GREMLIN Database
Q9HPB0 - Uncharacterized protein
UniProt: Q9HPB0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (303)
Sequences: 8585 (7169)
Seq/√Len: 411.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
282_D315_S4.1971.00
188_G201_E4.1351.00
191_A200_F3.8681.00
184_W208_E3.7151.00
315_S319_N3.6191.00
196_E199_R3.5411.00
192_D197_R3.2381.00
210_L340_E2.8471.00
205_R209_T2.8241.00
212_A216_D2.8091.00
188_G204_R2.8031.00
61_V67_A2.7851.00
201_E205_R2.7801.00
199_R202_A2.7721.00
44_V47_V2.7481.00
121_E124_A2.6881.00
58_R80_N2.5721.00
252_T257_A2.5171.00
306_R320_N2.4731.00
208_E212_A2.4261.00
209_T213_T2.2921.00
45_A49_D2.2801.00
284_D315_S2.2461.00
303_S307_G2.2351.00
43_A49_D2.2211.00
59_A194_F2.2071.00
213_T217_R2.1841.00
277_T280_D2.1311.00
226_T258_R2.1071.00
60_F122_C2.0871.00
285_V321_R2.0561.00
70_A194_F2.0011.00
46_P50_L1.9191.00
299_D303_S1.9171.00
313_R318_A1.8491.00
302_R306_R1.8431.00
202_A206_V1.8381.00
315_S318_A1.7761.00
41_H51_T1.7561.00
131_F190_V1.7501.00
149_E153_S1.7381.00
198_A202_A1.7151.00
40_H44_V1.6951.00
216_D219_P1.6881.00
212_A215_A1.6781.00
75_H194_F1.6521.00
285_V323_Y1.6231.00
16_A19_A1.6091.00
117_F122_C1.5991.00
44_V48_G1.5981.00
314_L317_V1.5951.00
277_T281_A1.5891.00
75_H196_E1.5501.00
249_L253_R1.5461.00
185_E188_G1.5331.00
60_F125_L1.5331.00
275_Y308_D1.5301.00
148_I152_A1.5291.00
81_A125_L1.5241.00
285_V346_L1.5061.00
286_I316_A1.4901.00
205_R208_E1.4861.00
210_L213_T1.4721.00
182_T185_E1.4711.00
331_G335_N1.4561.00
110_P121_E1.4551.00
80_N125_L1.4521.00
197_R201_E1.4461.00
41_H44_V1.4441.00
76_G79_V1.4431.00
60_F81_A1.4371.00
211_V339_L1.4321.00
145_A149_E1.4321.00
213_T216_D1.4241.00
303_S306_R1.4211.00
206_V210_L1.4161.00
206_V209_T1.4001.00
118_T121_E1.3961.00
120_E276_E1.3811.00
209_T212_A1.3761.00
199_R203_L1.3691.00
225_P321_R1.3681.00
150_T154_D1.3501.00
57_D78_A1.3421.00
257_A346_L1.3381.00
17_G20_L1.3271.00
227_A257_A1.3261.00
198_A201_E1.3191.00
332_P335_N1.2981.00
69_M187_F1.2971.00
129_V159_F1.2941.00
184_W204_R1.2921.00
70_A75_H1.2921.00
226_T284_D1.2861.00
144_D147_D1.2701.00
58_R126_D1.2681.00
300_A303_S1.2601.00
149_E152_A1.2531.00
92_M95_Y1.2531.00
57_D128_D1.2451.00
225_P285_V1.2351.00
159_F193_V1.2291.00
132_V160_G1.2191.00
159_F189_R1.2131.00
59_A129_V1.2121.00
188_G208_E1.2101.00
215_A219_P1.2071.00
48_G152_A1.2061.00
260_A281_A1.1841.00
323_Y345_Q1.1831.00
119_P150_T1.1771.00
