Q9HP91 - HALSA - GREMLIN Contacts

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Q9HP91 - Uncharacterized protein

UniProt:	Q9HP91	Sequences: MDSRTDELDERQAVTDAINVTYVLGSGGGAGERTAARLERVAGDVPIAVTPTTDPMSVSDDAGCVVAETGLHGVDIVSVVARLADADVPVVVVDDPDGSVAAGSAIDAGATAHVRARPDGDTARVLANRVRTAVERRRDRESMSHTERRLRRVIDSLPQCVLEKTLDGEYLLVNDSGASNYGLDPDAVEGHREDEFLPPDLVERFHREDEQVIADDEALHIPEQHVDDRVIGDDRVEEVYKLPFDDPDTDADTVLTVVADVTTAYERRHRLAGAATHIEDAISQMASADPDHDRIRSLLDAAHEYAVGDSERAVDPQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (254)
Sequences:	4929 (4396)
Seq/√Len:	275.8

HALSA - Q9HP91 BAT O51970 Q9HQB9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
159_Q	259_A	3.965	1.00
154_I	172_L	3.160	1.00
162_L	256_T	2.940	1.00
31_G	48_A	2.933	1.00
75_D	78_S	2.869	1.00
183_L	230_V	2.771	1.00
67_A	79_V	2.590	1.00
52_T	74_V	2.541	1.00
49_V	58_V	2.338	1.00
265_Y	268_R	2.330	1.00
136_R	140_R	2.289	1.00
157_L	161_V	2.274	1.00
19_N	44_D	2.257	1.00
53_T	73_G	2.200	1.00
23_V	55_P	2.173	1.00
165_T	169_E	2.094	1.00
160_C	180_N	2.053	1.00
238_E	259_A	2.043	1.00
67_A	90_V	2.036	1.00
69_T	92_V	2.016	1.00
147_E	151_R	1.998	1.00
271_L	275_A	1.982	1.00
264_A	268_R	1.977	1.00
80_V	90_V	1.975	1.00
51_P	73_G	1.902	1.00
84_A	111_T	1.900	1.00
50_T	54_D	1.888	1.00
129_R	133_A	1.888	1.00
27_G	30_A	1.873	1.00
130_V	134_V	1.814	1.00
150_L	154_I	1.797	1.00
46_P	62_A	1.795	1.00
271_L	274_A	1.774	1.00
160_C	258_V	1.768	1.00
26_S	68_E	1.745	1.00
35_A	48_A	1.744	1.00
238_E	264_A	1.742	1.00
19_N	46_P	1.726	1.00
178_A	185_P	1.696	1.00
51_P	54_D	1.688	1.00
151_R	155_D	1.682	1.00
21_T	49_V	1.681	1.00
176_S	179_S	1.650	1.00
198_P	201_L	1.648	1.00
52_T	79_V	1.644	1.00
146_T	149_R	1.638	1.00
136_R	139_D	1.633	1.00
130_V	133_A	1.628	1.00
31_G	50_T	1.569	1.00
175_D	179_S	1.567	1.00
222_P	265_Y	1.554	1.00
270_R	274_A	1.553	1.00
187_A	230_V	1.522	1.00
112_A	129_R	1.498	1.00
191_H	195_E	1.490	1.00
49_V	55_P	1.464	1.00
55_P	79_V	1.460	1.00
70_G	96_P	1.458	1.00
78_S	81_A	1.448	1.00
68_E	116_A	1.440	1.00
65_V	83_L	1.424	1.00
77_V	105_A	1.421	1.00
236_V	262_T	1.413	1.00
59_S	83_L	1.412	1.00
269_H	273_G	1.410	1.00
246_D	250_D	1.396	1.00
140_R	144_S	1.388	1.00
139_D	142_S	1.380	1.00
162_L	170_Y	1.372	1.00
243_P	251_A	1.354	1.00
184_D	187_A	1.343	1.00
160_C	177_G	1.342	1.00
163_E	253_T	1.321	1.00
49_V	52_T	1.304	1.00
94_D	116_A	1.292	1.00
35_A	39_E	1.274	1.00
92_V	110_A	1.261	1.00
68_E	94_D	1.261	1.00
144_S	147_E	1.258	1.00
