GREMLIN Database
HTR2 - Sensory rhodopsin II transducer
UniProt: Q9HP81 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 764 (664)
Sequences: 812 (736)
Seq/√Len: 28.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
412_A417_D5.4401.00
318_E323_D5.3321.00
375_R379_E4.2691.00
332_R337_G4.2541.00
372_E375_R4.1181.00
16_K334_D3.7201.00
716_T720_D3.6781.00
372_E379_E3.3381.00
372_E376_A3.0971.00
371_A375_R3.0631.00
591_N609_V2.9621.00
403_A406_Y2.9501.00
540_T663_A2.9201.00
372_E378_A2.8971.00
374_Q378_A2.8141.00
361_T364_A2.7701.00
550_V655_G2.7231.00
370_D375_R2.6941.00
375_R378_A2.6871.00
339_L346_M2.6661.00
360_A364_A2.6070.99
316_A339_L2.5630.99
593_S615_T2.5500.99
355_T359_R2.5400.99
547_M550_V2.4970.99
371_A374_Q2.4740.99
523_A684_R2.4690.99
611_D615_T2.4660.99
542_D661_D2.4510.99
515_V687_T2.3900.99
599_T603_G2.3860.99
316_A343_F2.3790.99
370_D373_Q2.2890.99
600_G603_G2.2850.99
422_V435_G2.2370.98
491_A715_A2.2360.98
713_A720_D2.2320.98
578_I655_G2.2270.98
377_D380_A2.2090.98
587_M597_A2.1810.98
550_V614_K2.1320.98
582_A607_A2.1180.98
422_V434_I2.0890.97
370_D376_A2.0690.97
432_A435_G2.0630.97
344_R347_R2.0500.97
593_S619_E2.0440.97
605_G612_E2.0270.97
584_Q595_E2.0200.97
17_L305_T2.0110.97
357_A360_A2.0010.97
590_L614_K1.9940.97
421_R446_E1.9750.96
399_L403_A1.9640.96
409_A438_L1.9520.96
732_V739_L1.9360.96
583_D594_I1.9340.96
491_A714_Q1.9320.96
631_L655_G1.9290.96
574_I630_R1.9270.96
375_R381_A1.9180.96
346_M350_L1.9160.96
406_Y435_G1.9150.96
362_A365_E1.9100.96
657_A697_V1.9100.96
113_Y119_T1.8970.95
435_G438_L1.8960.95
611_D621_R1.8930.95
339_L350_L1.8870.95
539_A594_I1.8790.95
400_E406_Y1.8790.95
549_D651_T1.8660.95
693_A700_A1.8650.95
518_T679_A1.8650.95
316_A346_M1.8600.95
339_L343_F1.8570.95
568_M658_T1.8480.95
586_N595_E1.8390.94
484_V722_A1.8310.94
597_A608_V1.8290.94
713_A716_T1.8220.94
72_Q107_V1.8180.94
137_G140_F1.8170.94
501_V700_A1.8140.94
509_S698_A1.8130.94
579_A583_D1.8120.94
312_F328_I1.8110.94
452_A570_D1.8110.94
658_T662_A1.8060.94
396_A406_Y1.8030.94
544_V691_A1.7980.94
536_G593_S1.7800.93
230_P233_L1.7780.93
550_V630_R1.7730.93
603_G607_A1.7650.93
377_D381_A1.7590.93
584_Q590_L1.7400.93
608_V612_E1.7360.93
568_M574_I1.7360.93
574_I631_L1.7320.92
319_M346_M1.7090.92
550_V590_L1.7010.92
338_T341_E1.6990.92
627_I655_G1.6890.91
494_Q715_A1.6880.91
579_A628_E1.6860.91
657_A661_D1.6750.91
614_K725_Q1.6610.91
308_A336_F1.6530.91
371_A380_A1.6490.90
312_F343_F1.6430.90
95_E98_A1.6280.90
485_D723_A1.6280.90
315_R326_T1.6240.90
615_T622_D1.6200.90
618_E715_A1.6180.90
582_A599_T1.6160.90
