Q9HPA0 - HALSA - GREMLIN Contacts

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Q9HPA0 - Uncharacterized protein

UniProt:	Q9HPA0	Sequences: MAAIAGLYVYPIKGLDSEHRSTATLRTHGQLHHDRTFTLVDSDTGSIVTAKRRPALHAFRTDYEPETGTLTVTDPDGQRASFSLGDDEGLSAAGDWFDSRLAVSVSMRSDPTGFVDRSDMGPAVVSTATLEAIADWFDSMTVAGARRRLRANIEIEGVPAFWEDRFVGDGAPAFEVGGVRFEGVTPCNRCVVPSRDPDTGEQLPEFRKTFCANRERTFPEWADGDAFDHEYAAMILARAPDISGGETLAVGDGVAVLDEAA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	261 (228)
Sequences:	2708 (2037)
Seq/√Len:	134.9

ECOLI - YCBX
HALSA - Q9HPA0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
4_I	153_I	4.163	1.00
22_T	249_A	3.050	1.00
12_I	15_L	3.048	1.00
127_T	131_E	3.014	1.00
132_A	136_W	2.905	1.00
181_F	235_I	2.569	1.00
173_A	180_R	2.558	1.00
23_A	31_L	2.532	1.00
175_E	255_A	2.470	1.00
164_D	214_R	2.448	1.00
123_A	187_C	2.441	1.00
9_V	18_E	2.414	1.00
132_A	161_F	2.334	1.00
24_T	32_H	2.297	1.00
6_G	19_H	2.293	1.00
249_A	252_D	2.284	1.00
136_W	213_N	2.235	1.00
7_L	153_I	2.228	1.00
183_G	235_I	2.206	1.00
50_A	57_H	2.188	1.00
39_L	97_F	2.122	1.00
175_E	180_R	2.120	1.00
151_A	154_E	2.101	1.00
193_P	207_R	2.035	1.00
132_A	135_D	2.017	1.00
5_A	156_E	2.009	1.00
124_V	235_I	1.999	1.00
90_L	94_G	1.974	1.00
14_G	192_V	1.958	1.00
147_R	197_P	1.925	1.00
83_S	86_D	1.901	1.00
48_V	105_V	1.827	1.00
5_A	127_T	1.816	1.00
205_E	209_T	1.810	1.00
130_L	146_R	1.799	1.00
22_T	247_T	1.755	1.00
145_A	197_P	1.737	1.00
9_V	20_R	1.709	1.00
73_T	79_R	1.685	1.00
41_D	44_T	1.678	1.00
50_A	197_P	1.665	1.00
50_A	192_V	1.624	1.00
3_A	156_E	1.605	1.00
8_Y	17_S	1.586	1.00
55_A	58_A	1.562	1.00
4_I	7_L	1.557	1.00
161_F	213_N	1.550	1.00
8_Y	19_H	1.542	1.00
173_A	182_E	1.507	1.00
125_V	146_R	1.496	1.00
121_G	234_M	1.496	1.00
91_S	94_G	1.487	1.00
127_T	156_E	1.484	1.00
12_I	72_V	1.478	1.00
182_E	243_S	1.472	1.00
181_F	237_A	1.440	1.00
56_L	59_F	1.435	1.00
155_I	254_V	1.426	1.00
147_R	198_D	1.423	1.00
25_L	179_V	1.418	1.00
72_V	97_F	1.414	1.00
40_V	108_R	1.394	1.00
132_A	213_N	1.392	1.00
64_E	71_T	1.383	1.00
38_T	108_R	1.379	1.00
95_D	99_S	1.355	1.00
74_D	100_R	1.354	1.00
85_G	89_G	1.344	1.00
196_D	199_T	1.342	1.00
24_T	247_T	1.342	1.00
19_H	250_V	1.328	1.00
16_D	60_R	1.328	1.00
153_I	248_L	1.321	1.00
185_T	234_M	1.292	1.00
74_D	77_G	1.289	1.00
216_R	230_E	1.287	1.00
195_R	202_Q	1.275	1.00
15_L	59_F	1.260	1.00
71_T	81_S	1.253	1.00
183_G	233_A	1.253	1.00
36_T	109_S	1.252	1.00
10_Y	151_A	1.244	1.00
153_I	176_V	1.244	1.00
51_K	119_D	1.230	1.00
134_A	137_F	1.224	1.00
53_R	103_V	1.219	1.00
126_S	158_V	1.219	1.00
162_W	165_R	1.218	1.00
120_M	185_T	1.216	1.00
56_L	101_L	1.208	1.00
130_L	231_Y	1.197	1.00
91_S	95_D	1.189	0.99
174_F	183_G	1.175	0.99
120_M	234_M	1.165	0.99
131_E	156_E	1.157	0.99
158_V	166_F	1.148	0.99
62_D	73_T	1.147	0.99
10_Y	17_S	1.124	0.99
124_V	183_G	1.122	0.99
123_A	232_A	1.121	0.99
117_R	122_P	1.117	0.99
83_S	89_G	1.112	0.99
38_T	47_I	1.102	0.99
94_G	106_S	1.091	0.99
