COST - HALSA - GREMLIN Contacts

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COST - Transducer protein CosT

UniProt:	Q9HP84	Sequences: MSEPTADAGDNSPSSTDTAPLDRVKAIALLPLRSYLVKFAVALLVILVIIAAGGFWVQADATATLEANTEQQLEQEAVSDATEIGDWLERNEQSVLIASNNPRLGFNTTAADKQAYVTQLVAAELDADRIADVHVADPTVGGASDARIVASTDEDARGTRVSADTHPWVDRTRSIGRDTVVSTNPYRTAGGQRVVSSMSVAADLTHVLVVEYTAGDLSDQFGAGIDGTFTQVVRPTSDATAVLFSDAGTDAVGQPYIPDRSQSEIPALDSATEQGQFTNTPTKDSVLDREYVAAYTTVPGKNWVVVKHAPSESAFALSNQIRTGILGFILVALVGVVLVGGTIGRNTAAAVQSLSAAAAEIEAGNYDVDVASSRRDEIGQLFASIGSMRDALVTQIDEAEAAREQATEAQQDAEAERERAEDARERAEDAKADAEALAAELEAQAERYSDVMAACADGDLTRRMPADDTDNEAMAAIAASFNEMLAQWEHTIIDIQEFADAVATASEEAEVGAADAERASGQVSESVQEIAGAADEQRNMLDTVSGEMTDLSAAIEEVAASADSVAEHSHQTAEIARDGEQTAEDAIERSLTVQEAIDATVQNVEALDDQMAEISEIVDLISDIAEQTNMLALNANIEAARADKSGDGFAVVADEVKDLAEETQESAGDIERRITEVQSQTTATVAEARAAEESMDAGIDAVEEVVDAFTAVSDHADETDTGVQEISDTTDDQAASTEEAVSMTEEVADLSDSTAGEAQSVSAAAEEQAASMSEISDSVESLSGQAEQLKALLSEFEVDADRDVTPTQTD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	810 (668)
Sequences:	683 (616)
Seq/√Len:	23.8

BACSU - MCPB TLPA MCPA TLPB MCPC
HALSA - COST HTR2 HTR4 Q9HRA1 Q9HR88 Q9HRN6 Q9HP10

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
360_E	365_N	6.311	1.00
454_A	459_D	4.232	1.00
374_R	379_G	4.224	1.00
403_R	406_A	3.618	1.00
634_N	652_V	3.603	1.00
642_A	646_G	3.154	1.00
625_A	650_A	3.112	1.00
38_K	376_D	3.079	1.00
388_M	392_L	3.025	1.00
438_A	442_E	3.006	1.00
441_L	445_A	2.991	1.00
381_L	388_M	2.985	1.00
441_L	444_Q	2.979	1.00
643_D	646_G	2.972	1.00
630_M	640_A	2.808	0.99
636_N	658_D	2.782	0.99
444_Q	447_R	2.719	0.99
593_V	657_K	2.700	0.99
633_L	657_K	2.607	0.99
617_I	674_I	2.587	0.99
654_D	658_D	2.586	0.99
381_L	392_L	2.577	0.99
39_F	347_T	2.521	0.99
625_A	642_A	2.494	0.98
358_A	385_I	2.460	0.98
646_G	650_A	2.422	0.98
478_A	481_F	2.402	0.98
611_M	617_I	2.361	0.98
381_L	385_I	2.359	0.98
488_W	502_V	2.355	0.98
399_A	402_A	2.350	0.98
695_M	698_G	2.333	0.98
640_A	651_V	2.302	0.97
627_Q	638_E	2.293	0.97
358_A	381_L	2.273	0.97
148_I	151_S	2.271	0.97
582_T	637_I	2.265	0.97
750_L	754_T	2.246	0.97
637_I	698_G	2.236	0.97
657_K	673_R	2.157	0.96
344_G	347_T	2.144	0.96
648_G	655_E	2.127	0.96
121_V	125_L	2.095	0.95
440_E	444_Q	2.086	0.95
538_R	738_E	2.077	0.95
688_A	698_G	2.062	0.95
650_A	655_E	2.061	0.95
475_A	478_A	2.061	0.95
636_N	705_V	2.055	0.95
621_I	655_E	2.051	0.95
84_I	214_A	2.027	0.95
622_S	626_E	2.016	0.94
448_Y	478_A	2.014	0.94
464_M	478_A	2.011	0.94
633_L	650_A	2.008	0.94
629_N	638_E	2.003	0.94
640_A	650_A	1.981	0.94
590_S	593_V	1.976	0.94
239_A	244_F	1.974	0.94
657_K	768_Q	1.954	0.93
646_G	652_V	1.947	0.93
733_Q	740_A	1.946	0.93
593_V	633_L	1.937	0.93
99_S	201_A	1.931	0.93
499_A	502_V	1.914	0.93
623_D	751_S	1.913	0.93
622_S	671_E	1.903	0.92
630_M	636_N	1.899	0.92
555_I	674_I	1.897	0.92
651_V	655_E	1.877	0.92
636_N	662_E	1.862	0.92
96_L	99_S	1.851	0.91
730_T	733_Q	1.849	0.91
442_E	445_A	1.839	0.91
303_W	306_V	1.838	0.91
200_V	297_T	1.833	0.91
633_L	640_A	1.832	0.91
562_A	695_M	1.822	0.91
632_A	641_R	1.822	0.91
464_M	477_I	1.815	0.91
674_I	692_E	1.807	0.90
705_V	733_Q	1.805	0.90
627_Q	633_L	1.804	0.90
