HTR2 - HALSA - GREMLIN Contacts

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HTR2 - Sensory rhodopsin II transducer

UniProt:	Q9HP81	Sequences: MGSGLVARIRGSYGTKLTLALVVVVVLSVGVGTFVYQQTTTQLETDVRADLTGSADARADHLDAWLSNARGQTQLASRHPVLASGNDTAITRYLEGLAASDERPDGVVAAHVYNTSTTTIEASSADAFTGVNPREQGAPFATDPPSFATTSDVVVAAPFTVPAADFPVLSVLSPIPGTTDKALIYMVNVNTLTDDFGQNVAGSTTTVVSADGTYVSHPDQDRVLTGHDGPSRLLNQSRTQPAYIDANGTVTAAAPVDGAPWSVLVRAPHDRAFALGDFVASSLVGLVLITIVSLSLIGVTVGSTTVTALRQFSRRADEMAAGDLDTDIDTSRNDEFGTLAESFRSMRDSLSESLTDAERATARAEDAREDAEQQRADAEAAREDAEAARKDAQETARALESAAADYEEALTAVADGDLTRRVDASRDHDAMARIGHALNDMLDDIETSVAAATAFSDHVSDAAQRVEADAGDAIDAGTDVSTAVDEISDGATEQTDRLHEVAGEVDDLSASAEEVAETVASLADTAGQAASAVDDGRQATEDAVETMDDVADDAEAAADAMDALDSEMADIGEIVDVIADIADQTNMLALNASIEAARTGADGDGFAVVADEVKTLAEESRDAAEDIESRLLALQGQVSDVADEMRATSDTVSDGRATVGDAATALDDVVSFVADTDTAAGEIRAATDRQAHAASRVASAVDEVAGISQETAAQATAVADSAATQTDTLSSVDDAAADLADRAAALDDLLAEFDAHDDTEPEDY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	764 (664)
Sequences:	812 (736)
Seq/√Len:	28.6

BACSU - TLPB TLPA MCPA MCPB MCPC
HALSA - HTR2 Q9HRA1 HTR4 COST Q9HR88 Q9HRN6 Q9HP10 Q9HS86

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
412_A	417_D	5.440	1.00
318_E	323_D	5.332	1.00
375_R	379_E	4.269	1.00
332_R	337_G	4.254	1.00
372_E	375_R	4.118	1.00
16_K	334_D	3.720	1.00
716_T	720_D	3.678	1.00
372_E	379_E	3.338	1.00
372_E	376_A	3.097	1.00
371_A	375_R	3.063	1.00
591_N	609_V	2.962	1.00
403_A	406_Y	2.950	1.00
540_T	663_A	2.920	1.00
372_E	378_A	2.897	1.00
374_Q	378_A	2.814	1.00
361_T	364_A	2.770	1.00
550_V	655_G	2.723	1.00
370_D	375_R	2.694	1.00
375_R	378_A	2.687	1.00
339_L	346_M	2.666	1.00
360_A	364_A	2.607	0.99
316_A	339_L	2.563	0.99
593_S	615_T	2.550	0.99
355_T	359_R	2.540	0.99
547_M	550_V	2.497	0.99
371_A	374_Q	2.474	0.99
523_A	684_R	2.469	0.99
611_D	615_T	2.466	0.99
542_D	661_D	2.451	0.99
515_V	687_T	2.390	0.99
599_T	603_G	2.386	0.99
316_A	343_F	2.379	0.99
370_D	373_Q	2.289	0.99
600_G	603_G	2.285	0.99
422_V	435_G	2.237	0.98
491_A	715_A	2.236	0.98
713_A	720_D	2.232	0.98
578_I	655_G	2.227	0.98
377_D	380_A	2.209	0.98
587_M	597_A	2.181	0.98
550_V	614_K	2.132	0.98
582_A	607_A	2.118	0.98
422_V	434_I	2.089	0.97
370_D	376_A	2.069	0.97
432_A	435_G	2.063	0.97
344_R	347_R	2.050	0.97
593_S	619_E	2.044	0.97
605_G	612_E	2.027	0.97
584_Q	595_E	2.020	0.97
17_L	305_T	2.011	0.97
357_A	360_A	2.001	0.97
590_L	614_K	1.994	0.97
421_R	446_E	1.975	0.96
399_L	403_A	1.964	0.96
409_A	438_L	1.952	0.96
732_V	739_L	1.936	0.96
583_D	594_I	1.934	0.96
491_A	714_Q	1.932	0.96
631_L	655_G	1.929	0.96
574_I	630_R	1.927	0.96
375_R	381_A	1.918	0.96
346_M	350_L	1.916	0.96
406_Y	435_G	1.915	0.96
362_A	365_E	1.910	0.96
657_A	697_V	1.910	0.96
113_Y	119_T	1.897	0.95
435_G	438_L	1.896	0.95
611_D	621_R	1.893	0.95
339_L	350_L	1.887	0.95
539_A	594_I	1.879	0.95
400_E	406_Y	1.879	0.95
549_D	651_T	1.866	0.95
693_A	700_A	1.865	0.95
518_T	679_A	1.865	0.95
316_A	346_M	1.860	0.95
339_L	343_F	1.857	0.95
568_M	658_T	1.848	0.95
586_N	595_E	1.839	0.94
484_V	722_A	1.831	0.94
597_A	608_V	1.829	0.94
713_A	716_T	1.822	0.94
72_Q	107_V	1.818	0.94
137_G	140_F	1.817	0.94
