GREMLIN Database
Q9HP91 - Uncharacterized protein
UniProt: Q9HP91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (254)
Sequences: 4929 (4396)
Seq/√Len: 275.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_Q259_A3.9651.00
154_I172_L3.1601.00
162_L256_T2.9401.00
31_G48_A2.9331.00
75_D78_S2.8691.00
183_L230_V2.7711.00
67_A79_V2.5901.00
52_T74_V2.5411.00
49_V58_V2.3381.00
265_Y268_R2.3301.00
136_R140_R2.2891.00
157_L161_V2.2741.00
19_N44_D2.2571.00
53_T73_G2.2001.00
23_V55_P2.1731.00
165_T169_E2.0941.00
160_C180_N2.0531.00
238_E259_A2.0431.00
67_A90_V2.0361.00
69_T92_V2.0161.00
147_E151_R1.9981.00
271_L275_A1.9821.00
264_A268_R1.9771.00
80_V90_V1.9751.00
51_P73_G1.9021.00
84_A111_T1.9001.00
50_T54_D1.8881.00
129_R133_A1.8881.00
27_G30_A1.8731.00
130_V134_V1.8141.00
150_L154_I1.7971.00
46_P62_A1.7951.00
271_L274_A1.7741.00
160_C258_V1.7681.00
26_S68_E1.7451.00
35_A48_A1.7441.00
238_E264_A1.7421.00
19_N46_P1.7261.00
178_A185_P1.6961.00
51_P54_D1.6881.00
151_R155_D1.6821.00
21_T49_V1.6811.00
176_S179_S1.6501.00
198_P201_L1.6481.00
52_T79_V1.6441.00
146_T149_R1.6381.00
136_R139_D1.6331.00
130_V133_A1.6281.00
31_G50_T1.5691.00
175_D179_S1.5671.00
222_P265_Y1.5541.00
270_R274_A1.5531.00
187_A230_V1.5221.00
112_A129_R1.4981.00
191_H195_E1.4901.00
49_V55_P1.4641.00
55_P79_V1.4601.00
70_G96_P1.4581.00
78_S81_A1.4481.00
68_E116_A1.4401.00
65_V83_L1.4241.00
77_V105_A1.4211.00
236_V262_T1.4131.00
59_S83_L1.4121.00
269_H273_G1.4101.00
246_D250_D1.3961.00
140_R144_S1.3881.00
139_D142_S1.3801.00
162_L170_Y1.3721.00
243_P251_A1.3541.00
184_D187_A1.3431.00
160_C177_G1.3421.00
163_E253_T1.3211.00
49_V52_T1.3041.00
94_D116_A1.2921.00
35_A39_E1.2741.00
92_V110_A1.2611.00
68_E94_D1.2611.00
144_S147_E1.2581.00
65_V88_V1.2511.00
98_G101_A1.2391.00
170_Y174_N1.2311.00
173_V177_G1.2301.00
59_S62_A1.2291.00
34_T93_V1.2181.00
133_A136_R1.2141.00
237_E258_V1.2061.00
163_E255_L1.2021.00
92_V105_A1.2001.00
69_T77_V1.1941.00
80_V92_V1.1921.00
77_V101_A1.1921.00
53_T57_S1.1861.00
23_V65_V1.1841.00
80_V110_A1.1831.00
19_N62_A1.1811.00
58_V62_A1.1751.00
266_E269_H1.1721.00
239_V258_V1.1561.00
25_G71_L1.1531.00
41_V124_R1.1411.00
71_L74_V1.1341.00
155_D175_D1.1291.00
74_V78_S1.1281.00
161_V174_N1.1151.00
160_C174_N1.1101.00
26_S71_L1.1081.00
25_G31_G1.1071.00
60_D85_D1.1021.00
67_A92_V1.0981.00
270_R273_G1.0971.00
192_R195_E1.0961.00
261_V265_Y1.0881.00
263_T266_E1.0861.00
56_M79_V1.0851.00
137_R141_E1.0831.00
131_R134_V1.0811.00
102_A122_T1.0801.00
177_G181_Y1.0771.00
52_T55_P1.0641.00
81_A104_S1.0621.00
74_V79_V1.0621.00
220_H238_E1.0611.00
206_H210_E1.0611.00
178_A184_D1.0601.00
137_R140_R1.0581.00
222_P238_E1.0581.00
162_L177_G1.0561.00
143_M147_E1.0551.00
