GREMLIN Database
Q9HPA2 - Htr17 transducer
UniProt: Q9HPA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 536 (449)
Sequences: 15978 (13353)
Seq/√Len: 630.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_K173_D3.1771.00
182_S188_T3.0011.00
88_T91_I2.9841.00
168_K176_V2.5421.00
195_N198_I2.3531.00
246_G463_I2.2841.00
51_T67_D2.2751.00
177_R202_E2.2181.00
163_S189_E2.1921.00
323_E389_N2.1671.00
162_Y191_G2.1601.00
167_E189_E2.1561.00
153_A157_K2.1531.00
132_D136_E2.1401.00
294_D298_A2.0611.00
152_D156_S2.0591.00
163_S193_A2.0501.00
167_E196_E2.0391.00
288_R424_E2.0271.00
322_A325_Q2.0151.00
185_D188_T1.9931.00
326_E329_R1.9631.00
167_E171_S1.9621.00
41_T45_G1.9281.00
110_E114_R1.9191.00
166_M197_M1.9161.00
305_D407_T1.9151.00
323_E393_S1.8991.00
319_A393_S1.8911.00
332_D336_D1.8861.00
195_N199_A1.8631.00
287_D291_Q1.8561.00
413_E417_N1.8311.00
300_V419_L1.8251.00
148_A152_D1.8041.00
169_A198_I1.8001.00
306_I411_G1.7971.00
64_P68_A1.7931.00
177_R199_A1.7861.00
34_A38_V1.7801.00
270_E273_A1.7721.00
166_M194_F1.7711.00
301_T305_D1.7661.00
169_A197_M1.7621.00
203_E207_R1.7171.00
420_T423_E1.7001.00
459_E462_D1.6951.00
79_G82_A1.6891.00
409_S413_E1.6891.00
82_A86_T1.6801.00
61_V65_V1.6801.00
135_E139_T1.6781.00
127_K131_Q1.6781.00
177_R198_I1.6761.00
65_V69_F1.6741.00
45_G49_L1.6731.00
431_D434_E1.6661.00
202_E206_A1.6591.00
60_G64_P1.6361.00
44_C48_F1.6351.00
177_R195_N1.6231.00
284_Q287_D1.6151.00
416_E420_T1.6131.00
291_Q294_D1.6091.00
48_F52_G1.6061.00
129_E133_A1.6021.00
78_I82_A1.6001.00
71_T75_A1.5981.00
58_W61_V1.5981.00
189_E192_Q1.5951.00
406_A410_S1.5911.00
166_M193_A1.5851.00
297_A301_T1.5831.00
167_E193_A1.5681.00
121_A125_E1.5611.00
277_Q280_D1.5571.00
298_A301_T1.5481.00
329_R332_D1.5471.00
33_I85_S1.5441.00
486_S490_D1.5431.00
317_A397_V1.5361.00
420_T424_E1.5331.00
136_E140_L1.5261.00
109_A112_A1.5221.00
480_Q483_A1.5201.00
110_E113_K1.5181.00
304_T416_E1.5181.00
376_T380_T1.5121.00
33_I37_W1.5111.00
384_E388_D1.5091.00
321_A398_V1.5011.00
280_D283_D1.5011.00
278_V436_V1.5001.00
37_W41_T1.4981.00
42_Y45_G1.4921.00
131_Q135_E1.4851.00
280_D284_Q1.4811.00
253_R459_E1.4751.00
316_E396_S1.4681.00
162_Y190_V1.4681.00
231_A235_Q1.4631.00
378_E382_E1.4561.00
487_D490_D1.4551.00
452_T455_S1.4531.00
316_E397_V1.4511.00
430_T434_E1.4441.00
64_P67_D1.4371.00
107_K111_Q1.4331.00
417_N420_T1.4311.00
298_A414_T1.4291.00
326_E382_E1.4261.00
323_E326_E1.4221.00
424_E427_D1.4201.00
290_R294_D1.4171.00
97_T100_A1.4151.00
444_D448_A1.4151.00
410_S413_E1.4121.00
48_F51_T1.4071.00
40_Y44_C1.4071.00
262_Q266_G1.3891.00
298_A417_N1.3791.00
371_E374_E1.3741.00
162_Y194_F1.3691.00
318_N322_A1.3641.00
295_D417_N1.3571.00
451_D455_S1.3521.00
242_E245_A1.3511.00
483_A487_D1.3481.00
160_S163_S1.3481.00
199_A203_E1.3461.00
163_S167_E1.3391.00
