GREMLIN Database
Q9HP88 - Phytoene dehydrogenase
UniProt: Q9HP88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 536 (459)
Sequences: 14106 (11141)
Seq/√Len: 520.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_D51_S4.5741.00
30_T292_T4.3961.00
258_A263_A4.0391.00
28_D293_D3.9591.00
53_T266_E3.8631.00
57_Q270_G3.8001.00
61_V267_T3.6571.00
41_A296_V3.6301.00
273_A284_A3.5381.00
104_E244_E3.3621.00
30_T55_L3.2621.00
500_G504_T3.0911.00
297_N304_A3.0781.00
61_V255_A2.9871.00
34_G61_V2.9441.00
59_D268_G2.8821.00
275_S284_A2.8061.00
51_S264_T2.7251.00
410_I413_Q2.6781.00
248_A252_D2.6021.00
269_V285_T2.5691.00
30_T283_L2.5641.00
55_L266_E2.5531.00
249_G252_D2.5411.00
32_V297_N2.5311.00
255_A259_V2.4431.00
191_G199_R2.4401.00
272_N286_D2.3991.00
423_A431_R2.3821.00
298_N483_V2.3441.00
29_V50_A2.3181.00
255_A265_I2.3141.00
266_E269_V2.2981.00
481_Y510_D2.2921.00
270_G286_D2.2511.00
44_Y501_E2.2451.00
28_D53_T2.2371.00
55_L292_T2.2211.00
69_E74_R2.2181.00
284_A290_R2.1791.00
294_L481_Y2.1591.00
32_V299_A2.1451.00
132_H147_A2.1141.00
48_A508_I2.1101.00
36_F493_M2.1051.00
253_A256_E2.0871.00
194_D198_S2.0831.00
134_L137_S2.0711.00
282_T291_T2.0561.00
106_T244_E2.0281.00
37_G298_N2.0171.00
40_A497_L2.0161.00
296_V507_V1.9951.00
27_R53_T1.9911.00
391_H435_V1.9561.00
60_T66_G1.9521.00
277_R282_T1.9341.00
416_D420_G1.9251.00
44_Y47_R1.8981.00
67_V74_R1.8771.00
50_A508_I1.8761.00
29_V294_L1.8651.00
272_N284_A1.8621.00
192_N195_D1.8571.00
423_A429_D1.8431.00
44_Y505_K1.8121.00
43_A257_L1.7981.00
198_S207_R1.7881.00
275_S282_T1.7861.00
269_V287_D1.7641.00
285_T288_G1.7611.00
338_E433_R1.7571.00
339_G433_R1.7481.00
412_A416_D1.7401.00
47_R94_H1.7351.00
55_L271_V1.7301.00
266_E289_T1.7261.00
483_V503_V1.7071.00
281_F295_V1.6951.00
42_A54_L1.6801.00
53_T264_T1.6601.00
93_D98_D1.6541.00
299_A304_A1.6341.00
338_E435_V1.6271.00
415_R437_E1.5911.00
349_L352_P1.5801.00
338_E391_H1.5641.00
61_V265_I1.5571.00
61_V251_V1.5471.00
281_F479_G1.5461.00
28_D50_A1.5381.00
194_D222_H1.5161.00
252_D256_E1.5141.00
90_R501_E1.5101.00
258_A265_I1.5091.00
274_I281_F1.5051.00
65_A251_V1.5041.00
53_T292_T1.4681.00
73_F336_G1.4671.00
38_G298_N1.4511.00
54_L265_I1.4501.00
29_V45_L1.4491.00
89_E93_D1.4451.00
34_G54_L1.4441.00
257_L261_Q1.4441.00
247_I493_M1.4321.00
397_L400_I1.4281.00
30_T53_T1.4241.00
259_V264_T1.4201.00
31_V42_A1.4161.00
43_A47_R1.4121.00