546_G	734_A	1.800	0.90
229_F	313_S	1.796	0.90
350_A	378_I	1.795	0.90
587_I	720_D	1.794	0.90
635_A	652_V	1.786	0.90
643_D	648_G	1.778	0.90
505_A	569_S	1.777	0.90
684_T	719_T	1.762	0.89
495_I	685_V	1.759	0.89
637_I	671_E	1.743	0.89
737_T	741_V	1.742	0.89
437_L	442_E	1.714	0.88
438_A	441_L	1.701	0.87
576_A	580_E	1.699	0.87
354_L	385_I	1.698	0.87
442_E	446_E	1.698	0.87
495_I	587_I	1.687	0.87
617_I	673_R	1.683	0.87
617_I	698_G	1.681	0.87
142_G	148_I	1.678	0.87
495_I	613_E	1.676	0.87
593_V	768_Q	1.670	0.86
227_G	233_V	1.669	0.86
617_I	620_L	1.664	0.86
621_I	629_N	1.655	0.86
399_A	406_A	1.649	0.86
449_S	452_M	1.646	0.86
663_T	670_I	1.638	0.85
637_I	684_T	1.635	0.85
559_A	562_A	1.634	0.85
579_G	751_S	1.617	0.85
654_D	664_Q	1.616	0.85
451_V	481_F	1.610	0.84
230_T	309_A	1.605	0.84
576_A	624_I	1.604	0.84
558_V	716_A	1.603	0.84
709_F	733_Q	1.602	0.84
681_T	687_E	1.597	0.84
626_E	684_T	1.596	0.84
664_Q	684_T	1.595	0.84
405_Q	408_E	1.593	0.84
484_M	747_V	1.588	0.83
642_A	653_A	1.575	0.83
358_A	388_M	1.571	0.83
618_V	698_G	1.570	0.83
361_I	392_L	1.564	0.82
627_Q	650_A	1.561	0.82
677_V	695_M	1.555	0.82
172_T	206_H	1.552	0.82
437_L	444_Q	1.551	0.82
572_T	724_Q	1.550	0.82
558_V	733_Q	1.549	0.82
253_G	287_L	1.547	0.82
370_V	382_F	1.541	0.82
386_G	389_R	1.530	0.81
354_L	368_V	1.530	0.81
719_T	740_A	1.529	0.81
626_E	664_Q	1.517	0.80
624_I	652_V	1.495	0.79
193_R	211_E	1.489	0.79
298_V	531_A	1.484	0.79
545_S	684_T	1.481	0.79
128_D	135_V	1.480	0.79
344_G	348_A	1.479	0.79
354_L	370_V	1.475	0.79
464_M	545_S	1.468	0.78
441_L	447_R	1.465	0.78
583_A	692_E	1.454	0.78
206_H	211_E	1.453	0.77
626_E	633_L	1.452	0.77
684_T	709_F	1.442	0.77
585_D	690_A	1.440	0.77
439_A	442_E	1.434	0.77
211_E	214_A	1.434	0.77
132_D	135_V	1.432	0.76
406_A	410_Q	1.426	0.76
544_V	547_E	1.422	0.76
230_T	275_G	1.422	0.76
478_A	482_N	1.421	0.76
542_D	738_E	1.411	0.75
663_T	735_A	1.402	0.75
626_E	637_I	1.397	0.75
118_T	122_A	1.396	0.75
629_N	652_V	1.395	0.74
622_S	664_Q	1.390	0.74
143_A	147_R	1.390	0.74
626_E	768_Q	1.386	0.74
621_I	646_G	1.381	0.74
197_S	212_Y	1.378	0.74
718_E	721_T	1.374	0.73
380_Q	383_A	1.372	0.73
480_S	627_Q	1.371	0.73
547_E	557_E	1.368	0.73
646_G	670_I	1.361	0.73
625_A	633_L	1.359	0.72
699_I	748_A	1.349	0.72
688_A	695_M	1.348	0.72
466_A	475_A	1.346	0.72
54_G	329_I	1.343	0.72
626_E	661_E	1.337	0.71
362_E	572_T	1.333	0.71
185_P	303_W	1.331	0.71
133_V	136_A	1.329	0.71
164_D	188_T	1.326	0.71
593_V	626_E	1.326	0.71
593_V	673_R	1.325	0.71
35_Y	347_T	1.321	0.70
484_M	531_A	1.319	0.70
626_E	657_K	1.314	0.70
681_T	709_F	1.313	0.70
116_Y	121_V	1.312	0.70
382_F	388_M	1.306	0.69
579_G	705_V	1.298	0.69
372_S	388_M	1.298	0.69
128_D	131_A	1.288	0.68
212_Y	581_Q	1.287	0.68
654_D	680_Q	1.282	0.68
45_V	343_I	1.277	0.68
473_A	583_A	1.276	0.68
754_T	761_V	1.273	0.67
623_D	661_E	1.273	0.67
484_M	488_W	1.272	0.67
398_E	406_A	1.270	0.67
385_I	392_L	1.266	0.67
463_R	489_E	1.265	0.67
572_T	650_A	1.263	0.67
228_T	232_V	1.260	0.67
402_A	406_A	1.259	0.66
538_R	741_V	1.256	0.66
288_D	338_L	1.251	0.66
658_D	665_E	1.250	0.66
677_V	681_T	1.245	0.66
84_I	234_R	1.245	0.66
629_N	634_N	1.244	0.66
626_E	740_A	1.244	0.66
622_S	637_I	1.240	0.65