65_V	88_V	1.251	1.00
98_G	101_A	1.239	1.00
170_Y	174_N	1.231	1.00
173_V	177_G	1.230	1.00
59_S	62_A	1.229	1.00
34_T	93_V	1.218	1.00
133_A	136_R	1.214	1.00
237_E	258_V	1.206	1.00
163_E	255_L	1.202	1.00
92_V	105_A	1.200	1.00
69_T	77_V	1.194	1.00
80_V	92_V	1.192	1.00
77_V	101_A	1.192	1.00
53_T	57_S	1.186	1.00
23_V	65_V	1.184	1.00
80_V	110_A	1.183	1.00
19_N	62_A	1.181	1.00
58_V	62_A	1.175	1.00
266_E	269_H	1.172	1.00
239_V	258_V	1.156	1.00
25_G	71_L	1.153	1.00
41_V	124_R	1.141	1.00
71_L	74_V	1.134	1.00
155_D	175_D	1.129	1.00
74_V	78_S	1.128	1.00
161_V	174_N	1.115	1.00
160_C	174_N	1.110	1.00
26_S	71_L	1.108	1.00
25_G	31_G	1.107	1.00
60_D	85_D	1.102	1.00
67_A	92_V	1.098	1.00
270_R	273_G	1.097	1.00
192_R	195_E	1.096	1.00
261_V	265_Y	1.088	1.00
263_T	266_E	1.086	1.00
56_M	79_V	1.085	1.00
137_R	141_E	1.083	1.00
131_R	134_V	1.081	1.00
102_A	122_T	1.080	1.00
177_G	181_Y	1.077	1.00
52_T	55_P	1.064	1.00
81_A	104_S	1.062	1.00
74_V	79_V	1.062	1.00
220_H	238_E	1.061	1.00
206_H	210_E	1.061	1.00
178_A	184_D	1.060	1.00
137_R	140_R	1.058	1.00
222_P	238_E	1.058	1.00
162_L	177_G	1.056	1.00
143_M	147_E	1.055	1.00
235_R	260_D	1.054	1.00
267_R	270_R	1.045	1.00
67_A	71_L	1.045	1.00
270_R	275_A	1.044	1.00
129_R	132_T	1.034	1.00
266_E	270_R	1.033	1.00
22_Y	34_T	1.030	1.00
71_L	76_I	1.029	1.00
222_P	225_H	1.023	1.00
69_T	105_A	1.023	1.00
236_V	265_Y	1.019	1.00
273_G	276_T	1.015	1.00
54_D	57_S	1.010	1.00
129_R	134_V	1.009	1.00
120_G	124_R	1.008	1.00
197_L	202_V	1.007	1.00
272_A	275_A	1.003	1.00
143_M	146_T	1.003	1.00
68_E	71_L	0.997	1.00
93_V	118_P	0.985	1.00
103_G	107_D	0.982	1.00
57_S	61_D	0.980	1.00
135_E	139_D	0.978	1.00
268_R	272_A	0.974	1.00
183_L	187_A	0.969	1.00
173_V	178_A	0.965	1.00
30_A	95_D	0.963	1.00
201_L	224_Q	0.949	1.00
224_Q	236_V	0.946	1.00
81_A	108_A	0.946	1.00
118_P	122_T	0.940	1.00
103_G	106_I	0.936	1.00
46_P	58_V	0.936	1.00
147_E	150_L	0.930	1.00
56_M	82_R	0.922	1.00
220_H	240_Y	0.919	1.00
142_S	145_H	0.915	1.00
241_K	254_V	0.911	1.00
106_I	110_A	0.907	1.00
139_D	143_M	0.902	1.00
169_E	192_R	0.900	1.00
37_R	120_G	0.893	1.00
175_D	178_A	0.892	1.00
102_A	106_I	0.886	1.00
107_D	112_A	0.886	1.00
30_A	33_R	0.882	1.00
164_K	193_E	0.881	1.00
83_L	90_V	0.879	1.00
129_R	136_R	0.878	1.00
223_E	239_V	0.874	1.00
118_P	123_A	0.871	1.00
211_Q	215_D	0.866	1.00
37_R	124_R	0.864	1.00
66_V	93_V	0.863	1.00
99_S	103_G	0.861	1.00
194_D	202_V	0.859	1.00
26_S	95_D	0.857	1.00
171_L	253_T	0.856	1.00
68_E	95_D	0.856	1.00
