KAD - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

KAD - Adenylate kinase

UniProt:	Q9HPA7	Sequences: MSHPNVLLLGAPGAGKGTQSRRLVDEFGVEHVTTGDALRANKTKDITHLDVEYDTPGAYMDAGELVPDAVVNEIVKTALDDADGYVLDGYPRNESQTEYLDSITDLDVVLYLDVDEDELVGRLTGRRVCEDCGATFHVSFNQPETEGVCDACGGSLYQREDDTEETARERITVYEENTAPVVEYFREQGVLAEVDGERTPDEVWTDVAAAVDERTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	216 (204)
Sequences:	4042 (2410)
Seq/√Len:	168.8

ECOLI - KAD AROK AROL
BACSU - KAD AROK YQAC
HALSA - KAD KCY Y2452 KAD6
SULSO - KCY KAD6 Y1041

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
116_E	175_E	3.616	1.00
57_G	61_D	2.942	1.00
121_G	139_S	2.850	1.00
38_L	71_V	2.750	1.00
59_Y	67_P	2.607	1.00
198_R	206_D	2.590	1.00
127_R	138_V	2.528	1.00
26_E	208_A	2.527	1.00
101_D	188_Q	2.414	1.00
52_E	58_A	2.328	1.00
40_A	44_K	2.300	1.00
198_R	202_E	2.294	1.00
160_E	163_T	2.282	1.00
129_C	132_C	2.276	1.00
113_D	193_E	2.273	1.00
72_N	90_Y	2.249	1.00
111_Y	193_E	2.249	1.00
125_G	137_H	2.231	1.00
41_N	77_T	2.221	1.00
22_R	204_W	2.209	1.00
112_L	196_G	2.146	1.00
172_T	176_E	2.123	1.00
186_R	193_E	2.086	1.00
130_E	157_Y	1.994	1.00
130_E	154_G	1.989	1.00
72_N	99_Y	1.900	1.00
46_I	51_V	1.861	1.00
27_F	208_A	1.829	1.00
78_A	81_D	1.793	1.00
169_E	172_T	1.724	1.00
148_V	155_S	1.649	1.00
123_L	167_A	1.638	1.00
48_H	52_E	1.628	1.00
108_V	192_A	1.621	1.00
42_K	60_M	1.621	1.00
101_D	184_Y	1.614	1.00
30_E	78_A	1.610	1.00
164_E	168_R	1.576	1.00
26_E	204_W	1.574	1.00
132_C	152_C	1.564	1.00
129_C	152_C	1.563	1.00
199_T	202_E	1.528	1.00
115_D	197_E	1.521	1.00
48_H	51_V	1.507	1.00
192_A	210_A	1.500	1.00
179_A	183_E	1.490	1.00
58_A	62_A	1.470	1.00
118_E	121_G	1.469	1.00
149_C	152_C	1.451	1.00
173_V	177_N	1.436	1.00
131_D	152_C	1.421	1.00
52_E	73_E	1.406	1.00
19_Q	207_V	1.406	1.00
114_V	196_G	1.371	1.00
130_E	155_S	1.366	1.00
118_E	197_E	1.364	1.00
145_T	148_V	1.351	1.00
22_R	201_D	1.340	1.00
120_V	168_R	1.332	1.00
14_A	114_V	1.320	1.00
129_C	149_C	1.280	1.00
125_G	138_V	1.280	1.00
132_C	149_C	1.277	1.00
204_W	208_A	1.264	1.00
202_E	206_D	1.259	1.00
41_N	74_I	1.239	1.00
116_E	168_R	1.235	1.00
13_G	123_L	1.221	1.00
205_T	209_A	1.206	1.00
128_V	135_T	1.203	1.00
70_V	73_E	1.200	1.00
67_P	70_V	1.196	1.00
95_S	98_E	1.194	1.00
44_K	47_T	1.180	1.00
127_R	158_Q	1.174	1.00
47_T	50_D	1.169	1.00
198_R	203_V	1.169	1.00
41_N	47_T	1.156	1.00
41_N	44_K	1.153	1.00
85_Y	106_L	1.151	1.00
7_L	106_L	1.139	1.00
169_E	173_V	1.130	1.00
111_Y	182_V	1.128	1.00
163_T	166_T	1.128	1.00
98_E	101_D	1.125	1.00
175_E	179_A	1.124	1.00
21_R	25_D	1.122	1.00
183_E	187_E	1.117	1.00
120_V	124_T	1.114	1.00
116_E	172_T	1.106	1.00