337_V419_L1.3991.00
120_D205_K1.3981.00
37_G499_S1.3911.00
294_L507_V1.3861.00
271_V283_L1.3841.00
292_T295_V1.3831.00
127_N130_N1.3661.00
481_Y503_V1.3611.00
148_T152_R1.3551.00
429_D432_D1.3491.00
46_A263_A1.3491.00
26_E51_S1.3371.00
191_G195_D1.3361.00
256_E259_V1.3201.00
125_E130_N1.3191.00
420_G431_R1.3101.00
55_L285_T1.3091.00
44_Y94_H1.3001.00
273_A310_D1.2921.00
145_A148_T1.2911.00
276_G281_F1.2911.00
46_A261_Q1.2911.00
243_P250_V1.2891.00
144_D148_T1.2861.00
183_L186_R1.2861.00
27_R293_D1.2821.00
55_L269_V1.2791.00
406_D409_E1.2751.00
31_V52_V1.2681.00
503_V506_A1.2671.00
416_D431_R1.2641.00
113_R123_T1.2551.00
275_S290_R1.2551.00
46_A52_V1.2481.00
90_R94_H1.2431.00
409_E413_Q1.2401.00
154_A158_D1.2331.00
252_D255_A1.2311.00
301_P486_Y1.2301.00
259_V262_G1.2301.00
69_E248_A1.2291.00
300_N303_Y1.2151.00
413_Q416_D1.2121.00
43_A254_L1.2091.00
36_F65_A1.2051.00
64_R485_A1.2021.00
502_H506_A1.2021.00
87_V501_E1.2001.00
315_D477_P1.1961.00
26_E293_D1.1941.00
45_L504_T1.1881.00
151_D154_A1.1851.00
255_A267_T1.1711.00
257_L260_E1.1691.00
27_R51_S1.1681.00
69_E72_G1.1681.00
274_I295_V1.1671.00
139_E142_A1.1671.00
280_E291_T1.1661.00
481_Y506_A1.1631.00
415_R419_L1.1601.00
335_L419_L1.1571.00
26_E291_T1.1461.00
429_D433_R1.1421.00
487_T499_S1.1341.00
43_A258_A1.1311.00
73_F388_P1.1271.00
421_T424_A1.1231.00
41_A500_G1.1221.00
427_G430_L1.1211.00
220_A223_N1.1201.00
37_G483_V1.1131.00
474_R510_D1.1131.00
44_Y500_G1.1121.00
501_E505_K1.1111.00
299_A308_L1.1081.00
285_T289_T1.1071.00
249_G253_A1.1021.00
256_E260_E1.0961.00
419_L423_A1.0961.00
481_Y507_V1.0931.00
148_T151_D1.0881.00
434_I437_E1.0851.00
168_D171_A1.0811.00
318_P322_D1.0711.00
43_A94_H1.0701.00
130_N133_E1.0651.00
417_R420_G1.0641.00
230_I236_L1.0631.00
68_L77_T1.0591.00
46_A258_A1.0591.00
428_V431_R1.0591.00
398_L418_L1.0591.00
487_T502_H1.0581.00
282_T290_R1.0581.00
97_H260_E1.0461.00
372_P378_V1.0451.00
221_P224_T1.0451.00
277_R291_T1.0421.00
413_Q417_R1.0411.00
53_T293_D1.0291.00
310_D313_G1.0221.00
232_S236_L1.0201.00
277_R280_E1.0161.00
503_V507_V1.0141.00
420_G424_A1.0141.00
151_D155_T1.0131.00
37_G496_C1.0111.00
303_Y306_R1.0111.00
297_N480_H1.0111.00
157_Y160_A1.0091.00
44_Y48_A0.9891.00
273_A311_T0.9861.00
204_P208_Q0.9861.00
58_H448_Q0.9791.00
276_G479_G0.9781.00
294_L479_G0.9771.00
34_G267_T0.9761.00
154_A157_Y0.9701.00
272_N275_S0.9691.00
415_R418_L0.9671.00
