GREMLIN Database
KAD - Adenylate kinase
UniProt: Q9HPA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (204)
Sequences: 4042 (2410)
Seq/√Len: 168.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_E175_E3.6161.00
57_G61_D2.9421.00
121_G139_S2.8501.00
38_L71_V2.7501.00
59_Y67_P2.6071.00
198_R206_D2.5901.00
127_R138_V2.5281.00
26_E208_A2.5271.00
101_D188_Q2.4141.00
52_E58_A2.3281.00
40_A44_K2.3001.00
198_R202_E2.2941.00
160_E163_T2.2821.00
129_C132_C2.2761.00
113_D193_E2.2731.00
72_N90_Y2.2491.00
111_Y193_E2.2491.00
125_G137_H2.2311.00
41_N77_T2.2211.00
22_R204_W2.2091.00
112_L196_G2.1461.00
172_T176_E2.1231.00
186_R193_E2.0861.00
130_E157_Y1.9941.00
130_E154_G1.9891.00
72_N99_Y1.9001.00
46_I51_V1.8611.00
27_F208_A1.8291.00
78_A81_D1.7931.00
169_E172_T1.7241.00
148_V155_S1.6491.00
123_L167_A1.6381.00
48_H52_E1.6281.00
108_V192_A1.6211.00
42_K60_M1.6211.00
101_D184_Y1.6141.00
30_E78_A1.6101.00
164_E168_R1.5761.00
26_E204_W1.5741.00
132_C152_C1.5641.00
129_C152_C1.5631.00
199_T202_E1.5281.00
115_D197_E1.5211.00
48_H51_V1.5071.00
192_A210_A1.5001.00
179_A183_E1.4901.00
58_A62_A1.4701.00
118_E121_G1.4691.00
149_C152_C1.4511.00
173_V177_N1.4361.00
131_D152_C1.4211.00
52_E73_E1.4061.00
19_Q207_V1.4061.00
114_V196_G1.3711.00
130_E155_S1.3661.00
118_E197_E1.3641.00
145_T148_V1.3511.00
22_R201_D1.3401.00
120_V168_R1.3321.00
14_A114_V1.3201.00
129_C149_C1.2801.00
125_G138_V1.2801.00
132_C149_C1.2771.00
204_W208_A1.2641.00
202_E206_D1.2591.00
41_N74_I1.2391.00
116_E168_R1.2351.00
13_G123_L1.2211.00
205_T209_A1.2061.00
128_V135_T1.2031.00
70_V73_E1.2001.00
67_P70_V1.1961.00
95_S98_E1.1941.00
44_K47_T1.1801.00
127_R158_Q1.1741.00
47_T50_D1.1691.00
198_R203_V1.1691.00
41_N47_T1.1561.00
41_N44_K1.1531.00
85_Y106_L1.1511.00
7_L106_L1.1391.00
169_E173_V1.1301.00
111_Y182_V1.1281.00
163_T166_T1.1281.00
98_E101_D1.1251.00
175_E179_A1.1241.00
21_R25_D1.1221.00
183_E187_E1.1171.00
120_V124_T1.1141.00
116_E172_T1.1061.00
76_K103_I1.0961.00
195_D198_R1.0931.00
78_A84_G1.0871.00
144_E150_D1.0801.00
5_N106_L1.0761.00
110_L207_V1.0721.00
137_H140_F1.0701.00
35_G39_R1.0691.00
9_L182_V1.0671.00
37_A41_N1.0460.99
59_Y64_E1.0420.99
195_D203_V1.0370.99
38_L42_K1.0250.99
124_T164_E1.0250.99
109_V191_L1.0220.99
29_V85_Y1.0160.99
116_E171_I1.0140.99
29_V84_G1.0140.99
28_G83_D1.0130.99
101_D185_F1.0130.99
11_A174_Y1.0020.99
143_P150_D1.0000.99
8_L23_L1.0000.99
202_E205_T0.9890.99
194_V203_V0.9840.99
171_I175_E0.9780.99
8_L20_S0.9750.99
40_A78_A0.9730.99
41_N53_Y0.9630.99
8_L112_L0.9630.99
76_K80_D0.9610.99
19_Q204_W0.9410.99
134_A151_A0.9400.99
98_E102_S0.9370.99
22_R25_D0.9350.99
149_C154_G0.9340.99
24_V31_H0.9320.99
17_G88_D0.9300.99
183_E186_R0.9300.99
129_C154_G0.9230.99
127_R156_L0.9200.99
64_E169_E0.9170.99
23_L86_V0.9150.98
134_A152_C0.9130.98
99_Y102_S0.9010.98
134_A141_N0.8950.98
53_Y59_Y0.8860.98
8_L86_V0.8850.98
120_V167_A0.8830.98
194_V210_A0.8830.98
23_L207_V0.8760.98
200_P204_W0.8740.98
168_R172_T0.8700.98
98_E184_Y0.8670.98
129_C134_A0.8630.98
68_D96_Q0.8580.98
152_C155_S0.8570.98
166_T169_E0.8550.98
194_V207_V0.8540.98
44_K81_D0.8530.98
106_L190_V0.8470.98
52_E69_A0.8460.97
5_N107_D0.8420.97
94_E98_E0.8410.97
145_T150_D0.8370.97
159_R162_D0.8340.97
174_Y178_T0.8330.97
53_Y60_M0.8270.97
73_E76_K0.8220.97
205_T208_A0.8190.97
