GREMLIN Database
Q9HP89 - Photolyase/cryptochrome
UniProt: Q9HP89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 462 (401)
Sequences: 5436 (4193)
Seq/√Len: 209.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
298_S301_H4.3731.00
228_Y233_N3.8641.00
314_L335_V3.5851.00
303_E307_R3.4901.00
323_R354_H3.3881.00
302_F350_R3.3021.00
302_F306_T3.2901.00
285_N291_A3.1851.00
320_R409_E2.9581.00
193_L239_V2.9101.00
57_R61_R2.8531.00
91_F121_H2.7231.00
318_G332_P2.6861.00
393_M403_V2.6551.00
52_G233_N2.5701.00
89_T119_A2.4901.00
92_H118_T2.4161.00
13_P238_E2.3991.00
92_H120_G2.3871.00
57_R66_D2.3501.00
323_R358_R2.3221.00
260_K263_Y2.3141.00
312_Y339_F2.2851.00
72_G77_V2.2791.00
55_A187_A2.2611.00
6_H29_P2.2361.00
77_V80_A2.2361.00
186_H190_T2.2041.00
186_H238_E2.1791.00
296_Q301_H2.1731.00
271_N370_N2.1441.00
332_P402_F2.1091.00
15_N93_A2.0801.00
321_Q325_E2.0711.00
90_V111_L2.0651.00
4_Y17_G2.0531.00
190_T238_E2.0191.00
194_A242_A1.9981.00
391_S395_K1.9581.00
324_A406_Y1.9471.00
73_D76_S1.9451.00
311_G316_D1.9421.00
49_L231_A1.9151.00
188_A191_D1.9061.00
325_E406_Y1.8981.00
354_H358_R1.8881.00
303_E306_T1.8751.00
52_G185_G1.8751.00
352_E368_A1.8691.00
4_Y15_N1.8611.00
242_A245_D1.8091.00
213_A221_A1.7981.00
89_T117_D1.7951.00
223_S261_Y1.7881.00
80_A84_E1.7521.00
143_Y263_Y1.7501.00
193_L242_A1.7351.00
79_P114_A1.7211.00
48_F231_A1.6891.00
70_R77_V1.6771.00
271_N369_A1.6681.00
253_N258_I1.6621.00
6_H60_Y1.6591.00
151_K154_P1.6461.00
320_R407_V1.6461.00
390_V393_M1.6431.00
240_W262_R1.6401.00
82_A87_A1.6341.00
30_V81_L1.6051.00
59_A186_H1.5991.00
203_S207_T1.5971.00
48_F228_Y1.5941.00
337_A374_T1.5911.00
388_D392_Q1.5881.00
143_Y266_S1.5811.00
29_P65_S1.5801.00
340_L346_V1.5741.00
306_T357_D1.5691.00
70_R84_E1.5601.00
211_L332_P1.5581.00
321_Q402_F1.5561.00
75_E106_R1.5361.00
75_E79_P1.5321.00
55_A59_A1.5141.00
229_L239_V1.5121.00
238_E242_A1.5021.00
163_L166_V1.5011.00
243_V258_I1.4841.00
313_P317_A1.4801.00
356_A362_Y1.4741.00
51_A184_A1.4691.00
189_A234_I1.4691.00
297_N350_R1.4631.00
304_A309_E1.4611.00
108_A120_G1.4601.00
97_D100_R1.4591.00
197_L201_I1.4491.00
312_Y343_H1.4461.00
225_L261_Y1.4351.00
142_F273_H1.4271.00
139_H263_Y1.4261.00
207_T213_A1.4151.00
61_R66_D1.4071.00
59_A187_A1.4051.00
47_A51_A1.4001.00
20_A23_D1.3991.00
243_V261_Y1.3951.00
205_N260_K1.3911.00
284_E291_A1.3841.00
274_L379_T1.3761.00
185_G188_A1.3741.00
281_L368_A1.3661.00
81_L85_F1.3581.00
13_P190_T1.3551.00
138_S381_T1.3541.00
340_L351_G1.3441.00
8_R95_H1.3441.00