64_C	134_V	0.848	1.00
52_T	56_M	0.847	1.00
165_T	171_L	0.846	1.00
173_V	188_V	0.845	1.00
55_P	59_S	0.843	1.00
53_T	74_V	0.837	1.00
59_S	88_V	0.836	1.00
245_D	251_A	0.834	1.00
153_V	158_P	0.829	1.00
162_L	258_V	0.828	1.00
244_F	253_T	0.826	0.99
74_V	82_R	0.826	0.99
150_L	153_V	0.825	0.99
30_A	71_L	0.822	0.99
160_C	176_S	0.822	0.99
149_R	163_E	0.817	0.99
78_S	82_R	0.809	0.99
42_A	45_V	0.808	0.99
92_V	111_T	0.806	0.99
219_L	241_K	0.806	0.99
43_G	47_I	0.806	0.99
17_A	44_D	0.806	0.99
203_E	207_R	0.802	0.99
246_D	253_T	0.799	0.99
58_V	61_D	0.793	0.99
49_V	54_D	0.787	0.99
67_A	80_V	0.782	0.99
153_V	163_E	0.780	0.99
76_I	94_D	0.779	0.99
57_S	60_D	0.770	0.99
80_V	108_A	0.770	0.99
22_Y	31_G	0.767	0.99
156_S	255_L	0.766	0.99
146_T	150_L	0.765	0.99
242_L	255_L	0.760	0.99
198_P	224_Q	0.760	0.99
170_Y	192_R	0.758	0.99
163_E	174_N	0.756	0.99
54_D	58_V	0.751	0.99
111_T	133_A	0.745	0.99
69_T	75_D	0.744	0.99
210_E	214_A	0.744	0.99
146_T	151_R	0.740	0.99
59_S	79_V	0.740	0.99
25_G	116_A	0.737	0.99
36_A	40_R	0.737	0.99
51_P	71_L	0.734	0.99
69_T	80_V	0.733	0.99
52_T	71_L	0.732	0.99
269_H	272_A	0.732	0.99
243_P	254_V	0.731	0.99
96_P	101_A	0.730	0.99
178_A	188_V	0.728	0.99
207_R	211_Q	0.725	0.99
105_A	110_A	0.719	0.99
29_G	32_E	0.717	0.99
173_V	185_P	0.714	0.99
163_E	172_L	0.713	0.99
94_D	102_A	0.712	0.98
28_G	32_E	0.707	0.98
31_G	92_V	0.704	0.98
23_V	52_T	0.700	0.98
177_G	256_T	0.700	0.98
82_R	85_D	0.698	0.98
265_Y	269_H	0.694	0.98
267_R	271_L	0.694	0.98
164_K	209_D	0.689	0.98
182_G	231_I	0.689	0.98
142_S	146_T	0.687	0.98
130_V	137_R	0.686	0.98
106_I	112_A	0.686	0.98
89_P	99_S	0.685	0.98
80_V	102_A	0.678	0.98
93_V	117_R	0.675	0.98
159_Q	176_S	0.673	0.98
71_L	116_A	0.670	0.98
20_V	64_C	0.669	0.98
23_V	49_V	0.666	0.98
65_V	89_P	0.666	0.98
141_E	144_S	0.662	0.98
75_D	104_S	0.662	0.98
212_V	254_V	0.660	0.98
69_T	101_A	0.656	0.97
80_V	101_A	0.656	0.97
235_R	262_T	0.654	0.97
76_I	92_V	0.650	0.97
153_V	157_L	0.649	0.97
104_S	108_A	0.648	0.97
52_T	72_H	0.647	0.97
37_R	41_V	0.643	0.97
240_Y	257_V	0.641	0.97
154_I	161_V	0.640	0.97
125_V	132_T	0.639	0.97
33_R	37_R	0.638	0.97
270_R	276_T	0.638	0.97
69_T	76_I	0.636	0.97
26_S	116_A	0.634	0.97
52_T	75_D	0.634	0.97
69_T	95_D	0.630	0.97
153_V	156_S	0.628	0.97
85_D	88_V	0.627	0.97
72_H	76_I	0.626	0.97
56_M	74_V	0.626	0.97
174_N	260_D	0.621	0.96
125_V	129_R	0.620	0.96
21_T	62_A	0.620	0.96
272_A	276_T	0.619	0.96
77_V	104_S	0.617	0.96
227_D	231_I	0.616	0.96
