GREMLIN Database
KCY - Cytidylate kinase
UniProt: Q9HPA5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (167)
Sequences: 9230 (5597)
Seq/√Len: 433.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_E133_Q3.8951.00
23_H168_L3.1391.00
102_M132_T2.7031.00
19_T164_T2.6301.00
99_D152_S2.4761.00
121_R125_E2.3681.00
50_N54_E2.3481.00
104_V107_R2.2411.00
66_R71_A2.1111.00
157_R166_I1.8791.00
37_G41_D1.8751.00
107_R111_E1.8531.00
24_L168_L1.8481.00
159_G162_A1.8281.00
126_A129_E1.8211.00
98_L155_T1.8061.00
146_I152_S1.7911.00
97_W152_S1.7591.00
126_A130_S1.7461.00
104_V156_A1.7401.00
66_R69_E1.7091.00
65_R69_E1.6851.00
101_P156_A1.6501.00
23_H164_T1.6431.00
151_L170_A1.6231.00
44_L47_A1.6221.00
145_D152_S1.6151.00
19_T22_D1.5991.00
39_A53_A1.5931.00
60_D82_R1.5921.00
48_E51_E1.5861.00
110_A114_D1.5851.00
117_P120_A1.5821.00
24_L172_D1.5661.00
109_I124_T1.5641.00
166_I169_D1.5571.00
19_T161_D1.5401.00
102_M125_E1.5241.00
130_S134_R1.5111.00
157_R162_A1.4981.00
111_E114_D1.4961.00
5_I17_A1.4801.00
38_L65_R1.4681.00
51_E55_E1.4511.00
16_V167_V1.4401.00
64_D68_R1.4391.00
168_L172_D1.4231.00
122_A126_A1.4141.00
165_D169_D1.3911.00
44_L48_E1.3651.00
106_A125_E1.3571.00
94_I151_L1.3501.00
26_Y76_D1.3331.00
16_V164_T1.3121.00
39_A50_N1.3081.00
62_D66_R1.3041.00
42_R47_A1.3031.00
15_T160_P1.2961.00
96_I167_V1.2531.00
164_T168_L1.2251.00
132_T136_E1.2241.00
136_E142_D1.2161.00
11_S100_A1.1901.00
86_W147_T1.1811.00
39_A49_F1.1771.00
97_W141_I1.1751.00
19_T23_H1.1741.00
155_T163_V1.1591.00
142_D146_I1.1411.00
95_K150_D1.1341.00
63_L67_L1.1291.00
18_S22_D1.1221.00
60_D63_L1.1221.00
29_I79_L1.1191.00
60_D66_R1.1041.00
96_I170_A1.0971.00
120_A123_E1.0971.00
94_I170_A1.0951.00
166_I170_A1.0931.00
32_G36_R1.0821.00
122_A125_E1.0731.00
61_K64_D1.0601.00
125_E129_E1.0591.00
71_A89_G1.0521.00
2_L89_G1.0491.00
47_A50_N1.0461.00
52_L57_P1.0441.00
128_E132_T1.0431.00
113_E116_T1.0401.00
98_L167_V1.0351.00
20_L167_V1.0351.00
6_S141_I1.0341.00
38_L43_D1.0321.00
51_E54_E1.0131.00
49_F52_L1.0101.00
165_D168_L1.0041.00
103_S121_R1.0031.00
162_A165_D0.9961.00
102_M129_E0.9961.00
100_A155_T0.9881.00
20_L164_T0.9871.00
87_M90_E0.9861.00
114_D117_P0.9801.00
43_D46_L0.9771.00
111_E115_K0.9691.00
153_V170_A0.9661.00
38_L41_D0.9621.00
2_L93_D0.9591.00
106_A121_R0.9581.00
103_S107_R0.9311.00
57_P126_A0.9291.00
119_A123_E0.9281.00
110_A121_R0.9211.00
70_T74_R0.9181.00
142_D145_D0.9141.00
30_S33_D0.9081.00
65_R68_R0.9071.00
23_H172_D0.8991.00
60_D64_D0.8911.00
86_W90_E0.8841.00
60_D71_A0.8811.00
97_W132_T0.8781.00
49_F53_A0.8701.00
8_P131_E0.8621.00
160_P164_T0.8601.00
79_L84_A0.8581.00
62_D65_R0.8551.00
4_T84_A0.8491.00
18_S28_H0.8471.00
162_A166_I0.8331.00
153_V163_V0.8281.00
