GREMLIN Database
Q9HPA0 - Uncharacterized protein
UniProt: Q9HPA0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 261 (228)
Sequences: 2708 (2037)
Seq/√Len: 134.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_I153_I4.1631.00
22_T249_A3.0501.00
12_I15_L3.0481.00
127_T131_E3.0141.00
132_A136_W2.9051.00
181_F235_I2.5691.00
173_A180_R2.5581.00
23_A31_L2.5321.00
175_E255_A2.4701.00
164_D214_R2.4481.00
123_A187_C2.4411.00
9_V18_E2.4141.00
132_A161_F2.3341.00
24_T32_H2.2971.00
6_G19_H2.2931.00
249_A252_D2.2841.00
136_W213_N2.2351.00
7_L153_I2.2281.00
183_G235_I2.2061.00
50_A57_H2.1881.00
39_L97_F2.1221.00
175_E180_R2.1201.00
151_A154_E2.1011.00
193_P207_R2.0351.00
132_A135_D2.0171.00
5_A156_E2.0091.00
124_V235_I1.9991.00
90_L94_G1.9741.00
14_G192_V1.9581.00
147_R197_P1.9251.00
83_S86_D1.9011.00
48_V105_V1.8271.00
5_A127_T1.8161.00
205_E209_T1.8101.00
130_L146_R1.7991.00
22_T247_T1.7551.00
145_A197_P1.7371.00
9_V20_R1.7091.00
73_T79_R1.6851.00
41_D44_T1.6781.00
50_A197_P1.6651.00
50_A192_V1.6241.00
3_A156_E1.6051.00
8_Y17_S1.5861.00
55_A58_A1.5621.00
4_I7_L1.5571.00
161_F213_N1.5501.00
8_Y19_H1.5421.00
173_A182_E1.5071.00
125_V146_R1.4961.00
121_G234_M1.4961.00
91_S94_G1.4871.00
127_T156_E1.4841.00
12_I72_V1.4781.00
182_E243_S1.4721.00
181_F237_A1.4401.00
56_L59_F1.4351.00
155_I254_V1.4261.00
147_R198_D1.4231.00
25_L179_V1.4181.00
72_V97_F1.4141.00
40_V108_R1.3941.00
132_A213_N1.3921.00
64_E71_T1.3831.00
38_T108_R1.3791.00
95_D99_S1.3551.00
74_D100_R1.3541.00
85_G89_G1.3441.00
196_D199_T1.3421.00
24_T247_T1.3421.00
19_H250_V1.3281.00
16_D60_R1.3281.00
153_I248_L1.3211.00
185_T234_M1.2921.00
74_D77_G1.2891.00
216_R230_E1.2871.00
195_R202_Q1.2751.00
15_L59_F1.2601.00
71_T81_S1.2531.00
183_G233_A1.2531.00
36_T109_S1.2521.00
10_Y151_A1.2441.00
153_I176_V1.2441.00
51_K119_D1.2301.00
134_A137_F1.2241.00
53_R103_V1.2191.00
126_S158_V1.2191.00
162_W165_R1.2181.00
120_M185_T1.2161.00
56_L101_L1.2081.00
130_L231_Y1.1971.00
91_S95_D1.1890.99
174_F183_G1.1750.99
120_M234_M1.1650.99
131_E156_E1.1570.99
158_V166_F1.1480.99
62_D73_T1.1470.99
10_Y17_S1.1240.99
124_V183_G1.1220.99
123_A232_A1.1210.99
117_R122_P1.1170.99
83_S89_G1.1120.99
38_T47_I1.1020.99
94_G106_S1.0910.99
90_L93_A1.0810.99
191_V202_Q1.0730.99
86_D89_G1.0640.99
155_I158_V1.0510.99
125_V231_Y1.0180.98
175_E178_G1.0180.98
127_T157_G1.0120.98
188_N230_E1.0050.98
187_C231_Y1.0000.98
180_R244_G0.9930.98
15_L61_T0.9680.98
59_F97_F0.9610.98