373_Q380_A1.6110.89
611_D628_E1.6040.89
65_W69_A1.6010.89
614_K630_R1.5970.89
577_V712_A1.5880.89
319_M350_L1.5860.89
376_A380_A1.5860.89
583_D711_T1.5850.89
583_D618_E1.5850.89
74_Q77_S1.5840.89
302_G305_T1.5800.88
574_I655_G1.5800.88
94_L98_A1.5760.88
537_R670_V1.5750.88
711_T714_Q1.5710.88
597_A607_A1.5700.88
13_Y305_T1.5690.88
583_D621_R1.5660.88
418_L445_I1.5620.88
357_A364_A1.5620.88
675_D678_T1.5590.88
371_A378_A1.5540.88
662_A666_L1.5530.88
498_L502_A1.5520.88
590_L607_A1.5500.87
628_E715_A1.5410.87
94_L97_L1.5380.87
77_S181_K1.5290.87
324_L351_S1.5280.87
119_T122_A1.5190.86
366_D370_D1.5120.86
662_A704_V1.5110.86
502_A701_V1.5090.86
494_Q537_R1.5040.86
499_H507_D1.4980.86
608_V655_G1.4940.85
589_A598_R1.4940.85
612_E655_G1.4910.85
407_E410_L1.4890.85
493_E704_V1.4890.85
580_D611_D1.4870.85
483_A714_Q1.4850.85
600_G605_G1.4850.85
614_K708_S1.4820.85
607_A612_E1.4770.85
661_D697_V1.4750.85
568_M739_L1.4640.84
516_A519_V1.4600.84
476_A715_A1.4590.84
567_E651_T1.4560.84
499_H503_G1.4550.84
421_R443_D1.4520.84
592_A609_V1.4480.84
578_I612_E1.4470.84
593_S611_D1.4330.83
23_V301_V1.4290.83
473_A486_E1.4270.83
302_G306_V1.4260.83
374_Q377_D1.4200.82
504_E536_G1.4140.82
343_F350_L1.4130.82
372_E380_A1.4080.82
261_W268_P1.3930.81
312_F339_L1.3760.80
371_A376_A1.3740.80
212_G217_H1.3730.80
496_D503_G1.3680.80
515_V611_D1.3640.80
587_M593_S1.3620.80
567_E659_V1.3600.79
505_V656_R1.3590.79
515_V593_S1.3450.79
494_Q694_A1.3420.79
590_L597_A1.3390.78
594_I628_E1.3320.78
620_S627_I1.3310.78
573_E593_S1.3260.78
497_R611_D1.3250.78
66_L217_H1.3160.77
504_E725_Q1.3150.77
425_S435_G1.3150.77
376_A381_A1.3070.77
526_A676_T1.3060.77
666_L690_Q1.3050.77
565_D624_A1.3040.76
579_A594_I1.3020.76
479_D720_D1.2980.76
666_L669_V1.2920.76
340_A346_M1.2870.76
479_D705_A1.2760.75
709_Q713_A1.2720.75
486_E490_G1.2610.74
543_A666_L1.2610.74
77_S175_I1.2550.74
515_V686_A1.2540.74
594_I705_A1.2480.73
574_I577_V1.2470.73
624_A648_T1.2450.73
504_E593_S1.2420.73
648_T652_V1.2380.73
422_V438_L1.2380.73
425_S432_A1.2360.72
20_A23_V1.2350.72
449_V741_D1.2350.72
705_A708_S1.2310.72
496_D709_Q1.2280.72
32_G287_V1.2260.72
583_D614_K1.2250.72
424_A431_M1.2210.72
605_G608_V1.2160.71
159_F186_M1.2150.71
17_L312_F1.2150.71
399_L402_A1.2120.71
400_E407_E1.2090.71
587_M666_L1.2070.71
422_V433_R1.2050.71
86_N90_I1.2000.70
603_G655_G1.1980.70
550_V725_Q1.1980.70
90_I93_Y1.1970.70
417_D442_L1.1880.69
494_Q628_E1.1860.69
73_T76_A1.1840.69
272_A309_L1.1840.69
546_T575_V1.1840.69
433_R437_A1.1800.69
583_D590_L1.1800.69
204_T217_H1.1760.69
708_S711_T1.1700.68
713_A717_A1.1690.68