90_L	93_A	1.081	0.99
191_V	202_Q	1.073	0.99
86_D	89_G	1.064	0.99
155_I	158_V	1.051	0.99
125_V	231_Y	1.018	0.98
175_E	178_G	1.018	0.98
127_T	157_G	1.012	0.98
188_N	230_E	1.005	0.98
187_C	231_Y	1.000	0.98
180_R	244_G	0.993	0.98
15_L	61_T	0.968	0.98
59_F	97_F	0.961	0.98
4_I	177_G	0.960	0.98
82_F	85_G	0.957	0.98
182_E	236_L	0.957	0.98
191_V	194_S	0.953	0.98
94_G	98_D	0.952	0.98
176_V	248_L	0.951	0.98
74_D	96_W	0.951	0.98
192_V	195_R	0.935	0.97
60_R	73_T	0.928	0.97
4_I	31_L	0.925	0.97
146_R	154_E	0.921	0.97
33_H	84_L	0.920	0.97
84_L	87_D	0.918	0.97
206_F	209_T	0.911	0.97
97_F	105_V	0.909	0.97
136_W	214_R	0.902	0.97
178_G	249_A	0.900	0.97
71_T	79_R	0.898	0.96
20_R	23_A	0.894	0.96
58_A	200_G	0.892	0.96
77_G	100_R	0.884	0.96
176_V	254_V	0.884	0.96
47_I	51_K	0.872	0.96
7_L	23_A	0.870	0.96
57_H	200_G	0.868	0.96
59_F	100_R	0.868	0.96
41_D	103_V	0.867	0.96
48_V	56_L	0.864	0.96
129_T	163_E	0.862	0.96
186_P	233_A	0.860	0.96
158_V	162_W	0.858	0.95
133_I	231_Y	0.858	0.95
25_L	31_L	0.857	0.95
174_F	254_V	0.855	0.95
137_F	209_T	0.852	0.95
125_V	232_A	0.848	0.95
121_G	236_L	0.846	0.95
193_P	206_F	0.844	0.95
3_A	253_G	0.844	0.95
48_V	53_R	0.843	0.95
39_L	105_V	0.843	0.95
42_S	104_S	0.839	0.95
58_A	100_R	0.838	0.95
128_A	131_E	0.829	0.95
123_A	234_M	0.829	0.95
129_T	161_F	0.828	0.95
80_A	93_A	0.826	0.94
119_D	122_P	0.824	0.94
57_H	195_R	0.823	0.94
184_V	236_L	0.821	0.94
133_I	149_L	0.817	0.94
179_V	246_E	0.813	0.94
77_G	99_S	0.809	0.94
207_R	229_H	0.805	0.94
62_D	71_T	0.804	0.94
53_R	56_L	0.800	0.93
61_T	72_V	0.797	0.93
72_V	75_P	0.792	0.93
145_A	148_R	0.792	0.93
4_I	176_V	0.790	0.93
15_L	97_F	0.790	0.93
218_F	230_E	0.787	0.93
159_P	165_R	0.787	0.93
17_S	147_R	0.787	0.93
7_L	248_L	0.777	0.92
211_C	215_E	0.774	0.92
146_R	151_A	0.771	0.92
39_L	72_V	0.762	0.92
123_A	151_A	0.754	0.91
14_G	49_T	0.754	0.91
28_H	36_T	0.752	0.91
159_P	162_W	0.752	0.91
57_H	192_V	0.750	0.91
39_L	59_F	0.748	0.91
211_C	229_H	0.745	0.91
188_N	228_D	0.734	0.90
125_V	154_E	0.730	0.90
51_K	234_M	0.729	0.90
57_H	197_P	0.727	0.90
18_E	61_T	0.726	0.90
136_W	212_A	0.726	0.90
174_F	235_I	0.725	0.90
215_E	229_H	0.724	0.90
144_G	148_R	0.723	0.89
33_H	63_Y	0.723	0.89
26_R	32_H	0.720	0.89
10_Y	147_R	0.716	0.89
162_W	166_F	0.714	0.89
69_T	81_S	0.710	0.89
47_I	50_A	0.709	0.89
125_V	130_L	0.708	0.88
18_E	63_Y	0.706	0.88
243_S	246_E	0.703	0.88
7_L	31_L	0.700	0.88
134_A	206_F	0.700	0.88
134_A	143_A	0.698	0.88
90_L	96_W	0.697	0.88
230_E	233_A	0.694	0.87
162_W	172_P	0.689	0.87
129_T	231_Y	0.687	0.87
237_A	246_E	0.684	0.87
52_R	192_V	0.684	0.87
178_G	244_G	0.684	0.87
117_R	120_M	0.683	0.87
196_D	200_G	0.681	0.86
59_F	77_G	0.680	0.86
14_G	51_K	0.672	0.86
123_A	231_Y	0.670	0.86
16_D	198_D	0.670	0.86
64_E	69_T	0.669	0.85
121_G	184_V	0.667	0.85
85_G	88_E	0.658	0.85
26_R	36_T	0.657	0.84
110_D	117_R	0.652	0.84
179_V	244_G	0.649	0.84
80_A	85_G	0.647	0.84
131_E	134_A	0.647	0.84
77_G	80_A	0.647	0.84
96_W	205_E	0.646	0.83