76_K	103_I	1.096	1.00
195_D	198_R	1.093	1.00
78_A	84_G	1.087	1.00
144_E	150_D	1.080	1.00
5_N	106_L	1.076	1.00
110_L	207_V	1.072	1.00
137_H	140_F	1.070	1.00
35_G	39_R	1.069	1.00
9_L	182_V	1.067	1.00
37_A	41_N	1.046	0.99
59_Y	64_E	1.042	0.99
195_D	203_V	1.037	0.99
38_L	42_K	1.025	0.99
124_T	164_E	1.025	0.99
109_V	191_L	1.022	0.99
29_V	85_Y	1.016	0.99
116_E	171_I	1.014	0.99
29_V	84_G	1.014	0.99
28_G	83_D	1.013	0.99
101_D	185_F	1.013	0.99
11_A	174_Y	1.002	0.99
143_P	150_D	1.000	0.99
8_L	23_L	1.000	0.99
202_E	205_T	0.989	0.99
194_V	203_V	0.984	0.99
171_I	175_E	0.978	0.99
8_L	20_S	0.975	0.99
40_A	78_A	0.973	0.99
41_N	53_Y	0.963	0.99
8_L	112_L	0.963	0.99
76_K	80_D	0.961	0.99
19_Q	204_W	0.941	0.99
134_A	151_A	0.940	0.99
98_E	102_S	0.937	0.99
22_R	25_D	0.935	0.99
149_C	154_G	0.934	0.99
24_V	31_H	0.932	0.99
17_G	88_D	0.930	0.99
183_E	186_R	0.930	0.99
129_C	154_G	0.923	0.99
127_R	156_L	0.920	0.99
64_E	169_E	0.917	0.99
23_L	86_V	0.915	0.98
134_A	152_C	0.913	0.98
99_Y	102_S	0.901	0.98
134_A	141_N	0.895	0.98
53_Y	59_Y	0.886	0.98
8_L	86_V	0.885	0.98
120_V	167_A	0.883	0.98
194_V	210_A	0.883	0.98
23_L	207_V	0.876	0.98
200_P	204_W	0.874	0.98
168_R	172_T	0.870	0.98
98_E	184_Y	0.867	0.98
129_C	134_A	0.863	0.98
68_D	96_Q	0.858	0.98
152_C	155_S	0.857	0.98
166_T	169_E	0.855	0.98
194_V	207_V	0.854	0.98
44_K	81_D	0.853	0.98
106_L	190_V	0.847	0.98
52_E	69_A	0.846	0.97
5_N	107_D	0.842	0.97
94_E	98_E	0.841	0.97
145_T	150_D	0.837	0.97
159_R	162_D	0.834	0.97
174_Y	178_T	0.833	0.97
53_Y	60_M	0.827	0.97
73_E	76_K	0.822	0.97
205_T	208_A	0.819	0.97
46_I	57_G	0.814	0.97
53_Y	73_E	0.799	0.96
72_N	75_V	0.785	0.96
154_G	157_Y	0.781	0.96
47_T	53_Y	0.777	0.96
30_E	84_G	0.776	0.96
134_A	149_C	0.775	0.96
195_D	206_D	0.766	0.96
181_V	191_L	0.765	0.95
125_G	140_F	0.759	0.95
40_A	81_D	0.758	0.95
119_L	167_A	0.754	0.95
29_V	78_A	0.754	0.95
206_D	209_A	0.751	0.95
51_V	58_A	0.748	0.95
33_T	36_D	0.748	0.95
117_D	168_R	0.737	0.94
49_L	73_E	0.735	0.94
184_Y	188_Q	0.727	0.94
4_P	107_D	0.720	0.94
52_E	59_Y	0.719	0.94
5_N	85_Y	0.718	0.94
113_D	182_V	0.718	0.94
137_H	143_P	0.717	0.94
132_C	154_G	0.716	0.94
51_V	57_G	0.715	0.94
38_L	60_M	0.711	0.93
97_T	185_F	0.708	0.93
9_L	174_Y	0.705	0.93
21_R	31_H	0.704	0.93
132_C	151_A	0.703	0.93
178_T	181_V	0.700	0.93
158_Q	163_T	0.700	0.93
37_A	74_I	0.699	0.93
9_L	181_V	0.698	0.93
77_T	81_D	0.695	0.93
206_D	210_A	0.694	0.93
35_G	92_R	0.693	0.92
148_V	153_G	0.692	0.92
17_G	39_R	0.690	0.92
10_G	13_G	0.687	0.92
31_H	36_D	0.679	0.92
68_D	93_N	0.677	0.92
128_V	157_Y	0.676	0.92
58_A	61_D	0.674	0.91
152_C	156_L	0.670	0.91
39_R	92_R	0.669	0.91
38_L	75_V	0.669	0.91
