GREMLIN Database
Q9HP83 - Putative ABC transporter
UniProt: Q9HP83 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (287)
Sequences: 2517 (1831)
Seq/√Len: 108.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_R320_N4.9241.00
164_E261_D4.3171.00
176_S269_D4.2571.00
304_D307_T3.8401.00
162_V172_I3.7231.00
147_R284_E3.5431.00
325_A329_Q3.2731.00
166_A170_T3.2381.00
164_E264_R2.9341.00
164_E168_E2.9181.00
173_Q264_R2.8061.00
192_A245_A2.7301.00
314_R326_D2.6641.00
307_T311_L2.6291.00
284_E288_T2.5661.00
301_A331_N2.5201.00
307_T331_N2.4771.00
146_I281_V2.3941.00
71_Y84_D2.3811.00
258_T310_A2.3531.00
150_D296_N2.3471.00
245_A248_G2.2561.00
161_F250_G2.2211.00
145_P284_E2.2201.00
206_A272_F2.2191.00
56_G103_V2.2041.00
130_D134_D2.0991.00
73_L294_A2.0811.00
96_E99_R2.0791.00
208_L214_D2.0591.00
54_V83_V2.0371.00
315_A323_A1.9861.00
57_S67_G1.9631.00
174_S267_D1.9531.00
72_E325_A1.8911.00
68_Y72_E1.8841.00
120_K139_E1.8511.00
52_S81_T1.8511.00
141_E284_E1.8461.00
160_V247_L1.8361.00
65_T315_A1.8191.00
301_A327_H1.8121.00
95_S144_H1.8051.00
73_L298_M1.7521.00
52_S83_V1.7431.00
128_T131_A1.7381.00
326_D330_N1.7121.00
306_E309_Q1.7031.00
320_N326_D1.6781.00
314_R318_S1.6681.00
159_A265_V1.6561.00
68_Y84_D1.6331.00
141_E147_R1.6261.00
148_I279_V1.6001.00
77_T297_T1.5901.00
159_A252_S1.5761.00
70_A107_Y1.5731.00
163_A243_G1.5701.00
147_R292_V1.5641.00
162_V166_A1.5621.00
173_Q267_D1.5461.00
27_A30_G1.5381.00
157_T252_S1.5371.00
113_L136_L1.5311.00
287_A291_V1.5081.00
321_Q325_A1.5021.00
118_P139_E1.4731.00
173_Q177_D1.4551.00
154_W308_M1.4481.00
73_L333_F1.4431.00
172_I181_H1.4201.00
61_G316_A1.4041.00
170_T181_H1.3931.00
53_I80_A1.3851.00
174_S269_D1.3811.00
258_T309_Q1.3801.00
189_I247_L1.3661.00
310_A314_R1.3661.00
194_G251_Y1.3391.00
134_D138_S1.3250.99
238_T242_E1.3250.99
66_L278_P1.3160.99
78_T294_A1.3140.99
322_Q326_D1.2900.99
72_E321_Q1.2900.99
95_S140_M1.2870.99
126_F131_A1.2820.99
163_A166_A1.2790.99
302_I311_L1.2670.99
149_L282_V1.2630.99
75_A84_D1.2570.99
167_V172_I1.2440.99
91_N117_H1.2330.99
154_W278_P1.2260.99
55_V105_A1.2250.99
80_A290_A1.2180.99
113_L140_M1.2130.99
155_Q305_A1.2040.99
140_M148_I1.1940.99
307_T327_H1.1880.99
70_A295_L1.1850.99
67_G86_T1.1690.99
313_S318_S1.1680.99
59_G87_G1.1520.99
210_Y272_F1.1460.98
190_R216_E1.1350.98
110_M133_Y1.1300.98
71_Y82_L1.1280.98
139_E143_E1.1250.98
149_L280_G1.1240.98
283_H286_V1.1110.98
287_A292_V1.1090.98
70_A280_G1.1010.98
134_D137_K1.1000.98
296_N299_P1.1000.98
58_K106_Y1.0990.98
243_G246_D1.0940.98
95_S99_R1.0910.98
69_V298_M1.0870.98
186_N213_F1.0860.98
153_D300_D1.0820.98
159_A175_I1.0790.98
31_C34_I1.0730.98
135_A139_E1.0520.97
69_V327_H1.0490.97
176_S270_R1.0420.97
161_F265_V1.0420.97
148_I281_V1.0410.97
126_F135_A1.0410.97
314_R322_Q1.0370.97
133_Y151_R1.0330.97
190_R246_D1.0300.97
57_S84_D1.0290.97
68_Y321_Q1.0280.97
54_V85_E1.0250.97
168_E267_D1.0240.97
113_L148_I1.0210.97
62_E253_T1.0190.97
194_G233_A1.0150.97
24_G27_A1.0080.97
236_A249_V1.0070.97
63_Q107_Y1.0060.96
175_I213_F1.0050.96
64_V87_G1.0000.96
