GREMLIN Database
Q9HP94 - Uncharacterized protein
UniProt: Q9HP94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (218)
Sequences: 588 (454)
Seq/√Len: 30.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_A27_L5.1001.00
17_P39_D4.3921.00
49_M52_I3.8231.00
45_V82_I3.6961.00
14_A213_I3.6881.00
23_V33_V3.2551.00
142_E190_T3.1441.00
187_A217_P2.9451.00
164_R176_Q2.9301.00
40_A72_T2.9101.00
70_L199_F2.8371.00
34_D162_R2.6621.00
12_L141_Y2.3670.99
17_P41_Y2.3460.99
120_A140_T2.2890.99
182_D220_D2.2630.99
68_L111_M2.2320.99
30_G76_V2.2250.99
15_S214_A2.0790.98
54_P94_G2.0730.98
111_M125_S2.0710.98
10_D217_P2.0300.98
66_G90_T2.0210.97
24_A33_V1.9260.97
153_G156_T1.8400.96
98_A106_Y1.8270.95
89_A95_V1.8260.95
104_L165_F1.8120.95
191_L213_I1.8060.95
26_R85_F1.7550.94
32_D75_T1.7270.94
19_D39_D1.7080.93
46_P139_A1.7030.93
8_W69_N1.6930.93
10_D31_V1.6770.93
35_T40_A1.6620.92
47_F67_E1.6550.92
7_R216_S1.6520.92
8_W47_F1.6500.92
154_S157_A1.6480.92
10_D115_R1.6410.92
68_L139_A1.6320.92
6_M165_F1.6180.91
18_V167_V1.5970.91
10_D215_Y1.5810.90
66_G113_I1.5800.90
11_V45_V1.5450.89
69_N84_F1.5370.89
9_A50_E1.5090.88
8_W67_E1.5000.88
41_Y156_T1.4910.87
81_G176_Q1.4640.86
88_D109_A1.4410.86
130_A133_P1.3950.84
115_R119_G1.3940.84
155_L159_L1.3910.83
180_D222_T1.3780.83
27_L83_Y1.3450.81
180_D224_G1.3390.81
49_M221_V1.3010.79
25_D33_V1.2970.79
175_Y226_P1.2860.78
93_L221_V1.2850.78
27_L33_V1.2770.78
31_V72_T1.2720.77
47_F65_F1.2640.77
15_S43_S1.2610.77
53_R57_L1.2600.77
124_R138_D1.2520.76
53_R58_P1.2340.75
6_M223_A1.2280.75
23_V27_L1.2160.74
96_R100_R1.2160.74
14_A139_A1.2090.74
114_E122_A1.2000.73
18_V23_V1.1980.73
102_F177_G1.1880.72
4_L223_A1.1860.72
45_V99_R1.1820.72
52_I94_G1.1730.71
46_P50_E1.1660.71
122_A138_D1.1480.70
82_I173_T1.1420.69
95_V108_T1.1290.68
166_F203_G1.1140.67
75_T80_P1.1120.67
75_T184_W1.1080.67
26_R204_F1.1010.66
153_G157_A1.0950.66
44_V139_A1.0940.66
31_V83_Y1.0930.66
120_A142_E1.0910.66
68_L212_H1.0880.66
45_V49_M1.0670.64
49_M65_F1.0620.64
144_A147_C1.0600.63
69_N106_Y1.0540.63
43_S156_T1.0520.63
135_L201_A1.0500.63
11_V111_M1.0460.62
143_Q187_A1.0420.62
200_T206_Q1.0120.60
69_N181_H1.0110.60
14_A210_S1.0010.59
147_C185_Q0.9920.58
13_V160_L0.9890.58
31_V174_V0.9830.58
83_Y158_F0.9830.58
20_P35_T0.9770.57
94_G104_L0.9740.57
46_P68_L0.9730.57