311_G317_V1.1761.00
150_T153_S1.1751.00
52_L55_V1.1721.00
311_G314_L1.1661.00
61_V70_A1.1601.00
263_D281_A1.1571.00
189_R192_D1.1411.00
104_F107_G1.1351.00
72_A203_L1.1311.00
258_R262_A1.1281.00
340_E344_K1.1241.00
338_Q341_M1.1221.00
315_S321_R1.1211.00
260_A263_D1.1151.00
43_A51_T1.1131.00
185_E189_R1.1121.00
300_A304_R1.1081.00
204_R208_E1.1001.00
203_L206_V1.0891.00
79_V109_L1.0851.00
331_G334_M1.0731.00
75_H79_V1.0681.00
228_V231_T1.0681.00
13_H17_G1.0561.00
210_L337_F1.0561.00
91_T95_Y1.0561.00
187_F200_F1.0521.00
54_G57_D1.0501.00
215_A254_P1.0371.00
52_L56_P1.0361.00
123_Y156_G1.0291.00
52_L157_P1.0281.00
214_I339_L1.0271.00
224_R258_R1.0151.00
214_I343_A1.0091.00
107_G110_P1.0081.00
15_A19_A1.0081.00
211_V215_A1.0081.00
309_A312_G1.0051.00
24_C28_S1.0031.00
342_T346_L1.0011.00
82_I109_L0.9961.00
59_A70_A0.9951.00
255_L346_L0.9951.00
306_R322_V0.9881.00
73_L196_E0.9871.00
131_F193_V0.9811.00
213_T340_E0.9801.00
129_V193_V0.9801.00
188_G192_D0.9741.00
227_A252_T0.9701.00
238_Y272_T0.9701.00
201_E204_R0.9571.00
83_Y86_E0.9541.00
106_Y109_L0.9471.00
46_P148_I0.9451.00
84_V111_D0.9421.00
19_A22_A0.9401.00
279_L314_L0.9281.00
152_A158_W0.9271.00
250_A254_P0.9261.00
40_H47_V0.9251.00
228_V278_M0.9191.00
105_D108_G0.9111.00
17_G21_L0.9061.00
56_P129_V0.9031.00
69_M190_V0.9001.00
106_Y110_P0.8941.00
228_V241_H0.8911.00
341_M345_Q0.8911.00
278_M314_L0.8901.00
207_H211_V0.8891.00
250_A253_R0.8881.00
40_H192_D0.8871.00
261_F281_A0.8841.00
123_Y154_D0.8821.00
40_H55_V0.8771.00
40_H46_P0.8751.00
186_L189_R0.8711.00
202_A205_R0.8681.00
218_L343_A0.8681.00
68_D335_N0.8661.00
251_D339_L0.8661.00
14_V18_A0.8661.00
221_K224_R0.8641.00
229_R252_T0.8621.00
261_F277_T0.8611.00
301_V304_R0.8611.00
40_H56_P0.8601.00
55_V196_E0.8591.00
341_M344_K0.8581.00
93_N96_Y0.8581.00
62_V130_H0.8541.00
317_V322_V0.8531.00
18_A22_A0.8521.00
127_S130_H0.8491.00
40_H195_Q0.8431.00
55_V195_Q0.8421.00
24_C27_H0.8411.00
81_A113_L0.8371.00
60_F112_P0.8341.00
75_H78_A0.8311.00
184_W211_V0.8281.00
279_L310_V0.8271.00
60_F80_N0.8241.00
244_E253_R0.8221.00
288_H324_A0.8191.00
200_F204_R0.8181.00
230_V308_D0.8181.00
59_A78_A0.8181.00
304_R307_G0.8151.00
130_H156_G0.8141.00
45_A48_G0.8131.00
46_P152_A0.8121.00
147_D150_T0.8121.00
14_V17_G0.8091.00
242_L246_G0.8031.00
40_H54_G0.8031.00
230_V233_D0.8031.00
95_Y98_R0.7951.00
76_G105_D0.7911.00
287_L342_T0.7891.00
273_V281_A0.7871.00