23_V	79_V	0.616	0.96
198_P	234_D	0.615	0.96
154_I	174_N	0.614	0.96
223_E	265_Y	0.608	0.96
71_L	95_D	0.607	0.96
201_L	204_R	0.607	0.96
26_S	76_I	0.606	0.96
132_T	136_R	0.606	0.96
177_G	258_V	0.605	0.96
71_L	79_V	0.605	0.96
174_N	177_G	0.604	0.96
109_G	112_A	0.603	0.96
92_V	108_A	0.595	0.96
22_Y	45_V	0.593	0.95
69_T	116_A	0.589	0.95
201_L	205_F	0.588	0.95
66_V	123_A	0.585	0.95
164_K	256_T	0.584	0.95
200_D	224_Q	0.581	0.95
105_A	132_T	0.581	0.95
134_V	138_R	0.577	0.95
153_V	255_L	0.576	0.95
177_G	188_V	0.571	0.94
63_G	89_P	0.570	0.94
69_T	117_R	0.570	0.94
161_V	255_L	0.568	0.94
104_S	107_D	0.566	0.94
150_L	172_L	0.565	0.94
71_L	113_H	0.564	0.94
101_A	104_S	0.564	0.94
221_I	224_Q	0.563	0.94
30_A	116_A	0.562	0.94
158_P	174_N	0.561	0.94
165_T	168_G	0.560	0.94
157_L	160_C	0.559	0.94
69_T	90_V	0.559	0.94
261_V	268_R	0.557	0.94
94_D	110_A	0.555	0.94
166_L	251_A	0.551	0.93
183_L	188_V	0.550	0.93
133_A	137_R	0.550	0.93
32_E	35_A	0.545	0.93
154_I	163_E	0.542	0.93
71_L	94_D	0.538	0.92
56_M	59_S	0.537	0.92
87_D	137_R	0.536	0.92
130_V	136_R	0.536	0.92
175_D	185_P	0.534	0.92
21_T	55_P	0.533	0.92
178_A	181_Y	0.533	0.92
209_D	241_K	0.533	0.92
227_D	234_D	0.530	0.92
191_H	196_F	0.529	0.92
135_E	138_R	0.529	0.92
92_V	106_I	0.528	0.92
26_S	94_D	0.528	0.92
138_R	142_S	0.526	0.92
172_L	185_P	0.524	0.91
80_V	111_T	0.523	0.91
30_A	69_T	0.523	0.91
34_T	117_R	0.522	0.91
156_S	257_V	0.521	0.91
164_K	170_Y	0.521	0.91
170_Y	256_T	0.520	0.91
181_Y	237_E	0.519	0.91
161_V	257_V	0.518	0.91
219_L	223_E	0.518	0.91
141_E	145_H	0.518	0.91
170_Y	173_V	0.515	0.91
203_E	206_H	0.514	0.91
33_R	36_A	0.514	0.91
121_D	125_V	0.511	0.90
224_Q	234_D	0.511	0.90
112_A	125_V	0.510	0.90
173_V	189_E	0.509	0.90
55_P	76_I	0.508	0.90
246_D	252_D	0.508	0.90
156_S	242_L	0.507	0.90
180_N	235_R	0.507	0.90
168_G	174_N	0.503	0.90
212_V	243_P	0.502	0.90
80_V	106_I	0.501	0.90
134_V	137_R	0.501	0.90
95_D	117_R	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4gczA	2	0.5615	99.9	0.634	Contact Map
1w25A	2	0.8801	99.9	0.645	Contact Map
4i5sA	2	0.6719	99.9	0.659	Contact Map
3n0rA	1	0.4227	99.9	0.66	Contact Map
4g97A	1	0.4479	99.9	0.665	Contact Map
3breA	4	0.7729	99.9	0.667	Contact Map
4r3aA	1	0.4763	99.9	0.67	Contact Map
3a0rA	2	0.4921	99.9	0.671	Contact Map
2ayxA	1	0.4353	99.9	0.672	Contact Map
4b09A	2	0.6341	99.9	0.673	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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