684_R735_A1.1660.68
533_V581_I1.1640.68
536_G722_A1.1640.68
511_S621_R1.1580.67
714_Q725_Q1.1550.67
409_A422_V1.1550.67
533_V537_R1.1540.67
609_V612_E1.1530.67
599_T610_A1.1510.67
709_Q714_Q1.1500.67
611_D719_A1.1500.67
108_V186_M1.1480.67
583_D705_A1.1470.67
496_D501_V1.1460.67
567_E739_L1.1450.67
581_I609_V1.1440.66
376_A379_E1.1420.66
618_E631_L1.1400.66
586_N609_V1.1400.66
97_L101_D1.1400.66
402_A405_D1.1350.66
371_A379_E1.1300.65
356_D364_A1.1250.65
663_A725_Q1.1110.64
374_Q381_A1.1080.64
202_G271_R1.1070.64
586_N591_N1.1060.64
58_R66_L1.1060.64
177_G183_L1.1050.64
615_T618_E1.1040.64
605_G626_D1.1020.63
441_M445_I1.0990.63
261_W264_L1.0990.63
515_V711_T1.0990.63
494_Q707_I1.0960.63
229_G233_L1.0950.63
652_V655_G1.0950.63
485_D695_S1.0940.63
495_T583_D1.0910.63
523_A681_G1.0910.63
441_M700_A1.0890.63
536_G735_A1.0860.62
659_V676_T1.0810.62
175_I189_V1.0810.62
512_A684_R1.0800.62
490_G711_T1.0770.62
582_A590_L1.0770.62
603_G609_V1.0740.61
400_E404_A1.0720.61
577_V655_G1.0710.61
630_R655_G1.0700.61
491_A575_V1.0690.61
704_V715_A1.0680.61
490_G583_D1.0650.61
296_L331_S1.0650.61
359_R362_A1.0600.60
88_T92_R1.0580.60
648_T676_T1.0570.60
628_E711_T1.0570.60
497_R575_V1.0560.60
219_D223_V1.0560.60
500_E709_Q1.0560.60
614_K619_E1.0520.60
580_D618_E1.0500.60
499_H709_Q1.0470.59
512_A673_V1.0450.59
453_T736_A1.0440.59
307_T326_T1.0430.59
481_S723_A1.0430.59
535_D538_Q1.0420.59
252_A256_V1.0420.59
332_R347_R1.0390.59
402_A406_Y1.0370.59
403_A431_M1.0350.59
665_A707_I1.0320.58
476_A526_A1.0300.58
570_D626_D1.0290.58
490_G707_I1.0280.58
662_A676_T1.0230.58
158_P170_S1.0220.58
520_A688_D1.0210.57
576_D628_E1.0190.57
606_F610_A1.0190.57
546_T708_S1.0170.57
344_R348_D1.0170.57
400_E403_A1.0150.57
594_I714_Q1.0150.57
430_A540_T1.0140.57
12_S488_S1.0140.57
540_T725_Q1.0120.57
148_A151_S1.0110.57
438_L445_I1.0110.57
352_E356_D1.0080.56
229_G237_S1.0050.56
77_S284_V1.0040.56
696_R712_A0.9990.56
111_H114_N0.9970.56
490_G714_Q0.9970.56
614_K700_A0.9960.56
684_R725_Q0.9950.55
603_G627_I0.9920.55
473_A673_V0.9900.55
495_T709_Q0.9900.55
413_V694_A0.9900.55
578_I586_N0.9890.55
50_D53_G0.9870.55
603_G608_V0.9860.55
434_I437_A0.9850.55
583_D602_D0.9850.55
580_D587_M0.9830.55
13_Y308_A0.9820.55
512_A631_L0.9810.54
62_L103_R0.9790.54
113_Y120_I0.9780.54
717_A720_D0.9760.54
456_S473_A0.9760.54
593_S714_Q0.9750.54
503_G705_A0.9750.54
581_I591_N0.9710.54
577_V648_T0.9690.54
529_A607_A0.9670.53
539_A705_A0.9660.53
546_T583_D0.9630.53
650_D654_D0.9620.53
647_A651_T0.9620.53
156_A159_F0.9580.53
501_V504_E0.9580.53
594_I611_D0.9560.52
63_D67_S0.9520.52
