GREMLIN Database
Q9HP92 - GTP-binding protein homolog
UniProt: Q9HP92 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (382)
Sequences: 389 (271)
Seq/√Len: 13.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
356_Y363_G5.4321.00
349_A353_D5.3341.00
108_I221_A5.2411.00
86_G89_E4.2481.00
322_P342_V4.2141.00
333_T336_G4.1051.00
312_A316_D3.9421.00
18_F22_A3.8381.00
276_A295_R3.5330.99
221_A251_V3.3650.99
37_I81_A3.3470.99
99_T102_N3.2170.98
109_H132_D3.1210.98
319_G347_P3.0670.98
118_D122_E2.9290.97
331_L336_G2.7380.95
356_Y364_D2.6610.94
345_L349_A2.6050.94
330_G333_T2.5000.92
330_G336_G2.4620.92
6_G17_T2.3780.90
149_E201_D2.3620.90
292_E295_R2.3570.90
169_L183_V2.3540.90
106_V313_A2.3510.90
262_A287_Q2.3320.89
9_G15_K2.3280.89
9_G14_G2.3280.89
27_V40_A2.3150.89
200_D203_D2.3090.89
108_I251_V2.2790.88
32_Y35_T2.2360.87
80_V101_L2.2330.87
368_H377_Q2.2290.87
11_P16_S2.2100.86
333_T337_R2.1920.86
329_N332_G2.1580.85
332_G336_G2.1530.85
328_A331_L2.0920.83
46_V310_I2.0810.83
127_H132_D2.0700.82
11_P32_Y2.0690.82
59_C66_C2.0660.82
20_N261_Q2.0230.81
329_N333_T2.0220.81
50_C66_C2.0100.80
141_D212_R1.9950.80
331_L334_A1.9820.80
6_G351_A1.9630.79
110_V251_V1.9240.77
189_A214_R1.8930.76
354_F384_L1.8850.76
55_F331_L1.8700.75
9_G16_S1.8230.73
330_G334_A1.7940.72
85_P136_L1.7670.71
366_F369_A1.7590.71
53_P389_V1.7500.70
141_D209_R1.7310.69
22_A77_L1.7230.69
5_V106_V1.7180.69
328_A333_T1.7090.68
6_G19_F1.7010.68
21_A42_G1.7000.68
100_D107_L1.6640.66
279_I282_E1.6270.64
371_D374_A1.5990.63
83_L95_N1.5950.63
8_V61_P1.5930.63
382_Q388_A1.5900.62
360_S363_G1.5830.62
276_A279_I1.5560.61
376_R385_D1.5560.61
328_A336_G1.5540.61
91_A316_D1.5340.60
111_V148_L1.5310.59
11_P136_L1.5220.59
321_K384_L1.5010.58
207_L364_D1.4830.57
66_C71_R1.4750.56
11_P35_T1.4660.56
321_K348_D1.4580.56
277_F291_L1.4480.55
311_E324_F1.4410.55
61_P107_L1.4210.54
119_I309_A1.3920.52
8_V107_L1.3900.52
221_A239_D1.3830.52
110_V221_A1.3810.51
202_A316_D1.3790.51
8_V13_V1.3790.51
73_V389_V1.3770.51
85_P120_E1.3710.51
367_L377_Q1.3700.51
17_T21_A1.3480.50
351_A366_F1.3410.49
20_N107_L1.3380.49
81_A85_P1.3370.49
20_N26_D1.3230.48
298_V303_G1.3230.48
133_I221_A1.3230.48
382_Q390_I1.3230.48
277_F280_V1.3200.48
322_P386_S1.3190.48
371_D382_Q1.3130.48
312_A317_A1.3080.47
96_Q100_D1.3070.47
310_I368_H1.2970.47
267_V290_G1.2850.46
230_A233_N1.2800.46
