Q9HPB0 - HALSA - GREMLIN Contacts

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Q9HPB0 - Uncharacterized protein

UniProt:	Q9HPB0	Sequences: MAGEATRRRCLGHVAAGAALLAGCTSHSDTSTSTEPPASHHAAVAPVGDLTLTGVPDRAFVVFPQYADMAVALGHGDAVNAIYVPEMSGPTMNAYYDRLDGVDFDYGGLPDPLTDGFTPEECYALDSDVHFVDPAYVSTQDAWDARDIETIASDVGPWFGNFYSGTRADPPQGYRDGYDYYTLWELFGRVADVFQERARFEALRRVHETLVATIADRLPPKRDRPTAVRVTYDEGSFYTYHLNEPGYWLADTRPLGARDAFADADWASLWGTVGYETMLDADPDVILHLWGATPNYEMDAVRSRLRGDAVGGRLSAVANNRVYASGMRYQGPIMNLFQLEMTAKQLYPDVFGAWPGFEDGGSYPALPASERLFDRSRVAAIVTGDAQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	387 (303)
Sequences:	8585 (7169)
Seq/√Len:	411.8

ECOLI - FEPB FECB FHUD BTUF
BACSU - YVRC YFIY YCLQ YFMC FHUD YXEB YHFQ FEUA
HALSA - Q9HPB0 Q9HMF9 Q9HMG8 BTUFA
SULSO - Q97ZU2 Q980Z0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
282_D	315_S	4.197	1.00
188_G	201_E	4.135	1.00
191_A	200_F	3.868	1.00
184_W	208_E	3.715	1.00
315_S	319_N	3.619	1.00
196_E	199_R	3.541	1.00
192_D	197_R	3.238	1.00
210_L	340_E	2.847	1.00
205_R	209_T	2.824	1.00
212_A	216_D	2.809	1.00
188_G	204_R	2.803	1.00
61_V	67_A	2.785	1.00
201_E	205_R	2.780	1.00
199_R	202_A	2.772	1.00
44_V	47_V	2.748	1.00
121_E	124_A	2.688	1.00
58_R	80_N	2.572	1.00
252_T	257_A	2.517	1.00
306_R	320_N	2.473	1.00
208_E	212_A	2.426	1.00
209_T	213_T	2.292	1.00
45_A	49_D	2.280	1.00
284_D	315_S	2.246	1.00
303_S	307_G	2.235	1.00
43_A	49_D	2.221	1.00
59_A	194_F	2.207	1.00
213_T	217_R	2.184	1.00
277_T	280_D	2.131	1.00
226_T	258_R	2.107	1.00
60_F	122_C	2.087	1.00
285_V	321_R	2.056	1.00
70_A	194_F	2.001	1.00
46_P	50_L	1.919	1.00
299_D	303_S	1.917	1.00
313_R	318_A	1.849	1.00
302_R	306_R	1.843	1.00
202_A	206_V	1.838	1.00
315_S	318_A	1.776	1.00
41_H	51_T	1.756	1.00
131_F	190_V	1.750	1.00
149_E	153_S	1.738	1.00
198_A	202_A	1.715	1.00
40_H	44_V	1.695	1.00
216_D	219_P	1.688	1.00
212_A	215_A	1.678	1.00
75_H	194_F	1.652	1.00
285_V	323_Y	1.623	1.00
16_A	19_A	1.609	1.00
117_F	122_C	1.599	1.00
44_V	48_G	1.598	1.00
314_L	317_V	1.595	1.00
277_T	281_A	1.589	1.00
75_H	196_E	1.550	1.00
249_L	253_R	1.546	1.00
185_E	188_G	1.533	1.00
60_F	125_L	1.533	1.00
275_Y	308_D	1.530	1.00
148_I	152_A	1.529	1.00
81_A	125_L	1.524	1.00
285_V	346_L	1.506	1.00
286_I	316_A	1.490	1.00
205_R	208_E	1.486	1.00
210_L	213_T	1.472	1.00
182_T	185_E	1.471	1.00
331_G	335_N	1.456	1.00
