GREMLIN Database
Q9HP98 - Htr-like protein
UniProt: Q9HP98 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 279 (218)
Sequences: 2074 (1449)
Seq/√Len: 98.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_M48_V4.0041.00
46_N161_L3.9851.00
43_A73_I3.5761.00
47_A105_V3.5331.00
39_L163_V3.3751.00
25_V224_G3.2301.00
40_Y89_I3.1641.00
97_I101_G3.0721.00
82_E86_Q2.8221.00
43_A163_V2.7991.00
154_D197_W2.7451.00
98_V102_A2.5631.00
45_M49_A2.5431.00
90_A97_I2.5201.00
266_R271_D2.5141.00
46_N51_A2.4071.00
86_Q100_A2.2581.00
3_T249_V2.2541.00
42_A161_L2.2401.00
74_H158_S2.2401.00
194_A201_I2.1731.00
47_A99_A2.1561.00
30_E33_A2.1141.00
11_L38_F2.1041.00
72_E160_S2.0601.00
51_A161_L2.0281.00
7_G12_D2.0081.00
224_G246_F1.9871.00
152_Y155_E1.9831.00
6_F19_A1.9711.00
37_E92_T1.9551.00
239_R256_D1.8501.00
37_E265_I1.8261.00
238_V260_Q1.8031.00
14_R259_V1.7851.00
38_F270_F1.7461.00
241_M272_I1.7241.00
40_Y85_L1.6971.00
88_E248_G1.6941.00
38_F228_F1.6941.00
29_G35_A1.6661.00
75_Y163_V1.6261.00
237_R242_F1.6181.00
206_T220_S1.5941.00
95_E103_D1.5871.00
42_A46_N1.5861.00
151_D155_E1.5711.00
108_A148_R1.5671.00
162_V199_G1.5661.00
43_A161_L1.5511.00
11_L15_I1.5391.00
43_A75_Y1.5381.00
51_A160_S1.4951.00
20_P246_F1.4731.00
72_E157_A1.4541.00
19_A202_L1.3970.99
80_A247_R1.3780.99
77_S85_L1.3690.99
162_V201_I1.3660.99
3_T246_F1.3090.99
240_T258_I1.2890.99
81_N84_E1.2800.99
11_L226_V1.2780.99
166_S204_H1.2660.99
72_E156_H1.2650.99
255_E259_V1.2640.99
19_A25_V1.2330.99
39_L204_H1.2190.99
27_L38_F1.2160.99
96_E105_V1.1920.98
75_Y204_H1.1750.98
72_E104_A1.1690.98
24_V191_R1.1570.98
36_R40_Y1.1480.98
44_M48_V1.1470.98
47_A104_A1.1440.98
246_F249_V1.1410.98
27_L202_L1.1410.98
44_M95_E1.1350.98
24_V201_I1.1240.98
229_A242_F1.1070.97
10_R272_I1.1050.97
231_E240_T1.1030.97
79_T184_V1.1010.97
16_G250_L1.0890.97
264_E271_D1.0860.97
148_R152_Y1.0850.97
225_T245_E1.0830.97
229_A232_S1.0800.97
47_A73_I1.0790.97
32_G245_E1.0780.97
73_I163_V1.0770.97
90_A95_E1.0730.97
20_P249_V1.0720.97
21_E160_S1.0660.97
10_R13_S1.0570.96
23_S186_T1.0540.96
106_T156_H1.0530.96
149_F153_L1.0500.96
268_S271_D1.0380.96
26_L222_V1.0290.96
41_T45_M1.0250.96
43_A47_A1.0140.96
44_M94_D1.0090.95
48_V98_V1.0000.95
222_V225_T0.9870.95
21_E51_A0.9780.95
250_L256_D0.9690.94
205_L208_D0.9670.94
264_E273_S0.9590.94
40_Y75_Y0.9530.94
99_A103_D0.9470.94
99_A102_A0.9450.94
34_G265_I0.9410.93
75_Y205_L0.9270.93
32_G165_D0.9160.92
250_L267_D0.9110.92
10_R271_D0.9090.92
95_E98_V0.9030.92
206_T209_A0.9000.92
77_S205_L0.8950.92
27_L270_F0.8950.92
6_F12_D0.8800.91
227_Q244_R0.8800.91
230_W237_R0.8790.91
29_G36_R0.8760.91
40_Y77_S0.8740.91
35_A247_R0.8710.90
24_V222_V0.8710.90
45_M51_A0.8670.90
41_T94_D0.8660.90
236_E256_D0.8640.90
164_V207_R0.8600.90
157_A160_S0.8530.89
152_Y156_H0.8460.89
84_E88_E0.8440.89
100_A103_D0.8380.89
265_I272_I0.8290.88
79_T195_R0.8280.88
85_L107_F0.8280.88
3_T27_L0.8260.88
232_S242_F0.8250.88
213_E243_V0.8190.87
37_E41_T0.8190.87
25_V200_L0.8110.87
164_V198_S0.8100.87
168_N222_V0.8090.87
151_D250_L0.8090.87
174_R183_V0.8090.87
87_R90_A0.8060.87
38_F202_L0.8030.86
193_A197_W0.7990.86
148_R151_D0.7980.86
76_V110_L0.7970.86
5_P12_D0.7970.86
239_R261_F0.7960.86
243_V270_F0.7930.86
242_F258_I0.7900.86
140_E144_D0.7890.85
51_A73_I0.7880.85
14_R254_E0.7850.85
79_T189_G0.7830.85
225_T242_F0.7770.85
8_I12_D0.7740.84
48_V99_A0.7650.84
261_F270_F0.7640.84
112_P244_R0.7640.84
157_A197_W0.7620.83
162_V194_A0.7540.83
147_E151_D0.7440.82
20_P224_G0.7410.82
166_S221_S0.7380.81