345_L357_A1.2670.45
81_A100_D1.2600.45
225_M234_W1.2480.44
12_S15_K1.2470.44
9_G12_S1.2470.44
201_D361_D1.2450.44
61_P64_G1.2330.43
34_F39_P1.2310.43
91_A329_N1.2250.43
18_F309_A1.2190.43
270_Y273_G1.2190.43
70_T310_I1.2070.42
151_G172_Q1.2060.42
93_L109_H1.2060.42
221_A309_A1.2050.42
35_T69_G1.2010.42
6_G9_G1.1990.42
6_G14_G1.1990.42
6_G15_K1.1990.42
11_P52_A1.1940.41
55_F372_C1.1880.41
49_E70_T1.1870.41
11_P14_G1.1810.41
11_P15_K1.1810.41
116_T125_E1.1700.40
113_F372_C1.1670.40
37_I80_V1.1620.40
59_C80_V1.1620.40
111_V376_R1.1600.40
72_F271_R1.1560.39
9_G17_T1.1470.39
14_G17_T1.1470.39
48_V386_S1.1350.38
276_A280_V1.1340.38
328_A332_G1.1300.38
329_N334_A1.1270.38
382_Q385_D1.1270.38
107_L192_L1.1170.37
14_G36_T1.1120.37
9_G36_T1.1120.37
15_K36_T1.1120.37
50_C59_C1.1080.37
92_G139_E1.1020.37
351_A380_A1.1000.37
94_G97_F1.0990.37
329_N336_G1.0950.36
259_L270_Y1.0830.36
20_N29_E1.0800.36
261_Q320_V1.0620.35
6_G389_V1.0570.34
81_A101_L1.0520.34
8_V136_L1.0520.34
38_D289_A1.0500.34
20_N27_V1.0430.34
73_V324_F1.0430.34
42_G215_T1.0370.33
170_A183_V1.0350.33
47_R274_D1.0280.33
331_L372_C1.0260.33
133_I349_A1.0230.33
136_L172_Q1.0220.33
112_D224_K1.0220.33
345_L353_D1.0140.32
48_V64_G1.0090.32
18_F106_V1.0060.32
98_L132_D1.0000.32
13_V174_S0.9960.32
308_S312_A0.9960.32
347_P385_D0.9810.31
330_G339_L0.9790.31
111_V351_A0.9750.31
20_N136_L0.9700.30
269_D278_T0.9590.30
11_P84_I0.9500.29
252_S255_A0.9460.29
292_E299_T0.9460.29
115_G121_G0.9410.29
379_A382_Q0.9400.29
384_L388_A0.9360.29
351_A363_G0.9340.29
108_I309_A0.9310.29
203_D324_F0.9300.29
35_T224_K0.9280.28
87_A92_G0.9250.28
41_V76_K0.9220.28
276_A281_G0.9200.28
85_P135_F0.9180.28
268_V338_V0.9130.28
196_P212_R0.9130.28
178_T216_K0.9130.28
38_D146_D0.9110.28
118_D315_F0.9110.28
212_R389_V0.9100.28
216_K349_A0.9090.28
126_G210_E0.9070.28
33_P36_T0.9030.27
94_G98_L0.9030.27
33_P37_I0.9020.27
45_Y180_P0.8990.27
152_I157_G0.8940.27
299_T303_G0.8930.27
46_V251_V0.8890.27
87_A139_E0.8870.27
352_E390_I0.8860.27
207_L211_M0.8860.27
123_A221_A0.8840.27
8_V228_P0.8820.26
101_L135_F0.8800.26
77_L88_H0.8760.26
209_R294_I0.8750.26
351_A356_Y0.8750.26
90_G139_E0.8740.26
134_D296_E0.8700.26
144_Y212_R0.8690.26
342_V391_E0.8690.26
330_G337_R0.8680.26
132_D142_Q0.8640.26
153_E389_V0.8640.26
34_F37_I0.8630.26
8_V20_N0.8610.26
109_H118_D0.8600.26
318_L388_A0.8600.26
37_I101_L0.8580.25