4_I177_G0.9600.98
82_F85_G0.9570.98
182_E236_L0.9570.98
191_V194_S0.9530.98
94_G98_D0.9520.98
176_V248_L0.9510.98
74_D96_W0.9510.98
192_V195_R0.9350.97
60_R73_T0.9280.97
4_I31_L0.9250.97
146_R154_E0.9210.97
33_H84_L0.9200.97
84_L87_D0.9180.97
206_F209_T0.9110.97
97_F105_V0.9090.97
136_W214_R0.9020.97
178_G249_A0.9000.97
71_T79_R0.8980.96
20_R23_A0.8940.96
58_A200_G0.8920.96
77_G100_R0.8840.96
176_V254_V0.8840.96
47_I51_K0.8720.96
7_L23_A0.8700.96
57_H200_G0.8680.96
59_F100_R0.8680.96
41_D103_V0.8670.96
48_V56_L0.8640.96
129_T163_E0.8620.96
186_P233_A0.8600.96
158_V162_W0.8580.95
133_I231_Y0.8580.95
25_L31_L0.8570.95
174_F254_V0.8550.95
137_F209_T0.8520.95
125_V232_A0.8480.95
121_G236_L0.8460.95
193_P206_F0.8440.95
3_A253_G0.8440.95
48_V53_R0.8430.95
39_L105_V0.8430.95
42_S104_S0.8390.95
58_A100_R0.8380.95
128_A131_E0.8290.95
123_A234_M0.8290.95
129_T161_F0.8280.95
80_A93_A0.8260.94
119_D122_P0.8240.94
57_H195_R0.8230.94
184_V236_L0.8210.94
133_I149_L0.8170.94
179_V246_E0.8130.94
77_G99_S0.8090.94
207_R229_H0.8050.94
62_D71_T0.8040.94
53_R56_L0.8000.93
61_T72_V0.7970.93
72_V75_P0.7920.93
145_A148_R0.7920.93
4_I176_V0.7900.93
15_L97_F0.7900.93
218_F230_E0.7870.93
159_P165_R0.7870.93
17_S147_R0.7870.93
7_L248_L0.7770.92
211_C215_E0.7740.92
146_R151_A0.7710.92
39_L72_V0.7620.92
123_A151_A0.7540.91
14_G49_T0.7540.91
28_H36_T0.7520.91
159_P162_W0.7520.91
57_H192_V0.7500.91
39_L59_F0.7480.91
211_C229_H0.7450.91
188_N228_D0.7340.90
125_V154_E0.7300.90
51_K234_M0.7290.90
57_H197_P0.7270.90
18_E61_T0.7260.90
136_W212_A0.7260.90
174_F235_I0.7250.90
215_E229_H0.7240.90
144_G148_R0.7230.89
33_H63_Y0.7230.89
26_R32_H0.7200.89
10_Y147_R0.7160.89
162_W166_F0.7140.89
69_T81_S0.7100.89
47_I50_A0.7090.89
125_V130_L0.7080.88
18_E63_Y0.7060.88
243_S246_E0.7030.88
7_L31_L0.7000.88
134_A206_F0.7000.88
134_A143_A0.6980.88
90_L96_W0.6970.88
230_E233_A0.6940.87
162_W172_P0.6890.87
129_T231_Y0.6870.87
237_A246_E0.6840.87
52_R192_V0.6840.87
178_G244_G0.6840.87
117_R120_M0.6830.87
196_D200_G0.6810.86
59_F77_G0.6800.86
14_G51_K0.6720.86
123_A231_Y0.6700.86
16_D198_D0.6700.86
64_E69_T0.6690.85
121_G184_V0.6670.85
85_G88_E0.6580.85
26_R36_T0.6570.84
110_D117_R0.6520.84
179_V244_G0.6490.84
80_A85_G0.6470.84
131_E134_A0.6470.84
77_G80_A0.6470.84
96_W205_E0.6460.83
14_G187_C0.6370.83
137_F206_F0.6360.83
24_T245_G0.6340.82
132_A214_R0.6330.82
176_V252_D0.6320.82
40_V106_S0.6300.82
194_S207_R0.6300.82