501_V	700_A	1.814	0.94
509_S	698_A	1.813	0.94
579_A	583_D	1.812	0.94
312_F	328_I	1.811	0.94
452_A	570_D	1.811	0.94
658_T	662_A	1.806	0.94
396_A	406_Y	1.803	0.94
544_V	691_A	1.798	0.94
536_G	593_S	1.780	0.93
230_P	233_L	1.778	0.93
550_V	630_R	1.773	0.93
603_G	607_A	1.765	0.93
377_D	381_A	1.759	0.93
584_Q	590_L	1.740	0.93
608_V	612_E	1.736	0.93
568_M	574_I	1.736	0.93
574_I	631_L	1.732	0.92
319_M	346_M	1.709	0.92
550_V	590_L	1.701	0.92
338_T	341_E	1.699	0.92
627_I	655_G	1.689	0.91
494_Q	715_A	1.688	0.91
579_A	628_E	1.686	0.91
657_A	661_D	1.675	0.91
614_K	725_Q	1.661	0.91
308_A	336_F	1.653	0.91
371_A	380_A	1.649	0.90
312_F	343_F	1.643	0.90
95_E	98_A	1.628	0.90
485_D	723_A	1.628	0.90
315_R	326_T	1.624	0.90
615_T	622_D	1.620	0.90
618_E	715_A	1.618	0.90
582_A	599_T	1.616	0.90
373_Q	380_A	1.611	0.89
611_D	628_E	1.604	0.89
65_W	69_A	1.601	0.89
614_K	630_R	1.597	0.89
577_V	712_A	1.588	0.89
319_M	350_L	1.586	0.89
376_A	380_A	1.586	0.89
583_D	711_T	1.585	0.89
583_D	618_E	1.585	0.89
74_Q	77_S	1.584	0.89
302_G	305_T	1.580	0.88
574_I	655_G	1.580	0.88
94_L	98_A	1.576	0.88
537_R	670_V	1.575	0.88
711_T	714_Q	1.571	0.88
597_A	607_A	1.570	0.88
13_Y	305_T	1.569	0.88
583_D	621_R	1.566	0.88
418_L	445_I	1.562	0.88
357_A	364_A	1.562	0.88
675_D	678_T	1.559	0.88
371_A	378_A	1.554	0.88
662_A	666_L	1.553	0.88
498_L	502_A	1.552	0.88
590_L	607_A	1.550	0.87
628_E	715_A	1.541	0.87
94_L	97_L	1.538	0.87
77_S	181_K	1.529	0.87
324_L	351_S	1.528	0.87
119_T	122_A	1.519	0.86
366_D	370_D	1.512	0.86
662_A	704_V	1.511	0.86
502_A	701_V	1.509	0.86
494_Q	537_R	1.504	0.86
499_H	507_D	1.498	0.86
608_V	655_G	1.494	0.85
589_A	598_R	1.494	0.85
612_E	655_G	1.491	0.85
407_E	410_L	1.489	0.85
493_E	704_V	1.489	0.85
580_D	611_D	1.487	0.85
483_A	714_Q	1.485	0.85
600_G	605_G	1.485	0.85
614_K	708_S	1.482	0.85
607_A	612_E	1.477	0.85
661_D	697_V	1.475	0.85
568_M	739_L	1.464	0.84
516_A	519_V	1.460	0.84
476_A	715_A	1.459	0.84
567_E	651_T	1.456	0.84
499_H	503_G	1.455	0.84
421_R	443_D	1.452	0.84
592_A	609_V	1.448	0.84
578_I	612_E	1.447	0.84
593_S	611_D	1.433	0.83
23_V	301_V	1.429	0.83
473_A	486_E	1.427	0.83
302_G	306_V	1.426	0.83
374_Q	377_D	1.420	0.82
504_E	536_G	1.414	0.82
343_F	350_L	1.413	0.82
372_E	380_A	1.408	0.82
261_W	268_P	1.393	0.81
312_F	339_L	1.376	0.80
371_A	376_A	1.374	0.80
212_G	217_H	1.373	0.80
496_D	503_G	1.368	0.80
515_V	611_D	1.364	0.80
587_M	593_S	1.362	0.80
567_E	659_V	1.360	0.79
505_V	656_R	1.359	0.79
515_V	593_S	1.345	0.79
494_Q	694_A	1.342	0.79
590_L	597_A	1.339	0.78
594_I	628_E	1.332	0.78
620_S	627_I	1.331	0.78
573_E	593_S	1.326	0.78
497_R	611_D	1.325	0.78
66_L	217_H	1.316	0.77
504_E	725_Q	1.315	0.77
425_S	435_G	1.315	0.77
376_A	381_A	1.307	0.77
526_A	676_T	1.306	0.77
666_L	690_Q	1.305	0.77
565_D	624_A	1.304	0.76
579_A	594_I	1.302	0.76
479_D	720_D	1.298	0.76
666_L	669_V	1.292	0.76
340_A	346_M	1.287	0.76
479_D	705_A	1.276	0.75
709_Q	713_A	1.272	0.75
486_E	490_G	1.261	0.74
543_A	666_L	1.261	0.74
77_S	175_I	1.255	0.74
515_V	686_A	1.254	0.74
594_I	705_A	1.248	0.73
574_I	577_V	1.247	0.73
624_A	648_T	1.245	0.73
504_E	593_S	1.242	0.73