145_L204_R0.8570.25
44_A291_L0.8500.25
19_F25_N0.8500.25
105_D365_G0.8490.25
100_D132_D0.8490.25
233_N236_A0.8490.25
112_D226_D0.8490.25
22_A46_V0.8470.25
8_V229_E0.8470.25
136_L158_Q0.8460.25
231_Q300_E0.8460.25
133_I248_F0.8450.25
27_V110_V0.8450.25
83_L87_A0.8430.25
97_F139_E0.8420.25
168_E281_G0.8390.25
201_D370_V0.8380.25
65_F72_F0.8360.25
49_E53_P0.8360.25
75_T202_A0.8290.24
84_I91_A0.8280.24
384_L393_I0.8260.24
51_A59_C0.8220.24
37_I100_D0.8220.24
359_H369_A0.8220.24
109_H127_H0.8200.24
267_V387_R0.8180.24
179_S185_Q0.8150.24
84_I146_D0.8150.24
285_D288_R0.8150.24
128_D236_A0.8150.24
54_E60_T0.8140.24
355_A369_A0.8140.24
99_T157_G0.8060.23
7_L17_T0.8050.23
36_T39_P0.8040.23
50_C71_R0.7990.23
290_G293_S0.7970.23
52_A155_Y0.7960.23
89_E249_V0.7950.23
218_M232_A0.7950.23
287_Q291_L0.7940.23
345_L352_E0.7930.23
83_L92_G0.7910.23
96_Q177_R0.7900.23
203_D232_A0.7870.23
24_N30_G0.7850.23
311_E377_Q0.7790.22
51_A199_W0.7780.22
51_A54_E0.7740.22
149_E204_R0.7740.22
121_G305_G0.7680.22
11_P101_L0.7670.22
329_N335_D0.7650.22
77_L93_L0.7640.22
276_A282_E0.7630.22
384_L390_I0.7580.22
239_D295_R0.7570.22
19_F41_V0.7530.21
331_L387_R0.7500.21
16_S37_I0.7470.21
378_I384_L0.7440.21
87_A90_G0.7430.21
116_T358_V0.7430.21
90_G256_E0.7420.21
254_H262_A0.7410.21
148_L163_A0.7400.21
219_V317_A0.7390.21
105_D177_R0.7380.21
129_P304_T0.7370.21
175_A305_G0.7350.21
326_G391_E0.7340.21
279_I292_E0.7300.21
91_A120_E0.7300.21
34_F40_A0.7250.20
378_I382_Q0.7250.20
354_F390_I0.7240.20
20_N25_N0.7240.20
254_H267_V0.7230.20
358_V361_D0.7200.20
160_M172_Q0.7190.20
210_E214_R0.7160.20
44_A48_V0.7140.20
244_D247_E0.7130.20
326_G354_F0.7120.20
120_E219_V0.7110.20
142_Q205_L0.7090.20
28_P44_A0.7090.20
34_F94_G0.7070.20
262_A328_A0.7060.20
106_V219_V0.7050.20
254_H293_S0.7040.20
54_E382_Q0.7030.20
189_A210_E0.7020.20
107_L259_L0.7010.20
35_T52_A0.7000.20
118_D262_A0.6990.20
328_A335_D0.6980.19
39_P51_A0.6960.19
269_D280_V0.6960.19
59_C101_L0.6950.19
16_S36_T0.6950.19
31_A88_H0.6930.19
87_A94_G0.6920.19
111_V249_V0.6920.19
119_I329_N0.6910.19
142_Q155_Y0.6900.19
328_A334_A0.6890.19
68_D316_D0.6890.19
220_V315_F0.6880.19
179_S357_A0.6880.19
104_A117_T0.6870.19
235_A347_P0.6860.19
116_T124_T0.6850.19
79_D82_G0.6840.19
81_A84_I0.6840.19
37_I40_A0.6820.19
281_G284_S0.6800.19
119_I306_V0.6780.19
180_P212_R0.6780.19
8_V380_A0.6770.19
83_L90_G0.6760.19
