Q9HP98 - HALSA - GREMLIN Contacts

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Q9HP98 - Htr-like protein

UniProt:	Q9HP98	Sequences: MATIPFGISRLDSRIGGGAPEGSVVLLSGEAGAGAREFLYTAAMMNAVATADPELFDLHYGSPHGSARQPEEIHYVSFTANEAELQREIAFTMDEEIVAAGADAVTFADLSPEYFQLSPVPRSWYADKHQTVRDLGNTGEDTRDVLERFADYLDEHASGSLVVVDSLNDLIGRRSSDMAFSDVVMTLKGLRKAARDWSGLILLHLTRDAVRSEEFGSLMSSVDGTVQFAWESGGNERVRTMFVREFRGVLGRLEEDDIVQFETEIRDSGFDISDVRKIR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	279 (218)
Sequences:	2074 (1449)
Seq/√Len:	98.1

HALSA - Q9HP98 Q9HNX8 GVPD2 RADB Q9HQY2
SULSO - Y1861 Q97WB6 Q97VZ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
45_M	48_V	4.004	1.00
46_N	161_L	3.985	1.00
43_A	73_I	3.576	1.00
47_A	105_V	3.533	1.00
39_L	163_V	3.375	1.00
25_V	224_G	3.230	1.00
40_Y	89_I	3.164	1.00
97_I	101_G	3.072	1.00
82_E	86_Q	2.822	1.00
43_A	163_V	2.799	1.00
154_D	197_W	2.745	1.00
98_V	102_A	2.563	1.00
45_M	49_A	2.543	1.00
90_A	97_I	2.520	1.00
266_R	271_D	2.514	1.00
46_N	51_A	2.407	1.00
86_Q	100_A	2.258	1.00
3_T	249_V	2.254	1.00
42_A	161_L	2.240	1.00
74_H	158_S	2.240	1.00
194_A	201_I	2.173	1.00
47_A	99_A	2.156	1.00
30_E	33_A	2.114	1.00
11_L	38_F	2.104	1.00
72_E	160_S	2.060	1.00
51_A	161_L	2.028	1.00
7_G	12_D	2.008	1.00
224_G	246_F	1.987	1.00
152_Y	155_E	1.983	1.00
6_F	19_A	1.971	1.00
37_E	92_T	1.955	1.00
239_R	256_D	1.850	1.00
37_E	265_I	1.826	1.00
238_V	260_Q	1.803	1.00
14_R	259_V	1.785	1.00
38_F	270_F	1.746	1.00
241_M	272_I	1.724	1.00
40_Y	85_L	1.697	1.00
88_E	248_G	1.694	1.00
38_F	228_F	1.694	1.00
29_G	35_A	1.666	1.00
75_Y	163_V	1.626	1.00
237_R	242_F	1.618	1.00
206_T	220_S	1.594	1.00
95_E	103_D	1.587	1.00
42_A	46_N	1.586	1.00
151_D	155_E	1.571	1.00
108_A	148_R	1.567	1.00
162_V	199_G	1.566	1.00
43_A	161_L	1.551	1.00
11_L	15_I	1.539	1.00
43_A	75_Y	1.538	1.00
51_A	160_S	1.495	1.00
20_P	246_F	1.473	1.00
72_E	157_A	1.454	1.00
19_A	202_L	1.397	0.99
80_A	247_R	1.378	0.99
77_S	85_L	1.369	0.99
162_V	201_I	1.366	0.99
3_T	246_F	1.309	0.99
240_T	258_I	1.289	0.99
81_N	84_E	1.280	0.99
11_L	226_V	1.278	0.99
166_S	204_H	1.266	0.99
72_E	156_H	1.265	0.99
255_E	259_V	1.264	0.99
19_A	25_V	1.233	0.99
39_L	204_H	1.219	0.99
27_L	38_F	1.216	0.99
96_E	105_V	1.192	0.98
75_Y	204_H	1.175	0.98
72_E	104_A	1.169	0.98
24_V	191_R	1.157	0.98
36_R	40_Y	1.148	0.98
44_M	48_V	1.147	0.98
47_A	104_A	1.144	0.98
246_F	249_V	1.141	0.98
27_L	202_L	1.141	0.98
44_M	95_E	1.135	0.98
24_V	201_I	1.124	0.98
229_A	242_F	1.107	0.97
10_R	272_I	1.105	0.97
231_E	240_T	1.103	0.97
79_T	184_V	1.101	0.97
16_G	250_L	1.089	0.97
264_E	271_D	1.086	0.97
148_R	152_Y	1.085	0.97
225_T	245_E	1.083	0.97
229_A	232_S	1.080	0.97
47_A	73_I	1.079	0.97
32_G	245_E	1.078	0.97
73_I	163_V	1.077	0.97
90_A	95_E	1.073	0.97
20_P	249_V	1.072	0.97
21_E	160_S	1.066	0.97
10_R	13_S	1.057	0.96
23_S	186_T	1.054	0.96
106_T	156_H	1.053	0.96