438_A	444_Q	1.237	0.65
623_D	654_D	1.234	0.65
627_Q	723_V	1.234	0.65
452_M	617_I	1.232	0.65
113_K	118_T	1.231	0.65
539_N	546_G	1.230	0.65
89_E	100_N	1.230	0.65
474_M	498_F	1.227	0.64
646_G	651_V	1.225	0.64
674_I	681_T	1.223	0.64
534_A	743_M	1.222	0.64
579_G	636_N	1.215	0.64
442_E	447_R	1.214	0.64
366_Y	393_V	1.213	0.64
467_D	475_A	1.213	0.64
636_N	698_G	1.212	0.63
398_E	401_A	1.211	0.63
573_A	577_R	1.211	0.63
667_A	691_A	1.207	0.63
402_A	409_A	1.206	0.63
458_G	632_A	1.205	0.63
737_T	740_A	1.205	0.63
579_G	691_A	1.203	0.63
547_E	555_I	1.202	0.63
640_A	655_E	1.201	0.63
387_S	392_L	1.198	0.63
620_L	684_T	1.196	0.62
677_V	692_E	1.193	0.62
743_M	768_Q	1.193	0.62
623_D	668_G	1.193	0.62
129_R	132_D	1.193	0.62
684_T	740_A	1.193	0.62
642_A	650_A	1.189	0.62
624_I	634_N	1.188	0.62
484_M	593_V	1.187	0.62
663_T	723_V	1.184	0.62
614_I	621_I	1.184	0.62
751_S	758_A	1.175	0.61
404_E	407_T	1.173	0.61
740_A	744_T	1.171	0.61
445_A	448_Y	1.167	0.60
529_E	533_A	1.166	0.60
361_I	381_L	1.161	0.60
691_A	695_M	1.159	0.60
638_E	643_D	1.159	0.60
701_A	705_V	1.157	0.60
667_A	701_A	1.155	0.60
87_W	91_N	1.153	0.60
194_V	702_V	1.152	0.59
376_D	379_G	1.152	0.59
681_T	705_V	1.151	0.59
361_I	389_R	1.151	0.59
39_F	354_L	1.148	0.59
481_F	484_M	1.143	0.59
636_N	654_D	1.141	0.59
576_A	765_A	1.141	0.59
620_L	685_V	1.140	0.59
558_V	715_H	1.135	0.58
505_A	743_M	1.135	0.58
496_Q	677_V	1.133	0.58
667_A	733_Q	1.132	0.58
610_Q	699_I	1.132	0.58
564_S	714_D	1.128	0.58
543_T	718_E	1.128	0.58
622_S	673_R	1.126	0.58
695_M	719_T	1.125	0.58
558_V	740_A	1.125	0.58
657_K	734_A	1.125	0.58
674_I	698_G	1.125	0.58
657_K	684_T	1.124	0.58
526_S	743_M	1.123	0.57
651_V	718_E	1.122	0.57
503_A	506_S	1.122	0.57
522_Q	746_E	1.121	0.57
654_D	671_E	1.120	0.57
622_S	743_M	1.118	0.57
72_Q	76_E	1.117	0.57
43_L	49_I	1.117	0.57
626_E	645_S	1.116	0.57
667_A	722_G	1.113	0.57
377_E	660_A	1.113	0.57
616_E	636_N	1.110	0.57
361_I	388_M	1.109	0.56
625_A	715_H	1.109	0.56
209_V	215_G	1.107	0.56
381_L	387_S	1.103	0.56
51_A	55_F	1.103	0.56
649_F	653_A	1.103	0.56
637_I	747_V	1.100	0.56
165_T	168_W	1.098	0.56
680_Q	722_G	1.098	0.56
545_S	549_T	1.096	0.56
658_D	680_Q	1.093	0.55
200_V	239_A	1.089	0.55
664_Q	715_H	1.088	0.55
661_E	684_T	1.087	0.55
214_A	230_T	1.086	0.55
99_S	199_S	1.085	0.55
330_L	334_V	1.083	0.55
640_A	685_V	1.077	0.54
473_A	484_M	1.077	0.54
452_M	620_L	1.073	0.54
545_S	593_V	1.073	0.54
719_T	734_A	1.069	0.54
617_I	666_S	1.068	0.54
611_M	681_T	1.068	0.54
681_T	692_E	1.067	0.54
527_V	681_T	1.067	0.54
705_V	709_F	1.067	0.54
684_T	687_E	1.067	0.54
620_L	681_T	1.067	0.54
677_V	709_F	1.065	0.53
690_A	726_I	1.063	0.53
252_V	256_Y	1.063	0.53
638_E	666_S	1.054	0.53
351_V	378_I	1.048	0.52
228_T	234_R	1.048	0.52
58_Q	295_Y	1.044	0.52
734_A	740_A	1.043	0.52
129_R	135_V	1.042	0.52
183_T	186_Y	1.040	0.52
550_D	735_A	1.038	0.51
677_V	719_T	1.037	0.51
522_Q	555_I	1.036	0.51
734_A	741_V	1.035	0.51
241_A	244_F	1.030	0.51
670_I	680_Q	1.029	0.51
677_V	698_G	1.029	0.51
481_F	488_W	1.024	0.50
745_E	749_D	1.024	0.50
638_E	648_G	1.021	0.50
558_V	654_D	1.020	0.50
472_E	481_F	1.019	0.50
541_L	545_S	1.018	0.50
444_Q	658_D	1.016	0.50