131_T149_A1.3281.00
34_D37_V1.3201.00
143_Y147_Q1.3191.00
154_P158_P1.3171.00
3_L87_A1.3161.00
19_H23_D1.3061.00
127_V146_W1.3001.00
16_R123_D1.2891.00
30_V70_R1.2881.00
30_V78_L1.2861.00
98_A102_N1.2861.00
146_W266_S1.2851.00
207_T221_A1.2841.00
243_V262_R1.2821.00
101_R105_T1.2791.00
195_A199_D1.2781.00
172_L175_P1.2691.00
6_H56_L1.2691.00
400_A404_T1.2631.00
242_A246_A1.2601.00
260_K264_E1.2581.00
95_H100_R1.2571.00
350_R353_R1.2541.00
60_Y65_S1.2431.00
100_R103_R1.2341.00
124_H272_Y1.2231.00
264_E366_N1.2181.00
299_D350_R1.2131.00
245_D249_D1.2121.00
166_V169_D1.2091.00
32_V78_L1.1971.00
322_L359_L1.1951.00
314_L393_M1.1941.00
76_S80_A1.1891.00
302_F346_V1.1851.00
7_Q104_R1.1841.00
31_Y49_L1.1741.00
122_V128_D1.1721.00
82_A116_V1.1711.00
164_A167_H1.1681.00
225_L239_V1.1651.00
351_G371_W1.1571.00
83_D114_A1.1541.00
306_T354_H1.1531.00
237_R241_A1.1531.00
364_P368_A1.1521.00
48_F227_P1.1411.00
170_H176_A1.1391.00
280_R284_E1.1381.00
401_A404_T1.1381.00
101_R276_Y1.1361.00
318_G402_F1.1311.00
203_S206_D1.1311.00
35_D71_E1.1301.00
203_S257_N1.1281.00
59_A63_R1.1281.00
208_R264_E1.1161.00
151_K158_P1.1101.00
102_N106_R1.1091.00
97_D364_P1.1081.00
210_D213_A1.1051.00
174_V177_P1.1051.00
28_V68_L1.1011.00
31_Y53_V1.1001.00
33_F38_L1.0981.00
13_P186_H1.0981.00
197_L243_V1.0941.00
185_G233_N1.0941.00
169_D173_S1.0841.00
244_A262_R1.0771.00
321_Q327_Y1.0751.00
173_S176_A1.0681.00
184_A188_A1.0561.00
174_V178_E1.0541.00
5_W107_V1.0521.00
134_D137_P1.0451.00
224_R327_Y1.0451.00
68_L81_L1.0451.00
391_S394_A1.0431.00
266_S269_E1.0361.00
90_V118_T1.0341.00
315_V335_V1.0291.00
58_A62_E1.0281.00
82_A111_L1.0201.00
79_P83_D1.0181.00
315_V319_M1.0181.00
20_A121_H1.0171.00
300_D304_A1.0161.00
105_T108_A1.0151.00
94_A122_V1.0081.00
185_G189_A1.0061.00
171_T175_P1.0031.00
107_V111_L1.0031.00
150_P153_D0.9991.00
302_F340_L0.9961.00
82_A90_V0.9921.00
171_T174_V0.9911.00
183_D188_A0.9841.00
50_A54_R0.9801.00
370_N374_T0.9791.00
105_T109_D0.9771.00
170_H174_V0.9751.00
220_S224_R0.9741.00
194_A198_D0.9701.00
202_A246_A0.9671.00
44_P358_R0.9631.00
147_Q259_G0.9591.00
12_V63_R0.9531.00
74_A79_P0.9510.99
170_H173_S0.9460.99
393_M400_A0.9450.99
3_L82_A0.9420.99
32_V77_V0.9410.99
222_V327_Y0.9390.99
163_L167_H0.9350.99
151_K155_V0.9340.99
41_V45_K0.9330.99
95_H103_R0.9320.99
169_D174_V0.9270.99
152_P155_V0.9250.99
320_R324_A0.9230.99
158_P161_D0.9200.99
28_V85_F0.9180.99
135_A278_T0.9130.99
136_Y141_Q0.9120.99
125_T272_Y0.9110.99
195_A200_G0.9110.99
165_D168_D0.9100.99