46_I57_G0.8140.97
53_Y73_E0.7990.96
72_N75_V0.7850.96
154_G157_Y0.7810.96
47_T53_Y0.7770.96
30_E84_G0.7760.96
134_A149_C0.7750.96
195_D206_D0.7660.96
181_V191_L0.7650.95
125_G140_F0.7590.95
40_A81_D0.7580.95
119_L167_A0.7540.95
29_V78_A0.7540.95
206_D209_A0.7510.95
51_V58_A0.7480.95
33_T36_D0.7480.95
117_D168_R0.7370.94
49_L73_E0.7350.94
184_Y188_Q0.7270.94
4_P107_D0.7200.94
52_E59_Y0.7190.94
5_N85_Y0.7180.94
113_D182_V0.7180.94
137_H143_P0.7170.94
132_C154_G0.7160.94
51_V57_G0.7150.94
38_L60_M0.7110.93
97_T185_F0.7080.93
9_L174_Y0.7050.93
21_R31_H0.7040.93
132_C151_A0.7030.93
178_T181_V0.7000.93
158_Q163_T0.7000.93
37_A74_I0.6990.93
9_L181_V0.6980.93
77_T81_D0.6950.93
206_D210_A0.6940.93
35_G92_R0.6930.92
148_V153_G0.6920.92
17_G39_R0.6900.92
10_G13_G0.6870.92
31_H36_D0.6790.92
68_D93_N0.6770.92
128_V157_Y0.6760.92
58_A61_D0.6740.91
152_C156_L0.6700.91
39_R92_R0.6690.91
38_L75_V0.6690.91
117_D121_G0.6650.91
25_D28_G0.6620.91
111_Y191_L0.6580.90
42_K50_D0.6570.90
136_F143_P0.6570.90
129_C155_S0.6520.90
125_G139_S0.6500.90
41_N73_E0.6490.90
120_V164_E0.6480.90
46_I50_D0.6470.90
138_V158_Q0.6470.90
147_G150_D0.6450.90
59_Y62_A0.6450.90
197_E203_V0.6420.89
19_Q194_V0.6350.89
109_V190_V0.6320.89
131_D154_G0.6320.89
6_V108_V0.6300.88
32_V85_Y0.6280.88
27_F204_W0.6210.88
124_T163_T0.6190.88
21_R24_V0.6140.87
108_V210_A0.6120.87
115_D118_E0.6110.87
6_V106_L0.6100.87
85_Y104_T0.6060.86
69_A73_E0.6040.86
15_G18_T0.6040.86
25_D151_A0.6010.86
91_P96_Q0.5980.86
7_L191_L0.5970.86
77_T80_D0.5960.86
19_Q203_V0.5950.85
114_V119_L0.5930.85
9_L109_V0.5930.85
181_V185_F0.5910.85
12_P166_T0.5850.84
13_G167_A0.5820.84
126_R162_D0.5820.84
94_E184_Y0.5800.84
139_S142_Q0.5800.84
22_R200_P0.5780.84
58_A70_V0.5770.84
11_A14_A0.5750.83
108_V190_V0.5670.83
9_L31_H0.5650.82
137_H142_Q0.5650.82
4_P211_V0.5610.82
73_E77_T0.5590.82
50_D53_Y0.5580.82
49_L70_V0.5550.81
197_E206_D0.5550.81
65_L92_R0.5520.81
89_G96_Q0.5510.81
196_G203_V0.5500.81
53_Y66_V0.5480.80
37_A75_V0.5470.80
17_G65_L0.5440.80
92_R126_R0.5410.80
61_D160_E0.5400.79
14_A20_S0.5380.79
65_L161_D0.5370.79
49_L74_I0.5370.79
158_Q164_E0.5370.79
44_K53_Y0.5370.79
6_V211_V0.5360.79
138_V143_P0.5350.79
59_Y70_V0.5340.79
143_P156_L0.5320.78
165_E169_E0.5290.78
92_R162_D0.5290.78
75_V99_Y0.5290.78
7_L103_I0.5270.78
79_L85_Y0.5270.78
101_D104_T0.5260.78
89_G92_R0.5230.77
126_R161_D0.5200.77
178_T182_V0.5190.77
35_G65_L0.5180.77
119_L171_I0.5180.77
151_A154_G0.5170.76
92_R159_R0.5170.76
18_T122_R0.5170.76
136_F142_Q0.5160.76
71_V75_V0.5150.76
100_L104_T0.5140.76
34_T75_V0.5140.76
116_E120_V0.5120.76
207_V210_A0.5120.76
12_P119_L0.5110.76
118_E199_T0.5100.76
23_L204_W0.5060.75
5_N9_L0.5060.75
130_E135_T0.5050.75
162_D166_T0.5050.75
17_G35_G0.5040.75
161_D170_R0.5000.74
98_E187_E0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qbgB 1 0.9676 100 0.348 Contact Map
3be4A 1 0.9491 100 0.362 Contact Map
1zd8A 1 0.9676 100 0.367 Contact Map
3tlxA 1 0.9676 100 0.368 Contact Map
4pzlA 2 0.9722 100 0.368 Contact Map
3gmtA 1 0.8704 100 0.369 Contact Map
1akyA 1 0.9676 100 0.369 Contact Map
2xb4A 4 0.9491 100 0.372 Contact Map
4jzkA 1 0.9491 100 0.375 Contact Map
1ak2A 1 0.9815 100 0.38 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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