667_A	725_E	1.012	0.50
667_A	698_G	1.012	0.50
168_W	303_W	1.008	0.49
541_L	667_A	1.003	0.49
566_A	724_Q	1.002	0.49
397_D	401_A	0.998	0.49
336_V	351_V	0.994	0.48
477_I	480_S	0.993	0.48
621_I	648_G	0.992	0.48
663_T	667_A	0.990	0.48
78_V	339_V	0.990	0.48
688_A	719_T	0.989	0.48
398_E	405_Q	0.985	0.48
684_T	734_A	0.985	0.48
196_S	211_E	0.983	0.48
208_L	212_Y	0.983	0.48
589_R	626_E	0.982	0.48
589_R	618_V	0.981	0.47
446_E	449_S	0.981	0.47
358_A	392_L	0.980	0.47
88_L	327_G	0.979	0.47
667_A	730_T	0.972	0.47
541_L	737_T	0.971	0.47
467_D	478_A	0.971	0.47
530_I	610_Q	0.968	0.47
583_A	593_V	0.968	0.47
458_G	641_R	0.968	0.47
555_I	727_S	0.965	0.46
484_M	713_S	0.963	0.46
332_A	396_I	0.962	0.46
45_V	268_L	0.961	0.46
621_I	638_E	0.960	0.46
530_I	719_T	0.958	0.46
481_F	636_N	0.958	0.46
648_G	651_V	0.957	0.46
167_P	330_L	0.957	0.46
630_M	728_D	0.954	0.46
354_L	381_L	0.952	0.45
673_R	713_S	0.952	0.45
692_E	695_M	0.951	0.45
637_I	654_D	0.950	0.45
562_A	642_A	0.948	0.45
171_R	210_V	0.947	0.45
573_A	720_D	0.945	0.45
535_D	745_E	0.944	0.45
582_T	734_A	0.944	0.45
622_S	668_G	0.944	0.45
620_L	664_Q	0.943	0.45
252_V	365_N	0.941	0.45
725_E	744_T	0.941	0.45
622_S	741_V	0.940	0.45
625_A	653_A	0.940	0.45
33_R	552_S	0.939	0.45
695_M	709_F	0.939	0.45
139_T	143_A	0.938	0.44
630_M	692_E	0.938	0.44
533_A	750_L	0.938	0.44
445_A	492_I	0.935	0.44
593_V	684_T	0.934	0.44
646_G	657_K	0.934	0.44
712_V	732_D	0.932	0.44
677_V	705_V	0.927	0.44
733_Q	744_T	0.927	0.44
538_R	671_E	0.926	0.44
547_E	636_N	0.926	0.44
551_L	691_A	0.924	0.43
633_L	651_V	0.923	0.43
537_Q	562_A	0.920	0.43
624_I	765_A	0.919	0.43
481_F	658_D	0.918	0.43
590_S	769_A	0.918	0.43
453_A	483_E	0.916	0.43
406_A	409_A	0.916	0.43
545_S	696_D	0.911	0.43
506_S	758_A	0.908	0.42
366_Y	396_I	0.906	0.42
233_V	241_A	0.906	0.42
621_I	666_S	0.904	0.42
402_A	405_Q	0.902	0.42
637_I	668_G	0.901	0.42
547_E	579_G	0.900	0.42
438_A	477_I	0.900	0.42
87_W	321_I	0.900	0.42
150_A	207_V	0.899	0.42
658_D	661_E	0.897	0.42
639_A	653_A	0.897	0.42
591_L	711_A	0.896	0.42
660_A	684_T	0.895	0.41
681_T	698_G	0.894	0.41
475_A	479_A	0.894	0.41
657_K	662_E	0.893	0.41
716_A	743_M	0.891	0.41
638_E	656_V	0.889	0.41
160_R	166_H	0.888	0.41
121_V	184_N	0.885	0.41
345_R	349_A	0.885	0.41
580_E	750_L	0.884	0.41
761_V	767_E	0.883	0.41
403_R	410_Q	0.882	0.41
484_M	492_I	0.876	0.40
57_V	350_A	0.875	0.40
698_G	705_V	0.874	0.40
677_V	691_A	0.874	0.40
485_L	623_D	0.872	0.40
534_A	559_A	0.872	0.40
459_D	484_M	0.871	0.40
137_D	141_G	0.870	0.40
626_E	734_A	0.867	0.40
666_S	729_T	0.865	0.39
621_I	640_A	0.863	0.39
626_E	738_E	0.863	0.39
372_S	386_G	0.862	0.39
223_A	330_L	0.861	0.39
576_A	712_V	0.859	0.39
621_I	643_D	0.859	0.39
684_T	698_G	0.858	0.39
648_G	669_D	0.858	0.39
677_V	740_A	0.856	0.39
54_G	328_F	0.855	0.39
327_G	331_V	0.855	0.39
444_Q	478_A	0.853	0.39
645_S	685_V	0.853	0.39
544_V	550_D	0.853	0.39
521_G	753_S	0.852	0.39
84_I	168_W	0.851	0.38
656_V	659_L	0.851	0.38
663_T	666_S	0.838	0.38
566_A	706_V	0.838	0.38
534_A	681_T	0.838	0.38
621_I	674_I	0.836	0.37
692_E	698_G	0.835	0.37
128_D	132_D	0.833	0.37
621_I	652_V	0.833	0.37
142_G	155_D	0.829	0.37
722_G	729_T	0.828	0.37
169_V	173_R	0.827	0.37