36_R88_E0.7370.81
29_G165_D0.7350.81
8_I38_F0.7350.81
80_A245_E0.7340.81
97_I102_A0.7290.81
46_N73_I0.7290.81
14_R255_E0.7250.80
39_L43_A0.7240.80
215_F218_L0.7230.80
86_Q97_I0.7210.80
259_V274_D0.7190.80
179_A182_D0.7180.80
76_V149_F0.7170.80
175_S179_A0.7140.79
22_G170_L0.7130.79
31_A222_V0.7130.79
203_L222_V0.7120.79
81_N205_L0.7110.79
73_I160_S0.7090.79
14_R241_M0.7080.79
146_L150_A0.7060.79
163_V204_H0.7050.78
41_T202_L0.7040.78
31_A225_T0.7020.78
23_S223_D0.7000.78
46_N49_A0.7000.78
111_S192_K0.6960.78
20_P248_G0.6940.77
190_L239_R0.6910.77
73_I105_V0.6910.77
108_A196_D0.6900.77
232_S258_I0.6880.77
88_E223_D0.6860.77
4_I24_V0.6860.77
84_E149_F0.6850.76
50_T72_E0.6800.76
105_V156_H0.6800.76
23_S84_E0.6740.75
15_I226_V0.6710.75
164_V272_I0.6630.74
191_R220_S0.6620.74
83_A151_D0.6600.74
232_S235_N0.6590.74
30_E237_R0.6590.74
244_R254_E0.6590.74
39_L75_Y0.6580.74
84_E248_G0.6560.73
141_D186_T0.6500.73
5_P97_I0.6460.72
227_Q242_F0.6450.72
38_F41_T0.6450.72
165_D245_E0.6400.71
153_L193_A0.6390.71
24_V187_L0.6360.71
4_I226_V0.6330.71
6_F45_M0.6310.70
162_V186_T0.6310.70
41_T48_V0.6280.70
75_Y107_F0.6270.70
12_D18_G0.6250.70
78_F112_P0.6250.70
4_I161_L0.6240.70
153_L199_G0.6210.69
195_R206_T0.6160.69
98_V101_G0.6160.69
29_G34_G0.6130.68
229_A240_T0.6100.68
27_L40_Y0.6060.67
142_T167_L0.6040.67
172_G243_V0.6010.67
166_S223_D0.6010.67
33_A77_S0.6000.67
79_T204_H0.5980.66
142_T174_R0.5980.66
27_L226_V0.5970.66
267_D270_F0.5970.66
36_R206_T0.5960.66
242_F257_D0.5950.66
35_A165_D0.5950.66
32_G80_A0.5880.65
39_L42_A0.5880.65
204_H214_E0.5840.64
73_I104_A0.5820.64
41_T238_V0.5820.64
7_G107_F0.5800.64
42_A202_L0.5800.64
6_F14_R0.5780.64
232_S237_R0.5740.63
215_F219_M0.5730.63
164_V203_L0.5730.63
37_E168_N0.5710.63
38_F94_D0.5690.62
212_S217_S0.5690.62
167_L207_R0.5670.62
153_L162_V0.5630.62
9_S45_M0.5630.62
80_A85_L0.5610.61
214_E226_V0.5610.61
30_E244_R0.5540.60
40_Y107_F0.5510.60
35_A80_A0.5510.60
89_I190_L0.5490.60
239_R265_I0.5480.60
79_T220_S0.5460.59
77_S248_G0.5460.59
167_L179_A0.5450.59
6_F41_T0.5450.59
145_V188_K0.5450.59
7_G45_M0.5440.59
179_A265_I0.5440.59
75_Y89_I0.5430.59
91_F267_D0.5430.59
197_W270_F0.5420.59
87_R167_L0.5380.58
82_E107_F0.5370.58
9_S103_D0.5360.58
47_A214_E0.5340.58
9_S72_E0.5330.58
30_E229_A0.5330.58
195_R223_D0.5320.57
143_R146_L0.5310.57
169_D246_F0.5250.56
144_D150_A0.5240.56
191_R206_T0.5230.56
209_A212_S0.5230.56
14_R243_V0.5210.56
219_M244_R0.5190.56
154_D198_S0.5180.55
31_A219_M0.5170.55
29_G247_R0.5160.55
33_A74_H0.5160.55
6_F15_I0.5140.55
23_S218_L0.5120.55
168_N171_I0.5110.54
194_A206_T0.5110.54
146_L255_E0.5110.54
217_S220_S0.5100.54
172_G205_L0.5080.54
156_H160_S0.5080.54
5_P11_L0.5080.54
93_M268_S0.5070.54
15_I245_E0.5070.54
27_L101_G0.5070.54
205_L215_F0.5060.54
142_T186_T0.5060.54
10_R274_D0.5060.54
24_V221_S0.5060.54
167_L205_L0.5050.54
31_A239_R0.5040.53
94_D200_L0.5040.53
153_L194_A0.5030.53
41_T269_G0.5020.53
26_L225_T0.5010.53
95_E268_S0.5010.53
89_I272_I0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bs4A 1 0.8065 100 0.417 Contact Map
2dr3A 3 0.853 100 0.442 Contact Map
4a8jA 1 0.8136 100 0.485 Contact Map
1tf7A 3 0.7957 100 0.498 Contact Map
2w0mA 1 0.7742 100 0.529 Contact Map
2cvhA 1 0.7563 100 0.539 Contact Map
1n0wA 1 0.7097 100 0.553 Contact Map
2ztsA 3 0.7957 100 0.553 Contact Map
4tl6A 3 0.8065 100 0.556 Contact Map
4bwyA 3 0.6523 100 0.557 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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