GREMLIN Database
Q9HPA9 - TRK potassium uptake system protein
UniProt: Q9HPA9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 558 (429)
Sequences: 2041 (1659)
Seq/√Len: 80.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
413_G419_V6.0391.00
292_L377_T4.1331.00
234_V260_L3.6011.00
141_H528_E3.5011.00
123_S139_P3.3111.00
166_R170_W3.2911.00
414_A424_I3.2501.00
233_G294_I3.2471.00
177_W230_T3.0731.00
137_R163_S3.0521.00
277_N281_T2.9631.00
159_I162_P2.9541.00
351_A355_W2.8801.00
350_D401_G2.8521.00
167_S171_W2.8471.00
393_P396_N2.8321.00
384_L405_V2.7111.00
496_F518_I2.6321.00
141_H157_M2.6091.00
238_F259_A2.6091.00
156_T160_H2.5911.00
169_Q257_W2.5321.00
288_E375_D2.4881.00
137_R164_L2.4841.00
349_P404_L2.4621.00
273_S276_D2.3821.00
489_V492_A2.3011.00
343_A346_P2.2961.00
406_V506_A2.2331.00
296_V381_V2.2091.00
487_V530_M2.2081.00
500_D516_S2.1751.00
492_A527_A2.1711.00
484_T534_N2.1591.00
147_M532_L2.1531.00
380_W384_L2.1341.00
251_P255_A2.1161.00
327_F330_L2.1121.00
237_L291_L2.1081.00
485_S502_L2.1001.00
145_E157_M2.0991.00
112_F536_W2.0691.00
350_D405_V2.0641.00
339_A343_A2.0551.00
336_V339_A2.0521.00
333_G339_A2.0301.00
127_T139_P2.0071.00
148_S272_F2.0011.00
330_L333_G1.9961.00
138_Q141_H1.9691.00
295_M382_S1.9571.00
402_K516_S1.9561.00
333_G336_V1.9461.00
164_L172_R1.9421.00
529_A533_F1.9371.00
140_L525_P1.9131.00
288_E391_S1.9081.00
331_G339_A1.8521.00
240_A284_A1.8431.00
488_L527_A1.8401.00
375_D379_Q1.8231.00
283_D371_D1.8191.00
266_G389_F1.7941.00
368_A371_D1.7931.00
488_L492_A1.7831.00
338_A428_Y1.7741.00
160_H164_L1.7661.00
173_S260_L1.7531.00
285_P374_R1.7301.00
415_A424_I1.7211.00
484_T530_M1.6861.00
339_A342_V1.6761.00
252_V256_A1.6571.00
130_L167_S1.6541.00
491_L527_A1.6511.00
367_P375_D1.6481.00
347_V373_A1.6481.00
295_M381_V1.6431.00
123_S127_T1.6421.00
140_L532_L1.6321.00
248_A251_P1.6301.00
176_Q270_G1.6271.00
523_M531_F1.6271.00
527_A531_F1.6221.00
394_I405_V1.6201.00
280_A390_Q1.6151.00
279_I391_S1.6011.00
139_P143_L1.5961.00
351_A372_A1.5941.00
351_A376_A1.5841.00
238_F252_V1.5781.00
326_L330_L1.5731.00
176_Q265_T1.5480.99
256_A260_L1.5460.99
238_F256_A1.5450.99
140_L528_E1.5440.99
229_Y297_A1.5400.99
394_I516_S1.5260.99
342_V346_P1.5260.99
355_W372_A1.5240.99
296_V377_T1.5150.99
346_P380_W1.5100.99
289_A292_L1.4950.99
477_W509_Q1.4910.99
430_A474_A1.4830.99
422_I427_A1.4760.99
295_M387_T1.4730.99
149_G272_F1.4710.99
275_T281_T1.4680.99
248_A255_A1.4580.99
336_V340_Q1.4560.99
140_L529_A1.4500.99
357_P365_L1.4480.99
280_A393_P1.4470.99
450_T457_T1.4230.99
289_A293_P1.4200.99
331_G334_V1.4160.99
238_F255_A1.4130.99
407_G411_I1.4070.99
488_L491_L1.3970.99
158_A163_S1.3930.99
247_G255_A1.3840.99
331_G336_V1.3830.99
149_G172_R1.3800.99