54_R58_A0.9090.99
240_W266_S0.9080.99
82_A85_F0.9060.99
44_P182_P0.9020.99
55_A184_A0.9010.99
205_N257_N0.8960.99
92_H108_A0.8950.99
79_P82_A0.8900.99
305_W319_M0.8870.99
93_A123_D0.8870.99
212_A405_E0.8850.99
32_V72_G0.8840.99
145_D148_Q0.8800.99
48_F233_N0.8790.99
79_P110_A0.8750.99
264_E334_Q0.8720.99
125_T129_P0.8660.99
381_T384_V0.8660.99
48_F52_G0.8640.99
72_G76_S0.8640.99
22_T27_V0.8630.99
109_D113_A0.8620.99
197_L246_A0.8610.99
150_P158_P0.8580.99
99_A103_R0.8550.99
272_Y366_N0.8540.99
239_V261_Y0.8520.99
59_A62_E0.8500.99
70_R80_A0.8490.99
126_L129_P0.8490.99
139_H142_F0.8470.99
403_V407_V0.8460.99
188_A192_R0.8440.99
275_L365_A0.8410.99
311_G401_A0.8400.99
169_D172_L0.8380.99
94_A120_G0.8310.99
280_R283_T0.8310.99
388_D391_S0.8310.99
32_V74_A0.8240.99
346_V350_R0.8240.99
28_V87_A0.8240.99
126_L130_A0.8190.98
126_L146_W0.8180.98
33_F69_V0.8160.98
172_L176_A0.8130.98
12_V60_Y0.8090.98
139_H143_Y0.8090.98
337_A355_F0.8080.98
191_D195_A0.8070.98
206_D257_N0.8070.98
48_F185_G0.8060.98
127_V132_L0.8040.98
347_D350_R0.8030.98
281_L286_Y0.8030.98
227_P360_V0.7990.98
91_F119_A0.7980.98
300_D350_R0.7960.98
274_L281_L0.7930.98
282_Q364_P0.7900.98
60_Y67_L0.7890.98
211_L314_L0.7890.98
316_D320_R0.7880.98
41_V46_R0.7850.98
152_P237_R0.7840.98
326_G360_V0.7830.98
225_L234_I0.7820.98
312_Y390_V0.7810.98
182_P360_V0.7770.98
308_G319_M0.7720.98
150_P154_P0.7710.98
171_T176_A0.7700.98
173_S177_P0.7700.98
36_T73_D0.7690.98
390_V394_A0.7670.98
167_H173_S0.7630.98
297_N301_H0.7610.98
139_H146_W0.7600.98
162_A165_D0.7590.98
16_R20_A0.7590.98
14_D237_R0.7580.98
278_T286_Y0.7570.97
78_L82_A0.7570.97
313_P316_D0.7570.97
55_A233_N0.7570.97
331_R392_Q0.7560.97
111_L116_V0.7560.97
96_Y128_D0.7530.97
152_P156_P0.7520.97
99_A102_N0.7520.97
306_T350_R0.7510.97
127_V266_S0.7490.97
168_D174_V0.7490.97
209_D264_E0.7480.97
366_N370_N0.7460.97
167_H172_L0.7430.97
5_W74_A0.7400.97
322_L328_V0.7400.97
94_A128_D0.7390.97
167_H175_P0.7370.97
154_P160_A0.7350.97
48_F184_A0.7350.97
288_S291_A0.7350.97
213_A220_S0.7350.97
152_P158_P0.7340.97
211_L396_Y0.7330.97
140_S144_D0.7320.97
163_L169_D0.7310.97
186_H189_A0.7300.97
373_W385_R0.7300.97
96_Y125_T0.7290.97
154_P157_A0.7290.97
142_F269_E0.7290.97
78_L81_L0.7280.97
40_Q357_D0.7270.97
6_H12_V0.7270.97
170_H175_P0.7260.97
321_Q406_Y0.7240.97
4_Y29_P0.7220.97
309_E407_V0.7220.97
393_M410_L0.7210.97
297_N346_V0.7190.97
138_S141_Q0.7180.97
175_P178_E0.7180.97
20_A91_F0.7170.97
247_Y258_I0.7170.97
263_Y267_W0.7140.96
182_P224_R0.7130.96