39_A46_L0.8221.00
38_L62_D0.8221.00
6_S95_K0.8181.00
4_T92_A0.8151.00
157_R163_V0.8121.00
131_E135_Y0.8061.00
48_E52_L0.8051.00
110_A120_A0.7991.00
111_E116_T0.7851.00
47_A51_E0.7851.00
34_I38_L0.7831.00
101_P104_V0.7821.00
97_W150_D0.7791.00
10_G109_I0.7711.00
113_E117_P0.7681.00
143_F147_T0.7641.00
18_S21_A0.7621.00
110_A113_E0.7501.00
48_E61_K0.7481.00
61_K65_R0.7481.00
154_N157_R0.7461.00
103_S125_E0.7441.00
91_Y149_Y0.7391.00
87_M137_E0.7381.00
145_D148_I0.7341.00
104_V157_R0.7301.00
34_I64_D0.7211.00
161_D165_D0.7211.00
45_T48_E0.7171.00
123_E126_A0.7151.00
92_A149_Y0.7131.00
69_E72_R0.7131.00
14_S80_E0.7101.00
27_E75_D0.7101.00
8_P105_R0.7061.00
102_M128_E0.7011.00
94_I171_V0.6921.00
16_V163_V0.6891.00
35_F39_A0.6841.00
3_V94_I0.6781.00
35_F63_L0.6671.00
17_A28_H0.6661.00
106_A110_A0.6651.00
84_A88_A0.6601.00
89_G143_F0.6570.99
29_I77_I0.6570.99
3_V171_V0.6560.99
60_D67_L0.6540.99
16_V160_P0.6480.99
12_G15_T0.6480.99
134_R138_Y0.6430.99
66_R70_T0.6400.99
52_L130_S0.6330.99
118_A121_R0.6300.99
5_I78_V0.6220.99
2_L77_I0.6170.99
76_D93_D0.6120.99
99_D141_I0.6070.99
21_A28_H0.6070.99
27_E66_R0.6070.99
26_Y77_I0.6070.99
20_L78_V0.6040.99
52_L55_E0.6030.99
20_L168_L0.6030.99
102_M121_R0.5990.99
42_R50_N0.5940.99
86_W145_D0.5930.99
57_P136_E0.5920.99
153_V166_I0.5900.99
154_N166_I0.5880.99
67_L71_A0.5870.99
155_T167_V0.5870.99
9_P123_E0.5860.99
52_L56_D0.5840.99
38_L46_L0.5790.99
5_I20_L0.5760.99
135_Y138_Y0.5690.99
37_G66_R0.5690.99
66_R72_R0.5680.99
103_S106_A0.5660.99
19_T160_P0.5660.99
8_P11_S0.5650.98
46_L49_F0.5620.98
27_E77_I0.5600.98
77_I92_A0.5600.98
64_D67_L0.5560.98
90_E143_F0.5510.98
130_S133_Q0.5490.98
12_G108_R0.5470.98
5_I98_L0.5450.98
31_G34_I0.5440.98
10_G124_T0.5410.98
119_A122_A0.5400.98
35_F53_A0.5390.98
50_N130_S0.5370.98
7_G10_G0.5360.98
7_G11_S0.5360.98
86_W143_F0.5350.98
127_R131_E0.5310.98
121_R124_T0.5290.98
129_E132_T0.5280.98
112_R116_T0.5240.98
86_W138_Y0.5230.98
23_H165_D0.5230.98
20_L171_V0.5210.97
67_L72_R0.5200.97
85_G88_A0.5180.97
99_D154_N0.5170.97
57_P61_K0.5160.97
64_D137_E0.5150.97
116_T119_A0.5090.97
2_L91_Y0.5090.97
141_I150_D0.5070.97
147_T150_D0.5060.97
79_L89_G0.5050.97
37_G69_E0.5040.97
118_A127_R0.5030.97
42_R56_D0.5010.97
83_L88_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qbgB 1 0.8958 100 0.384 Contact Map
2xb4A 4 0.8698 99.9 0.404 Contact Map
3tlxA 1 0.8802 99.9 0.407 Contact Map
4jzkA 1 0.875 99.9 0.408 Contact Map
1akyA 1 0.8906 99.9 0.408 Contact Map
3be4A 1 0.8594 99.9 0.411 Contact Map
2c95A 1 0.901 99.9 0.415 Contact Map
3gmtA 1 0.7865 99.9 0.416 Contact Map
4pzlA 2 0.8854 99.9 0.418 Contact Map
1zd8A 1 0.8906 99.9 0.42 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.