21_E210_S0.9660.56
12_L161_E0.9610.56
23_V204_F0.9530.55
97_V100_R0.9480.55
24_A30_G0.9480.55
100_R172_G0.9470.55
163_Y167_V0.9470.55
160_L184_W0.9440.54
92_A96_R0.9370.54
165_F223_A0.9340.54
12_L68_L0.9330.54
19_D51_N0.9330.54
47_F111_M0.9300.53
72_T83_Y0.9170.52
178_A224_G0.9170.52
15_S49_M0.9160.52
32_D76_V0.9160.52
84_F163_Y0.9150.52
10_D136_A0.9140.52
119_G142_E0.9120.52
22_V112_R0.9050.51
80_P83_Y0.9040.51
80_P166_F0.9010.51
160_L186_L0.8950.51
6_M15_S0.8910.50
15_S63_R0.8850.50
159_L162_R0.8810.49
83_Y212_H0.8730.49
63_R166_F0.8730.49
35_T107_Y0.8660.48
4_L165_F0.8630.48
92_A108_T0.8610.48
107_Y127_R0.8490.47
87_L223_A0.8490.47
16_W40_A0.8470.47
72_T85_F0.8400.46
88_D107_Y0.8390.46
147_C187_A0.8380.46
196_N199_F0.8350.46
49_M97_V0.8210.45
35_T157_A0.8130.44
42_L122_A0.8070.44
7_R10_D0.8040.43
24_A172_G0.8000.43
151_T213_I0.7980.43
134_S143_Q0.7960.43
6_M104_L0.7950.43
43_S173_T0.7930.42
198_L201_A0.7860.42
49_M219_V0.7860.42
142_E188_D0.7840.42
23_V79_R0.7790.41
11_V219_V0.7780.41
113_I121_L0.7690.41
37_D134_S0.7680.40
6_M162_R0.7660.40
208_A211_P0.7640.40
5_S56_G0.7590.40
30_G200_T0.7560.40
91_D226_P0.7440.39
136_A197_D0.7430.39
37_D41_Y0.7400.38
27_L44_V0.7340.38
67_E106_Y0.7340.38
54_P174_V0.7340.38
11_V46_P0.7230.37
25_D101_L0.7200.37
99_R107_Y0.7190.37
36_H210_S0.7180.37
159_L183_P0.7140.36
52_I93_L0.7130.36
30_G173_T0.7120.36
106_Y163_Y0.7110.36
48_V64_T0.7090.36
112_R146_A0.7050.36
33_V179_V0.7030.36
93_L152_P0.7010.35
49_M102_F0.7000.35
71_R184_W0.7000.35
12_L163_Y0.6960.35
52_I179_V0.6910.35
69_N163_Y0.6870.34
11_V31_V0.6830.34
33_V72_T0.6780.34
13_V105_P0.6760.34
143_Q147_C0.6740.33
48_V66_G0.6730.33
145_G187_A0.6700.33
165_F225_L0.6690.33
37_D151_T0.6610.33
98_A221_V0.6570.32
35_T88_D0.6560.32
175_Y225_L0.6560.32
87_L102_F0.6530.32
5_S51_N0.6510.32
50_E64_T0.6480.32
65_F97_V0.6470.32
156_T214_A0.6470.32
69_N184_W0.6430.31
86_N125_S0.6410.31
90_T111_M0.6400.31
130_A136_A0.6390.31
101_L222_T0.6390.31
7_R50_E0.6390.31
36_H138_D0.6370.31
80_P212_H0.6360.31
82_I160_L0.6350.31
51_N57_L0.6350.31
21_E131_G0.6340.31
52_I219_V0.6310.30
20_P39_D0.6300.30
52_I221_V0.6270.30
68_L123_V0.6260.30
116_R185_Q0.6250.30
140_T193_V0.6230.30
110_D126_T0.6230.30
83_Y174_V0.6190.30
201_A207_P0.6190.30
18_V83_Y0.6140.29
8_W13_V0.6140.29
185_Q189_A0.6130.29
94_G165_F0.6080.29