550_V583_D0.9510.52
676_T722_A0.9490.52
402_A407_E0.9490.52
231_S239_T0.9470.52
319_M347_R0.9470.52
648_T655_G0.9460.52
630_R663_A0.9450.52
324_L350_L0.9440.52
175_I180_D0.9420.51
513_E695_S0.9420.51
334_D337_G0.9390.51
567_E658_T0.9390.51
261_W273_F0.9390.51
328_I340_A0.9350.51
722_A726_T0.9340.51
581_I619_E0.9330.51
522_L540_T0.9320.51
672_F722_A0.9320.51
316_A350_L0.9300.50
594_I711_T0.9290.50
523_A676_T0.9280.50
182_A187_V0.9240.50
625_E704_V0.9240.50
174_P180_D0.9240.50
438_L446_E0.9240.50
598_R659_V0.9230.50
490_G594_I0.9220.50
583_D708_S0.9210.50
435_G441_M0.9190.50
568_M655_G0.9180.50
686_A691_A0.9180.50
600_G612_E0.9170.49
485_D701_V0.9170.49
523_A677_D0.9160.49
589_A666_L0.9160.49
120_I202_G0.9150.49
571_I578_I0.9150.49
568_M648_T0.9140.49
546_T711_T0.9140.49
322_G683_I0.9130.49
631_L648_T0.9120.49
121_E125_A0.9070.49
413_V442_L0.9070.49
578_I595_E0.9070.49
515_V714_Q0.9050.49
515_V594_I0.9050.49
620_S630_R0.9030.48
18_T58_R0.9020.48
580_D625_E0.9020.48
422_V431_M0.9010.48
578_I623_A0.9010.48
593_S652_V0.9000.48
363_R366_D0.8980.48
584_Q607_A0.8980.48
604_D611_D0.8950.48
203_S208_V0.8950.48
438_L441_M0.8950.48
518_T615_T0.8940.48
246_A296_L0.8920.48
572_G578_I0.8900.47
597_A612_E0.8900.47
595_E600_G0.8900.47
579_A714_Q0.8890.47
496_D711_T0.8870.47
66_L69_A0.8860.47
490_G715_A0.8840.47
546_T581_I0.8810.47
432_A436_H0.8780.46
292_V701_V0.8760.46
479_D724_T0.8760.46
498_L705_A0.8750.46
648_T663_A0.8750.46
623_A666_L0.8740.46
624_A630_R0.8730.46
667_D691_A0.8700.46
359_R363_R0.8690.46
574_I623_A0.8680.46
207_V734_D0.8680.46
578_I603_G0.8680.46
478_T710_E0.8670.46
490_G716_T0.8620.45
487_I658_T0.8620.45
594_I625_E0.8610.45
262_S312_F0.8600.45
70_R76_A0.8590.45
404_A407_E0.8580.45
533_V587_M0.8570.45
123_S128_F0.8570.45
476_A662_A0.8560.45
579_A708_S0.8550.45
499_H583_D0.8550.45
705_A711_T0.8540.45
429_D432_A0.8530.45
649_S653_S0.8500.44
575_V624_A0.8500.44
479_D710_E0.8500.44
509_S628_E0.8490.44
234_L238_R0.8470.44
523_A722_A0.8460.44
356_D360_A0.8450.44
548_D565_D0.8440.44
313_S358_E0.8410.44
174_P255_P0.8390.43
112_V183_L0.8390.43
183_L186_M0.8390.43
117_T177_G0.8370.43
537_R576_D0.8370.43
597_A655_G0.8340.43
698_A711_T0.8330.43
583_D593_S0.8310.43
374_Q380_A0.8310.43
519_V544_V0.8310.43
46_D296_L0.8300.43
621_R715_A0.8290.43
614_K739_L0.8290.43
158_P161_V0.8280.43
519_V736_A0.8280.43
725_Q738_D0.8270.43
578_I605_G0.8260.42
438_L570_D0.8260.42
378_A381_A0.8250.42
487_I739_L0.8230.42
177_G181_K0.8220.42
609_V613_V0.8220.42
159_F189_V0.8200.42
347_R351_S0.8190.42
402_A432_A0.8190.42
319_M339_L0.8170.42
504_E619_E0.8170.42