160_H172_R1.3770.99
119_W147_M1.3640.99
293_P297_A1.3610.99
237_L287_I1.3570.99
173_S264_M1.3550.99
143_L532_L1.3470.99
145_E160_H1.3450.99
279_I291_L1.3420.99
122_V175_T1.3410.98
229_Y305_H1.3300.98
341_N345_V1.3280.98
325_W330_L1.3050.98
369_Q373_A1.3040.98
529_A532_L1.2970.98
481_L509_Q1.2950.98
241_I246_Y1.2940.98
114_P183_V1.2920.98
289_A374_R1.2800.98
128_T167_S1.2800.98
411_I427_A1.2800.98
254_D258_Q1.2770.98
497_S500_D1.2730.98
286_V290_A1.2720.98
343_A381_V1.2720.98
173_S176_Q1.2690.98
170_W257_W1.2630.98
379_Q391_S1.2600.98
220_R224_K1.2600.98
236_V286_V1.2500.98
233_G290_A1.2490.98
234_V256_A1.2460.98
292_L381_V1.2410.98
492_A524_S1.2370.97
336_V343_A1.2210.97
288_E292_L1.2180.97
343_A347_V1.2090.97
218_T417_S1.2080.97
370_A374_R1.2020.97
435_I439_S1.2010.97
338_A342_V1.1890.97
395_G516_S1.1870.97
131_S136_F1.1860.97
137_R165_P1.1860.97
326_L329_L1.1830.97
398_I401_G1.1770.97
386_C512_V1.1740.96
334_V342_V1.1720.96
157_M160_H1.1650.96
262_H273_S1.1590.96
157_M528_E1.1570.96
166_R169_Q1.1560.96
105_P109_M1.1550.96
236_V290_A1.1520.96
273_S278_S1.1470.96
333_G342_V1.1460.96
275_T282_Y1.1450.96
138_Q525_P1.1370.96
330_L336_V1.1360.96
339_A346_P1.1310.96
158_A172_R1.1300.96
427_A431_V1.1250.96
225_L229_Y1.1250.96
496_F501_A1.1250.96
379_Q405_V1.1130.95
239_V286_V1.1050.95
145_E172_R1.1050.95
347_V380_W1.1040.95
118_T150_W1.1000.95
347_V377_T1.0960.95
160_H163_S1.0930.95
156_T161_E1.0800.94
524_S527_A1.0800.94
505_V531_F1.0800.94
131_S137_R1.0720.94
334_V339_A1.0710.94
288_E379_Q1.0690.94
364_V376_A1.0660.94
402_K500_D1.0640.94
415_A425_I1.0580.94
518_I522_D1.0560.94
505_V534_N1.0550.94
325_W328_V1.0530.94
292_L296_V1.0510.94
296_V343_A1.0450.93
226_V268_T1.0450.93
324_R327_F1.0430.93
403_I498_Y1.0360.93
332_G335_V1.0310.93
266_G291_L1.0300.93
258_Q262_H1.0280.93
173_S257_W1.0260.93
328_V331_G1.0220.93
228_G231_V1.0170.92
351_A369_Q1.0150.92
285_P370_A1.0150.92
234_V263_T1.0140.92
199_Y203_R1.0100.92
404_L486_L1.0070.92
347_V376_A1.0060.92
431_V435_I1.0010.92
303_P416_G0.9910.91
331_G335_V0.9850.91
137_R172_R0.9840.91
279_I382_S0.9830.91
127_T136_F0.9820.91
375_D391_S0.9730.91
116_D536_W0.9700.91
134_A165_P0.9700.91
296_V339_A0.9690.90
269_T385_T0.9650.90
432_R453_I0.9620.90
265_T389_F0.9610.90
285_P288_E0.9580.90
506_A510_G0.9580.90
127_T142_A0.9580.90
343_A377_T0.9560.90
397_W401_G0.9550.90
284_A287_I0.9500.90
333_G338_A0.9490.90
123_S143_L0.9440.89
340_Q344_A0.9400.89
250_L255_A0.9360.89
525_P528_E0.9300.89
251_P254_D0.9150.88
292_L347_V0.9140.88
277_N280_A0.9120.88
324_R328_V0.9090.87
155_L514_L0.9020.87
379_Q384_L0.8950.87
223_W227_V0.8880.86
200_A216_V0.8870.86
406_V499_A0.8830.86
351_A354_Q0.8750.85
278_S282_Y0.8740.85
333_G337_L0.8730.85
358_A365_L0.8720.85