235_R260_D1.0541.00
267_R270_R1.0451.00
67_A71_L1.0451.00
270_R275_A1.0441.00
129_R132_T1.0341.00
266_E270_R1.0331.00
22_Y34_T1.0301.00
71_L76_I1.0291.00
222_P225_H1.0231.00
69_T105_A1.0231.00
236_V265_Y1.0191.00
273_G276_T1.0151.00
54_D57_S1.0101.00
129_R134_V1.0091.00
120_G124_R1.0081.00
197_L202_V1.0071.00
272_A275_A1.0031.00
143_M146_T1.0031.00
68_E71_L0.9971.00
93_V118_P0.9851.00
103_G107_D0.9821.00
57_S61_D0.9801.00
135_E139_D0.9781.00
268_R272_A0.9741.00
183_L187_A0.9691.00
173_V178_A0.9651.00
30_A95_D0.9631.00
201_L224_Q0.9491.00
224_Q236_V0.9461.00
81_A108_A0.9461.00
118_P122_T0.9401.00
103_G106_I0.9361.00
46_P58_V0.9361.00
147_E150_L0.9301.00
56_M82_R0.9221.00
220_H240_Y0.9191.00
142_S145_H0.9151.00
241_K254_V0.9111.00
106_I110_A0.9071.00
139_D143_M0.9021.00
169_E192_R0.9001.00
37_R120_G0.8931.00
175_D178_A0.8921.00
102_A106_I0.8861.00
107_D112_A0.8861.00
30_A33_R0.8821.00
164_K193_E0.8811.00
83_L90_V0.8791.00
129_R136_R0.8781.00
223_E239_V0.8741.00
118_P123_A0.8711.00
211_Q215_D0.8661.00
37_R124_R0.8641.00
66_V93_V0.8631.00
99_S103_G0.8611.00
194_D202_V0.8591.00
26_S95_D0.8571.00
171_L253_T0.8561.00
68_E95_D0.8561.00
64_C134_V0.8481.00
52_T56_M0.8471.00
165_T171_L0.8461.00
173_V188_V0.8451.00
55_P59_S0.8431.00
53_T74_V0.8371.00
59_S88_V0.8361.00
245_D251_A0.8341.00
153_V158_P0.8291.00
162_L258_V0.8281.00
244_F253_T0.8260.99
74_V82_R0.8260.99
150_L153_V0.8250.99
30_A71_L0.8220.99
160_C176_S0.8220.99
149_R163_E0.8170.99
78_S82_R0.8090.99
42_A45_V0.8080.99
92_V111_T0.8060.99
219_L241_K0.8060.99
43_G47_I0.8060.99
17_A44_D0.8060.99
203_E207_R0.8020.99
246_D253_T0.7990.99
58_V61_D0.7930.99
49_V54_D0.7870.99
67_A80_V0.7820.99
153_V163_E0.7800.99
76_I94_D0.7790.99
57_S60_D0.7700.99
80_V108_A0.7700.99
22_Y31_G0.7670.99
156_S255_L0.7660.99
146_T150_L0.7650.99
242_L255_L0.7600.99
198_P224_Q0.7600.99
170_Y192_R0.7580.99
163_E174_N0.7560.99
54_D58_V0.7510.99
111_T133_A0.7450.99
69_T75_D0.7440.99
210_E214_A0.7440.99
146_T151_R0.7400.99
59_S79_V0.7400.99
25_G116_A0.7370.99
36_A40_R0.7370.99
51_P71_L0.7340.99
69_T80_V0.7330.99
52_T71_L0.7320.99
269_H272_A0.7320.99
243_P254_V0.7310.99
96_P101_A0.7300.99
178_A188_V0.7280.99
207_R211_Q0.7250.99
105_A110_A0.7190.99
29_G32_E0.7170.99
173_V185_P0.7140.99
163_E172_L0.7130.99
94_D102_A0.7120.98
28_G32_E0.7070.98
31_G92_V0.7040.98
23_V52_T0.7000.98
177_G256_T0.7000.98
82_R85_D0.6980.98
265_Y269_H0.6940.98
267_R271_L0.6940.98
164_K209_D0.6890.98
182_G231_I0.6890.98
142_S146_T0.6870.98
130_V137_R0.6860.98
106_I112_A0.6860.98
89_P99_S0.6850.98
80_V102_A0.6780.98
93_V117_R0.6750.98
159_Q176_S0.6730.98
71_L116_A0.6700.98
20_V64_C0.6690.98
23_V49_V0.6660.98
65_V89_P0.6660.98
141_E144_S0.6620.98
75_D104_S0.6620.98