149_F	153_L	1.050	0.96
268_S	271_D	1.038	0.96
26_L	222_V	1.029	0.96
41_T	45_M	1.025	0.96
43_A	47_A	1.014	0.96
44_M	94_D	1.009	0.95
48_V	98_V	1.000	0.95
222_V	225_T	0.987	0.95
21_E	51_A	0.978	0.95
250_L	256_D	0.969	0.94
205_L	208_D	0.967	0.94
264_E	273_S	0.959	0.94
40_Y	75_Y	0.953	0.94
99_A	103_D	0.947	0.94
99_A	102_A	0.945	0.94
34_G	265_I	0.941	0.93
75_Y	205_L	0.927	0.93
32_G	165_D	0.916	0.92
250_L	267_D	0.911	0.92
10_R	271_D	0.909	0.92
95_E	98_V	0.903	0.92
206_T	209_A	0.900	0.92
77_S	205_L	0.895	0.92
27_L	270_F	0.895	0.92
6_F	12_D	0.880	0.91
227_Q	244_R	0.880	0.91
230_W	237_R	0.879	0.91
29_G	36_R	0.876	0.91
40_Y	77_S	0.874	0.91
35_A	247_R	0.871	0.90
24_V	222_V	0.871	0.90
45_M	51_A	0.867	0.90
41_T	94_D	0.866	0.90
236_E	256_D	0.864	0.90
164_V	207_R	0.860	0.90
157_A	160_S	0.853	0.89
152_Y	156_H	0.846	0.89
84_E	88_E	0.844	0.89
100_A	103_D	0.838	0.89
265_I	272_I	0.829	0.88
79_T	195_R	0.828	0.88
85_L	107_F	0.828	0.88
3_T	27_L	0.826	0.88
232_S	242_F	0.825	0.88
213_E	243_V	0.819	0.87
37_E	41_T	0.819	0.87
25_V	200_L	0.811	0.87
164_V	198_S	0.810	0.87
168_N	222_V	0.809	0.87
151_D	250_L	0.809	0.87
174_R	183_V	0.809	0.87
87_R	90_A	0.806	0.87
38_F	202_L	0.803	0.86
193_A	197_W	0.799	0.86
148_R	151_D	0.798	0.86
76_V	110_L	0.797	0.86
5_P	12_D	0.797	0.86
239_R	261_F	0.796	0.86
243_V	270_F	0.793	0.86
242_F	258_I	0.790	0.86
140_E	144_D	0.789	0.85
51_A	73_I	0.788	0.85
14_R	254_E	0.785	0.85
79_T	189_G	0.783	0.85
225_T	242_F	0.777	0.85
8_I	12_D	0.774	0.84
48_V	99_A	0.765	0.84
261_F	270_F	0.764	0.84
112_P	244_R	0.764	0.84
157_A	197_W	0.762	0.83
162_V	194_A	0.754	0.83
147_E	151_D	0.744	0.82
20_P	224_G	0.741	0.82
166_S	221_S	0.738	0.81
36_R	88_E	0.737	0.81
29_G	165_D	0.735	0.81
8_I	38_F	0.735	0.81
80_A	245_E	0.734	0.81
97_I	102_A	0.729	0.81
46_N	73_I	0.729	0.81
14_R	255_E	0.725	0.80
39_L	43_A	0.724	0.80
215_F	218_L	0.723	0.80
86_Q	97_I	0.721	0.80
259_V	274_D	0.719	0.80
179_A	182_D	0.718	0.80
76_V	149_F	0.717	0.80
175_S	179_A	0.714	0.79
22_G	170_L	0.713	0.79
31_A	222_V	0.713	0.79
203_L	222_V	0.712	0.79
81_N	205_L	0.711	0.79
73_I	160_S	0.709	0.79
14_R	241_M	0.708	0.79
146_L	150_A	0.706	0.79
163_V	204_H	0.705	0.78
41_T	202_L	0.704	0.78
31_A	225_T	0.702	0.78
23_S	223_D	0.700	0.78
46_N	49_A	0.700	0.78
111_S	192_K	0.696	0.78
20_P	248_G	0.694	0.77
190_L	239_R	0.691	0.77
73_I	105_V	0.691	0.77
108_A	196_D	0.690	0.77
232_S	258_I	0.688	0.77
88_E	223_D	0.686	0.77
4_I	24_V	0.686	0.77
84_E	149_F	0.685	0.76
50_T	72_E	0.680	0.76
105_V	156_H	0.680	0.76
23_S	84_E	0.674	0.75
15_I	226_V	0.671	0.75
164_V	272_I	0.663	0.74
191_R	220_S	0.662	0.74
83_A	151_D	0.660	0.74
232_S	235_N	0.659	0.74
30_E	237_R	0.659	0.74
244_R	254_E	0.659	0.74
39_L	75_Y	0.658	0.74
84_E	248_G	0.656	0.73
141_D	186_T	0.650	0.73
5_P	97_I	0.646	0.72
227_Q	242_F	0.645	0.72
38_F	41_T	0.645	0.72
165_D	245_E	0.640	0.71
