GREMLIN Database
GTPC1 - Putative GTP cyclohydrolase 1 type 2
UniProt: Q9HP80 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (241)
Sequences: 3756 (2809)
Seq/√Len: 180.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_A225_T3.5981.00
51_S85_A3.3711.00
176_A194_V2.8671.00
137_Q174_D2.6631.00
142_T150_S2.5831.00
137_Q173_T2.5631.00
147_L196_A2.5251.00
42_A63_V2.4701.00
150_S154_A2.4331.00
143_S146_A2.2451.00
19_Y25_N2.2411.00
86_L93_L2.1941.00
37_E59_D2.1441.00
112_V155_L2.0991.00
40_A58_A2.0601.00
54_V89_G2.0501.00
199_T217_V2.0401.00
6_V60_L2.0041.00
141_P171_E1.9651.00
38_R59_D1.9271.00
119_T139_P1.9241.00
172_L196_A1.9081.00
47_A81_D1.8911.00
11_N16_V1.8761.00
52_D56_W1.8701.00
38_R243_E1.8581.00
54_V85_A1.8561.00
120_Q137_Q1.8441.00
38_R245_R1.8441.00
42_A49_T1.8201.00
201_E219_L1.7871.00
56_W245_R1.7491.00
9_R240_W1.7311.00
19_Y102_G1.7001.00
51_S55_E1.6931.00
3_V92_A1.6891.00
196_A218_F1.6841.00
141_P173_T1.6811.00
13_R235_A1.6701.00
86_L91_C1.6671.00
110_A134_L1.6301.00
42_A61_L1.6211.00
50_I61_L1.6161.00
151_L198_V1.6121.00
7_T94_Y1.6081.00
9_R235_A1.6051.00
50_I86_L1.5991.00
115_V231_R1.5961.00
145_P169_P1.5741.00
84_A88_D1.5741.00
50_I85_A1.5571.00
47_A85_A1.5291.00
45_A63_V1.5021.00
178_V185_W1.4941.00
109_A179_T1.4881.00
63_V95_A1.4801.00
3_V36_V1.4741.00
40_A61_L1.4541.00
123_P131_Q1.4441.00
199_T202_G1.4371.00
12_D239_D1.4261.00
151_L218_F1.4121.00
144_A216_S1.4001.00
200_G221_G1.3851.00
124_F192_N1.3731.00
106_L110_A1.3661.00
125_G188_E1.3631.00
68_A72_L1.3631.00
202_G217_V1.3561.00
3_V60_L1.3561.00
38_R57_G1.3491.00
40_A56_W1.3471.00
189_A194_V1.3461.00
135_Q194_V1.3401.00
6_V36_V1.3341.00
147_L198_V1.3271.00
114_D121_R1.3231.00
11_N94_Y1.3041.00
124_F133_G1.2931.00
111_H232_A1.2911.00
5_D8_S1.2861.00
47_A51_S1.2781.00
184_D205_K1.2741.00
144_A164_V1.2661.00
84_A87_V1.2571.00
100_L229_G1.2531.00
145_P149_K1.2511.00
41_F62_V1.2501.00
144_A218_F1.2251.00
163_Q219_L1.2131.00
173_T195_D1.2051.00
38_R56_W1.2001.00
108_N179_T1.2001.00
167_V170_A1.1981.00
113_A177_V1.1971.00
190_E213_A1.1951.00
34_R90_E1.1941.00
10_Y62_V1.1811.00
45_A61_L1.1761.00
24_T73_D1.1731.00
4_S33_D1.1641.00
7_T11_N1.1631.00
40_A52_D1.1601.00
144_A196_A1.1531.00
80_Y87_V1.1511.00
234_E238_D1.1491.00
196_A216_S1.1461.00
203_K206_L1.1451.00
13_R106_L1.1421.00
41_F236_V1.1381.00
46_A208_H1.1361.00
142_T146_A1.1301.00
183_A203_K1.1291.00
111_H114_D1.1191.00
60_L92_A1.1091.00
117_G150_S1.1041.00
114_D232_A1.0841.00
122_S192_N1.0831.00
187_R209_E1.0831.00
25_N99_P1.0821.00
118_L136_G1.0811.00
41_F230_V1.0791.00
170_A216_S1.0671.00
168_G171_E1.0641.00
152_A160_Q1.0551.00
50_I82_R1.0491.00
122_S174_D1.0421.00
187_R191_A1.0230.99
60_L94_Y1.0110.99
15_R18_D1.0050.99
29_V86_L0.9990.99
181_S203_K0.9970.99
41_F244_T0.9930.99
149_K153_A0.9930.99
186_L215_V0.9880.99
44_D204_G0.9870.99
10_Y96_A0.9840.99
159_D162_V0.9760.99
168_G216_S0.9720.99
77_G80_Y0.9680.99
34_R59_D0.9650.99