117_D	121_G	0.665	0.91
25_D	28_G	0.662	0.91
111_Y	191_L	0.658	0.90
42_K	50_D	0.657	0.90
136_F	143_P	0.657	0.90
129_C	155_S	0.652	0.90
125_G	139_S	0.650	0.90
41_N	73_E	0.649	0.90
120_V	164_E	0.648	0.90
46_I	50_D	0.647	0.90
138_V	158_Q	0.647	0.90
147_G	150_D	0.645	0.90
59_Y	62_A	0.645	0.90
197_E	203_V	0.642	0.89
19_Q	194_V	0.635	0.89
109_V	190_V	0.632	0.89
131_D	154_G	0.632	0.89
6_V	108_V	0.630	0.88
32_V	85_Y	0.628	0.88
27_F	204_W	0.621	0.88
124_T	163_T	0.619	0.88
21_R	24_V	0.614	0.87
108_V	210_A	0.612	0.87
115_D	118_E	0.611	0.87
6_V	106_L	0.610	0.87
85_Y	104_T	0.606	0.86
69_A	73_E	0.604	0.86
15_G	18_T	0.604	0.86
25_D	151_A	0.601	0.86
91_P	96_Q	0.598	0.86
7_L	191_L	0.597	0.86
77_T	80_D	0.596	0.86
19_Q	203_V	0.595	0.85
114_V	119_L	0.593	0.85
9_L	109_V	0.593	0.85
181_V	185_F	0.591	0.85
12_P	166_T	0.585	0.84
13_G	167_A	0.582	0.84
126_R	162_D	0.582	0.84
94_E	184_Y	0.580	0.84
139_S	142_Q	0.580	0.84
22_R	200_P	0.578	0.84
58_A	70_V	0.577	0.84
11_A	14_A	0.575	0.83
108_V	190_V	0.567	0.83
9_L	31_H	0.565	0.82
137_H	142_Q	0.565	0.82
4_P	211_V	0.561	0.82
73_E	77_T	0.559	0.82
50_D	53_Y	0.558	0.82
49_L	70_V	0.555	0.81
197_E	206_D	0.555	0.81
65_L	92_R	0.552	0.81
89_G	96_Q	0.551	0.81
196_G	203_V	0.550	0.81
53_Y	66_V	0.548	0.80
37_A	75_V	0.547	0.80
17_G	65_L	0.544	0.80
92_R	126_R	0.541	0.80
61_D	160_E	0.540	0.79
14_A	20_S	0.538	0.79
65_L	161_D	0.537	0.79
49_L	74_I	0.537	0.79
158_Q	164_E	0.537	0.79
44_K	53_Y	0.537	0.79
6_V	211_V	0.536	0.79
138_V	143_P	0.535	0.79
59_Y	70_V	0.534	0.79
143_P	156_L	0.532	0.78
165_E	169_E	0.529	0.78
92_R	162_D	0.529	0.78
75_V	99_Y	0.529	0.78
7_L	103_I	0.527	0.78
79_L	85_Y	0.527	0.78
101_D	104_T	0.526	0.78
89_G	92_R	0.523	0.77
126_R	161_D	0.520	0.77
178_T	182_V	0.519	0.77
35_G	65_L	0.518	0.77
119_L	171_I	0.518	0.77
151_A	154_G	0.517	0.76
92_R	159_R	0.517	0.76
18_T	122_R	0.517	0.76
136_F	142_Q	0.516	0.76
71_V	75_V	0.515	0.76
100_L	104_T	0.514	0.76
34_T	75_V	0.514	0.76
116_E	120_V	0.512	0.76
207_V	210_A	0.512	0.76
12_P	119_L	0.511	0.76
118_E	199_T	0.510	0.76
23_L	204_W	0.506	0.75
5_N	9_L	0.506	0.75
130_E	135_T	0.505	0.75
162_D	166_T	0.505	0.75
17_G	35_G	0.504	0.75
161_D	170_R	0.500	0.74
98_E	187_E	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qbgB	1	0.9676	100	0.348	Contact Map
3be4A	1	0.9491	100	0.362	Contact Map
1zd8A	1	0.9676	100	0.367	Contact Map
3tlxA	1	0.9676	100	0.368	Contact Map
4pzlA	2	0.9722	100	0.368	Contact Map
3gmtA	1	0.8704	100	0.369	Contact Map
1akyA	1	0.9676	100	0.369	Contact Map
2xb4A	4	0.9491	100	0.372	Contact Map
4jzkA	1	0.9491	100	0.375	Contact Map
1ak2A	1	0.9815	100	0.38	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.