GREMLIN Database
IF1A2 - Translation initiation factor 1A 2
UniProt: Q9HP87 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 94 (88)
Sequences: 328 (166)
Seq/√Len: 17.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_G73_A4.8551.00
33_L43_G3.1840.99
22_V55_I3.0900.99
20_A33_L2.5170.96
33_L61_V2.3130.94
33_L63_A2.2070.92
55_I72_K2.1510.91
31_V75_V2.0180.88
54_W59_D1.9460.86
22_V61_V1.8760.84
43_G63_A1.8650.84
49_M61_V1.7410.79
81_D93_I1.7220.79
42_M62_L1.5940.73
35_C41_R1.5690.72
8_R11_R1.5120.69
21_V93_I1.4960.68
24_R32_T1.4410.65
49_M53_T1.4390.65
19_F78_R1.4000.63
42_M75_V1.3710.61
62_L83_D1.3560.60
7_R10_L1.3500.60
33_L73_A1.3330.59
12_M90_E1.3060.57
25_H74_N1.2880.56
19_F66_W1.2610.54
33_L75_V1.2460.53
18_V40_E1.2290.52
47_G54_W1.2060.51
53_T77_W1.1560.48
32_T40_E1.1430.47
30_H57_E1.1390.47
18_V36_E1.1240.46
20_A43_G1.1240.46
61_V75_V1.1190.46
42_M69_Q1.0890.44
37_D41_R1.0520.42
6_G43_G1.0490.41
60_V84_A1.0430.41
73_A84_A1.0310.40
23_K34_Q1.0260.40
62_L89_E1.0250.40
85_D92_H1.0230.40
22_V73_A1.0150.39
22_V31_V1.0140.39
44_R66_W0.9840.38
48_R68_W0.9820.38
37_D79_Y0.9760.37
17_E82_Q0.9530.36
13_P72_K0.9390.35
42_M50_K0.9060.33
33_L48_R0.8880.32
52_R81_D0.8800.32
45_I54_W0.8700.31
49_M62_L0.8660.31
26_D36_E0.8620.31
29_N50_K0.8550.31
22_V72_K0.8540.31
29_N70_D0.8530.31
20_A73_A0.8500.30
8_R62_L0.8460.30
27_G79_Y0.8370.30
52_R78_R0.8310.29
62_L82_Q0.8060.28
86_Q89_E0.8060.28
9_N86_Q0.8010.28
29_N85_D0.7990.28
43_G50_K0.7920.27
69_Q74_N0.7790.27
20_A39_K0.7790.27
36_E78_R0.7660.26
46_P66_W0.7640.26
10_L19_F0.7560.26
28_G51_Y0.7520.26
6_G89_E0.7470.25
19_F92_H0.7450.25
39_K70_D0.7430.25
7_R11_R0.7420.25
39_K48_R0.7410.25
63_A73_A0.7410.25
49_M68_W0.7280.24
19_F85_D0.7160.24
31_V45_I0.7130.24
49_M76_E0.7070.24
76_E89_E0.7040.23
29_N34_Q0.7040.23
38_G46_P0.6970.23
65_P78_R0.6870.23
30_H77_W0.6730.22
64_E78_R0.6700.22
11_R17_E0.6690.22
43_G62_L0.6680.22
6_G11_R0.6530.21
57_E75_V0.6490.21
8_R12_M0.6420.21
15_D84_A0.6380.21
28_G46_P0.6370.21
14_N64_E0.6320.20
21_V30_H0.6310.20
22_V45_I0.6300.20
25_H53_T0.6280.20
12_M16_D0.6240.20
24_R39_K0.6190.20
56_N78_R0.6180.20
26_D42_M0.6120.20
58_G77_W0.6100.20
47_G53_T0.6080.19
44_R67_D0.5900.19
12_M18_V0.5860.19
12_M15_D0.5860.19
57_E77_W0.5790.18
19_F40_E0.5760.18
65_P77_W0.5700.18
72_K78_R0.5650.18
60_V78_R0.5640.18
29_N72_K0.5620.18
15_D64_E0.5560.18
88_R92_H0.5550.18
14_N76_E0.5500.17
44_R56_N0.5440.17
35_C52_R0.5340.17
13_P25_H0.5330.17
40_E49_M0.5320.17
8_R83_D0.5260.17
18_V66_W0.5240.16
25_H30_H0.5230.16
7_R12_M0.5180.16
34_Q55_I0.5100.16
64_E82_Q0.5050.16
13_P63_A0.5020.16
55_I61_V0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kzyn 1 0.8404 100 0.324 Contact Map
3j80i 1 0.9468 100 0.325 Contact Map
4bpe0 1 0.9787 100 0.328 Contact Map
3wbkC 1 0.0106 100 0.344 Contact Map
2oqkA 1 0.9468 99.9 0.358 Contact Map
1jt8A 1 1 99.9 0.366 Contact Map
4mnoA 1 0.9362 99.9 0.371 Contact Map
2dgyA 1 0.9894 99.9 0.383 Contact Map
4ql5A 4 0.7128 99.6 0.602 Contact Map
1ah9A 1 0.7447 99.6 0.603 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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