599_T607_A0.8150.42
573_E715_A0.8150.42
309_L338_T0.8140.42
600_G620_S0.8130.41
502_A550_V0.8130.41
595_E623_A0.8120.41
529_A672_F0.8120.41
684_R687_T0.8100.41
485_D529_A0.8090.41
249_T253_A0.8080.41
232_R241_P0.8070.41
620_S655_G0.8050.41
575_V679_A0.8040.41
607_A655_G0.8030.41
593_S728_T0.8030.41
109_A119_T0.8020.41
418_L431_M0.7990.40
192_L207_V0.7990.40
519_V652_V0.7970.40
577_V621_R0.7960.40
492_T669_V0.7960.40
183_L187_V0.7940.40
576_D703_E0.7920.40
504_E512_A0.7910.40
476_A573_E0.7910.40
550_V687_T0.7900.40
499_H579_A0.7900.40
590_L608_V0.7890.40
504_E573_E0.7890.40
109_A161_V0.7880.40
297_I303_S0.7850.39
437_A584_Q0.7850.39
23_V26_V0.7850.39
39_T305_T0.7840.39
438_L593_S0.7840.39
602_D696_R0.7820.39
666_L683_I0.7810.39
157_A161_V0.7810.39
92_R98_A0.7810.39
312_F319_M0.7800.39
76_A154_V0.7790.39
342_S349_S0.7790.39
429_D438_L0.7770.39
596_A608_V0.7750.39
165_D172_L0.7750.39
587_M676_T0.7750.39
166_F261_W0.7740.39
632_L725_Q0.7720.38
725_Q739_L0.7710.38
543_A577_V0.7710.38
69_A72_Q0.7680.38
507_D693_A0.7680.38
490_G708_S0.7660.38
453_T484_V0.7660.38
576_D626_D0.7650.38
116_S209_S0.7650.38
189_V200_V0.7640.38
681_G684_R0.7630.38
505_V723_A0.7620.38
539_A658_T0.7610.38
187_V191_T0.7610.38
614_K621_R0.7610.38
288_L292_V0.7600.38
312_F316_A0.7580.37
476_A686_A0.7580.37
492_T716_T0.7570.37
598_R705_A0.7570.37
236_Q240_Q0.7560.37
571_I655_G0.7560.37
117_T122_A0.7520.37
441_M550_V0.7490.37
567_E656_R0.7480.37
62_L97_L0.7480.37
566_S569_A0.7480.37
370_D381_A0.7470.37
533_V619_E0.7450.36
495_T499_H0.7450.36
109_A122_A0.7440.36
618_E720_D0.7430.36
172_L182_A0.7420.36
530_A534_D0.7400.36
543_A631_L0.7390.36
594_I694_A0.7370.36
583_D619_E0.7370.36
583_D714_Q0.7370.36
505_V604_D0.7360.36
16_K21_L0.7360.36
479_D716_T0.7350.36
701_V704_V0.7300.35
319_M735_A0.7290.35
623_A690_Q0.7290.35
16_K24_V0.7260.35
605_G609_V0.7250.35
55_A209_S0.7240.35
435_G518_T0.7240.35
595_E614_K0.7220.35
579_A625_E0.7210.35
497_R705_A0.7210.35
576_D725_Q0.7200.35
705_A714_Q0.7190.35
312_F326_T0.7190.35
179_T182_A0.7180.35
445_I631_L0.7180.35
445_I676_T0.7170.35
593_S613_V0.7150.34
512_A648_T0.7130.34
14_G303_S0.7120.34
501_V708_S0.7100.34
231_S234_L0.7100.34
579_A711_T0.7100.34
396_A400_E0.7080.34
580_D677_D0.7080.34
324_L354_L0.7060.34
546_T619_E0.7040.34
671_S678_T0.7040.34
700_A711_T0.7010.33
508_L698_A0.7010.33
690_Q697_V0.7000.33
594_I708_S0.7000.33
497_R625_E0.7000.33
493_E720_D0.7000.33
108_V111_H0.7000.33
579_A630_R0.6980.33
86_N89_A0.6970.33
316_A319_M0.6970.33
725_Q732_V0.6970.33
158_P184_I0.6960.33
617_A620_S0.6960.33
75_L80_P0.6960.33