176_F215_T0.6730.19
64_G233_N0.6720.19
55_F377_Q0.6710.19
29_E379_A0.6710.19
175_A304_T0.6700.19
213_T312_A0.6700.19
82_G223_N0.6690.19
310_I324_F0.6690.19
168_E358_V0.6680.18
44_A148_L0.6670.18
219_V301_Y0.6660.18
44_A365_G0.6660.18
94_G139_E0.6630.18
351_A379_A0.6620.18
359_H364_D0.6610.18
262_A371_D0.6610.18
280_V283_P0.6590.18
331_L335_D0.6590.18
12_S16_S0.6580.18
345_L367_L0.6580.18
77_L255_A0.6570.18
17_T389_V0.6570.18
348_D383_D0.6540.18
368_H393_I0.6530.18
143_W226_D0.6520.18
56_G186_V0.6510.18
71_R143_W0.6490.18
20_N230_A0.6470.18
71_R226_D0.6460.18
95_N109_H0.6460.18
120_E136_L0.6460.18
28_P255_A0.6430.18
46_V108_I0.6420.18
11_P30_G0.6410.18
118_D296_E0.6400.18
287_Q290_G0.6400.18
336_G369_A0.6400.18
155_Y298_V0.6390.18
117_T121_G0.6390.18
128_D352_E0.6350.17
104_A175_A0.6350.17
8_V11_P0.6280.17
83_L139_E0.6270.17
23_T34_F0.6260.17
104_A199_W0.6260.17
45_Y93_L0.6240.17
137_E309_A0.6230.17
129_P305_G0.6230.17
363_G366_F0.6230.17
212_R379_A0.6210.17
178_T192_L0.6200.17
101_L120_E0.6200.17
70_T271_R0.6200.17
362_V368_H0.6200.17
18_F119_I0.6200.17
13_V100_D0.6190.17
64_G71_R0.6160.17
279_I283_P0.6160.17
219_V249_V0.6150.17
6_G29_E0.6140.17
147_V176_F0.6120.17
96_Q107_L0.6100.17
127_H233_N0.6100.17
207_L376_R0.6100.17
61_P124_T0.6090.17
17_T23_T0.6070.17
49_E316_D0.6070.17
275_D285_D0.6050.17
185_Q289_A0.6040.16
33_P40_A0.6030.16
78_V127_H0.6030.16
169_L186_V0.6010.16
371_D387_R0.6000.16
93_L177_R0.6000.16
61_P174_S0.5990.16
100_D199_W0.5980.16
92_G97_F0.5970.16
325_P350_T0.5970.16
33_P39_P0.5970.16
6_G16_S0.5960.16
289_A292_E0.5950.16
234_W302_G0.5950.16
61_P74_P0.5940.16
48_V185_Q0.5940.16
35_T112_D0.5930.16
352_E380_A0.5930.16
64_G244_D0.5930.16
182_E265_G0.5920.16
206_E209_R0.5910.16
59_C64_G0.5910.16
207_L260_T0.5900.16
51_A65_F0.5890.16
115_G129_P0.5860.16
148_L252_S0.5860.16
138_T292_E0.5860.16
284_S310_I0.5850.16
255_A346_E0.5840.16
96_Q111_V0.5830.16
58_E168_E0.5820.16
275_D278_T0.5800.16
6_G23_T0.5800.16
369_A390_I0.5790.16
30_G35_T0.5770.16
179_S319_G0.5770.16
56_G158_Q0.5750.16
66_C224_K0.5740.16
13_V107_L0.5740.16
95_N139_E0.5740.16
12_S20_N0.5740.16
66_C69_G0.5730.16
84_I228_P0.5720.16
372_C377_Q0.5710.16
268_V298_V0.5700.16
143_W224_K0.5690.15
15_K79_D0.5680.15
14_G79_D0.5680.15
9_G79_D0.5680.15
136_L365_G0.5680.15
84_I110_V0.5680.15
189_A389_V0.5670.15
213_T316_D0.5670.15
218_M300_E0.5660.15