110_P	121_E	1.455	1.00
80_N	125_L	1.452	1.00
197_R	201_E	1.446	1.00
41_H	44_V	1.444	1.00
76_G	79_V	1.443	1.00
60_F	81_A	1.437	1.00
211_V	339_L	1.432	1.00
145_A	149_E	1.432	1.00
213_T	216_D	1.424	1.00
303_S	306_R	1.421	1.00
206_V	210_L	1.416	1.00
206_V	209_T	1.400	1.00
118_T	121_E	1.396	1.00
120_E	276_E	1.381	1.00
209_T	212_A	1.376	1.00
199_R	203_L	1.369	1.00
225_P	321_R	1.368	1.00
150_T	154_D	1.350	1.00
57_D	78_A	1.342	1.00
257_A	346_L	1.338	1.00
17_G	20_L	1.327	1.00
227_A	257_A	1.326	1.00
198_A	201_E	1.319	1.00
332_P	335_N	1.298	1.00
69_M	187_F	1.297	1.00
129_V	159_F	1.294	1.00
184_W	204_R	1.292	1.00
70_A	75_H	1.292	1.00
226_T	284_D	1.286	1.00
144_D	147_D	1.270	1.00
58_R	126_D	1.268	1.00
300_A	303_S	1.260	1.00
149_E	152_A	1.253	1.00
92_M	95_Y	1.253	1.00
57_D	128_D	1.245	1.00
225_P	285_V	1.235	1.00
159_F	193_V	1.229	1.00
132_V	160_G	1.219	1.00
159_F	189_R	1.213	1.00
59_A	129_V	1.212	1.00
188_G	208_E	1.210	1.00
215_A	219_P	1.207	1.00
48_G	152_A	1.206	1.00
260_A	281_A	1.184	1.00
323_Y	345_Q	1.183	1.00
119_P	150_T	1.177	1.00
311_G	317_V	1.176	1.00
150_T	153_S	1.175	1.00
52_L	55_V	1.172	1.00
311_G	314_L	1.166	1.00
61_V	70_A	1.160	1.00
263_D	281_A	1.157	1.00
189_R	192_D	1.141	1.00
104_F	107_G	1.135	1.00
72_A	203_L	1.131	1.00
258_R	262_A	1.128	1.00
340_E	344_K	1.124	1.00
338_Q	341_M	1.122	1.00
315_S	321_R	1.121	1.00
260_A	263_D	1.115	1.00
43_A	51_T	1.113	1.00
185_E	189_R	1.112	1.00
300_A	304_R	1.108	1.00
204_R	208_E	1.100	1.00
203_L	206_V	1.089	1.00
79_V	109_L	1.085	1.00
331_G	334_M	1.073	1.00
75_H	79_V	1.068	1.00
228_V	231_T	1.068	1.00
13_H	17_G	1.056	1.00
210_L	337_F	1.056	1.00
91_T	95_Y	1.056	1.00
187_F	200_F	1.052	1.00
54_G	57_D	1.050	1.00
215_A	254_P	1.037	1.00
52_L	56_P	1.036	1.00
123_Y	156_G	1.029	1.00
52_L	157_P	1.028	1.00
214_I	339_L	1.027	1.00
224_R	258_R	1.015	1.00
214_I	343_A	1.009	1.00
107_G	110_P	1.008	1.00
15_A	19_A	1.008	1.00
211_V	215_A	1.008	1.00
309_A	312_G	1.005	1.00
24_C	28_S	1.003	1.00
342_T	346_L	1.001	1.00
82_I	109_L	0.996	1.00
59_A	70_A	0.995	1.00
255_L	346_L	0.995	1.00
306_R	322_V	0.988	1.00
73_L	196_E	0.987	1.00
131_F	193_V	0.981	1.00
213_T	340_E	0.980	1.00
129_V	193_V	0.980	1.00
188_G	192_D	0.974	1.00
227_A	252_T	0.970	1.00
238_Y	272_T	0.970	1.00
201_E	204_R	0.957	1.00
83_Y	86_E	0.954	1.00
106_Y	109_L	0.947	1.00
46_P	148_I	0.945	1.00
84_V	111_D	0.942	1.00