212_V254_V0.6600.98
69_T101_A0.6560.97
80_V101_A0.6560.97
235_R262_T0.6540.97
76_I92_V0.6500.97
153_V157_L0.6490.97
104_S108_A0.6480.97
52_T72_H0.6470.97
37_R41_V0.6430.97
240_Y257_V0.6410.97
154_I161_V0.6400.97
125_V132_T0.6390.97
33_R37_R0.6380.97
270_R276_T0.6380.97
69_T76_I0.6360.97
26_S116_A0.6340.97
52_T75_D0.6340.97
69_T95_D0.6300.97
153_V156_S0.6280.97
85_D88_V0.6270.97
72_H76_I0.6260.97
56_M74_V0.6260.97
174_N260_D0.6210.96
125_V129_R0.6200.96
21_T62_A0.6200.96
272_A276_T0.6190.96
77_V104_S0.6170.96
227_D231_I0.6160.96
23_V79_V0.6160.96
198_P234_D0.6150.96
154_I174_N0.6140.96
223_E265_Y0.6080.96
71_L95_D0.6070.96
201_L204_R0.6070.96
26_S76_I0.6060.96
132_T136_R0.6060.96
177_G258_V0.6050.96
71_L79_V0.6050.96
174_N177_G0.6040.96
109_G112_A0.6030.96
92_V108_A0.5950.96
22_Y45_V0.5930.95
69_T116_A0.5890.95
201_L205_F0.5880.95
66_V123_A0.5850.95
164_K256_T0.5840.95
200_D224_Q0.5810.95
105_A132_T0.5810.95
134_V138_R0.5770.95
153_V255_L0.5760.95
177_G188_V0.5710.94
63_G89_P0.5700.94
69_T117_R0.5700.94
161_V255_L0.5680.94
104_S107_D0.5660.94
150_L172_L0.5650.94
71_L113_H0.5640.94
101_A104_S0.5640.94
221_I224_Q0.5630.94
30_A116_A0.5620.94
158_P174_N0.5610.94
165_T168_G0.5600.94
157_L160_C0.5590.94
69_T90_V0.5590.94
261_V268_R0.5570.94
94_D110_A0.5550.94
166_L251_A0.5510.93
183_L188_V0.5500.93
133_A137_R0.5500.93
32_E35_A0.5450.93
154_I163_E0.5420.93
71_L94_D0.5380.92
56_M59_S0.5370.92
87_D137_R0.5360.92
130_V136_R0.5360.92
175_D185_P0.5340.92
21_T55_P0.5330.92
178_A181_Y0.5330.92
209_D241_K0.5330.92
227_D234_D0.5300.92
191_H196_F0.5290.92
135_E138_R0.5290.92
92_V106_I0.5280.92
26_S94_D0.5280.92
138_R142_S0.5260.92
172_L185_P0.5240.91
80_V111_T0.5230.91
30_A69_T0.5230.91
34_T117_R0.5220.91
156_S257_V0.5210.91
164_K170_Y0.5210.91
170_Y256_T0.5200.91
181_Y237_E0.5190.91
161_V257_V0.5180.91
219_L223_E0.5180.91
141_E145_H0.5180.91
170_Y173_V0.5150.91
203_E206_H0.5140.91
33_R36_A0.5140.91
121_D125_V0.5110.90
224_Q234_D0.5110.90
112_A125_V0.5100.90
173_V189_E0.5090.90
55_P76_I0.5080.90
246_D252_D0.5080.90
156_S242_L0.5070.90
180_N235_R0.5070.90
168_G174_N0.5030.90
212_V243_P0.5020.90
80_V106_I0.5010.90
134_V137_R0.5010.90
95_D117_R0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gczA 2 0.5615 99.9 0.634 Contact Map
1w25A 2 0.8801 99.9 0.645 Contact Map
4i5sA 2 0.6719 99.9 0.659 Contact Map
3n0rA 1 0.4227 99.9 0.66 Contact Map
4g97A 1 0.4479 99.9 0.665 Contact Map
3breA 4 0.7729 99.9 0.667 Contact Map
4r3aA 1 0.4763 99.9 0.67 Contact Map
3a0rA 2 0.4921 99.9 0.671 Contact Map
2ayxA 1 0.4353 99.9 0.672 Contact Map
4b09A 2 0.6341 99.9 0.673 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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