88_L	96_L	0.826	0.37
537_Q	580_E	0.825	0.37
522_Q	734_A	0.825	0.37
48_V	173_R	0.824	0.37
478_A	484_M	0.823	0.37
505_A	723_V	0.823	0.37
637_I	734_A	0.820	0.36
555_I	677_V	0.819	0.36
687_E	691_A	0.818	0.36
578_D	581_Q	0.818	0.36
539_N	544_V	0.818	0.36
620_L	761_V	0.818	0.36
273_E	278_T	0.817	0.36
218_S	222_G	0.816	0.36
480_S	743_M	0.816	0.36
444_Q	475_A	0.816	0.36
663_T	673_R	0.816	0.36
695_M	705_V	0.816	0.36
565_V	583_A	0.813	0.36
558_V	637_I	0.813	0.36
611_M	698_G	0.811	0.36
586_A	737_T	0.810	0.36
530_I	663_T	0.809	0.36
562_A	587_I	0.808	0.36
125_L	150_A	0.808	0.36
464_M	476_A	0.806	0.35
750_L	759_Q	0.805	0.35
662_E	753_S	0.805	0.35
524_S	716_A	0.804	0.35
619_D	671_E	0.804	0.35
68_N	343_I	0.802	0.35
119_Q	122_A	0.799	0.35
554_A	664_Q	0.799	0.35
613_E	666_S	0.799	0.35
139_T	142_G	0.798	0.35
584_E	726_I	0.798	0.35
643_D	655_E	0.792	0.35
303_W	321_I	0.790	0.34
200_V	310_P	0.790	0.34
505_A	589_R	0.790	0.34
677_V	684_T	0.789	0.34
623_D	652_V	0.788	0.34
98_A	294_A	0.788	0.34
583_A	687_E	0.785	0.34
652_V	655_E	0.785	0.34
723_V	765_A	0.785	0.34
95_V	98_A	0.784	0.34
709_F	765_A	0.783	0.34
693_E	696_D	0.781	0.34
65_L	69_T	0.781	0.34
613_E	702_V	0.780	0.34
441_L	474_M	0.779	0.34
538_R	626_E	0.778	0.34
624_I	662_E	0.776	0.34
524_S	723_V	0.774	0.33
84_I	316_A	0.774	0.33
576_A	630_M	0.773	0.33
580_E	673_R	0.773	0.33
89_E	93_Q	0.773	0.33
667_A	684_T	0.772	0.33
621_I	657_K	0.771	0.33
119_Q	253_G	0.770	0.33
558_V	688_A	0.768	0.33
586_A	663_T	0.768	0.33
40_A	80_D	0.768	0.33
624_I	651_V	0.768	0.33
589_R	695_M	0.767	0.33
130_I	137_D	0.765	0.33
633_L	768_Q	0.765	0.33
555_I	692_E	0.764	0.33
480_S	768_Q	0.763	0.33
132_D	136_A	0.763	0.33
742_S	745_E	0.762	0.33
765_A	769_A	0.761	0.33
448_Y	452_M	0.761	0.33
38_K	47_L	0.761	0.33
88_L	97_I	0.761	0.33
526_S	757_E	0.760	0.33
667_A	740_A	0.759	0.33
98_A	221_F	0.759	0.33
303_W	310_P	0.759	0.33
527_V	750_L	0.758	0.32
576_A	610_Q	0.756	0.32
681_T	684_T	0.756	0.32
77_A	367_D	0.755	0.32
632_A	745_E	0.755	0.32
647_D	654_D	0.752	0.32
72_Q	75_Q	0.751	0.32
330_L	337_V	0.750	0.32
620_L	743_M	0.749	0.32
633_L	655_E	0.746	0.32
582_T	692_E	0.746	0.32
312_E	697_A	0.745	0.32
328_F	347_T	0.745	0.32
274_Q	278_T	0.745	0.32
566_A	705_V	0.744	0.32
61_A	347_T	0.741	0.31
329_I	384_S	0.739	0.31
384_S	554_A	0.739	0.31
547_E	685_V	0.738	0.31
680_Q	725_E	0.737	0.31
97_I	101_N	0.737	0.31
668_G	738_E	0.737	0.31
641_R	702_V	0.736	0.31
628_T	642_A	0.736	0.31
231_Q	243_L	0.735	0.31
388_M	558_V	0.734	0.31
88_L	494_D	0.734	0.31
657_K	664_Q	0.733	0.31
451_V	464_M	0.732	0.31
328_F	358_A	0.732	0.31
558_V	636_N	0.731	0.31
652_V	662_E	0.731	0.31
551_L	678_Q	0.730	0.31
652_V	656_V	0.729	0.31
528_Q	572_T	0.729	0.31
492_I	669_D	0.726	0.30
621_I	670_I	0.726	0.30
484_M	657_K	0.724	0.30
48_V	497_E	0.724	0.30
559_A	748_A	0.723	0.30
381_L	391_A	0.722	0.30
685_V	689_R	0.722	0.30
43_L	340_G	0.721	0.30
684_T	691_A	0.721	0.30
448_Y	481_F	0.720	0.30
478_A	733_Q	0.718	0.30
272_T	397_D	0.717	0.30
39_F	344_G	0.717	0.30
228_T	245_S	0.716	0.30
491_T	743_M	0.715	0.30
674_I	755_A	0.714	0.30
641_R	748_A	0.710	0.30
132_D	137_D	0.710	0.30
401_A	405_Q	0.709	0.29
617_I	633_L	0.709	0.29