19_A	22_A	0.940	1.00
279_L	314_L	0.928	1.00
152_A	158_W	0.927	1.00
250_A	254_P	0.926	1.00
40_H	47_V	0.925	1.00
228_V	278_M	0.919	1.00
105_D	108_G	0.911	1.00
17_G	21_L	0.906	1.00
56_P	129_V	0.903	1.00
69_M	190_V	0.900	1.00
106_Y	110_P	0.894	1.00
228_V	241_H	0.891	1.00
341_M	345_Q	0.891	1.00
278_M	314_L	0.890	1.00
207_H	211_V	0.889	1.00
250_A	253_R	0.888	1.00
40_H	192_D	0.887	1.00
261_F	281_A	0.884	1.00
123_Y	154_D	0.882	1.00
40_H	55_V	0.877	1.00
40_H	46_P	0.875	1.00
186_L	189_R	0.871	1.00
202_A	205_R	0.868	1.00
218_L	343_A	0.868	1.00
68_D	335_N	0.866	1.00
251_D	339_L	0.866	1.00
14_V	18_A	0.866	1.00
221_K	224_R	0.864	1.00
229_R	252_T	0.862	1.00
261_F	277_T	0.861	1.00
301_V	304_R	0.861	1.00
40_H	56_P	0.860	1.00
55_V	196_E	0.859	1.00
341_M	344_K	0.858	1.00
93_N	96_Y	0.858	1.00
62_V	130_H	0.854	1.00
317_V	322_V	0.853	1.00
18_A	22_A	0.852	1.00
127_S	130_H	0.849	1.00
40_H	195_Q	0.843	1.00
55_V	195_Q	0.842	1.00
24_C	27_H	0.841	1.00
81_A	113_L	0.837	1.00
60_F	112_P	0.834	1.00
75_H	78_A	0.831	1.00
184_W	211_V	0.828	1.00
279_L	310_V	0.827	1.00
60_F	80_N	0.824	1.00
244_E	253_R	0.822	1.00
288_H	324_A	0.819	1.00
200_F	204_R	0.818	1.00
230_V	308_D	0.818	1.00
59_A	78_A	0.818	1.00
304_R	307_G	0.815	1.00
130_H	156_G	0.814	1.00
45_A	48_G	0.813	1.00
46_P	152_A	0.812	1.00
147_D	150_T	0.812	1.00
14_V	17_G	0.809	1.00
242_L	246_G	0.803	1.00
40_H	54_G	0.803	1.00
230_V	233_D	0.803	1.00
95_Y	98_R	0.795	1.00
76_G	105_D	0.791	1.00
287_L	342_T	0.789	1.00
273_V	281_A	0.787	1.00
13_H	16_A	0.786	1.00
214_I	336_L	0.786	1.00
161_N	189_R	0.784	1.00
224_R	228_V	0.783	1.00
94_A	97_D	0.782	1.00
40_H	53_T	0.780	1.00
228_V	232_Y	0.775	1.00
333_I	336_L	0.774	1.00
326_G	341_M	0.771	1.00
41_H	49_D	0.769	1.00
239_T	242_L	0.764	1.00
238_Y	242_L	0.760	1.00
61_V	79_V	0.757	1.00
207_H	254_P	0.756	1.00
297_E	300_A	0.754	1.00
302_R	324_A	0.753	1.00
70_A	131_F	0.744	1.00
191_A	204_R	0.739	1.00
70_A	79_V	0.739	1.00
228_V	283_P	0.738	1.00
130_H	155_V	0.737	1.00
72_A	187_F	0.734	1.00
130_H	151_I	0.728	1.00
110_P	113_L	0.727	1.00
18_A	21_L	0.726	1.00
255_L	339_L	0.725	1.00
69_M	72_A	0.724	1.00
78_A	196_E	0.717	1.00
13_H	20_L	0.717	1.00
122_C	151_I	0.716	1.00
56_P	128_D	0.716	1.00
60_F	130_H	0.716	1.00
71_V	79_V	0.716	1.00
273_V	278_M	0.715	1.00
41_H	55_V	0.711	1.00
9_R	19_A	0.710	1.00
189_R	193_V	0.709	1.00