153_L	193_A	0.639	0.71
24_V	187_L	0.636	0.71
4_I	226_V	0.633	0.71
6_F	45_M	0.631	0.70
162_V	186_T	0.631	0.70
41_T	48_V	0.628	0.70
75_Y	107_F	0.627	0.70
12_D	18_G	0.625	0.70
78_F	112_P	0.625	0.70
4_I	161_L	0.624	0.70
153_L	199_G	0.621	0.69
195_R	206_T	0.616	0.69
98_V	101_G	0.616	0.69
29_G	34_G	0.613	0.68
229_A	240_T	0.610	0.68
27_L	40_Y	0.606	0.67
142_T	167_L	0.604	0.67
172_G	243_V	0.601	0.67
166_S	223_D	0.601	0.67
33_A	77_S	0.600	0.67
79_T	204_H	0.598	0.66
142_T	174_R	0.598	0.66
27_L	226_V	0.597	0.66
267_D	270_F	0.597	0.66
36_R	206_T	0.596	0.66
242_F	257_D	0.595	0.66
35_A	165_D	0.595	0.66
32_G	80_A	0.588	0.65
39_L	42_A	0.588	0.65
204_H	214_E	0.584	0.64
73_I	104_A	0.582	0.64
41_T	238_V	0.582	0.64
7_G	107_F	0.580	0.64
42_A	202_L	0.580	0.64
6_F	14_R	0.578	0.64
232_S	237_R	0.574	0.63
215_F	219_M	0.573	0.63
164_V	203_L	0.573	0.63
37_E	168_N	0.571	0.63
38_F	94_D	0.569	0.62
212_S	217_S	0.569	0.62
167_L	207_R	0.567	0.62
153_L	162_V	0.563	0.62
9_S	45_M	0.563	0.62
80_A	85_L	0.561	0.61
214_E	226_V	0.561	0.61
30_E	244_R	0.554	0.60
40_Y	107_F	0.551	0.60
35_A	80_A	0.551	0.60
89_I	190_L	0.549	0.60
239_R	265_I	0.548	0.60
79_T	220_S	0.546	0.59
77_S	248_G	0.546	0.59
167_L	179_A	0.545	0.59
6_F	41_T	0.545	0.59
145_V	188_K	0.545	0.59
7_G	45_M	0.544	0.59
179_A	265_I	0.544	0.59
75_Y	89_I	0.543	0.59
91_F	267_D	0.543	0.59
197_W	270_F	0.542	0.59
87_R	167_L	0.538	0.58
82_E	107_F	0.537	0.58
9_S	103_D	0.536	0.58
47_A	214_E	0.534	0.58
9_S	72_E	0.533	0.58
30_E	229_A	0.533	0.58
195_R	223_D	0.532	0.57
143_R	146_L	0.531	0.57
169_D	246_F	0.525	0.56
144_D	150_A	0.524	0.56
191_R	206_T	0.523	0.56
209_A	212_S	0.523	0.56
14_R	243_V	0.521	0.56
219_M	244_R	0.519	0.56
154_D	198_S	0.518	0.55
31_A	219_M	0.517	0.55
29_G	247_R	0.516	0.55
33_A	74_H	0.516	0.55
6_F	15_I	0.514	0.55
23_S	218_L	0.512	0.55
168_N	171_I	0.511	0.54
194_A	206_T	0.511	0.54
146_L	255_E	0.511	0.54
217_S	220_S	0.510	0.54
172_G	205_L	0.508	0.54
156_H	160_S	0.508	0.54
5_P	11_L	0.508	0.54
93_M	268_S	0.507	0.54
15_I	245_E	0.507	0.54
27_L	101_G	0.507	0.54
205_L	215_F	0.506	0.54
142_T	186_T	0.506	0.54
10_R	274_D	0.506	0.54
24_V	221_S	0.506	0.54
167_L	205_L	0.505	0.54
31_A	239_R	0.504	0.53
94_D	200_L	0.504	0.53
153_L	194_A	0.503	0.53
41_T	269_G	0.502	0.53
26_L	225_T	0.501	0.53
95_E	268_S	0.501	0.53
89_I	272_I	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bs4A	1	0.8065	100	0.417	Contact Map
2dr3A	3	0.853	100	0.442	Contact Map
4a8jA	1	0.8136	100	0.485	Contact Map
1tf7A	3	0.7957	100	0.498	Contact Map
2w0mA	1	0.7742	100	0.529	Contact Map
2cvhA	1	0.7563	100	0.539	Contact Map
1n0wA	1	0.7097	100	0.553	Contact Map
2ztsA	3	0.7957	100	0.553	Contact Map
4tl6A	3	0.8065	100	0.556	Contact Map
4bwyA	3	0.6523	100	0.557	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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