Q9HP83 - HALSA - GREMLIN Contacts

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Q9HP83 - Putative ABC transporter

UniProt:	Q9HP83	Sequences: MMDTPEHASTSSRRQLLGMLAAGGTTAVAGCTTITGGGDTTSTGGGDSGSSSIVVGSKGYGEQVTLGYVAYELLANTTNATLVDETGFGGNAAISEAYRTGNVHAYYDYMGSLWSSHPPKHDSADFDTPDAQYDALKSEMESEHPIRILDRADWQNTWAVFVAERAVEGTGIQSISDLAAHVNSRNYDIRPAFGDGFRSRSDGLDALLDYYEFDPERVTAWASEREFLETASAQAAGTAVDEGYADLGVGYSTSAWLTDVDSVRVLDDDRNFWPFFHPVGVVHEDVATDAVVAALNTMPDAIPDAETMQALNSRAAASGNQQAAADHLQNNDFI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	334 (287)
Sequences:	2517 (1831)
Seq/√Len:	108.1

ECOLI - OSMF
BACSU - OPUBC OPUCC
HALSA - Q9HP83

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
314_R	320_N	4.924	1.00
164_E	261_D	4.317	1.00
176_S	269_D	4.257	1.00
304_D	307_T	3.840	1.00
162_V	172_I	3.723	1.00
147_R	284_E	3.543	1.00
325_A	329_Q	3.273	1.00
166_A	170_T	3.238	1.00
164_E	264_R	2.934	1.00
164_E	168_E	2.918	1.00
173_Q	264_R	2.806	1.00
192_A	245_A	2.730	1.00
314_R	326_D	2.664	1.00
307_T	311_L	2.629	1.00
284_E	288_T	2.566	1.00
301_A	331_N	2.520	1.00
307_T	331_N	2.477	1.00
146_I	281_V	2.394	1.00
71_Y	84_D	2.381	1.00
258_T	310_A	2.353	1.00
150_D	296_N	2.347	1.00
245_A	248_G	2.256	1.00
161_F	250_G	2.221	1.00
145_P	284_E	2.220	1.00
206_A	272_F	2.219	1.00
56_G	103_V	2.204	1.00
130_D	134_D	2.099	1.00
73_L	294_A	2.081	1.00
96_E	99_R	2.079	1.00
208_L	214_D	2.059	1.00
54_V	83_V	2.037	1.00
315_A	323_A	1.986	1.00
57_S	67_G	1.963	1.00
174_S	267_D	1.953	1.00
72_E	325_A	1.891	1.00
68_Y	72_E	1.884	1.00
120_K	139_E	1.851	1.00
52_S	81_T	1.851	1.00
141_E	284_E	1.846	1.00
160_V	247_L	1.836	1.00
65_T	315_A	1.819	1.00
301_A	327_H	1.812	1.00
95_S	144_H	1.805	1.00
73_L	298_M	1.752	1.00
52_S	83_V	1.743	1.00
128_T	131_A	1.738	1.00
326_D	330_N	1.712	1.00
306_E	309_Q	1.703	1.00
320_N	326_D	1.678	1.00
314_R	318_S	1.668	1.00
159_A	265_V	1.656	1.00
68_Y	84_D	1.633	1.00
141_E	147_R	1.626	1.00
148_I	279_V	1.600	1.00
77_T	297_T	1.590	1.00
159_A	252_S	1.576	1.00
70_A	107_Y	1.573	1.00
163_A	243_G	1.570	1.00
147_R	292_V	1.564	1.00
162_V	166_A	1.562	1.00
173_Q	267_D	1.546	1.00
27_A	30_G	1.538	1.00
157_T	252_S	1.537	1.00
113_L	136_L	1.531	1.00
287_A	291_V	1.508	1.00
321_Q	325_A	1.502	1.00
118_P	139_E	1.473	1.00
173_Q	177_D	1.455	1.00
154_W	308_M	1.448	1.00
73_L	333_F	1.443	1.00
172_I	181_H	1.420	1.00
61_G	316_A	1.404	1.00
170_T	181_H	1.393	1.00
53_I	80_A	1.385	1.00
174_S	269_D	1.381	1.00
258_T	309_Q	1.380	1.00
189_I	247_L	1.366	1.00
310_A	314_R	1.366	1.00
194_G	251_Y	1.339	1.00
134_D	138_S	1.325	0.99
238_T	242_E	1.325	0.99
66_L	278_P	1.316	0.99
78_T	294_A	1.314	0.99
322_Q	326_D	1.290	0.99
72_E	321_Q	1.290	0.99
95_S	140_M	1.287	0.99
126_F	131_A	1.282	0.99
163_A	166_A	1.279	0.99
302_I	311_L	1.267	0.99
149_L	282_V	1.263	0.99