214_I	255_L	0.706	1.00
20_L	23_G	0.703	1.00
66_Y	161_N	0.703	1.00
190_V	194_F	0.700	1.00
148_I	158_W	0.699	1.00
240_Y	243_N	0.697	1.00
134_P	162_F	0.696	1.00
291_G	327_M	0.695	1.00
227_A	230_V	0.694	1.00
210_L	214_I	0.692	1.00
52_L	193_V	0.692	1.00
299_D	302_R	0.691	1.00
238_Y	241_H	0.689	1.00
211_V	336_L	0.687	1.00
15_A	18_A	0.686	1.00
50_L	159_F	0.686	1.00
21_L	24_C	0.684	1.00
50_L	157_P	0.683	1.00
227_A	231_T	0.681	1.00
217_R	220_P	0.679	1.00
251_D	342_T	0.678	1.00
93_N	97_D	0.676	1.00
56_P	194_F	0.674	0.99
279_L	313_R	0.672	0.99
14_V	20_L	0.670	0.99
60_F	127_S	0.669	0.99
249_L	262_A	0.668	0.99
78_A	194_F	0.668	0.99
52_L	129_V	0.665	0.99
12_G	16_A	0.663	0.99
58_R	128_D	0.662	0.99
73_L	203_L	0.660	0.99
257_A	285_V	0.659	0.99
81_A	112_P	0.656	0.99
29_D	32_T	0.656	0.99
338_Q	342_T	0.654	0.99
42_A	192_D	0.653	0.99
337_F	341_M	0.651	0.99
247_Y	250_A	0.649	0.99
229_R	289_L	0.647	0.99
155_V	158_W	0.647	0.99
39_S	42_A	0.646	0.99
235_G	238_Y	0.643	0.99
184_W	188_G	0.642	0.99
296_Y	299_D	0.641	0.99
261_F	264_A	0.641	0.99
207_H	210_L	0.640	0.99
41_H	54_G	0.640	0.99
56_P	59_A	0.638	0.99
22_A	25_T	0.638	0.99
211_V	254_P	0.636	0.99
259_D	263_D	0.635	0.99
288_H	322_V	0.635	0.99
218_L	221_K	0.635	0.99
87_M	111_D	0.633	0.99
76_G	108_G	0.633	0.99
190_V	193_V	0.631	0.99
221_K	225_P	0.630	0.99
241_H	244_E	0.628	0.99
73_L	191_A	0.625	0.99
289_L	325_S	0.624	0.99
42_A	52_L	0.620	0.99
326_G	329_Y	0.619	0.99
183_L	207_H	0.619	0.99
53_T	157_P	0.617	0.99
325_S	338_Q	0.616	0.99
124_A	280_D	0.615	0.99
91_T	94_A	0.615	0.99
187_F	203_L	0.614	0.99
314_L	318_A	0.614	0.99
240_Y	244_E	0.611	0.99
286_I	311_G	0.609	0.99
73_L	194_F	0.608	0.99
73_L	200_F	0.606	0.99
119_P	151_I	0.605	0.99
230_V	286_I	0.605	0.99
181_Y	185_E	0.605	0.99
32_T	35_E	0.605	0.99
70_A	190_V	0.604	0.99
152_A	157_P	0.603	0.99
287_L	346_L	0.599	0.99
332_P	336_L	0.597	0.99
283_P	286_I	0.594	0.99
122_C	130_H	0.593	0.99
253_R	262_A	0.593	0.99
264_A	271_G	0.593	0.99
227_A	287_L	0.589	0.99
301_V	305_L	0.587	0.99
146_R	149_E	0.587	0.99
312_G	317_V	0.586	0.99
41_H	47_V	0.585	0.99
225_P	284_D	0.585	0.99
142_A	147_D	0.584	0.99
184_W	207_H	0.581	0.99
110_P	125_L	0.580	0.98
66_Y	131_F	0.580	0.98
40_H	48_G	0.577	0.98
305_L	308_D	0.575	0.98
42_A	159_F	0.574	0.98
259_D	262_A	0.572	0.98
336_L	340_E	0.569	0.98
225_P	257_A	0.566	0.98
217_R	343_A	0.564	0.98