648_T	652_V	1.238	0.73
422_V	438_L	1.238	0.73
425_S	432_A	1.236	0.72
20_A	23_V	1.235	0.72
449_V	741_D	1.235	0.72
705_A	708_S	1.231	0.72
496_D	709_Q	1.228	0.72
32_G	287_V	1.226	0.72
583_D	614_K	1.225	0.72
424_A	431_M	1.221	0.72
605_G	608_V	1.216	0.71
159_F	186_M	1.215	0.71
17_L	312_F	1.215	0.71
399_L	402_A	1.212	0.71
400_E	407_E	1.209	0.71
587_M	666_L	1.207	0.71
422_V	433_R	1.205	0.71
86_N	90_I	1.200	0.70
603_G	655_G	1.198	0.70
550_V	725_Q	1.198	0.70
90_I	93_Y	1.197	0.70
417_D	442_L	1.188	0.69
494_Q	628_E	1.186	0.69
73_T	76_A	1.184	0.69
272_A	309_L	1.184	0.69
546_T	575_V	1.184	0.69
433_R	437_A	1.180	0.69
583_D	590_L	1.180	0.69
204_T	217_H	1.176	0.69
708_S	711_T	1.170	0.68
713_A	717_A	1.169	0.68
684_R	735_A	1.166	0.68
533_V	581_I	1.164	0.68
536_G	722_A	1.164	0.68
511_S	621_R	1.158	0.67
714_Q	725_Q	1.155	0.67
409_A	422_V	1.155	0.67
533_V	537_R	1.154	0.67
609_V	612_E	1.153	0.67
599_T	610_A	1.151	0.67
709_Q	714_Q	1.150	0.67
611_D	719_A	1.150	0.67
108_V	186_M	1.148	0.67
583_D	705_A	1.147	0.67
496_D	501_V	1.146	0.67
567_E	739_L	1.145	0.67
581_I	609_V	1.144	0.66
376_A	379_E	1.142	0.66
618_E	631_L	1.140	0.66
586_N	609_V	1.140	0.66
97_L	101_D	1.140	0.66
402_A	405_D	1.135	0.66
371_A	379_E	1.130	0.65
356_D	364_A	1.125	0.65
663_A	725_Q	1.111	0.64
374_Q	381_A	1.108	0.64
202_G	271_R	1.107	0.64
586_N	591_N	1.106	0.64
58_R	66_L	1.106	0.64
177_G	183_L	1.105	0.64
615_T	618_E	1.104	0.64
605_G	626_D	1.102	0.63
441_M	445_I	1.099	0.63
261_W	264_L	1.099	0.63
515_V	711_T	1.099	0.63
494_Q	707_I	1.096	0.63
229_G	233_L	1.095	0.63
652_V	655_G	1.095	0.63
485_D	695_S	1.094	0.63
495_T	583_D	1.091	0.63
523_A	681_G	1.091	0.63
441_M	700_A	1.089	0.63
536_G	735_A	1.086	0.62
659_V	676_T	1.081	0.62
175_I	189_V	1.081	0.62
512_A	684_R	1.080	0.62
490_G	711_T	1.077	0.62
582_A	590_L	1.077	0.62
603_G	609_V	1.074	0.61
400_E	404_A	1.072	0.61
577_V	655_G	1.071	0.61
630_R	655_G	1.070	0.61
491_A	575_V	1.069	0.61
704_V	715_A	1.068	0.61
490_G	583_D	1.065	0.61
296_L	331_S	1.065	0.61
359_R	362_A	1.060	0.60
88_T	92_R	1.058	0.60
648_T	676_T	1.057	0.60
628_E	711_T	1.057	0.60
497_R	575_V	1.056	0.60
219_D	223_V	1.056	0.60
500_E	709_Q	1.056	0.60
614_K	619_E	1.052	0.60
580_D	618_E	1.050	0.60
499_H	709_Q	1.047	0.59
512_A	673_V	1.045	0.59
453_T	736_A	1.044	0.59
307_T	326_T	1.043	0.59
481_S	723_A	1.043	0.59
535_D	538_Q	1.042	0.59
252_A	256_V	1.042	0.59
332_R	347_R	1.039	0.59
402_A	406_Y	1.037	0.59
403_A	431_M	1.035	0.59
665_A	707_I	1.032	0.58
476_A	526_A	1.030	0.58
570_D	626_D	1.029	0.58
490_G	707_I	1.028	0.58
662_A	676_T	1.023	0.58
158_P	170_S	1.022	0.58
520_A	688_D	1.021	0.57
576_D	628_E	1.019	0.57
606_F	610_A	1.019	0.57
546_T	708_S	1.017	0.57
344_R	348_D	1.017	0.57
400_E	403_A	1.015	0.57
594_I	714_Q	1.015	0.57
430_A	540_T	1.014	0.57
12_S	488_S	1.014	0.57
540_T	725_Q	1.012	0.57
148_A	151_S	1.011	0.57
438_L	445_I	1.011	0.57
352_E	356_D	1.008	0.56
229_G	237_S	1.005	0.56
77_S	284_V	1.004	0.56
696_R	712_A	0.999	0.56
111_H	114_N	0.997	0.56
490_G	714_Q	0.997	0.56
614_K	700_A	0.996	0.56
684_R	725_Q	0.995	0.55
603_G	627_I	0.992	0.55
473_A	673_V	0.990	0.55
495_T	709_Q	0.990	0.55