627_Q	666_S	0.705	0.29
215_G	343_I	0.704	0.29
639_A	649_F	0.703	0.29
454_A	624_I	0.703	0.29
627_Q	651_V	0.702	0.29
459_D	724_Q	0.701	0.29
586_A	623_D	0.700	0.29
451_V	478_A	0.699	0.29
617_I	684_T	0.699	0.29
103_R	242_V	0.698	0.29
641_R	698_G	0.698	0.29
698_G	719_T	0.697	0.29
558_V	719_T	0.696	0.29
677_V	734_A	0.696	0.29
441_L	534_A	0.692	0.28
662_E	716_A	0.692	0.28
291_Y	310_P	0.691	0.28
622_S	727_S	0.691	0.28
637_I	740_A	0.690	0.28
188_T	211_E	0.690	0.28
638_E	657_K	0.690	0.28
542_D	550_D	0.689	0.28
610_Q	702_V	0.689	0.28
562_A	674_I	0.687	0.28
399_A	403_R	0.686	0.28
561_S	708_A	0.686	0.28
551_L	722_G	0.686	0.28
95_V	195_V	0.686	0.28
677_V	687_E	0.684	0.28
87_W	314_A	0.683	0.28
532_G	569_S	0.683	0.28
168_W	186_Y	0.682	0.28
485_L	488_W	0.681	0.28
705_V	708_A	0.681	0.28
613_E	617_I	0.680	0.28
674_I	766_E	0.680	0.28
325_I	344_G	0.680	0.28
614_I	638_E	0.680	0.28
88_L	185_P	0.680	0.28
195_V	244_F	0.679	0.28
253_G	256_Y	0.678	0.28
226_D	230_T	0.677	0.28
69_T	318_S	0.677	0.28
437_L	441_L	0.675	0.28
636_N	701_A	0.675	0.28
385_I	388_M	0.673	0.27
538_R	666_S	0.673	0.27
594_Q	727_S	0.673	0.27
626_E	747_V	0.672	0.27
691_A	719_T	0.672	0.27
68_N	73_L	0.672	0.27
542_D	626_E	0.671	0.27
183_T	214_A	0.669	0.27
151_S	169_V	0.669	0.27
146_A	206_H	0.669	0.27
400_E	486_A	0.667	0.27
637_I	677_V	0.665	0.27
622_S	684_T	0.665	0.27
268_L	274_Q	0.664	0.27
540_M	618_V	0.664	0.27
684_T	741_V	0.664	0.27
481_F	706_V	0.663	0.27
589_R	740_A	0.663	0.27
622_S	768_Q	0.662	0.27
141_G	307_K	0.662	0.27
541_L	583_A	0.661	0.27
303_W	315_F	0.659	0.27
542_D	546_G	0.659	0.27
98_A	351_V	0.659	0.27
626_E	688_A	0.659	0.27
685_V	698_G	0.658	0.27
671_E	744_T	0.657	0.27
478_A	561_S	0.657	0.27
316_A	404_E	0.657	0.27
298_V	321_I	0.657	0.27
148_I	152_T	0.657	0.27
695_M	740_A	0.656	0.26
551_L	688_A	0.655	0.26
648_G	652_V	0.654	0.26
267_A	271_A	0.654	0.26
141_G	172_T	0.653	0.26
180_V	201_A	0.653	0.26
478_A	636_N	0.652	0.26
472_E	589_R	0.651	0.26
38_K	350_A	0.651	0.26
537_Q	666_S	0.649	0.26
499_A	559_A	0.648	0.26
540_M	654_D	0.648	0.26
648_G	670_I	0.646	0.26
687_E	720_D	0.646	0.26
48_V	404_E	0.646	0.26
739_E	754_T	0.645	0.26
536_E	661_E	0.645	0.26
88_L	91_N	0.644	0.26
627_Q	655_E	0.643	0.26
403_R	407_T	0.642	0.26
667_A	673_R	0.642	0.26
614_I	648_G	0.642	0.26
586_A	594_Q	0.640	0.26
130_I	133_V	0.640	0.26
530_I	629_N	0.638	0.25
211_E	228_T	0.638	0.25
623_D	630_M	0.638	0.25
661_E	681_T	0.637	0.25
547_E	616_E	0.635	0.25
646_G	659_L	0.634	0.25
180_V	294_A	0.634	0.25
540_M	757_E	0.633	0.25
388_M	492_I	0.633	0.25
709_F	761_V	0.633	0.25
633_L	725_E	0.632	0.25
444_Q	474_M	0.631	0.25
617_I	692_E	0.630	0.25
593_V	623_D	0.630	0.25
117_V	121_V	0.629	0.25
610_Q	613_E	0.628	0.25
151_S	198_M	0.628	0.25
159_T	162_S	0.627	0.25
536_E	733_Q	0.627	0.25
459_D	485_L	0.626	0.25
580_E	699_I	0.626	0.25
629_N	657_K	0.625	0.25
540_M	733_Q	0.625	0.25
490_H	710_T	0.624	0.25
639_A	651_V	0.624	0.25
481_F	489_E	0.624	0.25
637_I	655_E	0.624	0.25
620_L	662_E	0.622	0.25
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534_A	747_V	0.621	0.25
670_I	698_G	0.621	0.25
611_M	687_E	0.620	0.25
616_E	723_V	0.620	0.25
59_A	331_V	0.619	0.24