403_A410_L0.6940.33
527_G530_A0.6940.33
613_V626_D0.6930.33
402_A438_L0.6930.33
540_T722_A0.6930.33
167_P186_M0.6920.33
19_L290_T0.6920.33
718_V728_T0.6920.33
91_T98_A0.6910.33
652_V656_R0.6910.33
109_A121_E0.6910.33
110_A114_N0.6890.33
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412_A581_I0.6870.32
488_S701_V0.6870.32
543_A587_M0.6860.32
438_L694_A0.6850.32
502_A704_V0.6830.32
305_T328_I0.6830.32
74_Q156_A0.6830.32
171_V261_W0.6830.32
430_A441_M0.6820.32
584_Q680_A0.6800.32
24_V308_A0.6800.32
575_V628_E0.6750.32
428_H432_A0.6740.32
452_A544_V0.6740.32
437_A543_A0.6740.32
536_G679_A0.6730.31
398_A402_A0.6720.31
573_E676_T0.6710.31
611_D708_S0.6700.31
690_Q709_Q0.6700.31
521_S682_E0.6700.31
51_L54_S0.6680.31
694_A711_T0.6680.31
705_A712_A0.6680.31
117_T121_E0.6680.31
186_M189_V0.6670.31
285_G289_I0.6670.31
418_L438_L0.6640.31
547_M655_G0.6640.31
624_A712_A0.6630.31
618_E655_G0.6630.31
579_A621_R0.6620.31
618_E725_Q0.6610.31
290_T301_V0.6610.31
505_V508_L0.6610.31
480_V648_T0.6600.31
567_E618_E0.6600.31
203_S261_W0.6600.31
580_D609_V0.6600.31
574_I648_T0.6580.30
56_D59_A0.6570.30
532_A672_F0.6570.30
718_V721_S0.6570.30
287_V298_G0.6560.30
360_A363_R0.6560.30
582_A610_A0.6540.30
494_Q519_V0.6530.30
67_S185_Y0.6530.30
416_G666_L0.6530.30
533_V722_A0.6520.30
108_V112_V0.6510.30
327_D344_R0.6510.30
508_L604_D0.6510.30
403_A449_V0.6500.30
69_A80_P0.6490.30
518_T714_Q0.6460.30
364_A371_A0.6450.30
58_R62_L0.6450.30
337_G340_A0.6440.30
120_I123_S0.6440.30
508_L547_M0.6430.30
399_L491_A0.6390.29
61_H69_A0.6370.29
508_L516_A0.6350.29
431_M455_F0.6350.29
567_E570_D0.6340.29
503_G507_D0.6330.29
673_V676_T0.6320.29
595_E605_G0.6310.29
429_D533_V0.6300.29
417_D441_M0.6300.29
615_T655_G0.6300.29
659_V669_V0.6290.29
502_A506_D0.6290.29
435_G593_S0.6280.29
476_A546_T0.6280.29
192_L196_F0.6270.28
519_V599_T0.6250.28
113_Y184_I0.6250.28
614_K729_L0.6250.28
579_A715_A0.6250.28
156_A189_V0.6230.28
90_I95_E0.6220.28
203_S263_V0.6220.28
581_I608_V0.6220.28
617_A705_A0.6220.28
480_V673_V0.6220.28
498_L624_A0.6210.28
230_P348_D0.6200.28
575_V711_T0.6200.28
265_V272_A0.6190.28
526_A722_A0.6190.28
21_L24_V0.6190.28
611_D704_V0.6190.28
697_V704_V0.6190.28
211_D331_S0.6180.28
540_T652_V0.6180.28
41_T337_G0.6180.28
496_D583_D0.6180.28
500_E503_G0.6170.28
504_E514_E0.6170.28
487_I624_A0.6160.28
406_Y438_L0.6140.28
158_P186_M0.6130.28
250_V253_A0.6130.28
522_L728_T0.6130.28
170_S184_I0.6110.27
131_V137_G0.6100.27
346_M593_S0.6100.27
412_A722_A0.6100.27
492_T713_A0.6100.27
23_V250_V0.6090.27
116_S124_S0.6090.27
140_F186_M0.6090.27
593_S696_R0.6090.27