68_L85_F0.7130.96
182_P227_P0.7100.96
33_F53_V0.7050.96
112_A115_G0.7040.96
126_L240_W0.7030.96
234_I239_V0.7010.96
68_L84_E0.7000.96
108_A112_A0.7000.96
130_A277_H0.7000.96
197_L242_A0.6960.96
355_F367_N0.6950.96
190_T194_A0.6940.96
271_N379_T0.6930.96
169_D175_P0.6930.96
33_F71_E0.6870.96
3_L30_V0.6860.96
259_G263_Y0.6860.96
193_L197_L0.6860.96
198_D246_A0.6850.95
273_H277_H0.6850.95
385_R392_Q0.6840.95
172_L177_P0.6830.95
201_I243_V0.6830.95
4_Y91_F0.6800.95
95_H98_A0.6800.95
307_R323_R0.6780.95
3_L81_L0.6770.95
184_A189_A0.6770.95
156_P159_D0.6770.95
301_H346_V0.6750.95
147_Q263_Y0.6740.95
193_L234_I0.6730.95
19_H155_V0.6710.95
51_A55_A0.6700.95
247_Y255_A0.6690.95
104_R107_V0.6680.95
70_R81_L0.6680.95
55_A58_A0.6670.95
352_E371_W0.6670.95
247_Y259_G0.6660.95
227_P327_Y0.6650.95
263_Y266_S0.6650.95
82_A110_A0.6640.95
168_D172_L0.6600.94
152_P157_A0.6600.94
281_L369_A0.6600.94
240_W265_L0.6550.94
102_N105_T0.6550.94
402_F406_Y0.6540.94
313_P403_V0.6540.94
380_D385_R0.6530.94
305_W346_V0.6510.94
22_T161_D0.6510.94
169_D177_P0.6480.94
20_A119_A0.6450.94
320_R323_R0.6440.94
349_R352_E0.6440.94
272_Y363_D0.6420.94
142_F146_W0.6420.94
163_L168_D0.6410.94
377_T382_V0.6410.94
169_D176_A0.6400.94
29_P60_Y0.6370.93
151_K156_P0.6370.93
17_G93_A0.6360.93
328_V359_L0.6360.93
108_A118_T0.6340.93
305_W341_T0.6290.93
153_D156_P0.6280.93
321_Q324_A0.6270.93
167_H171_T0.6220.93
285_N377_T0.6210.93
222_V329_H0.6200.92
296_Q345_L0.6190.92
153_D157_A0.6180.92
342_K380_D0.6170.92
137_P145_D0.6170.92
267_W369_A0.6170.92
166_V172_L0.6160.92
168_D171_T0.6150.92
55_A185_G0.6150.92
314_L332_P0.6150.92
45_K230_A0.6150.92
192_R224_R0.6140.92
168_D173_S0.6120.92
5_W78_L0.6120.92
137_P278_T0.6060.92
73_D106_R0.6050.92
319_M336_V0.6040.91
147_Q266_S0.6030.91
19_H22_T0.6030.91
373_W378_G0.6020.91
337_A367_N0.6010.91
270_Q379_T0.6010.91
35_D38_L0.6000.91
201_I258_I0.5980.91
165_D169_D0.5970.91
151_K157_A0.5970.91
387_F392_Q0.5970.91
130_A276_Y0.5970.91
309_E409_E0.5970.91
61_R65_S0.5960.91
143_Y146_W0.5950.91
110_A113_A0.5950.91
342_K385_R0.5950.91
331_R385_R0.5920.91
299_D303_E0.5910.91
164_A169_D0.5880.90
201_I257_N0.5870.90
235_G238_E0.5860.90
80_A83_D0.5860.90
318_G328_V0.5850.90
338_S374_T0.5830.90
342_K384_V0.5830.90
290_D293_I0.5820.90
397_D400_A0.5800.90
76_S79_P0.5790.90
107_V110_A0.5770.90
5_W92_H0.5770.90
372_Q385_R0.5770.90
58_A187_A0.5760.89
162_A170_H0.5750.89
31_Y37_V0.5750.89
125_T132_L0.5740.89
38_L46_R0.5730.89
34_D74_A0.5730.89
153_D158_P0.5730.89