224_K228_G0.8680.85
231_V260_L0.8660.85
460_R464_E0.8650.85
299_A387_T0.8600.84
480_L534_N0.8580.84
332_G336_V0.8580.84
379_Q394_I0.8570.84
307_R311_D0.8560.84
270_G386_C0.8500.84
333_G343_A0.8500.84
352_V355_W0.8490.84
507_S512_V0.8480.84
357_P366_S0.8480.84
485_S501_A0.8450.83
152_G386_C0.8410.83
256_A264_M0.8380.83
498_Y502_L0.8370.83
132_S165_P0.8360.83
441_V452_R0.8330.82
359_I396_N0.8310.82
113_V117_A0.8300.82
295_M380_W0.8290.82
176_Q268_T0.8290.82
138_Q142_A0.8250.82
325_W329_L0.8210.82
394_I397_W0.8170.81
255_A259_A0.8160.81
399_A499_A0.8150.81
282_Y287_I0.8100.81
410_T422_I0.8090.81
153_S511_N0.8080.80
426_R466_E0.8060.80
356_T398_I0.8050.80
477_W481_L0.8050.80
273_S390_Q0.8040.80
263_T293_P0.8010.80
297_A305_H0.7990.80
406_V502_L0.7970.80
333_G346_P0.7950.79
503_F515_S0.7920.79
285_P289_A0.7900.79
292_L391_S0.7870.79
257_W392_A0.7870.79
151_T420_G0.7860.79
224_K543_I0.7840.78
249_A282_Y0.7830.78
144_F157_M0.7820.78
235_A239_V0.7820.78
262_H389_F0.7800.78
331_G343_A0.7770.78
504_E515_S0.7770.78
137_R158_A0.7750.78
300_I305_H0.7740.78
342_V380_W0.7720.77
132_S169_Q0.7710.77
345_V349_P0.7700.77
349_P353_T0.7680.77
407_G482_F0.7680.77
262_H275_T0.7670.77
502_L506_A0.7610.76
524_S531_F0.7590.76
241_I287_I0.7580.76
119_W150_W0.7560.76
355_W365_L0.7560.76
358_A366_S0.7550.76
151_T268_T0.7540.76
203_R206_A0.7520.76
166_R257_W0.7510.75
330_L339_A0.7500.75
151_T226_V0.7480.75
338_A431_V0.7470.75
329_L333_G0.7440.75
214_S217_S0.7440.75
228_G232_V0.7410.74
496_F522_D0.7380.74
143_L529_A0.7380.74
170_W173_S0.7350.74
393_P517_G0.7340.74
273_S277_N0.7330.74
437_Q468_S0.7320.74
384_L394_I0.7310.73
227_V231_V0.7300.73
331_G342_V0.7300.73
504_E519_T0.7260.73
343_A380_W0.7190.72
291_L391_S0.7190.72
142_A164_L0.7190.72
430_A434_F0.7180.72
119_W151_T0.7180.72
142_A146_S0.7160.72
382_S387_T0.7160.72
247_G251_P0.7140.72
344_A347_V0.7130.72
480_L537_I0.7110.71
126_N129_T0.7110.71
233_G263_T0.7100.71
366_S372_A0.7100.71
429_T458_L0.7090.71
283_D367_P0.7090.71
222_V539_R0.7080.71
200_A214_S0.7070.71
157_M392_A0.7060.71
481_L485_S0.7060.71
334_V338_A0.7000.70
489_V527_A0.6980.70
235_A238_F0.6980.70
270_G387_T0.6970.70
501_A518_I0.6970.70
329_L343_A0.6960.70
453_I458_L0.6950.70
253_W257_W0.6950.70
302_F510_G0.6930.69
323_T330_L0.6930.69
338_A424_I0.6930.69
179_G535_M0.6930.69
357_P364_V0.6920.69
289_A377_T0.6910.69
410_T477_W0.6870.69
337_L454_D0.6870.69
330_L335_V0.6850.69
367_P372_A0.6840.68
487_V526_I0.6820.68
350_D380_W0.6800.68
148_S153_S0.6790.68
321_L325_W0.6790.68
155_L503_F0.6780.68
378_F389_F0.6760.68
498_Y501_A0.6750.67
327_F333_G0.6740.67
216_V220_R0.6730.67
155_L508_A0.6710.67
200_A203_R0.6700.67
158_A164_L0.6700.67
247_G252_V0.6700.67
159_I276_D0.6700.67
152_G269_T0.6680.67