663_A722_A0.6080.27
619_E705_A0.6070.27
665_A672_F0.6060.27
619_E673_V0.6050.27
526_A663_A0.6050.27
702_D722_A0.6050.27
546_T579_A0.6040.27
13_Y406_Y0.6040.27
21_L286_L0.6040.27
416_G598_R0.6030.27
568_M652_V0.6020.27
203_S218_P0.6020.27
581_I722_A0.6010.27
421_R681_G0.6000.27
402_A615_T0.5990.27
537_R630_R0.5980.27
445_I452_A0.5980.27
597_A689_R0.5970.27
62_L352_E0.5950.27
583_D709_Q0.5940.26
66_L70_R0.5940.26
596_A610_A0.5940.26
202_G206_T0.5940.26
69_A75_L0.5930.26
17_L302_G0.5930.26
452_A455_F0.5930.26
258_G263_V0.5930.26
590_L612_E0.5920.26
578_I631_L0.5920.26
437_A725_Q0.5920.26
623_A655_G0.5920.26
109_A186_M0.5920.26
306_V336_F0.5920.26
487_I567_E0.5910.26
174_P334_D0.5900.26
585_T590_L0.5900.26
301_V309_L0.5900.26
13_Y282_S0.5890.26
202_G261_W0.5870.26
473_A719_A0.5870.26
526_A680_A0.5860.26
203_S267_A0.5860.26
43_L55_A0.5850.26
361_T536_G0.5850.26
149_T154_V0.5830.26
122_A147_F0.5830.26
502_A607_A0.5820.26
169_L215_V0.5810.26
577_V620_S0.5810.26
331_S695_S0.5790.26
339_L735_A0.5790.26
493_E703_E0.5780.26
287_V291_I0.5770.25
10_R15_T0.5770.25
511_S515_V0.5770.25
212_G261_W0.5770.25
483_A593_S0.5770.25
582_A672_F0.5760.25
209_S261_W0.5760.25
483_A704_V0.5750.25
123_S130_G0.5750.25
399_L407_E0.5750.25
17_L20_A0.5740.25
214_Y247_N0.5740.25
424_A575_V0.5730.25
580_D621_R0.5730.25
247_N292_V0.5720.25
410_L435_G0.5710.25
598_R713_A0.5700.25
497_R704_V0.5700.25
55_A59_A0.5670.25
458_H518_T0.5670.25
111_H122_A0.5660.25
662_A690_Q0.5650.25
274_A313_S0.5640.25
441_M715_A0.5640.25
422_V502_A0.5630.25
339_L349_S0.5630.25
449_V570_D0.5630.25
598_R716_T0.5620.25
504_E679_A0.5620.25
578_I609_V0.5610.25
522_L659_V0.5600.24
430_A433_R0.5600.24
204_T218_P0.5600.24
621_R655_G0.5590.24
648_T666_L0.5590.24
707_I711_T0.5590.24
590_L600_G0.5590.24
519_V683_I0.5590.24
533_V663_A0.5590.24
399_L441_M0.5590.24
593_S676_T0.5580.24
666_L712_A0.5580.24
360_A593_S0.5580.24
158_P261_W0.5580.24
624_A709_Q0.5580.24
71_G76_A0.5570.24
544_V666_L0.5570.24
495_T579_A0.5570.24
72_Q76_A0.5560.24
599_T605_G0.5560.24
373_Q377_D0.5550.24
117_T181_K0.5550.24
576_D710_E0.5550.24
656_R665_A0.5540.24
112_V129_T0.5540.24
585_T607_A0.5530.24
23_V28_S0.5510.24
12_S304_T0.5500.24
113_Y122_A0.5490.24
249_T261_W0.5490.24
231_S235_N0.5480.24
309_L312_F0.5480.24
594_I718_V0.5480.24
597_A613_V0.5480.24
533_V625_E0.5480.24
501_V705_A0.5470.24
501_V625_E0.5470.24
603_G614_K0.5470.24
353_S357_A0.5450.24
435_G679_A0.5440.24
515_V694_A0.5440.24
122_A129_T0.5440.24
184_I268_P0.5440.24
113_Y170_S0.5430.23
422_V705_A0.5430.23
420_R434_I0.5430.23
362_A699_S0.5430.23