702_V	762_S	0.618	0.24
187_R	370_V	0.618	0.24
675_T	705_V	0.617	0.24
488_W	495_I	0.616	0.24
583_A	611_M	0.616	0.24
128_D	133_V	0.615	0.24
300_G	303_W	0.615	0.24
685_V	729_T	0.615	0.24
459_D	585_D	0.614	0.24
395_Q	399_A	0.614	0.24
594_Q	609_D	0.614	0.24
462_R	477_I	0.613	0.24
561_S	658_D	0.612	0.24
553_A	571_Q	0.612	0.24
314_A	351_V	0.611	0.24
594_Q	692_E	0.610	0.24
35_Y	395_Q	0.610	0.24
374_R	749_D	0.608	0.24
364_G	712_V	0.606	0.24
550_D	734_A	0.604	0.24
366_Y	392_L	0.604	0.24
230_T	245_S	0.604	0.24
666_S	709_F	0.604	0.24
488_W	674_I	0.603	0.24
472_E	484_M	0.603	0.24
609_D	612_A	0.602	0.24
166_H	169_V	0.602	0.24
626_E	636_N	0.601	0.24
637_I	681_T	0.601	0.24
77_A	305_V	0.600	0.23
125_L	221_F	0.599	0.23
620_L	723_V	0.599	0.23
626_E	695_M	0.598	0.23
166_H	188_T	0.598	0.23
255_P	270_S	0.598	0.23
614_I	670_I	0.597	0.23
582_T	687_E	0.597	0.23
580_E	619_D	0.597	0.23
47_L	54_G	0.595	0.23
586_A	705_V	0.595	0.23
687_E	692_E	0.594	0.23
689_R	699_I	0.594	0.23
499_A	571_Q	0.594	0.23
734_A	737_T	0.593	0.23
647_D	741_V	0.593	0.23
448_Y	474_M	0.591	0.23
159_T	262_Q	0.591	0.23
556_E	724_Q	0.591	0.23
148_I	156_A	0.591	0.23
529_E	555_I	0.591	0.23
640_A	660_A	0.591	0.23
620_L	663_T	0.590	0.23
684_T	737_T	0.590	0.23
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565_V	610_Q	0.590	0.23
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539_N	560_A	0.588	0.23
698_G	754_T	0.587	0.23
351_V	391_A	0.586	0.23
370_V	386_G	0.585	0.23
141_G	201_A	0.585	0.23
445_A	474_M	0.585	0.23
637_I	664_Q	0.583	0.23
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329_I	333_L	0.582	0.23
698_G	733_Q	0.581	0.23
614_I	629_N	0.581	0.23
667_A	705_V	0.580	0.22
610_Q	661_E	0.580	0.22
349_A	353_S	0.579	0.22
136_A	140_V	0.579	0.22
159_T	168_W	0.579	0.22
615_S	709_F	0.576	0.22
292_V	314_A	0.576	0.22
676_E	714_D	0.574	0.22
357_A	368_V	0.573	0.22
533_A	684_T	0.572	0.22
262_Q	269_D	0.572	0.22
192_Q	303_W	0.571	0.22
630_M	719_T	0.571	0.22
388_M	636_N	0.570	0.22
358_A	362_E	0.569	0.22
66_E	357_A	0.569	0.22
571_Q	703_E	0.569	0.22
228_T	231_Q	0.568	0.22
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661_E	674_I	0.567	0.22
133_V	137_D	0.566	0.22
272_T	278_T	0.566	0.22
460_L	487_Q	0.565	0.22
65_L	80_D	0.565	0.22
54_G	73_L	0.565	0.22
464_M	474_M	0.564	0.22
200_V	276_Q	0.563	0.22
694_S	698_G	0.562	0.22
678_Q	709_F	0.561	0.22
346_N	350_A	0.561	0.22
547_E	734_A	0.561	0.22
84_I	217_L	0.561	0.22
252_V	274_Q	0.561	0.22
626_E	652_V	0.561	0.22
474_M	733_Q	0.560	0.22
627_Q	637_I	0.560	0.22
92_E	98_A	0.559	0.21
539_N	761_V	0.558	0.21
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264_E	337_V	0.557	0.21
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589_R	624_I	0.557	0.21
227_G	243_L	0.556	0.21
617_I	687_E	0.556	0.21
177_R	201_A	0.556	0.21
695_M	699_I	0.556	0.21
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93_Q	97_I	0.555	0.21
367_D	440_E	0.555	0.21
531_A	713_S	0.555	0.21
270_S	274_Q	0.555	0.21
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477_I	549_T	0.555	0.21
91_N	99_S	0.554	0.21
549_T	732_D	0.554	0.21
701_A	768_Q	0.554	0.21
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480_S	661_E	0.552	0.21