13_H16_A0.7861.00
214_I336_L0.7861.00
161_N189_R0.7841.00
224_R228_V0.7831.00
94_A97_D0.7821.00
40_H53_T0.7801.00
228_V232_Y0.7751.00
333_I336_L0.7741.00
326_G341_M0.7711.00
41_H49_D0.7691.00
239_T242_L0.7641.00
238_Y242_L0.7601.00
61_V79_V0.7571.00
207_H254_P0.7561.00
297_E300_A0.7541.00
302_R324_A0.7531.00
70_A131_F0.7441.00
191_A204_R0.7391.00
70_A79_V0.7391.00
228_V283_P0.7381.00
130_H155_V0.7371.00
72_A187_F0.7341.00
130_H151_I0.7281.00
110_P113_L0.7271.00
18_A21_L0.7261.00
255_L339_L0.7251.00
69_M72_A0.7241.00
78_A196_E0.7171.00
13_H20_L0.7171.00
122_C151_I0.7161.00
56_P128_D0.7161.00
60_F130_H0.7161.00
71_V79_V0.7161.00
273_V278_M0.7151.00
41_H55_V0.7111.00
9_R19_A0.7101.00
189_R193_V0.7091.00
214_I255_L0.7061.00
20_L23_G0.7031.00
66_Y161_N0.7031.00
190_V194_F0.7001.00
148_I158_W0.6991.00
240_Y243_N0.6971.00
134_P162_F0.6961.00
291_G327_M0.6951.00
227_A230_V0.6941.00
210_L214_I0.6921.00
52_L193_V0.6921.00
299_D302_R0.6911.00
238_Y241_H0.6891.00
211_V336_L0.6871.00
15_A18_A0.6861.00
50_L159_F0.6861.00
21_L24_C0.6841.00
50_L157_P0.6831.00
227_A231_T0.6811.00
217_R220_P0.6791.00
251_D342_T0.6781.00
93_N97_D0.6761.00
56_P194_F0.6740.99
279_L313_R0.6720.99
14_V20_L0.6700.99
60_F127_S0.6690.99
249_L262_A0.6680.99
78_A194_F0.6680.99
52_L129_V0.6650.99
12_G16_A0.6630.99
58_R128_D0.6620.99
73_L203_L0.6600.99
257_A285_V0.6590.99
81_A112_P0.6560.99
29_D32_T0.6560.99
338_Q342_T0.6540.99
42_A192_D0.6530.99
337_F341_M0.6510.99
247_Y250_A0.6490.99
229_R289_L0.6470.99
155_V158_W0.6470.99
39_S42_A0.6460.99
235_G238_Y0.6430.99
184_W188_G0.6420.99
296_Y299_D0.6410.99
261_F264_A0.6410.99
207_H210_L0.6400.99
41_H54_G0.6400.99
56_P59_A0.6380.99
22_A25_T0.6380.99
211_V254_P0.6360.99
259_D263_D0.6350.99
288_H322_V0.6350.99
218_L221_K0.6350.99
87_M111_D0.6330.99
76_G108_G0.6330.99
190_V193_V0.6310.99
221_K225_P0.6300.99
241_H244_E0.6280.99
73_L191_A0.6250.99
289_L325_S0.6240.99
42_A52_L0.6200.99
326_G329_Y0.6190.99
183_L207_H0.6190.99
53_T157_P0.6170.99
325_S338_Q0.6160.99
124_A280_D0.6150.99
91_T94_A0.6150.99
187_F203_L0.6140.99
314_L318_A0.6140.99
240_Y244_E0.6110.99
286_I311_G0.6090.99
73_L194_F0.6080.99
73_L200_F0.6060.99
119_P151_I0.6050.99
230_V286_I0.6050.99
181_Y185_E0.6050.99
32_T35_E0.6050.99
70_A190_V0.6040.99
152_A157_P0.6030.99
287_L346_L0.5990.99
332_P336_L0.5970.99
283_P286_I0.5940.99
122_C130_H0.5930.99
253_R262_A0.5930.99
264_A271_G0.5930.99