85_P152_I0.5660.15
132_D167_V0.5640.15
30_G111_V0.5640.15
58_E232_A0.5640.15
87_A98_L0.5630.15
33_P97_F0.5620.15
274_D277_F0.5610.15
380_A391_E0.5600.15
234_W364_D0.5600.15
73_V372_C0.5590.15
189_A288_R0.5580.15
34_F98_L0.5580.15
7_L113_F0.5560.15
39_P105_D0.5540.15
38_D41_V0.5540.15
327_S354_F0.5540.15
96_Q156_E0.5530.15
115_G226_D0.5530.15
178_T215_T0.5520.15
38_D76_K0.5510.15
36_T79_D0.5490.15
211_M323_V0.5480.15
290_G296_E0.5480.15
378_I392_I0.5470.15
109_H136_L0.5470.15
49_E292_E0.5470.15
355_A359_H0.5450.15
112_D143_W0.5440.15
12_S342_V0.5440.15
96_Q389_V0.5430.15
235_A238_T0.5410.15
362_V365_G0.5400.15
293_S390_I0.5400.15
255_A331_L0.5390.15
155_Y246_L0.5390.15
48_V75_T0.5390.15
34_F97_F0.5390.15
92_G95_N0.5380.15
389_V392_I0.5370.15
20_N68_D0.5370.15
5_V21_A0.5350.15
5_V249_V0.5350.15
31_A37_I0.5340.15
81_A95_N0.5340.15
40_A80_V0.5330.14
35_T226_D0.5330.14
49_E54_E0.5320.14
178_T275_D0.5320.14
87_A97_F0.5310.14
234_W257_Q0.5300.14
80_V83_L0.5290.14
34_F87_A0.5290.14
143_W325_P0.5270.14
155_Y176_F0.5250.14
365_G369_A0.5250.14
217_P313_A0.5250.14
6_G151_G0.5240.14
12_S36_T0.5230.14
121_G175_A0.5230.14
115_G344_L0.5230.14
35_T50_C0.5210.14
113_F248_F0.5210.14
118_D190_L0.5190.14
60_T337_R0.5180.14
86_G92_G0.5180.14
327_S391_E0.5170.14
149_E283_P0.5160.14
83_L94_G0.5160.14
148_L172_Q0.5150.14
374_A378_I0.5130.14
186_V190_L0.5130.14
351_A367_L0.5120.14
135_F147_V0.5120.14
384_L392_I0.5120.14
8_V14_G0.5100.14
8_V15_K0.5100.14
277_F282_E0.5100.14
77_L219_V0.5100.14
58_E192_L0.5100.14
144_Y208_A0.5080.14
106_V122_E0.5080.14
7_L105_D0.5070.14
125_E227_T0.5060.14
184_K261_Q0.5060.14
206_E210_E0.5060.14
140_L214_R0.5050.14
148_L173_M0.5050.14
130_R236_A0.5040.14
10_K175_A0.5040.14
98_L148_L0.5040.14
30_G293_S0.5030.14
222_A248_F0.5020.14
53_P335_D0.5010.14
71_R112_D0.5010.14
121_G143_W0.5000.14
134_D191_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wxqA 1 0.8636 100 0.376 Contact Map
1jalA 1 0.8283 100 0.509 Contact Map
2dbyA 1 0.8384 100 0.517 Contact Map
1ni3A 1 0.8662 100 0.535 Contact Map
2ohfA 1 0.75 100 0.607 Contact Map
4a9aA 1 0.7348 100 0.666 Contact Map
1lnzA 1 0.4697 100 0.786 Contact Map
4csu9 1 0.447 100 0.798 Contact Map
1udxA 1 0.5732 100 0.808 Contact Map
3ievA 1 0.7348 100 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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