73_L	199_R	0.564	0.98
243_N	246_G	0.562	0.98
308_D	312_G	0.562	0.98
41_H	53_T	0.562	0.98
40_H	45_A	0.562	0.98
120_E	274_G	0.560	0.98
80_N	127_S	0.559	0.98
146_R	150_T	0.559	0.98
239_T	243_N	0.558	0.98
71_V	76_G	0.558	0.98
310_V	313_R	0.557	0.98
308_D	311_G	0.557	0.98
94_A	98_R	0.557	0.98
23_G	26_S	0.557	0.98
211_V	214_I	0.557	0.98
287_L	323_Y	0.556	0.98
230_V	241_H	0.556	0.98
210_L	336_L	0.555	0.98
279_L	283_P	0.554	0.98
42_A	47_V	0.553	0.98
188_G	191_A	0.553	0.98
40_H	52_L	0.553	0.98
31_S	35_E	0.552	0.98
24_C	29_D	0.549	0.98
248_W	270_W	0.548	0.98
25_T	28_S	0.541	0.98
148_I	160_G	0.541	0.98
275_Y	311_G	0.541	0.98
274_G	277_T	0.540	0.98
242_L	270_W	0.540	0.98
335_N	338_Q	0.540	0.98
105_D	109_L	0.539	0.98
119_P	147_D	0.538	0.98
112_P	125_L	0.538	0.98
40_H	43_A	0.537	0.98
130_H	158_W	0.537	0.98
214_I	217_R	0.535	0.97
181_Y	184_W	0.534	0.97
228_V	260_A	0.533	0.97
203_L	207_H	0.531	0.97
62_V	117_F	0.530	0.97
340_E	343_A	0.529	0.97
23_G	27_H	0.529	0.97
145_A	148_I	0.526	0.97
40_H	51_T	0.526	0.97
238_Y	243_N	0.525	0.97
214_I	218_L	0.524	0.97
215_A	218_L	0.523	0.97
230_V	235_G	0.522	0.97
63_F	133_D	0.521	0.97
122_C	125_L	0.521	0.97
91_T	96_Y	0.518	0.97
121_E	125_L	0.518	0.97
134_P	142_A	0.517	0.97
184_W	254_P	0.516	0.97
301_V	306_R	0.516	0.97
48_G	148_I	0.516	0.97
180_Y	254_P	0.513	0.97
33_S	36_P	0.512	0.97
34_T	220_P	0.512	0.97
215_A	222_R	0.511	0.97
337_F	340_E	0.510	0.97
131_F	161_N	0.509	0.97
52_L	159_F	0.509	0.97
222_R	225_P	0.508	0.97
74_G	199_R	0.508	0.97
12_G	32_T	0.508	0.97
161_N	190_V	0.507	0.97
92_M	96_Y	0.506	0.96
232_Y	235_G	0.505	0.96
58_R	127_S	0.504	0.96
119_P	122_C	0.504	0.96
106_Y	111_D	0.504	0.96
43_A	46_P	0.503	0.96
311_G	322_V	0.502	0.96
302_R	305_L	0.501	0.96
229_R	248_W	0.501	0.96
41_H	48_G	0.501	0.96
332_P	338_Q	0.500	0.96
331_G	338_Q	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ovkA	1	0.814	100	0.296	Contact Map
4mo9A	1	0.832	100	0.319	Contact Map
4pagA	2	0.801	100	0.326	Contact Map
4hn9A	1	0.7804	100	0.328	Contact Map
4n01A	1	0.7442	100	0.328	Contact Map
3pshA	1	0.8062	100	0.34	Contact Map
4inoA	1	0.7726	100	0.352	Contact Map
2etvA	2	0.7674	100	0.364	Contact Map
4mlzA	1	0.7649	100	0.364	Contact Map
4ljsA	1	0.7933	100	0.394	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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