227_A287_L0.5890.99
301_V305_L0.5870.99
146_R149_E0.5870.99
312_G317_V0.5860.99
41_H47_V0.5850.99
225_P284_D0.5850.99
142_A147_D0.5840.99
184_W207_H0.5810.99
110_P125_L0.5800.98
66_Y131_F0.5800.98
40_H48_G0.5770.98
305_L308_D0.5750.98
42_A159_F0.5740.98
259_D262_A0.5720.98
336_L340_E0.5690.98
225_P257_A0.5660.98
217_R343_A0.5640.98
73_L199_R0.5640.98
243_N246_G0.5620.98
308_D312_G0.5620.98
41_H53_T0.5620.98
40_H45_A0.5620.98
120_E274_G0.5600.98
80_N127_S0.5590.98
146_R150_T0.5590.98
239_T243_N0.5580.98
71_V76_G0.5580.98
310_V313_R0.5570.98
308_D311_G0.5570.98
94_A98_R0.5570.98
23_G26_S0.5570.98
211_V214_I0.5570.98
287_L323_Y0.5560.98
230_V241_H0.5560.98
210_L336_L0.5550.98
279_L283_P0.5540.98
42_A47_V0.5530.98
188_G191_A0.5530.98
40_H52_L0.5530.98
31_S35_E0.5520.98
24_C29_D0.5490.98
248_W270_W0.5480.98
25_T28_S0.5410.98
148_I160_G0.5410.98
275_Y311_G0.5410.98
274_G277_T0.5400.98
242_L270_W0.5400.98
335_N338_Q0.5400.98
105_D109_L0.5390.98
119_P147_D0.5380.98
112_P125_L0.5380.98
40_H43_A0.5370.98
130_H158_W0.5370.98
214_I217_R0.5350.97
181_Y184_W0.5340.97
228_V260_A0.5330.97
203_L207_H0.5310.97
62_V117_F0.5300.97
340_E343_A0.5290.97
23_G27_H0.5290.97
145_A148_I0.5260.97
40_H51_T0.5260.97
238_Y243_N0.5250.97
214_I218_L0.5240.97
215_A218_L0.5230.97
230_V235_G0.5220.97
63_F133_D0.5210.97
122_C125_L0.5210.97
91_T96_Y0.5180.97
121_E125_L0.5180.97
134_P142_A0.5170.97
184_W254_P0.5160.97
301_V306_R0.5160.97
48_G148_I0.5160.97
180_Y254_P0.5130.97
33_S36_P0.5120.97
34_T220_P0.5120.97
215_A222_R0.5110.97
337_F340_E0.5100.97
131_F161_N0.5090.97
52_L159_F0.5090.97
222_R225_P0.5080.97
74_G199_R0.5080.97
12_G32_T0.5080.97
161_N190_V0.5070.97
92_M96_Y0.5060.96
232_Y235_G0.5050.96
58_R127_S0.5040.96
119_P122_C0.5040.96
106_Y111_D0.5040.96
43_A46_P0.5030.96
311_G322_V0.5020.96
302_R305_L0.5010.96
229_R248_W0.5010.96
41_H48_G0.5010.96
332_P338_Q0.5000.96
331_G338_Q0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ovkA 1 0.814 100 0.296 Contact Map
4mo9A 1 0.832 100 0.319 Contact Map
4pagA 2 0.801 100 0.326 Contact Map
4hn9A 1 0.7804 100 0.328 Contact Map
4n01A 1 0.7442 100 0.328 Contact Map
3pshA 1 0.8062 100 0.34 Contact Map
4inoA 1 0.7726 100 0.352 Contact Map
2etvA 2 0.7674 100 0.364 Contact Map
4mlzA 1 0.7649 100 0.364 Contact Map
4ljsA 1 0.7933 100 0.394 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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