698_A708_S0.5420.23
512_A579_A0.5410.23
370_D380_A0.5400.23
345_S350_L0.5400.23
51_L158_P0.5400.23
139_P293_S0.5400.23
570_D647_A0.5390.23
23_V42_Q0.5390.23
148_A175_I0.5380.23
481_S485_D0.5380.23
299_V310_R0.5370.23
474_I726_T0.5360.23
293_S296_L0.5350.23
19_L512_A0.5340.23
89_A96_G0.5320.23
578_I627_I0.5320.23
486_E526_A0.5320.23
316_A320_A0.5310.23
621_R676_T0.5300.23
335_E617_A0.5300.23
536_G699_S0.5290.23
422_V437_A0.5280.23
441_M488_S0.5280.23
582_A690_Q0.5280.23
624_A690_Q0.5260.23
505_V701_V0.5260.23
575_V655_G0.5250.23
594_I621_R0.5250.23
62_L143_D0.5250.23
193_T205_T0.5250.23
597_A603_G0.5240.22
410_L422_V0.5230.22
700_A725_Q0.5230.22
441_M449_V0.5230.22
568_M627_I0.5220.22
80_P168_V0.5220.22
649_S722_A0.5220.22
495_T500_E0.5220.22
53_G151_S0.5220.22
435_G704_V0.5210.22
599_T609_V0.5210.22
339_L345_S0.5210.22
480_V601_A0.5200.22
77_S183_L0.5200.22
501_V583_D0.5200.22
577_V627_I0.5200.22
694_A698_A0.5200.22
235_N289_I0.5190.22
601_A604_D0.5180.22
24_V27_L0.5170.22
516_A683_I0.5170.22
32_G253_A0.5170.22
85_G90_I0.5170.22
584_Q593_S0.5170.22
492_T673_V0.5160.22
569_A651_T0.5160.22
371_A381_A0.5150.22
340_A347_R0.5150.22
439_N445_I0.5150.22
347_R360_A0.5140.22
544_V683_I0.5140.22
192_L203_S0.5130.22
613_V659_V0.5130.22
543_A620_S0.5130.22
506_D693_A0.5120.22
36_Y279_V0.5120.22
158_P168_V0.5120.22
289_I296_L0.5110.22
487_I620_S0.5110.22
75_L79_H0.5110.22
579_A607_A0.5110.22
19_L106_G0.5100.22
416_G589_A0.5100.22
285_G293_S0.5100.22
184_I190_N0.5090.22
539_A575_V0.5090.22
597_A617_A0.5090.22
577_V604_D0.5080.22
129_T170_S0.5080.22
437_A722_A0.5080.22
709_Q716_T0.5080.22
492_T714_Q0.5080.22
677_D684_R0.5070.22
249_T266_R0.5070.22
403_A409_A0.5060.21
497_R539_A0.5060.21
583_D655_G0.5060.21
593_S602_D0.5060.21
120_I216_S0.5060.21
473_A666_L0.5060.21
544_V680_A0.5050.21
215_V219_D0.5050.21
324_L357_A0.5050.21
595_E609_V0.5050.21
658_T683_I0.5050.21
19_L210_A0.5050.21
501_V594_I0.5040.21
169_L174_P0.5040.21
343_F403_A0.5030.21
266_R291_I0.5020.21
599_T608_V0.5020.21
44_E250_V0.5010.21
720_D723_A0.5010.21
536_G666_L0.5000.21
540_T648_T0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.3979 100 0.625 Contact Map
1qu7A 2 0.2971 100 0.683 Contact Map
2ch7A 2 0.4045 100 0.696 Contact Map
3g67A 2 0.2736 100 0.755 Contact Map
4i3mA 2 0.1963 99.9 0.856 Contact Map
3lifA 1 0.301 99.8 0.886 Contact Map
3e4oA 2 0.2762 99.7 0.888 Contact Map
4cq4A 4 0.1126 99.7 0.891 Contact Map
3c8cA 2 0.3037 99.7 0.894 Contact Map
3licA 2 0.2971 99.7 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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