69_V72_E1.0000.96
137_K141_E0.9990.96
67_G84_D0.9970.96
196_G200_R0.9890.96
306_E310_A0.9880.96
24_G28_V0.9780.96
256_W316_A0.9720.96
250_G257_L0.9680.96
198_R230_T0.9650.96
133_Y137_K0.9630.96
292_V296_N0.9590.95
112_S202_D0.9570.95
104_H283_H0.9570.95
193_F197_F0.9540.95
135_A138_S0.9510.95
75_A82_L0.9500.95
57_S86_T0.9330.95
97_A102_N0.9320.95
236_A248_G0.9290.95
307_T310_A0.9270.94
59_G251_Y0.9230.94
28_V31_C0.9220.94
68_Y71_Y0.9210.94
178_L247_L0.9190.94
110_M279_V0.9170.94
114_W132_Q0.9140.94
20_L24_G0.9080.94
69_V73_L0.9060.94
162_V170_T0.9040.94
310_A313_S0.8940.93
105_A282_V0.8940.93
255_A316_A0.8910.93
98_Y146_I0.8800.93
26_T29_A0.8730.93
210_Y270_R0.8700.92
282_V287_A0.8670.92
105_A295_L0.8620.92
291_V294_A0.8600.92
163_A246_D0.8530.92
190_R217_R0.8480.91
72_E75_A0.8470.91
179_A186_N0.8460.91
286_V291_V0.8440.91
133_Y279_V0.8370.91
305_A309_Q0.8340.91
166_A169_G0.8300.90
131_A135_A0.8280.90
108_D113_L0.8200.90
172_I177_D0.8180.90
326_D329_Q0.8140.90
302_I308_M0.8140.90
241_D263_V0.8120.90
166_A189_I0.8090.89
179_A213_F0.8060.89
201_S205_D0.8050.89
74_L78_T0.8030.89
20_L25_T0.8020.89
278_P308_M0.7980.89
313_S317_A0.7930.88
231_A251_Y0.7900.88
155_Q252_S0.7890.88
194_G249_V0.7850.88
250_G265_V0.7830.88
168_E293_A0.7810.88
117_H140_M0.7810.88
165_R169_G0.7810.88
151_R277_H0.7810.88
167_V177_D0.7800.88
140_M281_V0.7770.87
194_G236_A0.7770.87
240_V248_G0.7760.87
131_A134_D0.7730.87
53_I286_V0.7650.87
152_A278_P0.7610.86
191_P204_L0.7590.86
186_N216_E0.7590.86
71_Y75_A0.7580.86
181_H189_I0.7560.86
180_A186_N0.7550.86
51_S80_A0.7540.86
177_D180_A0.7530.86
160_V175_I0.7520.86
54_V82_L0.7490.85
178_L189_I0.7440.85
69_V311_L0.7400.85
140_M144_H0.7400.85
230_T233_A0.7370.84
165_R330_N0.7360.84
58_K108_D0.7360.84
212_E270_R0.7340.84
72_E77_T0.7340.84
61_G315_A0.7340.84
57_S63_Q0.7320.84
237_G256_W0.7320.84
231_A245_A0.7300.84
23_G27_A0.7300.84
121_H126_F0.7260.84
296_N300_D0.7260.84
241_D260_V0.7200.83
175_I266_L0.7190.83
294_A298_M0.7150.83
149_L292_V0.7140.83
61_G255_A0.7110.82
95_S281_V0.7090.82
194_G231_A0.7080.82
204_L215_P0.7080.82
204_L208_L0.7060.82
171_G180_A0.7060.82
141_E145_P0.7050.82
257_L263_V0.7030.82
166_A181_H0.7010.81
282_V286_V0.7000.81
181_H188_D0.6970.81
297_T333_F0.6910.80
56_G88_F0.6880.80
145_P171_G0.6880.80
88_F93_A0.6850.80
89_G93_A0.6840.80
169_G173_Q0.6810.79
164_E173_Q0.6810.79
207_L213_F0.6730.79
132_Q275_F0.6670.78
168_E171_G0.6660.78
112_S276_F0.6660.78
159_A250_G0.6650.78
169_G270_R0.6620.78
23_G26_T0.6590.77
172_I175_I0.6590.77
202_D274_P0.6590.77
120_K135_A0.6580.77
60_Y109_Y0.6570.77
74_L79_N0.6570.77
161_F257_L0.6550.77
60_Y196_G0.6530.77
97_A103_V0.6510.76
145_P330_N0.6500.76
58_K196_G0.6430.76
168_E261_D0.6430.76
211_Y270_R0.6400.75
134_D168_E0.6390.75
95_S117_H0.6370.75
137_K147_R0.6360.75
98_Y283_H0.6350.75
121_H135_A0.6340.74
236_A256_W0.6320.74
74_L291_V0.6320.74
158_W276_F0.6310.74
126_F132_Q0.6310.74
192_A239_A0.6260.74
16_L19_M0.6210.73
96_E100_T0.6210.73
138_S288_T0.6190.73
160_V207_L0.6170.72
22_A26_T0.6160.72
55_V70_A0.6150.72
22_A25_T0.6140.72