75_A	84_D	1.257	0.99
167_V	172_I	1.244	0.99
91_N	117_H	1.233	0.99
154_W	278_P	1.226	0.99
55_V	105_A	1.225	0.99
80_A	290_A	1.218	0.99
113_L	140_M	1.213	0.99
155_Q	305_A	1.204	0.99
140_M	148_I	1.194	0.99
307_T	327_H	1.188	0.99
70_A	295_L	1.185	0.99
67_G	86_T	1.169	0.99
313_S	318_S	1.168	0.99
59_G	87_G	1.152	0.99
210_Y	272_F	1.146	0.98
190_R	216_E	1.135	0.98
110_M	133_Y	1.130	0.98
71_Y	82_L	1.128	0.98
139_E	143_E	1.125	0.98
149_L	280_G	1.124	0.98
283_H	286_V	1.111	0.98
287_A	292_V	1.109	0.98
70_A	280_G	1.101	0.98
134_D	137_K	1.100	0.98
296_N	299_P	1.100	0.98
58_K	106_Y	1.099	0.98
243_G	246_D	1.094	0.98
95_S	99_R	1.091	0.98
69_V	298_M	1.087	0.98
186_N	213_F	1.086	0.98
153_D	300_D	1.082	0.98
159_A	175_I	1.079	0.98
31_C	34_I	1.073	0.98
135_A	139_E	1.052	0.97
69_V	327_H	1.049	0.97
176_S	270_R	1.042	0.97
161_F	265_V	1.042	0.97
148_I	281_V	1.041	0.97
126_F	135_A	1.041	0.97
314_R	322_Q	1.037	0.97
133_Y	151_R	1.033	0.97
190_R	246_D	1.030	0.97
57_S	84_D	1.029	0.97
68_Y	321_Q	1.028	0.97
54_V	85_E	1.025	0.97
168_E	267_D	1.024	0.97
113_L	148_I	1.021	0.97
62_E	253_T	1.019	0.97
194_G	233_A	1.015	0.97
24_G	27_A	1.008	0.97
236_A	249_V	1.007	0.97
63_Q	107_Y	1.006	0.96
175_I	213_F	1.005	0.96
64_V	87_G	1.000	0.96
69_V	72_E	1.000	0.96
137_K	141_E	0.999	0.96
67_G	84_D	0.997	0.96
196_G	200_R	0.989	0.96
306_E	310_A	0.988	0.96
24_G	28_V	0.978	0.96
256_W	316_A	0.972	0.96
250_G	257_L	0.968	0.96
198_R	230_T	0.965	0.96
133_Y	137_K	0.963	0.96
292_V	296_N	0.959	0.95
112_S	202_D	0.957	0.95
104_H	283_H	0.957	0.95
193_F	197_F	0.954	0.95
135_A	138_S	0.951	0.95
75_A	82_L	0.950	0.95
57_S	86_T	0.933	0.95
97_A	102_N	0.932	0.95
236_A	248_G	0.929	0.95
307_T	310_A	0.927	0.94
59_G	251_Y	0.923	0.94
28_V	31_C	0.922	0.94
68_Y	71_Y	0.921	0.94
178_L	247_L	0.919	0.94
110_M	279_V	0.917	0.94
114_W	132_Q	0.914	0.94
20_L	24_G	0.908	0.94
69_V	73_L	0.906	0.94
162_V	170_T	0.904	0.94
310_A	313_S	0.894	0.93
105_A	282_V	0.894	0.93
255_A	316_A	0.891	0.93
98_Y	146_I	0.880	0.93
26_T	29_A	0.873	0.93
210_Y	270_R	0.870	0.92
282_V	287_A	0.867	0.92
105_A	295_L	0.862	0.92
291_V	294_A	0.860	0.92
163_A	246_D	0.853	0.92
190_R	217_R	0.848	0.91
72_E	75_A	0.847	0.91
179_A	186_N	0.846	0.91
286_V	291_V	0.844	0.91
133_Y	279_V	0.837	0.91
305_A	309_Q	0.834	0.91
166_A	169_G	0.830	0.90
131_A	135_A	0.828	0.90
108_D	113_L	0.820	0.90
172_I	177_D	0.818	0.90
326_D	329_Q	0.814	0.90
302_I	308_M	0.814	0.90
241_D	263_V	0.812	0.90
166_A	189_I	0.809	0.89
179_A	213_F	0.806	0.89
201_S	205_D	0.805	0.89
74_L	78_T	0.803	0.89
20_L	25_T	0.802	0.89
278_P	308_M	0.798	0.89
313_S	317_A	0.793	0.88
231_A	251_Y	0.790	0.88
155_Q	252_S	0.789	0.88
194_G	249_V	0.785	0.88
250_G	265_V	0.783	0.88
168_E	293_A	0.781	0.88
117_H	140_M	0.781	0.88
165_R	169_G	0.781	0.88