117_D121_A1.3351.00
57_E60_G1.3261.00
328_R391_L1.3241.00
111_Q114_R1.3231.00
68_A72_S1.3221.00
374_E378_E1.3211.00
180_S195_N1.3181.00
423_E427_D1.3171.00
311_E315_S1.3121.00
319_A322_A1.3101.00
75_A79_G1.3061.00
289_G426_G1.3061.00
56_L59_I1.2971.00
65_V68_A1.2961.00
173_D176_V1.2931.00
367_A370_K1.2921.00
57_E61_V1.2781.00
308_S312_A1.2771.00
290_R430_T1.2741.00
161_E179_N1.2741.00
479_Q483_A1.2741.00
335_N384_E1.2741.00
128_A132_D1.2721.00
82_A85_S1.2721.00
322_A326_E1.2701.00
427_D431_D1.2681.00
128_A131_Q1.2681.00
252_T255_A1.2681.00
229_I233_S1.2601.00
301_T304_T1.2561.00
349_S370_K1.2561.00
283_D287_D1.2551.00
271_V443_T1.2471.00
111_Q115_R1.2431.00
349_S367_A1.2431.00
166_M190_V1.2371.00
164_S167_E1.2221.00
34_A37_W1.2181.00
476_A480_Q1.2171.00
83_I88_T1.2161.00
276_S280_D1.2151.00
238_E242_E1.2141.00
47_G51_T1.2081.00
69_F72_S1.2061.00
67_D71_T1.2051.00
302_Q410_S1.2051.00
256_D259_D1.2001.00
38_V42_Y1.1961.00
293_S423_E1.1831.00
381_D385_T1.1811.00
269_E273_A1.1781.00
76_V79_G1.1761.00
132_D135_E1.1751.00
50_W59_I1.1741.00
124_Q128_A1.1691.00
49_L52_G1.1691.00
112_A115_R1.1681.00
286_A290_R1.1671.00
206_A210_E1.1651.00
473_S476_A1.1641.00
273_A277_Q1.1641.00
149_A153_A1.1541.00
406_A409_S1.1521.00
310_T408_V1.1501.00
118_E122_Q1.1501.00
287_D290_R1.1491.00
120_R124_Q1.1481.00
469_S473_S1.1471.00
32_D35_G1.1461.00
312_A315_S1.1451.00
462_D466_Q1.1431.00
292_G425_I1.1381.00
198_I202_E1.1381.00
40_Y78_I1.1351.00
299_A415_V1.1341.00
90_S94_D1.1331.00
200_A203_E1.1331.00
308_S311_E1.1331.00
469_S472_A1.1331.00
299_A418_A1.1321.00
378_E381_D1.1241.00
122_Q126_A1.1231.00
458_E462_D1.1201.00
168_K171_S1.1201.00
62_A65_V1.1191.00
208_T211_F1.1081.00
180_S191_G1.1081.00
241_Q245_A1.1051.00
44_C74_L1.1001.00
462_D465_E1.0981.00
281_V431_D1.0971.00
249_R252_T1.0951.00
239_S470_E1.0941.00
119_Q122_Q1.0931.00
207_R210_E1.0931.00
248_D252_T1.0931.00
38_V41_T1.0901.00
96_K100_A1.0891.00
165_V178_A1.0881.00
333_L379_A1.0871.00
180_S192_Q1.0861.00
381_D384_E1.0861.00
441_D445_A1.0831.00
317_A398_V1.0821.00
252_T256_D1.0811.00
293_S297_A1.0811.00
245_A249_R1.0791.00
178_A195_N1.0771.00
171_S196_E1.0771.00
133_A136_E1.0761.00
108_D111_Q1.0751.00
45_G48_F1.0741.00
276_S444_D1.0681.00
388_D392_S1.0661.00
116_A120_R1.0651.00
109_A114_R1.0631.00
31_T34_A1.0611.00
291_Q424_E1.0561.00
123_A127_K1.0551.00
466_Q469_S1.0451.00
154_Q158_K1.0441.00
291_Q417_N1.0441.00
43_I47_G1.0421.00
441_D444_D1.0421.00
74_L78_I1.0391.00
73_L77_L1.0381.00
324_A394_T1.0381.00
77_L81_V1.0371.00
90_S93_E1.0361.00
385_T389_N1.0331.00
293_S426_G1.0331.00
182_S185_D1.0301.00
162_Y166_M1.0201.00
160_S164_S1.0181.00
191_G195_N1.0171.00
116_A119_Q1.0111.00
245_A248_D1.0111.00
269_E451_D1.0111.00
294_D297_A1.0101.00
70_S74_L1.0101.00
161_E164_S1.0101.00
108_D112_A1.0091.00
