224_N0.7640.78
91_L485_E0.7620.78
179_W453_S0.7600.78
221_I244_A0.7590.78
132_F155_E0.7560.77
393_P397_A0.7560.77
19_R23_H0.7560.77
32_W175_V0.7560.77
187_L191_A0.7540.77
51_I54_A0.7520.77
57_D63_R0.7480.77
83_T87_V0.7480.77
189_I296_I0.7470.77
394_D415_G0.7460.77
462_S466_K0.7450.76
71_G162_I0.7440.76
248_G450_G0.7390.76
104_D107_D0.7380.76
250_L256_Y0.7370.76
95_N169_L0.7360.76
334_G340_L0.7360.76
37_L376_I0.7340.75
25_P474_E0.7340.75
262_A283_F0.7330.75
472_A483_M0.7290.75
267_V305_I0.7290.75
255_I442_M0.7280.75
94_A114_L0.7270.75
295_M299_R0.7260.75
245_G249_L0.7240.74
96_L114_L0.7220.74
95_N269_I0.7220.74
190_V194_S0.7190.74
112_Q174_E0.7170.74
277_K405_M0.7140.73
91_L94_A0.7140.73
29_K40_Y0.7130.73
475_Q478_E0.7130.73
374_M440_A0.7120.73
247_L251_T0.7110.73
374_M453_S0.7110.73
111_Y301_L0.7110.73
292_V454_G0.7090.73
157_L160_A0.7080.73
262_A287_L0.7060.72
93_G388_T0.7060.72
373_F380_I0.7050.72
334_G337_F0.7030.72
40_Y191_A0.7020.72
200_G451_N0.7020.72
55_G73_V0.7010.72
73_V148_P0.6990.72
271_L484_R0.6990.72
302_Q306_Q0.6970.72
333_T340_L0.6960.71
396_T435_L0.6960.71
191_A254_F0.6950.71
32_W286_K0.6940.71
181_V187_L0.6940.71
100_D263_E0.6920.71
135_N152_F0.6890.71
315_T372_S0.6870.70
72_T385_W0.6870.70
73_V168_L0.6870.70
309_G337_F0.6850.70
149_G155_E0.6830.70
29_K310_Q0.6830.70
73_V105_P0.6830.70
252_T255_I0.6820.70
371_L444_N0.6810.70
435_L464_T0.6800.70
335_G341_A0.6790.70
40_Y188_F0.6790.70
192_G195_Q0.6780.69
75_Q111_Y0.6780.69
197_L200_G0.6780.69
287_L290_A0.6780.69
16_A20_P0.6780.69
100_D108_Q0.6760.69
126_T427_Q0.6750.69
64_S257_V0.6750.69
276_V279_A0.6740.69
127_G248_G0.6730.69
337_F342_P0.6730.69
20_P23_H0.6730.69
20_P26_F0.6710.69
131_V155_E0.6700.69
92_G96_L0.6680.68
333_T341_A0.6660.68
151_A253_L0.6660.68
116_K292_V0.6650.68
84_A264_S0.6640.68
466_K469_E0.6630.68
47_P197_L0.6610.67
91_L96_L0.6610.67
142_Q151_A0.6600.67
249_L338_Y0.6590.67
85_S296_I0.6590.67
252_T446_L0.6590.67
73_V386_V0.6590.67
40_Y77_G0.6580.67
40_Y98_G0.6570.67
263_E266_R0.6570.67
26_F128_A0.6560.67
35_G39_L0.6560.67
163_A167_I0.6540.67
481_P485_E0.6530.67
267_V424_Y0.6530.67
76_L83_T0.6510.66
137_L439_L0.6510.66
125_L168_L0.6510.66
62_F421_M0.6490.66
139_P485_E0.6480.66
187_L439_L0.6480.66
426_P430_V0.6460.66
286_K389_A0.6460.66
46_V438_L0.6430.65
396_T480_H0.6430.65
243_Q313_N0.6420.65
78_I169_L0.6390.65
275_R282_R0.6370.65
121_V221_I0.6340.64
36_V176_I0.6330.64
41_F195_Q0.6310.64
115_Q188_F0.6280.64
406_Q473_E0.6280.64
60_G63_R0.6250.63
28_R35_G0.6240.63
82_V459_L0.6240.63
269_I408_P0.6230.63
140_S147_M0.6220.63
459_L463_I0.6220.63
40_Y148_P0.6210.63
298_V374_M0.6210.63
315_T398_R0.6210.63
138_Q141_Q0.6200.63
194_S460_T0.6190.62
267_V408_P0.6190.62
338_Y341_A0.6180.62
225_V240_L0.6180.62
309_G484_R0.6180.62
94_A370_D0.6180.62
289_Y429_T0.6170.62
296_I454_G0.6160.62
44_T70_Q0.6150.62
71_G293_L0.6130.62
46_V141_Q0.6120.62
296_I466_K0.6110.61
295_M462_S0.6090.61
121_V312_L0.6080.61
78_I97_L0.6070.61
393_P425_I0.6070.61
83_T422_E0.6060.61
253_L257_V0.6030.60
32_W483_M0.6020.60
269_I410_F0.6020.60
465_Y469_E0.6000.60
44_T476_M0.6000.60
83_T295_M0.6000.60
430_V445_M0.5990.60
271_L405_M0.5980.60
114_L290_A0.5970.60
23_H477_M0.5970.60
190_V385_W0.5950.59
194_S268_E0.5950.59
316_L335_G0.5930.59
393_P421_M0.5930.59
446_L450_G0.5930.59
339_Y342_P0.5920.59
201_L218_F0.5920.59
20_P428_V0.5900.59
250_L315_T0.5900.59
246_I341_A0.5900.59
32_W288_I0.5890.59
440_A462_S0.5880.58
16_A19_R0.5870.58