151_R	277_H	0.781	0.88
167_V	177_D	0.780	0.88
140_M	281_V	0.777	0.87
194_G	236_A	0.777	0.87
240_V	248_G	0.776	0.87
131_A	134_D	0.773	0.87
53_I	286_V	0.765	0.87
152_A	278_P	0.761	0.86
191_P	204_L	0.759	0.86
186_N	216_E	0.759	0.86
71_Y	75_A	0.758	0.86
181_H	189_I	0.756	0.86
180_A	186_N	0.755	0.86
51_S	80_A	0.754	0.86
177_D	180_A	0.753	0.86
160_V	175_I	0.752	0.86
54_V	82_L	0.749	0.85
178_L	189_I	0.744	0.85
69_V	311_L	0.740	0.85
140_M	144_H	0.740	0.85
230_T	233_A	0.737	0.84
165_R	330_N	0.736	0.84
58_K	108_D	0.736	0.84
212_E	270_R	0.734	0.84
72_E	77_T	0.734	0.84
61_G	315_A	0.734	0.84
57_S	63_Q	0.732	0.84
237_G	256_W	0.732	0.84
231_A	245_A	0.730	0.84
23_G	27_A	0.730	0.84
121_H	126_F	0.726	0.84
296_N	300_D	0.726	0.84
241_D	260_V	0.720	0.83
175_I	266_L	0.719	0.83
294_A	298_M	0.715	0.83
149_L	292_V	0.714	0.83
61_G	255_A	0.711	0.82
95_S	281_V	0.709	0.82
194_G	231_A	0.708	0.82
204_L	215_P	0.708	0.82
204_L	208_L	0.706	0.82
171_G	180_A	0.706	0.82
141_E	145_P	0.705	0.82
257_L	263_V	0.703	0.82
166_A	181_H	0.701	0.81
282_V	286_V	0.700	0.81
181_H	188_D	0.697	0.81
297_T	333_F	0.691	0.80
56_G	88_F	0.688	0.80
145_P	171_G	0.688	0.80
88_F	93_A	0.685	0.80
89_G	93_A	0.684	0.80
169_G	173_Q	0.681	0.79
164_E	173_Q	0.681	0.79
207_L	213_F	0.673	0.79
132_Q	275_F	0.667	0.78
168_E	171_G	0.666	0.78
112_S	276_F	0.666	0.78
159_A	250_G	0.665	0.78
169_G	270_R	0.662	0.78
23_G	26_T	0.659	0.77
172_I	175_I	0.659	0.77
202_D	274_P	0.659	0.77
120_K	135_A	0.658	0.77
60_Y	109_Y	0.657	0.77
74_L	79_N	0.657	0.77
161_F	257_L	0.655	0.77
60_Y	196_G	0.653	0.77
97_A	103_V	0.651	0.76
145_P	330_N	0.650	0.76
58_K	196_G	0.643	0.76
168_E	261_D	0.643	0.76
211_Y	270_R	0.640	0.75
134_D	168_E	0.639	0.75
95_S	117_H	0.637	0.75
137_K	147_R	0.636	0.75
98_Y	283_H	0.635	0.75
121_H	135_A	0.634	0.74
236_A	256_W	0.632	0.74
74_L	291_V	0.632	0.74
158_W	276_F	0.631	0.74
126_F	132_Q	0.631	0.74
192_A	239_A	0.626	0.74
16_L	19_M	0.621	0.73
96_E	100_T	0.621	0.73
138_S	288_T	0.619	0.73
160_V	207_L	0.617	0.72
22_A	26_T	0.616	0.72
55_V	70_A	0.615	0.72
22_A	25_T	0.614	0.72
193_F	204_L	0.614	0.72
152_A	302_I	0.614	0.72
70_A	299_P	0.612	0.72
56_G	93_A	0.610	0.72
179_A	212_E	0.607	0.71
198_R	204_L	0.604	0.71
53_I	104_H	0.603	0.71
99_R	144_H	0.602	0.71
258_T	261_D	0.601	0.71
58_K	112_S	0.601	0.71
60_Y	112_S	0.600	0.70
197_F	249_V	0.597	0.70
261_D	264_R	0.592	0.69
256_W	260_V	0.591	0.69
110_M	202_D	0.588	0.69
59_G	91_N	0.587	0.69
167_V	175_I	0.586	0.69
58_K	63_Q	0.585	0.68
231_A	235_A	0.584	0.68
258_T	306_E	0.583	0.68
98_Y	106_Y	0.583	0.68
166_A	246_D	0.582	0.68
202_D	276_F	0.579	0.68
202_D	273_W	0.579	0.68
110_M	276_F	0.579	0.68
162_V	247_L	0.579	0.68
111_G	276_F	0.578	0.68
71_Y	86_T	0.578	0.68
155_Q	276_F	0.576	0.67
134_D	180_A	0.575	0.67
153_D	278_P	0.574	0.67