43_I46_L1.0081.00
263_S266_G1.0071.00
100_A104_R1.0061.00
307_Q412_T1.0051.00
326_E389_N1.0041.00
192_Q195_N1.0011.00
273_A276_S1.0011.00
292_G422_L1.0001.00
159_A187_M1.0001.00
490_D493_T0.9991.00
264_L450_A0.9981.00
95_L98_S0.9971.00
75_A78_I0.9951.00
227_D231_A0.9951.00
89_I93_E0.9941.00
455_S459_E0.9931.00
309_E407_T0.9931.00
465_E469_S0.9911.00
164_S168_K0.9851.00
315_S319_A0.9851.00
227_D489_T0.9801.00
321_A395_Q0.9791.00
72_S75_A0.9791.00
335_N380_T0.9791.00
304_T308_S0.9771.00
235_Q238_E0.9721.00
204_M208_T0.9711.00
178_A191_G0.9701.00
259_D263_S0.9681.00
174_L201_F0.9681.00
413_E416_E0.9671.00
35_G38_V0.9611.00
315_S318_N0.9611.00
58_W62_A0.9581.00
81_V85_S0.9561.00
79_G83_I0.9531.00
249_R253_R0.9481.00
382_E385_T0.9471.00
489_T493_T0.9461.00
165_V168_K0.9461.00
179_N195_N0.9431.00
205_V208_T0.9391.00
176_V198_I0.9381.00
47_G50_W0.9381.00
150_E153_A0.9371.00
61_V64_P0.9351.00
159_A190_V0.9341.00
254_L460_I0.9331.00
155_L158_K0.9291.00
107_K110_E0.9291.00
395_Q399_D0.9281.00
472_A476_A0.9271.00
121_A124_Q0.9231.00
375_E378_E0.9221.00
44_C47_G0.9191.00
196_E199_A0.9191.00
157_K161_E0.9171.00
68_A71_T0.9131.00
316_E400_D0.9121.00
165_V176_V0.9121.00
163_S190_V0.9061.00
46_L49_L0.9021.00
257_A453_T0.9001.00
109_A113_K0.8921.00
187_M191_G0.8901.00
325_Q395_Q0.8861.00
434_E438_Q0.8801.00
296_A418_A0.8801.00
414_T417_N0.8771.00
124_Q127_K0.8761.00
165_V194_F0.8751.00
59_I62_A0.8741.00
196_E200_A0.8741.00
184_S188_T0.8731.00
377_N381_D0.8731.00
37_W40_Y0.8731.00
117_D120_R0.8731.00
330_V386_L0.8731.00
51_T64_P0.8711.00
194_F197_M0.8681.00
158_K187_M0.8641.00
169_A194_F0.8601.00
234_E238_E0.8601.00
39_N42_Y0.8591.00
407_T410_S0.8581.00
285_A429_V0.8571.00
288_R428_H0.8571.00
207_R487_D0.8551.00
35_G39_N0.8521.00
180_S188_T0.8511.00
286_A430_T0.8511.00
114_R118_E0.8471.00
203_E206_A0.8451.00
244_S248_D0.8441.00
274_S438_Q0.8421.00
129_E132_D0.8411.00
303_M411_G0.8411.00
42_Y46_L0.8391.00
230_E234_E0.8391.00
437_Q441_D0.8381.00
161_E165_V0.8361.00
40_Y77_L0.8351.00
455_S458_E0.8331.00
335_N339_D0.8281.00
264_L446_Q0.8281.00
306_I408_V0.8251.00
311_E405_A0.8251.00
385_T388_D0.8251.00
230_E233_S0.8231.00
139_T143_K0.8181.00
325_Q329_R0.8141.00
288_R291_Q0.8131.00
206_A209_R0.8101.00
321_A325_Q0.8091.00
156_S160_S0.8081.00
255_A259_D0.8081.00
284_Q288_R0.8071.00
307_Q409_S0.8071.00
266_G270_E0.8041.00
303_M306_I0.8011.00
43_I70_S0.8011.00
41_T44_C0.8011.00
122_Q125_E0.7981.00
234_E482_T0.7921.00
261_L457_I0.7891.00
54_V63_G0.7881.00
228_E231_A0.7881.00
305_D308_S0.7871.00
84_S88_T0.7831.00
336_D339_D0.7831.00
427_D430_T0.7801.00
158_K186_A0.7801.00
284_Q428_H0.7771.00
137_A141_A0.7751.00
166_M169_A0.7741.00
483_A486_S0.7711.00
438_Q441_D0.7701.00
91_I94_D0.7681.00
51_T63_G0.7671.00
40_Y74_L0.7661.00
240_V474_V0.7651.00