413_V	694_A	0.990	0.55
578_I	586_N	0.989	0.55
50_D	53_G	0.987	0.55
603_G	608_V	0.986	0.55
434_I	437_A	0.985	0.55
583_D	602_D	0.985	0.55
580_D	587_M	0.983	0.55
13_Y	308_A	0.982	0.55
512_A	631_L	0.981	0.54
62_L	103_R	0.979	0.54
113_Y	120_I	0.978	0.54
717_A	720_D	0.976	0.54
456_S	473_A	0.976	0.54
593_S	714_Q	0.975	0.54
503_G	705_A	0.975	0.54
581_I	591_N	0.971	0.54
577_V	648_T	0.969	0.54
529_A	607_A	0.967	0.53
539_A	705_A	0.966	0.53
546_T	583_D	0.963	0.53
650_D	654_D	0.962	0.53
647_A	651_T	0.962	0.53
156_A	159_F	0.958	0.53
501_V	504_E	0.958	0.53
594_I	611_D	0.956	0.52
63_D	67_S	0.952	0.52
550_V	583_D	0.951	0.52
676_T	722_A	0.949	0.52
402_A	407_E	0.949	0.52
231_S	239_T	0.947	0.52
319_M	347_R	0.947	0.52
648_T	655_G	0.946	0.52
630_R	663_A	0.945	0.52
324_L	350_L	0.944	0.52
175_I	180_D	0.942	0.51
513_E	695_S	0.942	0.51
334_D	337_G	0.939	0.51
567_E	658_T	0.939	0.51
261_W	273_F	0.939	0.51
328_I	340_A	0.935	0.51
722_A	726_T	0.934	0.51
581_I	619_E	0.933	0.51
522_L	540_T	0.932	0.51
672_F	722_A	0.932	0.51
316_A	350_L	0.930	0.50
594_I	711_T	0.929	0.50
523_A	676_T	0.928	0.50
182_A	187_V	0.924	0.50
625_E	704_V	0.924	0.50
174_P	180_D	0.924	0.50
438_L	446_E	0.924	0.50
598_R	659_V	0.923	0.50
490_G	594_I	0.922	0.50
583_D	708_S	0.921	0.50
435_G	441_M	0.919	0.50
568_M	655_G	0.918	0.50
686_A	691_A	0.918	0.50
600_G	612_E	0.917	0.49
485_D	701_V	0.917	0.49
523_A	677_D	0.916	0.49
589_A	666_L	0.916	0.49
120_I	202_G	0.915	0.49
571_I	578_I	0.915	0.49
568_M	648_T	0.914	0.49
546_T	711_T	0.914	0.49
322_G	683_I	0.913	0.49
631_L	648_T	0.912	0.49
121_E	125_A	0.907	0.49
413_V	442_L	0.907	0.49
578_I	595_E	0.907	0.49
515_V	714_Q	0.905	0.49
515_V	594_I	0.905	0.49
620_S	630_R	0.903	0.48
18_T	58_R	0.902	0.48
580_D	625_E	0.902	0.48
422_V	431_M	0.901	0.48
578_I	623_A	0.901	0.48
593_S	652_V	0.900	0.48
363_R	366_D	0.898	0.48
584_Q	607_A	0.898	0.48
604_D	611_D	0.895	0.48
203_S	208_V	0.895	0.48
438_L	441_M	0.895	0.48
518_T	615_T	0.894	0.48
246_A	296_L	0.892	0.48
572_G	578_I	0.890	0.47
597_A	612_E	0.890	0.47
595_E	600_G	0.890	0.47
579_A	714_Q	0.889	0.47
496_D	711_T	0.887	0.47
66_L	69_A	0.886	0.47
490_G	715_A	0.884	0.47
546_T	581_I	0.881	0.47
432_A	436_H	0.878	0.46
292_V	701_V	0.876	0.46
479_D	724_T	0.876	0.46
498_L	705_A	0.875	0.46
648_T	663_A	0.875	0.46
623_A	666_L	0.874	0.46
624_A	630_R	0.873	0.46
667_D	691_A	0.870	0.46
359_R	363_R	0.869	0.46
574_I	623_A	0.868	0.46
207_V	734_D	0.868	0.46
578_I	603_G	0.868	0.46
478_T	710_E	0.867	0.46
490_G	716_T	0.862	0.45
487_I	658_T	0.862	0.45
594_I	625_E	0.861	0.45
262_S	312_F	0.860	0.45
70_R	76_A	0.859	0.45
404_A	407_E	0.858	0.45
533_V	587_M	0.857	0.45
123_S	128_F	0.857	0.45
476_A	662_A	0.856	0.45
579_A	708_S	0.855	0.45
499_H	583_D	0.855	0.45
705_A	711_T	0.854	0.45
429_D	432_A	0.853	0.45
649_S	653_S	0.850	0.44
575_V	624_A	0.850	0.44
479_D	710_E	0.850	0.44
509_S	628_E	0.849	0.44
234_L	238_R	0.847	0.44
523_A	722_A	0.846	0.44
356_D	360_A	0.845	0.44
548_D	565_D	0.844	0.44
313_S	358_E	0.841	0.44
174_P	255_P	0.839	0.43
112_V	183_L	0.839	0.43
183_L	186_M	0.839	0.43
117_T	177_G	0.837	0.43
537_R	576_D	0.837	0.43