100_D395_A0.5870.58
127_G131_V0.5870.58
75_Q401_Q0.5870.58
138_Q142_Q0.5870.58
376_I379_A0.5860.58
421_M428_V0.5860.58
93_G271_L0.5860.58
388_T405_M0.5850.58
42_F46_V0.5850.58
131_V159_F0.5850.58
23_H472_A0.5840.58
50_G364_L0.5840.58
262_A439_L0.5840.58
394_D398_R0.5830.58
33_T36_V0.5830.58
94_A97_L0.5820.58
438_L442_M0.5810.58
42_F306_Q0.5810.58
111_Y197_L0.5810.58
33_T181_V0.5800.57
78_I266_R0.5790.57
56_N389_A0.5790.57
243_Q449_I0.5790.57
128_A132_F0.5780.57
85_S169_L0.5780.57
290_A484_R0.5760.57
73_V442_M0.5750.57
89_Q188_F0.5740.57
124_V128_A0.5730.57
72_T130_M0.5730.57
64_S83_T0.5730.57
173_D256_Y0.5730.57
239_F340_L0.5720.56
74_L168_L0.5720.56
123_V167_I0.5720.56
125_L223_G0.5710.56
299_R302_Q0.5710.56
132_F196_S0.5710.56
252_T256_Y0.5700.56
16_A21_E0.5690.56
377_G380_I0.5690.56
342_P444_N0.5690.56
73_V450_G0.5680.56
167_I474_E0.5680.56
32_W467_L0.5670.56
78_I100_D0.5650.56
374_M402_N0.5650.56
222_V225_V0.5620.55
56_N61_Q0.5610.55
196_S442_M0.5600.55
258_V460_T0.5600.55
137_L140_S0.5590.55
78_I170_L0.5580.55
315_T373_F0.5570.54
18_E396_T0.5570.54
248_G263_E0.5560.54
420_V424_Y0.5560.54
128_A156_V0.5560.54
78_I293_L0.5560.54
373_F377_G0.5550.54
250_L257_V0.5540.54
44_T392_G0.5540.54
54_A335_G0.5530.54
259_V300_A0.5530.54
289_Y391_M0.5520.54
259_V269_I0.5510.54
104_D413_N0.5510.54
69_G407_I0.5510.54
135_N147_M0.5500.54
428_V433_G0.5500.54
406_Q452_V0.5490.53
300_A303_A0.5480.53
125_L375_I0.5480.53
50_G162_I0.5470.53
82_V292_V0.5460.53
137_L142_Q0.5450.53
401_Q424_Y0.5450.53
189_I458_L0.5440.53
139_P338_Y0.5440.53
37_L197_L0.5420.52
280_R483_M0.5410.52
203_F314_S0.5410.52
269_I283_F0.5400.52
119_V255_I0.5390.52
112_Q423_R0.5390.52
385_W405_M0.5380.52
292_V297_L0.5370.52
187_L467_L0.5370.52
140_S149_G0.5360.52
287_L415_G0.5360.52
283_F377_G0.5360.52
47_P187_L0.5350.52
371_L483_M0.5340.51
78_I85_S0.5330.51
56_N442_M0.5330.51
263_E283_F0.5320.51
260_V264_S0.5310.51
246_I394_D0.5310.51
20_P483_M0.5310.51
54_A223_G0.5300.51
253_L373_F0.5290.51
36_V169_L0.5290.51
72_T120_G0.5290.51
298_V305_I0.5290.51
389_A421_M0.5290.51
174_E456_G0.5280.51
271_L277_K0.5260.50
287_L302_Q0.5250.50
55_G253_L0.5250.50
339_Y373_F0.5250.50
81_I297_L0.5240.50
151_A316_L0.5220.50
315_T335_G0.5220.50
48_L77_G0.5220.50
263_E295_M0.5200.50
23_H27_R0.5200.50
221_I242_M0.5190.49
72_T402_N0.5180.49
162_I452_V0.5180.49
150_G155_E0.5160.49
140_S397_A0.5150.49
122_M304_N0.5140.49
169_L290_A0.5120.49
270_P274_A0.5110.48
428_V447_G0.5100.48
197_L457_L0.5100.48
112_Q447_G0.5100.48
257_V261_Y0.5100.48
24_V27_R0.5080.48
60_G166_G0.5080.48
88_L124_V0.5080.48
23_H26_F0.5080.48
186_G459_L0.5070.48
204_W245_G0.5070.48
311_I400_I0.5070.48
337_F341_A0.5060.48
82_V381_F0.5050.48
430_V434_A0.5050.48
302_Q373_F0.5040.47
111_Y483_M0.5040.47
301_L380_I0.5040.47
134_G137_L0.5040.47
286_K291_S0.5040.47
172_M188_F0.5040.47
368_A371_L0.5030.47
247_L485_E0.5020.47
198_V305_I0.5010.47
23_H478_E0.5000.47
303_A402_N0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mp7A 1 0.7658 100 0.121 Contact Map
2ww9A 1 0.9369 100 0.146 Contact Map
1rh5A 1 0.833 100 0.151 Contact Map
4w251 1 0.7862 100 0.194 Contact Map
3dinC 1 0.7739 100 0.238 Contact Map
2zjsY 2 0.8065 100 0.244 Contact Map
3dl8G 1 0.7963 100 0.248 Contact Map
3j01A 1 0.831 100 0.255 Contact Map
4j72A 2 0.1996 12.6 0.979 Contact Map
3b8cA 1 0.2383 11.7 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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