58_H66_G0.9651.00
144_D147_A0.9631.00
222_H225_P0.9631.00
472_G475_D0.9621.00
371_D424_A0.9611.00
90_R93_D0.9581.00
274_I297_N0.9571.00
229_S237_N0.9571.00
152_R155_T0.9511.00
245_G249_G0.9511.00
484_G499_S0.9481.00
310_D314_R0.9461.00
243_P249_G0.9441.00
47_R261_Q0.9361.00
95_F254_L0.9331.00
40_A500_G0.9301.00
28_D291_T0.9281.00
58_H452_P0.9221.00
73_F391_H0.9221.00
70_R438_E0.9221.00
54_L258_A0.9211.00
274_I283_L0.9191.00
36_F496_C0.9191.00
92_F97_H0.9181.00
27_R30_T0.9141.00
88_F497_L0.9141.00
319_D322_D0.9121.00
272_N285_T0.9101.00
275_S311_T0.9101.00
233_H236_L0.9101.00
172_F175_Y0.9081.00
67_V248_A0.9051.00
348_S352_P0.9031.00
155_T158_D0.9031.00
50_A53_T0.8991.00
87_V90_R0.8961.00
196_Y200_F0.8961.00
505_K509_D0.8921.00
32_V271_V0.8921.00
396_I400_I0.8911.00
42_A258_A0.8901.00
198_S203_H0.8901.00
474_R506_A0.8861.00
319_D323_D0.8831.00
269_V289_T0.8821.00
420_G423_A0.8811.00
423_A432_D0.8781.00
146_L149_Y0.8751.00
335_L396_I0.8741.00
504_T507_V0.8741.00
374_F377_S0.8721.00
31_V296_V0.8691.00
50_A293_D0.8681.00
395_V400_I0.8661.00
91_F95_F0.8661.00
49_G52_V0.8651.00
496_C500_G0.8631.00
43_A95_F0.8621.00
422_L430_L0.8601.00
411_R442_V0.8551.00
251_V255_A0.8541.00
219_G225_P0.8541.00
461_H464_F0.8521.00
51_S293_D0.8511.00
375_Y379_A0.8481.00
149_Y152_R0.8471.00
57_Q451_D0.8471.00
55_L283_L0.8461.00
395_V399_P0.8451.00
147_A151_D0.8451.00
56_E267_T0.8411.00
333_F439_S0.8401.00
232_S235_D0.8381.00
270_G451_D0.8351.00
462_T465_Q0.8351.00
233_H237_N0.8331.00
220_A225_P0.8301.00
373_A376_L0.8281.00
229_S232_S0.8251.00
136_E141_G0.8241.00
218_G226_A0.8211.00
483_V500_G0.8171.00
219_G223_N0.8161.00
133_E137_S0.8161.00
171_A174_D0.8151.00
54_L61_V0.8151.00
295_V479_G0.8141.00
443_S446_S0.8141.00
197_V211_E0.8111.00
415_R439_S0.8091.00
105_L108_L0.8071.00
229_S236_L0.8021.00
36_F251_V0.8011.00
104_E107_R0.8001.00
64_R78_G0.8001.00
301_P321_W0.8001.00
395_V398_L0.7981.00
103_Y106_T0.7951.00
412_A415_R0.7951.00
230_I234_V0.7921.00
221_P225_P0.7891.00
48_A505_K0.7871.00
155_T159_L0.7861.00
228_Y236_L0.7851.00
172_F176_A0.7841.00
65_A79_P0.7841.00
375_Y378_V0.7841.00
173_R176_A0.7831.00
31_V38_G0.7831.00
40_A91_F0.7801.00
27_R50_A0.7741.00
167_P170_T0.7721.00
125_E134_L0.7711.00
143_G147_A0.7711.00
152_R156_N0.7711.00
133_E136_E0.7701.00
477_P480_H0.7691.00
184_A187_L0.7681.00
40_A44_Y0.7651.00
39_L54_L0.7651.00
147_A150_L0.7641.00
283_L295_V0.7631.00