597_A	655_G	0.834	0.43
698_A	711_T	0.833	0.43
583_D	593_S	0.831	0.43
374_Q	380_A	0.831	0.43
519_V	544_V	0.831	0.43
46_D	296_L	0.830	0.43
621_R	715_A	0.829	0.43
614_K	739_L	0.829	0.43
158_P	161_V	0.828	0.43
519_V	736_A	0.828	0.43
725_Q	738_D	0.827	0.43
578_I	605_G	0.826	0.42
438_L	570_D	0.826	0.42
378_A	381_A	0.825	0.42
487_I	739_L	0.823	0.42
177_G	181_K	0.822	0.42
609_V	613_V	0.822	0.42
159_F	189_V	0.820	0.42
347_R	351_S	0.819	0.42
402_A	432_A	0.819	0.42
319_M	339_L	0.817	0.42
504_E	619_E	0.817	0.42
599_T	607_A	0.815	0.42
573_E	715_A	0.815	0.42
309_L	338_T	0.814	0.42
600_G	620_S	0.813	0.41
502_A	550_V	0.813	0.41
595_E	623_A	0.812	0.41
529_A	672_F	0.812	0.41
684_R	687_T	0.810	0.41
485_D	529_A	0.809	0.41
249_T	253_A	0.808	0.41
232_R	241_P	0.807	0.41
620_S	655_G	0.805	0.41
575_V	679_A	0.804	0.41
607_A	655_G	0.803	0.41
593_S	728_T	0.803	0.41
109_A	119_T	0.802	0.41
418_L	431_M	0.799	0.40
192_L	207_V	0.799	0.40
519_V	652_V	0.797	0.40
577_V	621_R	0.796	0.40
492_T	669_V	0.796	0.40
183_L	187_V	0.794	0.40
576_D	703_E	0.792	0.40
504_E	512_A	0.791	0.40
476_A	573_E	0.791	0.40
550_V	687_T	0.790	0.40
499_H	579_A	0.790	0.40
590_L	608_V	0.789	0.40
504_E	573_E	0.789	0.40
109_A	161_V	0.788	0.40
297_I	303_S	0.785	0.39
437_A	584_Q	0.785	0.39
23_V	26_V	0.785	0.39
39_T	305_T	0.784	0.39
438_L	593_S	0.784	0.39
602_D	696_R	0.782	0.39
666_L	683_I	0.781	0.39
157_A	161_V	0.781	0.39
92_R	98_A	0.781	0.39
312_F	319_M	0.780	0.39
76_A	154_V	0.779	0.39
342_S	349_S	0.779	0.39
429_D	438_L	0.777	0.39
596_A	608_V	0.775	0.39
165_D	172_L	0.775	0.39
587_M	676_T	0.775	0.39
166_F	261_W	0.774	0.39
632_L	725_Q	0.772	0.38
725_Q	739_L	0.771	0.38
543_A	577_V	0.771	0.38
69_A	72_Q	0.768	0.38
507_D	693_A	0.768	0.38
490_G	708_S	0.766	0.38
453_T	484_V	0.766	0.38
576_D	626_D	0.765	0.38
116_S	209_S	0.765	0.38
189_V	200_V	0.764	0.38
681_G	684_R	0.763	0.38
505_V	723_A	0.762	0.38
539_A	658_T	0.761	0.38
187_V	191_T	0.761	0.38
614_K	621_R	0.761	0.38
288_L	292_V	0.760	0.38
312_F	316_A	0.758	0.37
476_A	686_A	0.758	0.37
492_T	716_T	0.757	0.37
598_R	705_A	0.757	0.37
236_Q	240_Q	0.756	0.37
571_I	655_G	0.756	0.37
117_T	122_A	0.752	0.37
441_M	550_V	0.749	0.37
567_E	656_R	0.748	0.37
62_L	97_L	0.748	0.37
566_S	569_A	0.748	0.37
370_D	381_A	0.747	0.37
533_V	619_E	0.745	0.36
495_T	499_H	0.745	0.36
109_A	122_A	0.744	0.36
618_E	720_D	0.743	0.36
172_L	182_A	0.742	0.36
530_A	534_D	0.740	0.36
543_A	631_L	0.739	0.36
594_I	694_A	0.737	0.36
583_D	619_E	0.737	0.36
583_D	714_Q	0.737	0.36
505_V	604_D	0.736	0.36
16_K	21_L	0.736	0.36
479_D	716_T	0.735	0.36
701_V	704_V	0.730	0.35
319_M	735_A	0.729	0.35
623_A	690_Q	0.729	0.35
16_K	24_V	0.726	0.35
605_G	609_V	0.725	0.35
55_A	209_S	0.724	0.35
435_G	518_T	0.724	0.35
595_E	614_K	0.722	0.35
579_A	625_E	0.721	0.35
497_R	705_A	0.721	0.35
576_D	725_Q	0.720	0.35
705_A	714_Q	0.719	0.35
312_F	326_T	0.719	0.35
179_T	182_A	0.718	0.35
445_I	631_L	0.718	0.35
445_I	676_T	0.717	0.35
593_S	613_V	0.715	0.34
512_A	648_T	0.713	0.34
14_G	303_S	0.712	0.34
501_V	708_S	0.710	0.34
231_S	234_L	0.710	0.34
579_A	711_T	0.710	0.34
396_A	400_E	0.708	0.34
580_D	677_D	0.708	0.34