248_A259_A0.6670.66
198_S203_R0.6670.66
382_S514_L0.6640.66
226_V267_L0.6620.66
373_A376_A0.6620.66
316_V332_G0.6610.66
155_L519_T0.6590.66
486_L490_N0.6580.65
327_F343_A0.6560.65
258_Q275_T0.6550.65
384_L408_A0.6520.65
145_E156_T0.6520.65
221_T306_Y0.6500.64
106_P109_M0.6500.64
377_T381_V0.6490.64
509_Q534_N0.6480.64
485_S505_V0.6460.64
215_V223_W0.6460.64
122_V299_A0.6430.64
410_T481_L0.6400.63
390_Q514_L0.6400.63
177_W226_V0.6380.63
234_V259_A0.6370.63
226_V230_T0.6370.63
224_K231_V0.6360.63
288_E374_R0.6320.62
359_I365_L0.6300.62
279_I387_T0.6300.62
422_I474_A0.6290.62
122_V126_N0.6280.62
156_T172_R0.6280.62
518_I531_F0.6270.62
235_A293_P0.6260.62
341_N344_A0.6260.62
349_P352_V0.6250.61
272_F416_G0.6250.61
156_T231_V0.6250.61
400_G486_L0.6250.61
419_V477_W0.6240.61
156_T390_Q0.6230.61
328_V333_G0.6220.61
124_V341_N0.6210.61
238_F248_A0.6210.61
269_T387_T0.6210.61
116_D120_T0.6200.61
542_I546_L0.6180.61
386_C391_S0.6160.60
177_W268_T0.6160.60
262_H274_V0.6160.60
494_P497_S0.6150.60
481_L506_A0.6150.60
384_L514_L0.6150.60
295_M386_C0.6130.60
122_V179_G0.6120.60
157_M548_F0.6110.60
237_L241_I0.6100.60
460_R463_M0.6100.60
329_L336_V0.6080.59
117_A121_A0.6060.59
140_L315_G0.6060.59
317_L332_G0.6050.59
141_H163_S0.6050.59
433_G467_F0.6040.59
201_L206_A0.6040.59
155_L515_S0.6030.59
327_F331_G0.6030.59
496_F500_D0.6020.59
482_F486_L0.6010.58
409_M517_G0.6000.58
386_C511_N0.5990.58
149_G261_N0.5990.58
126_N171_W0.5980.58
247_G259_A0.5970.58
370_A373_A0.5970.58
468_S543_I0.5970.58
392_A397_W0.5950.58
433_G463_M0.5940.58
414_A419_V0.5930.57
300_I308_L0.5930.57
152_G387_T0.5920.57
386_C424_I0.5920.57
328_V332_G0.5900.57
195_G222_V0.5900.57
157_M163_S0.5890.57
437_Q464_E0.5890.57
181_V226_V0.5880.57
248_A252_V0.5880.57
331_G338_A0.5870.57
403_I482_F0.5860.57
231_V234_V0.5850.56
249_A255_A0.5850.56
156_T163_S0.5850.56
170_W174_L0.5850.56
336_V342_V0.5840.56
338_A341_N0.5840.56
412_G421_G0.5830.56
235_A263_T0.5830.56
474_A478_V0.5830.56
546_L550_R0.5820.56
123_S142_A0.5820.56
117_A474_A0.5820.56
113_V429_T0.5810.56
452_R455_G0.5800.56
168_I541_E0.5780.56
131_S163_S0.5770.55
330_L343_A0.5760.55
515_S554_S0.5760.55
504_E508_A0.5750.55
176_Q389_F0.5730.55
261_N265_T0.5730.55
115_T151_T0.5730.55
225_L305_H0.5710.55
355_W369_Q0.5710.55
503_F507_S0.5710.55
429_T432_R0.5700.55
354_Q401_G0.5690.54
266_G451_A0.5660.54
429_T462_A0.5650.54
519_T523_M0.5650.54
173_S265_T0.5640.54
322_Q330_L0.5640.54
173_S230_T0.5630.54
344_A489_V0.5630.54
237_L272_F0.5620.53
340_Q343_A0.5620.53
411_I535_M0.5620.53
518_I527_A0.5620.53
201_L205_E0.5620.53
463_M466_E0.5610.53
308_L312_R0.5600.53
183_V401_G0.5600.53
338_A343_A0.5600.53
152_G295_M0.5590.53
334_V341_N0.5590.53
283_D375_D0.5560.53