103_G160_L0.6060.29
107_Y129_H0.6060.29
94_G98_A0.6040.29
16_W87_L0.6040.29
58_P105_P0.6030.29
26_R42_L0.6000.28
54_P223_A0.6000.28
4_L45_V0.5990.28
177_G226_P0.5960.28
140_T143_Q0.5950.28
48_V110_D0.5940.28
135_L197_D0.5930.28
199_F204_F0.5880.28
43_S215_Y0.5880.28
125_S217_P0.5870.28
42_L202_N0.5850.27
61_V199_F0.5850.27
12_L215_Y0.5840.27
161_E171_D0.5830.27
46_P67_E0.5820.27
23_V76_V0.5820.27
140_T204_F0.5790.27
63_R165_F0.5790.27
27_L38_G0.5770.27
134_S216_S0.5760.27
6_M70_L0.5740.27
207_P211_P0.5720.27
82_I214_A0.5710.26
88_D127_R0.5710.26
66_G166_F0.5700.26
65_F156_T0.5690.26
57_L81_G0.5690.26
4_L177_G0.5690.26
30_G172_G0.5670.26
43_S213_I0.5660.26
179_V223_A0.5650.26
25_D64_T0.5640.26
103_G226_P0.5630.26
82_I106_Y0.5630.26
173_T186_L0.5610.26
54_P102_F0.5610.26
121_L127_R0.5600.26
62_G70_L0.5600.26
68_L129_H0.5560.26
123_V141_Y0.5530.25
138_D195_R0.5530.25
72_T159_L0.5510.25
36_H154_S0.5510.25
86_N107_Y0.5490.25
19_D22_V0.5480.25
59_S142_E0.5480.25
31_V166_F0.5460.25
115_R126_T0.5460.25
65_F79_R0.5450.25
94_G177_G0.5420.25
66_G111_M0.5390.25
16_W164_R0.5380.24
26_R99_R0.5380.24
150_A154_S0.5380.24
79_R224_G0.5370.24
6_M61_V0.5370.24
29_D112_R0.5340.24
179_V196_N0.5320.24
91_D224_G0.5310.24
18_V21_E0.5300.24
86_N155_L0.5290.24
13_V141_Y0.5290.24
43_S61_V0.5280.24
70_L154_S0.5270.24
21_E112_R0.5260.24
31_V212_H0.5250.24
209_G222_T0.5230.24
8_W181_H0.5220.24
4_L52_I0.5210.23
210_S217_P0.5200.23
178_A184_W0.5170.23
145_G153_G0.5160.23
160_L164_R0.5160.23
181_H184_W0.5160.23
20_P182_D0.5160.23
172_G203_G0.5150.23
122_A188_D0.5130.23
114_E151_T0.5130.23
15_S88_D0.5100.23
22_V205_E0.5080.23
69_N161_E0.5060.23
91_D96_R0.5060.23
6_M89_A0.5050.23
146_A220_D0.5040.23
167_V178_A0.5020.22
44_V196_N0.5020.22
10_D53_R0.5020.22
216_S219_V0.5020.22
89_A165_F0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jmdA 4 0.9258 99.9 0.738 Contact Map
3bgtA 6 0.9039 99.8 0.763 Contact Map
3c8wA 6 0.9083 99.8 0.767 Contact Map
4zboA 4 0.9476 99.4 0.823 Contact Map
3bh2A 6 0.9127 99.2 0.84 Contact Map
3cmbA 4 0.9301 97.2 0.908 Contact Map
3q6kA 1 0.8297 4.3 0.973 Contact Map
1k3sA 2 0.1616 3.4 0.974 Contact Map
4zcnA 3 0.3275 3.1 0.975 Contact Map
4bhuA 6 0.476 3 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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