324_L	354_L	0.706	0.34
546_T	619_E	0.704	0.34
671_S	678_T	0.704	0.34
700_A	711_T	0.701	0.33
508_L	698_A	0.701	0.33
690_Q	697_V	0.700	0.33
594_I	708_S	0.700	0.33
497_R	625_E	0.700	0.33
493_E	720_D	0.700	0.33
108_V	111_H	0.700	0.33
579_A	630_R	0.698	0.33
86_N	89_A	0.697	0.33
316_A	319_M	0.697	0.33
725_Q	732_V	0.697	0.33
158_P	184_I	0.696	0.33
617_A	620_S	0.696	0.33
75_L	80_P	0.696	0.33
403_A	410_L	0.694	0.33
527_G	530_A	0.694	0.33
613_V	626_D	0.693	0.33
402_A	438_L	0.693	0.33
540_T	722_A	0.693	0.33
167_P	186_M	0.692	0.33
19_L	290_T	0.692	0.33
718_V	728_T	0.692	0.33
91_T	98_A	0.691	0.33
652_V	656_R	0.691	0.33
109_A	121_E	0.691	0.33
110_A	114_N	0.689	0.33
594_I	704_V	0.689	0.33
412_A	581_I	0.687	0.32
488_S	701_V	0.687	0.32
543_A	587_M	0.686	0.32
438_L	694_A	0.685	0.32
502_A	704_V	0.683	0.32
305_T	328_I	0.683	0.32
74_Q	156_A	0.683	0.32
171_V	261_W	0.683	0.32
430_A	441_M	0.682	0.32
584_Q	680_A	0.680	0.32
24_V	308_A	0.680	0.32
575_V	628_E	0.675	0.32
428_H	432_A	0.674	0.32
452_A	544_V	0.674	0.32
437_A	543_A	0.674	0.32
536_G	679_A	0.673	0.31
398_A	402_A	0.672	0.31
573_E	676_T	0.671	0.31
611_D	708_S	0.670	0.31
690_Q	709_Q	0.670	0.31
521_S	682_E	0.670	0.31
51_L	54_S	0.668	0.31
694_A	711_T	0.668	0.31
705_A	712_A	0.668	0.31
117_T	121_E	0.668	0.31
186_M	189_V	0.667	0.31
285_G	289_I	0.667	0.31
418_L	438_L	0.664	0.31
547_M	655_G	0.664	0.31
624_A	712_A	0.663	0.31
618_E	655_G	0.663	0.31
579_A	621_R	0.662	0.31
618_E	725_Q	0.661	0.31
290_T	301_V	0.661	0.31
505_V	508_L	0.661	0.31
480_V	648_T	0.660	0.31
567_E	618_E	0.660	0.31
203_S	261_W	0.660	0.31
580_D	609_V	0.660	0.31
574_I	648_T	0.658	0.30
56_D	59_A	0.657	0.30
532_A	672_F	0.657	0.30
718_V	721_S	0.657	0.30
287_V	298_G	0.656	0.30
360_A	363_R	0.656	0.30
582_A	610_A	0.654	0.30
494_Q	519_V	0.653	0.30
67_S	185_Y	0.653	0.30
416_G	666_L	0.653	0.30
533_V	722_A	0.652	0.30
108_V	112_V	0.651	0.30
327_D	344_R	0.651	0.30
508_L	604_D	0.651	0.30
403_A	449_V	0.650	0.30
69_A	80_P	0.649	0.30
518_T	714_Q	0.646	0.30
364_A	371_A	0.645	0.30
58_R	62_L	0.645	0.30
337_G	340_A	0.644	0.30
120_I	123_S	0.644	0.30
508_L	547_M	0.643	0.30
399_L	491_A	0.639	0.29
61_H	69_A	0.637	0.29
508_L	516_A	0.635	0.29
431_M	455_F	0.635	0.29
567_E	570_D	0.634	0.29
503_G	507_D	0.633	0.29
673_V	676_T	0.632	0.29
595_E	605_G	0.631	0.29
429_D	533_V	0.630	0.29
417_D	441_M	0.630	0.29
615_T	655_G	0.630	0.29
659_V	669_V	0.629	0.29
502_A	506_D	0.629	0.29
435_G	593_S	0.628	0.29
476_A	546_T	0.628	0.29
192_L	196_F	0.627	0.28
519_V	599_T	0.625	0.28
113_Y	184_I	0.625	0.28
614_K	729_L	0.625	0.28
579_A	715_A	0.625	0.28
156_A	189_V	0.623	0.28
90_I	95_E	0.622	0.28
203_S	263_V	0.622	0.28
581_I	608_V	0.622	0.28
617_A	705_A	0.622	0.28
480_V	673_V	0.622	0.28
498_L	624_A	0.621	0.28
230_P	348_D	0.620	0.28
575_V	711_T	0.620	0.28
265_V	272_A	0.619	0.28
526_A	722_A	0.619	0.28
21_L	24_V	0.619	0.28
611_D	704_V	0.619	0.28
697_V	704_V	0.619	0.28
211_D	331_S	0.618	0.28
540_T	652_V	0.618	0.28
41_T	337_G	0.618	0.28
496_D	583_D	0.618	0.28
500_E	503_G	0.617	0.28
504_E	514_E	0.617	0.28
487_I	624_A	0.616	0.28
406_Y	438_L	0.614	0.28
158_P	186_M	0.613	0.28