192_V197_P0.6260.82
93_A96_W0.6260.82
123_A185_T0.6250.81
84_L89_G0.6240.81
132_A160_A0.6230.81
161_F193_P0.6210.81
81_S89_G0.6150.80
19_H24_T0.6140.80
11_P14_G0.6140.80
174_F256_V0.6130.80
217_T228_D0.6130.80
95_D104_S0.6110.80
69_T83_S0.6100.80
129_T210_F0.6090.80
8_Y147_R0.6070.79
59_F96_W0.6060.79
137_F144_G0.6060.79
131_E135_D0.6050.79
81_S84_L0.6040.79
205_E208_K0.6030.79
6_G154_E0.6020.79
97_F107_M0.6020.79
25_L237_A0.6010.79
76_D253_G0.6000.79
188_N234_M0.5990.79
25_L181_F0.5990.79
80_A83_S0.5980.78
208_K212_A0.5950.78
105_V110_D0.5950.78
99_S178_G0.5940.78
111_P115_V0.5940.78
196_D201_E0.5930.78
79_R82_F0.5910.78
179_V248_L0.5890.77
64_E81_S0.5880.77
137_F174_F0.5880.77
126_S161_F0.5860.77
91_S106_S0.5860.77
180_R243_S0.5860.77
177_G246_E0.5840.77
125_V161_F0.5840.77
179_V237_A0.5840.77
237_A245_G0.5830.77
90_L106_S0.5800.76
237_A244_G0.5800.76
6_G147_R0.5790.76
7_L254_V0.5790.76
142_V203_L0.5750.76
195_R200_G0.5740.76
71_T75_P0.5700.75
117_R121_G0.5690.75
38_T49_T0.5680.75
126_S130_L0.5640.74
126_S157_G0.5630.74
55_A100_R0.5610.74
187_C234_M0.5580.74
15_L70_L0.5570.73
118_S122_P0.5560.73
149_L206_F0.5550.73
92_A95_D0.5550.73
50_A195_R0.5550.73
183_G186_P0.5520.73
149_L231_Y0.5520.73
111_P114_F0.5500.73
148_R203_L0.5490.72
186_P234_M0.5490.72
58_A61_T0.5480.72
83_S87_D0.5470.72
135_D160_A0.5460.72
59_F72_V0.5420.71
134_A145_A0.5410.71
133_I209_T0.5400.71
248_L252_D0.5390.71
209_T213_N0.5380.71
161_F164_D0.5360.71
126_S131_E0.5320.70
51_K120_M0.5320.70
157_G162_W0.5300.70
132_A212_A0.5290.70
8_Y151_A0.5280.69
65_P69_T0.5280.69
45_G49_T0.5230.69
72_V96_W0.5180.68
80_A96_W0.5180.68
146_R231_Y0.5160.68
44_T162_W0.5150.68
50_A200_G0.5140.67
112_T115_V0.5140.67
211_C228_D0.5130.67
172_P183_G0.5110.67
5_A21_S0.5100.67
91_S244_G0.5080.67
149_L232_A0.5070.66
164_D186_P0.5050.66
98_D107_M0.5040.66
129_T136_W0.5040.66
98_D104_S0.5020.66
216_R228_D0.5000.65
60_R113_G0.5000.65
157_G210_F0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oruA 2 0.6628 100 0.571 Contact Map
2exnA 1 0.4215 99.9 0.65 Contact Map
1o65A 1 0.5824 99.8 0.726 Contact Map
2qwuA 1 0.2644 12.1 0.963 Contact Map
1ug1A 1 0.1877 5.9 0.968 Contact Map
3c0cA 1 0.1379 5.8 0.968 Contact Map
1v1cA 1 0.1226 4.9 0.969 Contact Map
2ma3A 1 0.2107 4.8 0.969 Contact Map
2jp3A 1 0.2146 4.7 0.97 Contact Map
2mkvA 1 0.1839 4.5 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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