309_L313_G0.7631.00
87_V498_I0.7621.00
43_A261_Q0.7611.00
218_G223_N0.7601.00
36_F40_A0.7581.00
280_E478_D0.7581.00
309_L312_G0.7561.00
129_R132_H0.7551.00
40_A254_L0.7551.00
416_D437_E0.7541.00
229_S235_D0.7541.00
228_Y232_S0.7531.00
374_F378_V0.7521.00
73_F435_V0.7511.00
300_N452_P0.7501.00
41_A503_V0.7481.00
336_G391_H0.7471.00
301_P305_E0.7471.00
296_V481_Y0.7461.00
36_F497_L0.7461.00
191_G196_Y0.7451.00
416_D419_L0.7451.00
46_A264_T0.7451.00
224_T229_S0.7441.00
317_A476_G0.7431.00
28_D292_T0.7401.00
371_D421_T0.7381.00
336_G436_V0.7381.00
504_T508_I0.7371.00
142_A145_A0.7371.00
171_A175_Y0.7351.00
302_A306_R0.7321.00
128_R132_H0.7311.00
146_L152_R0.7301.00
306_R453_G0.7301.00
378_V381_K0.7271.00
47_R257_L0.7251.00
348_S353_P0.7241.00
430_L433_R0.7181.00
39_L258_A0.7171.00
131_A134_L0.7171.00
299_A303_Y0.7151.00
435_V438_E0.7141.00
173_R177_S0.7131.00
317_A320_Y0.7121.00
46_A262_G0.7081.00
145_A149_Y0.7081.00
397_L401_A0.7071.00
349_L354_D0.7071.00
493_M497_L0.7061.00
498_I502_H0.7061.00
36_F254_L0.7061.00
347_H351_L0.7061.00
463_L466_T0.7031.00
130_N134_L0.7001.00
144_D155_T0.7001.00
296_V503_V0.6971.00
219_G222_H0.6941.00
42_A263_A0.6941.00
348_S351_L0.6941.00
145_A153_A0.6941.00
403_G406_D0.6941.00
270_G450_G0.6891.00
201_F210_L0.6891.00
374_F379_A0.6871.00
380_S392_E0.6861.00
272_N287_D0.6861.00
29_V507_V0.6861.00
76_D247_I0.6821.00
285_T290_R0.6821.00
145_A152_R0.6821.00
197_V201_F0.6821.00
182_P185_S0.6811.00
136_E143_G0.6801.00
79_P247_I0.6791.00
444_E447_E0.6791.00
183_L187_L0.6771.00
440_A444_E0.6751.00
203_H207_R0.6741.00
373_A379_A0.6731.00
283_L286_D0.6731.00
30_T295_V0.6711.00
271_V285_T0.6711.00
65_A493_M0.6711.00
156_N160_A0.6691.00
432_D435_V0.6681.00
144_D149_Y0.6681.00
433_R436_V0.6671.00
221_P227_L0.6661.00
152_R159_L0.6641.00
150_L153_A0.6631.00
91_F94_H0.6621.00
460_A465_Q0.6611.00
392_E395_V0.6611.00
140_E143_G0.6601.00
181_L184_A0.6591.00
222_H226_A0.6581.00
417_R421_T0.6551.00
92_F243_P0.6531.00
158_D161_M0.6531.00
147_A154_A0.6521.00
149_Y157_Y0.6501.00
144_D151_D0.6501.00
419_L434_I0.6481.00
111_Q114_V0.6481.00
396_I422_L0.6471.00
44_Y91_F0.6461.00
131_A135_F0.6461.00
93_D96_D0.6461.00
411_R441_C0.6441.00
219_G224_T0.6401.00
196_Y226_A0.6401.00
149_Y154_A0.6401.00
140_E144_D0.6391.00
441_C444_E0.6391.00
276_G477_P0.6391.00
132_H136_E0.6381.00
80_S395_V0.6381.00
204_P207_R0.6361.00