14_G	187_C	0.637	0.83
137_F	206_F	0.636	0.83
24_T	245_G	0.634	0.82
132_A	214_R	0.633	0.82
176_V	252_D	0.632	0.82
40_V	106_S	0.630	0.82
194_S	207_R	0.630	0.82
192_V	197_P	0.626	0.82
93_A	96_W	0.626	0.82
123_A	185_T	0.625	0.81
84_L	89_G	0.624	0.81
132_A	160_A	0.623	0.81
161_F	193_P	0.621	0.81
81_S	89_G	0.615	0.80
19_H	24_T	0.614	0.80
11_P	14_G	0.614	0.80
174_F	256_V	0.613	0.80
217_T	228_D	0.613	0.80
95_D	104_S	0.611	0.80
69_T	83_S	0.610	0.80
129_T	210_F	0.609	0.80
8_Y	147_R	0.607	0.79
59_F	96_W	0.606	0.79
137_F	144_G	0.606	0.79
131_E	135_D	0.605	0.79
81_S	84_L	0.604	0.79
205_E	208_K	0.603	0.79
6_G	154_E	0.602	0.79
97_F	107_M	0.602	0.79
25_L	237_A	0.601	0.79
76_D	253_G	0.600	0.79
188_N	234_M	0.599	0.79
25_L	181_F	0.599	0.79
80_A	83_S	0.598	0.78
208_K	212_A	0.595	0.78
105_V	110_D	0.595	0.78
99_S	178_G	0.594	0.78
111_P	115_V	0.594	0.78
196_D	201_E	0.593	0.78
79_R	82_F	0.591	0.78
179_V	248_L	0.589	0.77
64_E	81_S	0.588	0.77
137_F	174_F	0.588	0.77
126_S	161_F	0.586	0.77
91_S	106_S	0.586	0.77
180_R	243_S	0.586	0.77
177_G	246_E	0.584	0.77
125_V	161_F	0.584	0.77
179_V	237_A	0.584	0.77
237_A	245_G	0.583	0.77
90_L	106_S	0.580	0.76
237_A	244_G	0.580	0.76
6_G	147_R	0.579	0.76
7_L	254_V	0.579	0.76
142_V	203_L	0.575	0.76
195_R	200_G	0.574	0.76
71_T	75_P	0.570	0.75
117_R	121_G	0.569	0.75
38_T	49_T	0.568	0.75
126_S	130_L	0.564	0.74
126_S	157_G	0.563	0.74
55_A	100_R	0.561	0.74
187_C	234_M	0.558	0.74
15_L	70_L	0.557	0.73
118_S	122_P	0.556	0.73
149_L	206_F	0.555	0.73
92_A	95_D	0.555	0.73
50_A	195_R	0.555	0.73
183_G	186_P	0.552	0.73
149_L	231_Y	0.552	0.73
111_P	114_F	0.550	0.73
148_R	203_L	0.549	0.72
186_P	234_M	0.549	0.72
58_A	61_T	0.548	0.72
83_S	87_D	0.547	0.72
135_D	160_A	0.546	0.72
59_F	72_V	0.542	0.71
134_A	145_A	0.541	0.71
133_I	209_T	0.540	0.71
248_L	252_D	0.539	0.71
209_T	213_N	0.538	0.71
161_F	164_D	0.536	0.71
126_S	131_E	0.532	0.70
51_K	120_M	0.532	0.70
157_G	162_W	0.530	0.70
132_A	212_A	0.529	0.70
8_Y	151_A	0.528	0.69
65_P	69_T	0.528	0.69
45_G	49_T	0.523	0.69
72_V	96_W	0.518	0.68
80_A	96_W	0.518	0.68
146_R	231_Y	0.516	0.68
44_T	162_W	0.515	0.68
50_A	200_G	0.514	0.67
112_T	115_V	0.514	0.67
211_C	228_D	0.513	0.67
172_P	183_G	0.511	0.67
5_A	21_S	0.510	0.67
91_S	244_G	0.508	0.67
149_L	232_A	0.507	0.66
164_D	186_P	0.505	0.66
98_D	107_M	0.504	0.66
129_T	136_W	0.504	0.66
98_D	104_S	0.502	0.66
216_R	228_D	0.500	0.65
60_R	113_G	0.500	0.65
157_G	210_F	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1oruA	2	0.6628	100	0.571	Contact Map
2exnA	1	0.4215	99.9	0.65	Contact Map
1o65A	1	0.5824	99.8	0.726	Contact Map
2qwuA	1	0.2644	12.1	0.963	Contact Map
1ug1A	1	0.1877	5.9	0.968	Contact Map
3c0cA	1	0.1379	5.8	0.968	Contact Map
1v1cA	1	0.1226	4.9	0.969	Contact Map
2ma3A	1	0.2107	4.8	0.969	Contact Map
2jp3A	1	0.2146	4.7	0.97	Contact Map
2mkvA	1	0.1839	4.5	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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