250_V	253_A	0.613	0.28
522_L	728_T	0.613	0.28
170_S	184_I	0.611	0.27
131_V	137_G	0.610	0.27
346_M	593_S	0.610	0.27
412_A	722_A	0.610	0.27
492_T	713_A	0.610	0.27
23_V	250_V	0.609	0.27
116_S	124_S	0.609	0.27
140_F	186_M	0.609	0.27
593_S	696_R	0.609	0.27
663_A	722_A	0.608	0.27
619_E	705_A	0.607	0.27
665_A	672_F	0.606	0.27
619_E	673_V	0.605	0.27
526_A	663_A	0.605	0.27
702_D	722_A	0.605	0.27
546_T	579_A	0.604	0.27
13_Y	406_Y	0.604	0.27
21_L	286_L	0.604	0.27
416_G	598_R	0.603	0.27
568_M	652_V	0.602	0.27
203_S	218_P	0.602	0.27
581_I	722_A	0.601	0.27
421_R	681_G	0.600	0.27
402_A	615_T	0.599	0.27
537_R	630_R	0.598	0.27
445_I	452_A	0.598	0.27
597_A	689_R	0.597	0.27
62_L	352_E	0.595	0.27
583_D	709_Q	0.594	0.26
66_L	70_R	0.594	0.26
596_A	610_A	0.594	0.26
202_G	206_T	0.594	0.26
69_A	75_L	0.593	0.26
17_L	302_G	0.593	0.26
452_A	455_F	0.593	0.26
258_G	263_V	0.593	0.26
590_L	612_E	0.592	0.26
578_I	631_L	0.592	0.26
437_A	725_Q	0.592	0.26
623_A	655_G	0.592	0.26
109_A	186_M	0.592	0.26
306_V	336_F	0.592	0.26
487_I	567_E	0.591	0.26
174_P	334_D	0.590	0.26
585_T	590_L	0.590	0.26
301_V	309_L	0.590	0.26
13_Y	282_S	0.589	0.26
202_G	261_W	0.587	0.26
473_A	719_A	0.587	0.26
526_A	680_A	0.586	0.26
203_S	267_A	0.586	0.26
43_L	55_A	0.585	0.26
361_T	536_G	0.585	0.26
149_T	154_V	0.583	0.26
122_A	147_F	0.583	0.26
502_A	607_A	0.582	0.26
169_L	215_V	0.581	0.26
577_V	620_S	0.581	0.26
331_S	695_S	0.579	0.26
339_L	735_A	0.579	0.26
493_E	703_E	0.578	0.26
287_V	291_I	0.577	0.25
10_R	15_T	0.577	0.25
511_S	515_V	0.577	0.25
212_G	261_W	0.577	0.25
483_A	593_S	0.577	0.25
582_A	672_F	0.576	0.25
209_S	261_W	0.576	0.25
483_A	704_V	0.575	0.25
123_S	130_G	0.575	0.25
399_L	407_E	0.575	0.25
17_L	20_A	0.574	0.25
214_Y	247_N	0.574	0.25
424_A	575_V	0.573	0.25
580_D	621_R	0.573	0.25
247_N	292_V	0.572	0.25
410_L	435_G	0.571	0.25
598_R	713_A	0.570	0.25
497_R	704_V	0.570	0.25
55_A	59_A	0.567	0.25
458_H	518_T	0.567	0.25
111_H	122_A	0.566	0.25
662_A	690_Q	0.565	0.25
274_A	313_S	0.564	0.25
441_M	715_A	0.564	0.25
422_V	502_A	0.563	0.25
339_L	349_S	0.563	0.25
449_V	570_D	0.563	0.25
598_R	716_T	0.562	0.25
504_E	679_A	0.562	0.25
578_I	609_V	0.561	0.25
522_L	659_V	0.560	0.24
430_A	433_R	0.560	0.24
204_T	218_P	0.560	0.24
621_R	655_G	0.559	0.24
648_T	666_L	0.559	0.24
707_I	711_T	0.559	0.24
590_L	600_G	0.559	0.24
519_V	683_I	0.559	0.24
533_V	663_A	0.559	0.24
399_L	441_M	0.559	0.24
593_S	676_T	0.558	0.24
666_L	712_A	0.558	0.24
360_A	593_S	0.558	0.24
158_P	261_W	0.558	0.24
624_A	709_Q	0.558	0.24
71_G	76_A	0.557	0.24
544_V	666_L	0.557	0.24
495_T	579_A	0.557	0.24
72_Q	76_A	0.556	0.24
599_T	605_G	0.556	0.24
373_Q	377_D	0.555	0.24
117_T	181_K	0.555	0.24
576_D	710_E	0.555	0.24
656_R	665_A	0.554	0.24
112_V	129_T	0.554	0.24
585_T	607_A	0.553	0.24
23_V	28_S	0.551	0.24
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113_Y	122_A	0.549	0.24
249_T	261_W	0.549	0.24
231_S	235_N	0.548	0.24
309_L	312_F	0.548	0.24
594_I	718_V	0.548	0.24
597_A	613_V	0.548	0.24
533_V	625_E	0.548	0.24
501_V	705_A	0.547	0.24
501_V	625_E	0.547	0.24
603_G	614_K	0.547	0.24
353_S	357_A	0.545	0.24
435_G	679_A	0.544	0.24