193_F204_L0.6140.72
152_A302_I0.6140.72
70_A299_P0.6120.72
56_G93_A0.6100.72
179_A212_E0.6070.71
198_R204_L0.6040.71
53_I104_H0.6030.71
99_R144_H0.6020.71
258_T261_D0.6010.71
58_K112_S0.6010.71
60_Y112_S0.6000.70
197_F249_V0.5970.70
261_D264_R0.5920.69
256_W260_V0.5910.69
110_M202_D0.5880.69
59_G91_N0.5870.69
167_V175_I0.5860.69
58_K63_Q0.5850.68
231_A235_A0.5840.68
258_T306_E0.5830.68
98_Y106_Y0.5830.68
166_A246_D0.5820.68
202_D276_F0.5790.68
202_D273_W0.5790.68
110_M276_F0.5790.68
162_V247_L0.5790.68
111_G276_F0.5780.68
71_Y86_T0.5780.68
155_Q276_F0.5760.67
134_D180_A0.5750.67
153_D278_P0.5740.67
31_C46_G0.5730.67
97_A253_T0.5730.67
141_E144_H0.5730.67
120_K143_E0.5720.67
117_H144_H0.5720.67
255_A309_Q0.5720.67
230_T234_Q0.5710.67
16_L27_A0.5690.66
172_I266_L0.5680.66
160_V197_F0.5680.66
28_V33_T0.5670.66
203_G206_A0.5670.66
74_L80_A0.5640.66
161_F263_V0.5630.66
101_G282_V0.5630.66
293_A296_N0.5630.66
189_I246_D0.5630.66
261_D271_N0.5630.66
69_V328_L0.5630.66
301_A306_E0.5620.65
191_P247_L0.5610.65
94_I106_Y0.5600.65
91_N94_I0.5590.65
21_A28_V0.5580.65
160_V249_V0.5570.65
53_I105_A0.5570.65
280_G299_P0.5570.65
79_N288_T0.5560.65
25_T29_A0.5520.64
18_G23_G0.5520.64
209_D326_D0.5520.64
64_V86_T0.5490.64
290_A294_A0.5480.63
257_L265_V0.5470.63
209_D289_D0.5470.63
133_Y149_L0.5460.63
240_V244_Y0.5450.63
129_P275_F0.5430.63
173_Q216_E0.5430.63
58_K94_I0.5430.63
61_G323_A0.5420.63
149_L296_N0.5410.62
20_L27_A0.5410.62
166_A172_I0.5400.62
101_G283_H0.5390.62
60_Y63_Q0.5370.62
19_M26_T0.5360.62
162_V167_V0.5360.62
193_F198_R0.5350.62
62_E66_L0.5340.61
238_T241_D0.5330.61
257_L260_V0.5330.61
112_S118_P0.5320.61
259_D317_A0.5320.61
29_A32_T0.5300.61
283_H287_A0.5280.61
241_D257_L0.5270.60
21_A25_T0.5270.60
145_P288_T0.5270.60
187_Y214_D0.5270.60
55_V74_L0.5270.60
58_K91_N0.5270.60
167_V264_R0.5260.60
197_F273_W0.5240.60
145_P285_D0.5230.60
280_G295_L0.5230.60
197_F203_G0.5220.60
22_A50_S0.5220.60
285_D292_V0.5220.60
55_V85_E0.5210.60
158_W194_G0.5200.59
103_V106_Y0.5200.59
134_D288_T0.5200.59
217_R229_E0.5200.59
237_G254_S0.5200.59
158_W251_Y0.5190.59
89_G240_V0.5190.59
158_W203_G0.5180.59
300_D304_D0.5180.59
298_M327_H0.5180.59
91_N116_S0.5160.59
25_T31_C0.5160.59
59_G90_G0.5160.59
150_D299_P0.5150.59
248_G256_W0.5140.59
207_L272_F0.5140.59
198_R246_D0.5120.58
114_W280_G0.5110.58
59_G196_G0.5090.58
22_A27_A0.5090.58
200_R312_N0.5070.58
22_A296_N0.5070.58
205_D209_D0.5060.57
46_G49_G0.5040.57
98_Y242_E0.5030.57
61_G155_Q0.5030.57
17_L21_A0.5010.57
152_A300_D0.5010.57
18_G32_T0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o66A 1 0.7964 100 0.428 Contact Map
4ne4A 1 0.8024 100 0.451 Contact Map
3r6uA 1 0.7904 100 0.481 Contact Map
1sw5A 1 0.7964 100 0.509 Contact Map
1r9lA 1 0.7545 100 0.617 Contact Map
2rinA 1 0.7335 100 0.692 Contact Map
3l6gA 1 0.7126 99.9 0.725 Contact Map
3tmgA 1 0.7186 99.9 0.726 Contact Map
2b4lA 1 0.4341 99.9 0.77 Contact Map
3un6A 1 0.7096 99.6 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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