31_T35_G0.7641.00
476_A479_Q0.7641.00
326_E386_L0.7641.00
207_R211_F0.7641.00
96_K99_N0.7641.00
101_R104_R0.7621.00
324_A390_L0.7621.00
77_L80_V0.7621.00
160_S189_E0.7621.00
491_G494_R0.7621.00
262_Q454_V0.7611.00
319_A323_E0.7571.00
157_K160_S0.7561.00
279_A283_D0.7541.00
32_D36_F0.7541.00
108_D113_K0.7521.00
238_E241_Q0.7511.00
103_H107_K0.7481.00
265_S454_V0.7471.00
170_A196_E0.7451.00
84_S87_G0.7431.00
375_E382_E0.7411.00
47_G67_D0.7341.00
246_G467_N0.7331.00
277_Q435_A0.7331.00
286_A433_N0.7331.00
66_M70_S0.7331.00
235_Q473_S0.7311.00
71_T74_L0.7301.00
313_V400_D0.7291.00
176_V180_S0.7281.00
229_I232_A0.7281.00
174_L205_V0.7271.00
311_E409_S0.7271.00
127_K130_A0.7261.00
146_E149_A0.7261.00
243_I247_T0.7261.00
156_S187_M0.7221.00
329_R333_L0.7201.00
434_E437_Q0.7191.00
99_N106_R0.7191.00
101_R106_R0.7181.00
125_E129_E0.7171.00
312_A400_D0.7161.00
445_A448_A0.7161.00
208_T212_A0.7151.00
171_S200_A0.7131.00
320_L390_L0.7111.00
194_F198_I0.7091.00
152_D155_L0.7091.00
55_A59_I0.7041.00
104_R108_D0.7041.00
229_I485_L0.7031.00
102_A105_R0.7031.00
231_A234_E0.7011.00
204_M207_R0.7011.00
283_D437_Q0.7001.00
100_A103_H0.6991.00
197_M201_F0.6991.00
461_E465_E0.6971.00
268_V443_T0.6951.00
392_S396_S0.6941.00
266_G269_E0.6941.00
165_V191_G0.6941.00
47_G53_V0.6891.00
481_Q495_L0.6811.00
367_A371_E0.6801.00
134_R138_E0.6791.00
50_W63_G0.6791.00
126_A130_A0.6791.00
168_K197_M0.6771.00
331_V335_N0.6771.00
494_R497_D0.6761.00
394_T397_V0.6741.00
81_V84_S0.6731.00
492_V495_L0.6701.00
141_A145_Q0.6691.00
479_Q482_T0.6691.00
112_A119_Q0.6681.00
32_D39_N0.6671.00
99_N103_H0.6641.00
113_K116_A0.6621.00
170_A193_A0.6611.00
331_V384_E0.6591.00
416_E419_L0.6591.00
47_G63_G0.6591.00
291_Q295_D0.6591.00
83_I91_I0.6581.00
51_T54_V0.6581.00
39_N47_G0.6581.00
488_V495_L0.6561.00
312_A316_E0.6551.00
342_H370_K0.6551.00
83_I87_G0.6541.00
73_L102_A0.6531.00
313_V404_M0.6521.00
426_G430_T0.6521.00
448_A452_T0.6511.00
470_E473_S0.6511.00
278_V435_A0.6491.00
72_S76_V0.6491.00
65_V108_D0.6491.00
54_V60_G0.6461.00
88_T92_V0.6461.00
296_A415_V0.6451.00
250_E254_L0.6441.00
36_F40_Y0.6441.00
318_N321_A0.6431.00
257_A457_I0.6421.00
39_N43_I0.6411.00
268_V450_A0.6411.00
36_F77_L0.6401.00
80_V84_S0.6401.00
116_A123_A0.6391.00
339_D377_N0.6381.00
85_S89_I0.6361.00
302_Q305_D0.6361.00
237_A475_S0.6351.00
83_I86_T0.6331.00
33_I36_F0.6311.00
131_Q134_R0.6301.00
126_A129_E0.6291.00
490_D494_R0.6271.00
329_R382_E0.6261.00
320_L397_V0.6261.00
452_T456_M0.6251.00
200_A494_R0.6251.00
265_S450_A0.6241.00
240_V471_A0.6221.00
463_I467_N0.6211.00
69_F108_D0.6191.00
105_R112_A0.6181.00
309_E312_A0.6181.00
282_S429_V0.6181.00
103_H106_R0.6171.00
289_G293_S0.6161.00
145_Q148_A0.6151.00
165_V169_A0.6151.00
257_A456_M0.6131.00
422_L425_I0.6111.00
295_D298_A0.6111.00
46_L50_W0.6111.00