153_S535_M0.5560.53
475_L478_V0.5560.53
150_W539_R0.5540.52
481_L505_V0.5540.52
200_A450_T0.5540.52
429_T551_A0.5540.52
155_L504_E0.5520.52
387_T511_N0.5520.52
130_L162_P0.5520.52
434_F464_E0.5510.52
257_W419_V0.5500.52
500_D518_I0.5500.52
330_L334_V0.5500.52
256_A259_A0.5490.52
382_S386_C0.5480.52
312_R317_L0.5480.52
508_A531_F0.5470.52
434_F550_R0.5470.52
137_R141_H0.5470.52
217_S220_R0.5460.51
335_V414_A0.5460.51
474_A479_V0.5460.51
262_H272_F0.5450.51
335_V339_A0.5450.51
386_C423_K0.5440.51
205_E208_E0.5440.51
328_V336_V0.5440.51
163_S166_R0.5430.51
526_I530_M0.5420.51
177_W264_M0.5420.51
474_A477_W0.5410.51
121_A125_G0.5410.51
518_I523_M0.5410.51
112_F540_L0.5400.51
465_Q543_I0.5400.51
492_A531_F0.5390.51
241_I257_W0.5380.50
152_G380_W0.5370.50
485_S506_A0.5370.50
264_M290_A0.5360.50
116_D121_A0.5360.50
240_A246_Y0.5350.50
238_F247_G0.5340.50
138_Q163_S0.5330.50
305_H309_L0.5320.50
215_V407_G0.5320.50
199_Y202_Y0.5320.50
432_R451_A0.5310.49
108_A151_T0.5300.49
118_T178_V0.5300.49
173_S261_N0.5280.49
477_W534_N0.5270.49
297_A300_I0.5270.49
231_V345_V0.5270.49
112_F548_F0.5260.49
176_Q264_M0.5260.49
353_T490_N0.5260.49
337_L341_N0.5250.49
170_W217_S0.5240.49
494_P524_S0.5240.49
122_V270_G0.5230.48
297_A308_L0.5230.48
298_G301_A0.5230.48
307_R433_G0.5220.48
379_Q392_A0.5210.48
151_T343_A0.5210.48
225_L228_G0.5210.48
240_A286_V0.5200.48
412_G420_G0.5190.48
253_W548_F0.5180.48
303_P428_Y0.5170.48
109_M112_F0.5170.48
528_E532_L0.5160.48
111_R434_F0.5150.47
389_F418_T0.5150.47
170_W239_V0.5150.47
152_G385_T0.5140.47
386_C389_F0.5130.47
133_L136_F0.5100.47
411_I510_G0.5100.47
190_I476_L0.5090.47
324_R330_L0.5090.47
278_S390_Q0.5090.47
276_D281_T0.5090.47
409_M508_A0.5090.47
400_G459_D0.5080.47
475_L479_V0.5080.47
238_F251_P0.5080.47
236_V247_G0.5070.46
278_S512_V0.5070.46
166_R183_V0.5070.46
369_Q380_W0.5070.46
302_F417_S0.5060.46
209_K416_G0.5060.46
189_S215_V0.5060.46
134_A193_R0.5050.46
138_Q528_E0.5050.46
278_S387_T0.5050.46
180_G412_G0.5050.46
494_P527_A0.5050.46
213_P496_F0.5040.46
159_I390_Q0.5040.46
212_H549_A0.5040.46
278_S307_R0.5030.46
522_D526_I0.5030.46
246_Y250_L0.5030.46
113_V533_F0.5030.46
170_W296_V0.5030.46
474_A480_L0.5020.46
357_P398_I0.5010.46
350_D379_Q0.5010.46
480_L484_T0.5000.45
379_Q382_S0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j7cI 2 0.7455 100 0.334 Contact Map
3pjzA 2 0.8262 100 0.341 Contact Map
3ukmA 2 0.362 97.5 0.941 Contact Map
4twkA 2 0.3853 95.9 0.953 Contact Map
4wfeA 2 0.362 95.6 0.954 Contact Map
4bw5A 2 0.3638 95.5 0.954 Contact Map
2a9hA 4 0.1738 77.4 0.968 Contact Map
2ih3C 4 0.1738 77 0.968 Contact Map
1lnqA 6 0.1398 74.6 0.968 Contact Map
3effK 4 0.1649 70.7 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0129 seconds.