230_I235_D0.6361.00
331_L439_S0.6361.00
475_D482_Y0.6361.00
478_D510_D0.6351.00
330_A456_A0.6351.00
65_A247_I0.6351.00
398_L401_A0.6341.00
171_A176_A0.6341.00
300_N486_Y0.6321.00
294_L510_D0.6321.00
335_L415_R0.6321.00
308_L312_G0.6321.00
457_L463_L0.6311.00
148_T154_A0.6311.00
264_T267_T0.6301.00
296_V483_V0.6301.00
50_A294_L0.6291.00
207_R211_E0.6291.00
182_P186_R0.6281.00
372_P379_A0.6281.00
71_D436_V0.6281.00
195_D198_S0.6281.00
253_A257_L0.6271.00
335_L430_L0.6271.00
229_S233_H0.6261.00
219_G226_A0.6261.00
87_V497_L0.6261.00
31_V54_L0.6261.00
229_S234_V0.6261.00
165_V168_D0.6251.00
255_A263_A0.6241.00
273_A309_L0.6231.00
208_Q212_Y0.6231.00
259_V263_A0.6231.00
59_D267_T0.6221.00
483_V499_S0.6211.00
343_P346_H0.6191.00
272_N288_G0.6191.00
297_N482_Y0.6191.00
419_L431_R0.6181.00
394_V397_L0.6171.00
221_P226_A0.6171.00
507_V510_D0.6161.00
88_F494_P0.6161.00
228_Y231_M0.6151.00
234_V237_N0.6141.00
215_V219_G0.6131.00
203_H206_L0.6131.00
60_T248_A0.6081.00
399_P402_P0.6071.00
107_R110_P0.6061.00
150_L156_N0.6051.00
211_E221_P0.6041.00
338_E432_D0.6041.00
75_F336_G0.6041.00
294_L297_N0.6031.00
436_V439_S0.6011.00
393_A397_L0.6001.00
232_S237_N0.5991.00
91_F497_L0.5980.99
162_N165_V0.5980.99
347_H350_V0.5970.99
154_A159_L0.5960.99
434_I438_E0.5960.99
87_V494_P0.5950.99
435_V439_S0.5930.99
112_Y115_F0.5920.99
350_V353_P0.5920.99
174_D177_S0.5910.99
419_L437_E0.5910.99
37_G40_A0.5910.99
207_R212_Y0.5900.99
339_G392_E0.5900.99
255_A258_A0.5880.99
150_L157_Y0.5880.99
372_P377_S0.5870.99
231_M235_D0.5850.99
224_T227_L0.5850.99
156_N159_L0.5840.99
373_A378_V0.5830.99
411_R415_R0.5820.99
147_A152_R0.5810.99
79_P494_P0.5810.99
407_T411_R0.5800.99
135_F139_E0.5790.99
336_G435_V0.5790.99
218_G225_P0.5770.99
301_P324_Q0.5760.99
128_R131_A0.5750.99
347_H352_P0.5750.99
479_G510_D0.5750.99
394_V398_L0.5740.99
151_D158_D0.5710.99
427_G431_R0.5710.99
344_L347_H0.5710.99
75_F334_Y0.5700.99
34_G255_A0.5690.99
314_R318_P0.5690.99
438_E441_C0.5660.99
246_G249_G0.5660.99
373_A421_T0.5650.99
158_D162_N0.5650.99
245_G383_D0.5640.99
231_M237_N0.5640.99
197_V207_R0.5630.99
76_D81_W0.5620.99
293_D479_G0.5620.99
194_D211_E0.5610.99
92_F95_F0.5610.99
76_D248_A0.5600.99
224_T231_M0.5600.99
249_G256_E0.5580.99
333_F415_R0.5580.99
181_L185_S0.5580.99
411_R414_Y0.5570.99
88_F493_M0.5570.99
70_R75_F0.5570.99
121_S124_I0.5570.99
167_P171_A0.5560.99
152_R200_F0.5560.99