44_P47_A0.5710.89
34_D38_L0.5710.89
98_A101_R0.5710.89
285_N288_S0.5690.89
373_W380_D0.5680.89
52_G184_A0.5680.89
124_H127_V0.5660.89
196_F223_S0.5640.88
3_L78_L0.5610.88
47_A184_A0.5610.88
172_L178_E0.5600.88
166_V170_H0.5590.88
95_H230_A0.5580.88
94_A129_P0.5580.88
33_F50_A0.5560.88
271_N274_L0.5540.88
57_R67_L0.5530.87
262_R266_S0.5530.87
308_G407_V0.5530.87
135_A138_S0.5520.87
207_T210_D0.5520.87
205_N256_R0.5520.87
368_A379_T0.5510.87
212_A321_Q0.5510.87
206_D209_D0.5490.87
145_D149_A0.5480.87
166_V174_V0.5480.87
390_V400_A0.5470.87
163_L175_P0.5470.87
95_H99_A0.5460.87
192_R195_A0.5460.87
190_T242_A0.5460.87
183_D228_Y0.5450.87
122_V131_T0.5440.87
256_R259_G0.5440.87
297_N302_F0.5430.87
385_R388_D0.5420.86
96_Y99_A0.5420.86
210_D221_A0.5410.86
352_E356_A0.5400.86
254_A257_N0.5400.86
356_A364_P0.5390.86
181_L224_R0.5360.86
243_V246_A0.5360.86
223_S226_S0.5350.86
264_E267_W0.5340.86
285_N292_P0.5340.86
330_N334_Q0.5330.86
94_A130_A0.5330.86
239_V242_A0.5330.86
367_N371_W0.5330.86
182_P362_Y0.5320.85
165_D171_T0.5320.85
400_A410_L0.5320.85
272_Y365_A0.5320.85
21_A91_F0.5310.85
6_H10_L0.5300.85
317_A321_Q0.5300.85
163_L172_L0.5300.85
128_D131_T0.5290.85
328_V355_F0.5280.85
334_Q396_Y0.5280.85
334_Q387_F0.5280.85
25_D88_D0.5270.85
370_N381_T0.5260.85
35_D39_S0.5250.85
328_V336_V0.5240.85
339_F342_K0.5230.84
197_L200_G0.5210.84
372_Q377_T0.5210.84
151_K161_D0.5180.84
318_G336_V0.5170.84
205_N209_D0.5170.84
90_V107_V0.5170.84
29_P32_V0.5160.84
275_L278_T0.5150.84
351_G372_Q0.5140.83
152_P161_D0.5140.83
225_L229_L0.5140.83
153_D160_A0.5130.83
54_R57_R0.5120.83
78_L107_V0.5120.83
4_Y21_A0.5120.83
22_T25_D0.5110.83
120_G128_D0.5110.83
258_I262_R0.5110.83
167_H174_V0.5100.83
105_T120_G0.5090.83
208_R334_Q0.5080.83
21_A27_V0.5080.83
125_T130_A0.5080.83
135_A146_W0.5070.83
260_K366_N0.5040.82
340_L344_L0.5040.82
58_A61_R0.5030.82
203_S221_A0.5020.82
53_V57_R0.5010.82
87_A116_V0.5010.82
192_R200_G0.5010.82
238_E241_A0.5000.82
296_Q299_D0.5000.82
8_R124_H0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1owlA 1 0.9719 100 0.069 Contact Map
3fy4A 1 0.9913 100 0.069 Contact Map
1np7A 1 0.9654 100 0.07 Contact Map
4u63A 1 0.974 100 0.072 Contact Map
1u3dA 1 0.987 100 0.073 Contact Map
4gu5A 1 0.9913 100 0.085 Contact Map
1dnpA 1 0.9654 100 0.086 Contact Map
4k0rA 1 0.9437 100 0.089 Contact Map
4mlpC 1 0.9892 100 0.093 Contact Map
2wq7A 1 0.9892 100 0.094 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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