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620_L	692_E	0.550	0.21
99_S	166_H	0.550	0.21
136_A	143_A	0.550	0.21
484_M	758_A	0.549	0.21
539_N	626_E	0.549	0.21
480_S	633_L	0.548	0.21
501_A	751_S	0.548	0.21
328_F	360_E	0.547	0.21
611_M	691_A	0.546	0.21
154_E	157_R	0.546	0.21
149_V	332_A	0.546	0.21
615_S	621_I	0.546	0.21
573_A	702_V	0.546	0.21
527_V	733_Q	0.545	0.21
562_A	610_Q	0.545	0.21
365_N	368_V	0.545	0.21
121_V	290_E	0.545	0.21
622_S	740_A	0.544	0.21
41_V	212_Y	0.544	0.21
589_R	636_N	0.544	0.21
726_I	733_Q	0.544	0.21
453_A	480_S	0.544	0.21
701_A	751_S	0.543	0.21
614_I	659_L	0.542	0.21
381_L	398_E	0.542	0.21
185_P	188_T	0.541	0.21
172_T	251_A	0.541	0.21
394_T	398_E	0.540	0.21
178_D	191_G	0.539	0.21
155_D	158_G	0.539	0.21
625_A	656_V	0.539	0.21
765_A	768_Q	0.538	0.20
556_E	569_S	0.537	0.20
150_A	154_E	0.536	0.20
667_A	671_E	0.535	0.20
91_N	94_S	0.535	0.20
533_A	626_E	0.535	0.20
84_I	140_V	0.534	0.20
580_E	663_T	0.534	0.20
291_Y	295_Y	0.534	0.20
181_V	198_M	0.533	0.20
579_G	622_S	0.532	0.20
657_K	719_T	0.530	0.20
545_S	744_T	0.530	0.20
529_E	726_I	0.530	0.20
373_S	527_V	0.529	0.20
168_W	309_A	0.529	0.20
145_D	174_S	0.529	0.20
655_E	698_G	0.529	0.20
140_V	185_P	0.528	0.20
666_S	670_I	0.528	0.20
500_D	527_V	0.528	0.20
630_M	744_T	0.528	0.20
406_A	757_E	0.527	0.20
150_A	196_S	0.527	0.20
158_G	191_G	0.526	0.20
768_Q	771_S	0.526	0.20
480_S	654_D	0.526	0.20
79_S	234_R	0.525	0.20
523_V	680_Q	0.524	0.20
231_Q	245_S	0.524	0.20
474_M	726_I	0.523	0.20
643_D	663_T	0.523	0.20
184_N	198_M	0.522	0.20
674_I	695_M	0.522	0.20
265_I	272_T	0.522	0.20
535_D	698_G	0.522	0.20
562_A	677_V	0.522	0.20
82_T	104_L	0.521	0.20
364_G	458_G	0.520	0.20
234_R	238_D	0.520	0.20
555_I	558_V	0.519	0.20
642_A	648_G	0.518	0.20
677_V	689_R	0.518	0.20
47_L	61_A	0.517	0.20
642_A	651_V	0.517	0.20
642_A	674_I	0.516	0.19
165_T	169_V	0.515	0.19
474_M	761_V	0.515	0.19
566_A	709_F	0.514	0.19
484_M	506_S	0.514	0.19
617_I	681_T	0.513	0.19
642_A	652_V	0.513	0.19
402_A	407_T	0.513	0.19
562_A	685_V	0.513	0.19
452_M	464_M	0.513	0.19
309_A	390_D	0.513	0.19
625_A	628_T	0.512	0.19
640_A	646_G	0.512	0.19
129_R	137_D	0.511	0.19
125_L	296_T	0.511	0.19
131_A	273_E	0.510	0.19
70_E	670_I	0.510	0.19
48_V	326_L	0.509	0.19
560_A	564_S	0.509	0.19
591_L	706_V	0.508	0.19
536_E	746_E	0.508	0.19
549_T	616_E	0.507	0.19
586_A	630_M	0.505	0.19
533_A	623_D	0.505	0.19
688_A	741_V	0.505	0.19
124_E	137_D	0.505	0.19
485_L	524_S	0.504	0.19
192_Q	197_S	0.504	0.19
675_T	758_A	0.503	0.19
39_F	42_A	0.503	0.19
355_S	361_I	0.501	0.19
574_E	707_D	0.501	0.19
472_E	624_I	0.501	0.19
158_G	310_P	0.501	0.19
131_A	137_D	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.3753	100	0.66	Contact Map
1qu7A	2	0.2802	100	0.711	Contact Map
2ch7A	2	0.3815	100	0.712	Contact Map
3g67A	2	0.258	100	0.766	Contact Map
4i3mA	2	0.1852	99.9	0.865	Contact Map
3li9A	2	0.2901	99.8	0.885	Contact Map
3libA	3	0.3012	99.8	0.886	Contact Map
4cq4A	4	0.1062	99.8	0.889	Contact Map
3lifA	1	0.2951	99.8	0.889	Contact Map
3lidA	2	0.3198	99.8	0.891	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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