484_S487_D0.6111.00
319_A396_S0.6091.00
70_S73_L0.6081.00
51_T60_G0.6081.00
373_A376_T0.6071.00
163_S187_M0.6061.00
314_V405_A0.6051.00
291_Q421_A0.6041.00
310_T313_V0.6031.00
50_W54_V0.6031.00
282_S432_V0.6011.00
36_F39_N0.6011.00
304_T307_Q0.6011.00
259_D262_Q0.6011.00
298_A302_Q0.5991.00
133_A137_A0.5981.00
165_V198_I0.5971.00
114_R117_D0.5961.00
119_Q123_A0.5951.00
186_A189_E0.5951.00
454_V458_E0.5931.00
253_R456_M0.5931.00
405_A409_S0.5921.00
63_G66_M0.5921.00
263_S449_S0.5921.00
327_I387_V0.5921.00
310_T404_M0.5911.00
392_S395_Q0.5831.00
303_M415_V0.5831.00
272_A275_A0.5811.00
431_D435_A0.5791.00
70_S77_L0.5791.00
300_V415_V0.5781.00
267_A445_A0.5781.00
118_E121_A0.5771.00
370_K374_E0.5761.00
242_E470_E0.5751.00
295_D414_T0.5751.00
120_R123_A0.5741.00
148_A156_S0.5741.00
270_E438_Q0.5741.00
336_D375_E0.5731.00
229_I481_Q0.5711.00
62_A66_M0.5711.00
274_S435_A0.5701.00
290_R426_G0.5681.00
391_L395_Q0.5671.00
106_R110_E0.5661.00
474_V477_A0.5631.00
102_A112_A0.5621.00
441_D448_A0.5591.00
250_E464_S0.5571.00
136_E139_T0.5571.00
296_A299_A0.5561.00
408_V411_G0.5561.00
253_R256_D0.5551.00
33_I81_V0.5531.00
295_D418_A0.5511.00
271_V442_A0.5511.00
284_Q424_E0.5501.00
451_D454_V0.5501.00
40_Y43_I0.5461.00
88_T94_D0.5461.00
190_V194_F0.5461.00
389_N393_S0.5451.00
62_A111_Q0.5441.00
289_G292_G0.5431.00
330_V387_V0.5431.00
158_K161_E0.5420.99
87_G92_V0.5420.99
297_A423_E0.5410.99
62_A115_R0.5400.99
78_I81_V0.5390.99
251_H465_E0.5380.99
185_D191_G0.5370.99
172_G197_M0.5360.99
97_T101_R0.5350.99
445_A449_S0.5350.99
421_A425_I0.5350.99
102_A109_A0.5340.99
466_Q470_E0.5310.99
249_R459_E0.5310.99
304_T412_T0.5310.99
478_A482_T0.5300.99
254_L457_I0.5300.99
488_V492_V0.5280.99
282_S436_V0.5270.99
330_V379_A0.5260.99
154_Q157_K0.5240.99
265_S447_A0.5240.99
242_E466_Q0.5240.99
257_A261_L0.5230.99
120_R127_K0.5220.99
275_A278_V0.5210.99
262_Q265_S0.5210.99
263_S445_A0.5190.99
240_V243_I0.5180.99
281_V435_A0.5160.99
74_L77_L0.5160.99
233_S478_A0.5150.99
175_T202_E0.5140.99
169_A174_L0.5140.99
95_L99_N0.5130.99
267_A442_A0.5120.99
387_V391_L0.5110.99
260_E449_S0.5110.99
156_S163_S0.5090.99
297_A419_L0.5090.99
415_V419_L0.5080.99
295_D421_A0.5080.99
324_A391_L0.5080.99
263_S267_A0.5080.99
69_F73_L0.5070.99
346_L354_R0.5070.99
269_E447_A0.5010.99
419_L423_E0.5010.99
279_A433_N0.5000.99
229_I484_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.5672 100 0.389 Contact Map
2ch7A 2 0.5765 100 0.492 Contact Map
1qu7A 2 0.4235 100 0.527 Contact Map
3g67A 2 0.3899 100 0.593 Contact Map
4i3mA 2 0.2743 99.9 0.751 Contact Map
2f95B 2 0.0914 99.1 0.865 Contact Map
4cq4A 4 0.1604 99.1 0.868 Contact Map
3zccA 2 0.2052 98.8 0.879 Contact Map
4gycB 2 0.1063 98.8 0.879 Contact Map
2rm8A 1 0.1269 98.1 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0132 seconds.