515_V	694_A	0.544	0.24
122_A	129_T	0.544	0.24
184_I	268_P	0.544	0.24
113_Y	170_S	0.543	0.23
422_V	705_A	0.543	0.23
420_R	434_I	0.543	0.23
362_A	699_S	0.543	0.23
698_A	708_S	0.542	0.23
512_A	579_A	0.541	0.23
370_D	380_A	0.540	0.23
345_S	350_L	0.540	0.23
51_L	158_P	0.540	0.23
139_P	293_S	0.540	0.23
570_D	647_A	0.539	0.23
23_V	42_Q	0.539	0.23
148_A	175_I	0.538	0.23
481_S	485_D	0.538	0.23
299_V	310_R	0.537	0.23
474_I	726_T	0.536	0.23
293_S	296_L	0.535	0.23
19_L	512_A	0.534	0.23
89_A	96_G	0.532	0.23
578_I	627_I	0.532	0.23
486_E	526_A	0.532	0.23
316_A	320_A	0.531	0.23
621_R	676_T	0.530	0.23
335_E	617_A	0.530	0.23
536_G	699_S	0.529	0.23
422_V	437_A	0.528	0.23
441_M	488_S	0.528	0.23
582_A	690_Q	0.528	0.23
624_A	690_Q	0.526	0.23
505_V	701_V	0.526	0.23
575_V	655_G	0.525	0.23
594_I	621_R	0.525	0.23
62_L	143_D	0.525	0.23
193_T	205_T	0.525	0.23
597_A	603_G	0.524	0.22
410_L	422_V	0.523	0.22
700_A	725_Q	0.523	0.22
441_M	449_V	0.523	0.22
568_M	627_I	0.522	0.22
80_P	168_V	0.522	0.22
649_S	722_A	0.522	0.22
495_T	500_E	0.522	0.22
53_G	151_S	0.522	0.22
435_G	704_V	0.521	0.22
599_T	609_V	0.521	0.22
339_L	345_S	0.521	0.22
480_V	601_A	0.520	0.22
77_S	183_L	0.520	0.22
501_V	583_D	0.520	0.22
577_V	627_I	0.520	0.22
694_A	698_A	0.520	0.22
235_N	289_I	0.519	0.22
601_A	604_D	0.518	0.22
24_V	27_L	0.517	0.22
516_A	683_I	0.517	0.22
32_G	253_A	0.517	0.22
85_G	90_I	0.517	0.22
584_Q	593_S	0.517	0.22
492_T	673_V	0.516	0.22
569_A	651_T	0.516	0.22
371_A	381_A	0.515	0.22
340_A	347_R	0.515	0.22
439_N	445_I	0.515	0.22
347_R	360_A	0.514	0.22
544_V	683_I	0.514	0.22
192_L	203_S	0.513	0.22
613_V	659_V	0.513	0.22
543_A	620_S	0.513	0.22
506_D	693_A	0.512	0.22
36_Y	279_V	0.512	0.22
158_P	168_V	0.512	0.22
289_I	296_L	0.511	0.22
487_I	620_S	0.511	0.22
75_L	79_H	0.511	0.22
579_A	607_A	0.511	0.22
19_L	106_G	0.510	0.22
416_G	589_A	0.510	0.22
285_G	293_S	0.510	0.22
184_I	190_N	0.509	0.22
539_A	575_V	0.509	0.22
597_A	617_A	0.509	0.22
577_V	604_D	0.508	0.22
129_T	170_S	0.508	0.22
437_A	722_A	0.508	0.22
709_Q	716_T	0.508	0.22
492_T	714_Q	0.508	0.22
677_D	684_R	0.507	0.22
249_T	266_R	0.507	0.22
403_A	409_A	0.506	0.21
497_R	539_A	0.506	0.21
583_D	655_G	0.506	0.21
593_S	602_D	0.506	0.21
120_I	216_S	0.506	0.21
473_A	666_L	0.506	0.21
544_V	680_A	0.505	0.21
215_V	219_D	0.505	0.21
324_L	357_A	0.505	0.21
595_E	609_V	0.505	0.21
658_T	683_I	0.505	0.21
19_L	210_A	0.505	0.21
501_V	594_I	0.504	0.21
169_L	174_P	0.504	0.21
343_F	403_A	0.503	0.21
266_R	291_I	0.502	0.21
599_T	608_V	0.502	0.21
44_E	250_V	0.501	0.21
720_D	723_A	0.501	0.21
536_G	666_L	0.500	0.21
540_T	648_T	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.3979	100	0.625	Contact Map
1qu7A	2	0.2971	100	0.683	Contact Map
2ch7A	2	0.4045	100	0.696	Contact Map
3g67A	2	0.2736	100	0.755	Contact Map
4i3mA	2	0.1963	99.9	0.856	Contact Map
3lifA	1	0.301	99.8	0.886	Contact Map
3e4oA	2	0.2762	99.7	0.888	Contact Map
4cq4A	4	0.1126	99.7	0.891	Contact Map
3c8cA	2	0.3037	99.7	0.894	Contact Map
3licA	2	0.2971	99.7	0.894	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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