31_C	46_G	0.573	0.67
97_A	253_T	0.573	0.67
141_E	144_H	0.573	0.67
120_K	143_E	0.572	0.67
117_H	144_H	0.572	0.67
255_A	309_Q	0.572	0.67
230_T	234_Q	0.571	0.67
16_L	27_A	0.569	0.66
172_I	266_L	0.568	0.66
160_V	197_F	0.568	0.66
28_V	33_T	0.567	0.66
203_G	206_A	0.567	0.66
74_L	80_A	0.564	0.66
161_F	263_V	0.563	0.66
101_G	282_V	0.563	0.66
293_A	296_N	0.563	0.66
189_I	246_D	0.563	0.66
261_D	271_N	0.563	0.66
69_V	328_L	0.563	0.66
301_A	306_E	0.562	0.65
191_P	247_L	0.561	0.65
94_I	106_Y	0.560	0.65
91_N	94_I	0.559	0.65
21_A	28_V	0.558	0.65
160_V	249_V	0.557	0.65
53_I	105_A	0.557	0.65
280_G	299_P	0.557	0.65
79_N	288_T	0.556	0.65
25_T	29_A	0.552	0.64
18_G	23_G	0.552	0.64
209_D	326_D	0.552	0.64
64_V	86_T	0.549	0.64
290_A	294_A	0.548	0.63
257_L	265_V	0.547	0.63
209_D	289_D	0.547	0.63
133_Y	149_L	0.546	0.63
240_V	244_Y	0.545	0.63
129_P	275_F	0.543	0.63
173_Q	216_E	0.543	0.63
58_K	94_I	0.543	0.63
61_G	323_A	0.542	0.63
149_L	296_N	0.541	0.62
20_L	27_A	0.541	0.62
166_A	172_I	0.540	0.62
101_G	283_H	0.539	0.62
60_Y	63_Q	0.537	0.62
19_M	26_T	0.536	0.62
162_V	167_V	0.536	0.62
193_F	198_R	0.535	0.62
62_E	66_L	0.534	0.61
238_T	241_D	0.533	0.61
257_L	260_V	0.533	0.61
112_S	118_P	0.532	0.61
259_D	317_A	0.532	0.61
29_A	32_T	0.530	0.61
283_H	287_A	0.528	0.61
241_D	257_L	0.527	0.60
21_A	25_T	0.527	0.60
145_P	288_T	0.527	0.60
187_Y	214_D	0.527	0.60
55_V	74_L	0.527	0.60
58_K	91_N	0.527	0.60
167_V	264_R	0.526	0.60
197_F	273_W	0.524	0.60
145_P	285_D	0.523	0.60
280_G	295_L	0.523	0.60
197_F	203_G	0.522	0.60
22_A	50_S	0.522	0.60
285_D	292_V	0.522	0.60
55_V	85_E	0.521	0.60
158_W	194_G	0.520	0.59
103_V	106_Y	0.520	0.59
134_D	288_T	0.520	0.59
217_R	229_E	0.520	0.59
237_G	254_S	0.520	0.59
158_W	251_Y	0.519	0.59
89_G	240_V	0.519	0.59
158_W	203_G	0.518	0.59
300_D	304_D	0.518	0.59
298_M	327_H	0.518	0.59
91_N	116_S	0.516	0.59
25_T	31_C	0.516	0.59
59_G	90_G	0.516	0.59
150_D	299_P	0.515	0.59
248_G	256_W	0.514	0.59
207_L	272_F	0.514	0.59
198_R	246_D	0.512	0.58
114_W	280_G	0.511	0.58
59_G	196_G	0.509	0.58
22_A	27_A	0.509	0.58
200_R	312_N	0.507	0.58
22_A	296_N	0.507	0.58
205_D	209_D	0.506	0.57
46_G	49_G	0.504	0.57
98_Y	242_E	0.503	0.57
61_G	155_Q	0.503	0.57
17_L	21_A	0.501	0.57
152_A	300_D	0.501	0.57
18_G	32_T	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3o66A	1	0.7964	100	0.428	Contact Map
4ne4A	1	0.8024	100	0.451	Contact Map
3r6uA	1	0.7904	100	0.481	Contact Map
1sw5A	1	0.7964	100	0.509	Contact Map
1r9lA	1	0.7545	100	0.617	Contact Map
2rinA	1	0.7335	100	0.692	Contact Map
3l6gA	1	0.7126	99.9	0.725	Contact Map
3tmgA	1	0.7186	99.9	0.726	Contact Map
2b4lA	1	0.4341	99.9	0.77	Contact Map
3un6A	1	0.7096	99.6	0.828	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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