445_F451_D0.5560.99
394_V400_I0.5540.99
27_R264_T0.5540.99
281_F480_H0.5540.99
141_G203_H0.5520.99
340_D392_E0.5520.99
242_Y247_I0.5510.99
52_V258_A0.5510.99
337_V341_V0.5500.99
321_W324_Q0.5500.99
393_A400_I0.5490.99
39_L251_V0.5490.99
215_V218_G0.5480.99
226_A229_S0.5480.99
148_T155_T0.5470.99
118_D205_K0.5470.99
110_P113_R0.5470.99
27_R294_L0.5470.99
349_L355_W0.5470.99
414_Y418_L0.5460.99
67_V76_D0.5430.99
287_D290_R0.5420.99
428_V432_D0.5410.99
115_F348_S0.5400.99
79_P83_L0.5400.99
369_P372_P0.5390.99
325_T460_A0.5390.99
60_T252_D0.5390.99
380_S393_A0.5390.99
458_G486_Y0.5380.99
305_E322_D0.5380.99
146_L150_L0.5380.99
129_R133_E0.5380.99
159_L162_N0.5380.99
86_D494_P0.5380.99
161_M164_V0.5360.99
350_V354_D0.5350.99
238_G241_F0.5350.99
230_I233_H0.5340.99
231_M234_V0.5340.99
129_R147_A0.5330.99
218_G221_P0.5330.99
317_A477_P0.5320.99
394_V399_P0.5320.99
34_G39_L0.5300.99
460_A463_L0.5300.99
406_D410_I0.5300.99
372_P376_L0.5300.99
151_D156_N0.5290.99
152_R158_D0.5280.99
45_L507_V0.5280.99
43_A263_A0.5270.99
325_T328_P0.5250.99
269_V290_R0.5240.99
105_L109_D0.5240.99
280_E293_D0.5240.99
193_M229_S0.5230.99
502_H505_K0.5230.99
30_T291_T0.5210.99
164_V167_P0.5210.99
252_D259_V0.5210.99
457_L485_A0.5190.99
70_R336_G0.5180.99
491_I496_C0.5180.99
225_P228_Y0.5170.99
76_D80_S0.5170.99
443_S447_E0.5150.99
392_E396_I0.5130.98
393_A399_P0.5120.98
149_Y153_A0.5110.98
436_V441_C0.5110.98
472_G476_G0.5110.98
79_P493_M0.5110.98
222_H227_L0.5100.98
83_L494_P0.5090.98
351_L354_D0.5080.98
337_V342_E0.5080.98
414_Y417_R0.5080.98
80_S377_S0.5080.98
81_W492_G0.5070.98
211_E222_H0.5070.98
331_L414_Y0.5060.98
163_R167_P0.5050.98
149_Y159_L0.5050.98
339_G342_E0.5050.98
88_F91_F0.5040.98
35_G38_G0.5030.98
143_G150_L0.5030.98
457_L460_A0.5020.98
484_G487_T0.5010.98
108_L111_Q0.5010.98
60_T267_T0.5010.98
337_V394_V0.5000.98
141_G144_D0.5000.98
275_S291_T0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dgkA 1 0.7425 100 0.366 Contact Map
4repA 1 0.9011 100 0.396 Contact Map
4i59A 1 0.7985 100 0.452 Contact Map
2yg5A 2 0.8022 100 0.459 Contact Map
1s3eA 2 0.8526 100 0.471 Contact Map
2ivdA 1 0.7836 100 0.473 Contact Map
1sezA 3 0.791 100 0.484 Contact Map
3i6dA 1 0.7593 100 0.49 Contact Map
2vvmA 2 0.8433 100 0.496 Contact Map
3x0vA 2 0.8563 100 0.499 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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