188_E191_A0.9620.99
118_L147_L0.9600.99
204_G223_Y0.9470.99
235_A239_D0.9420.99
174_D193_G0.9400.99
135_Q192_N0.9360.99
52_D55_E0.9320.99
100_L233_L0.9260.99
51_S54_V0.9200.99
111_H115_V0.9170.99
117_G139_P0.9170.99
49_T61_L0.9140.99
14_L100_L0.9120.99
183_A206_L0.9100.99
146_A149_K0.9050.99
80_Y84_A0.9040.99
147_L175_V0.9010.99
188_E192_N0.8990.99
6_V39_I0.8950.99
102_G132_I0.8930.99
81_D85_A0.8930.99
178_V197_L0.8910.99
113_A121_R0.8880.99
116_L151_L0.8830.98
138_L175_V0.8830.98
47_A212_E0.8810.98
189_A193_G0.8710.98
148_S164_V0.8700.98
27_L92_A0.8670.98
18_D130_E0.8650.98
204_G208_H0.8620.98
80_Y83_I0.8580.98
113_A136_G0.8560.98
9_R12_D0.8550.98
198_V218_F0.8530.98
178_V182_G0.8510.98
108_N229_G0.8490.98
116_L198_V0.8480.98
147_L151_L0.8430.98
108_N111_H0.8400.98
140_D146_A0.8350.98
20_A102_G0.8340.98
34_R92_A0.8320.98
202_G207_Y0.8320.98
234_E237_A0.8270.98
147_L218_F0.8230.98
204_G221_G0.8150.97
31_P34_R0.8150.97
150_S153_A0.8130.97
187_R213_A0.8120.97
223_Y227_T0.8110.97
28_Q95_A0.8020.97
10_Y94_Y0.8000.97
9_R239_D0.7920.97
14_L103_H0.7920.97
207_Y217_V0.7890.97
48_A211_R0.7870.97
110_A114_D0.7870.97
124_F131_Q0.7860.97
46_A49_T0.7850.97
16_V94_Y0.7850.97
142_T147_L0.7850.97
4_S32_G0.7830.97
10_Y233_L0.7800.97
102_G127_H0.7730.97
121_R137_Q0.7720.96
117_G154_A0.7710.96
39_I60_L0.7700.96
9_R13_R0.7690.96
172_L218_F0.7690.96
29_V83_I0.7670.96
54_V91_C0.7670.96
115_V154_A0.7630.96
7_T16_V0.7590.96
118_L121_R0.7560.96
135_Q174_D0.7550.96
143_S171_E0.7530.96
4_S8_S0.7510.96
148_S218_F0.7480.96
115_V119_T0.7470.96
40_A91_C0.7470.96
145_P168_G0.7450.96
170_A195_D0.7440.96
37_E57_G0.7350.95
108_N228_G0.7340.95
123_P126_D0.7230.95
49_T52_D0.7190.95
174_D194_V0.7180.95
75_V83_I0.7170.95
27_L30_G0.7140.95
45_A50_I0.7070.94
136_G189_A0.7040.94
96_A99_P0.7020.94
67_V79_E0.7010.94
100_L232_A0.7000.94
142_T196_A0.6960.94
7_T60_L0.6910.94
122_S137_Q0.6870.93
122_S135_Q0.6870.93
119_T137_Q0.6860.93
220_A224_A0.6850.93
106_L235_A0.6820.93
138_L142_T0.6820.93
47_A82_R0.6780.93
20_A185_W0.6780.93
165_L207_Y0.6780.93
111_H229_G0.6770.93
85_A89_G0.6740.93
103_H110_A0.6710.93
8_S12_D0.6710.93
155_L225_T0.6710.93
3_V94_Y0.6660.92
18_D102_G0.6640.92
206_L209_E0.6630.92
23_A207_Y0.6610.92
190_E215_V0.6600.92
144_A148_S0.6570.92
75_V87_V0.6550.92
242_V245_R0.6550.92
111_H228_G0.6530.92
22_A66_G0.6530.92
209_E213_A0.6500.91
54_V57_G0.6420.91
25_N28_Q0.6420.91
202_G219_L0.6410.91
166_D216_S0.6400.91
186_L190_E0.6400.91
138_L141_P0.6380.91
147_L195_D0.6370.91
165_L217_V0.6320.90
184_D203_K0.6320.90
24_T28_Q0.6310.90
3_V34_R0.6300.90
79_E82_R0.6280.90
31_P88_D0.6260.90
66_G95_A0.6230.90
182_G197_L0.6210.89
115_V228_G0.6210.89
143_S148_S0.6200.89
138_L147_L0.6180.89
186_L213_A0.6140.89
113_A118_L0.6110.89
11_N17_T0.6110.89
10_Y13_R0.6080.88
164_V218_F0.6040.88
78_R213_A0.6040.88
124_F189_A0.5990.88
207_Y211_R0.5980.88
22_A181_S0.5950.87
144_A169_P0.5930.87
16_V25_N0.5920.87
120_Q136_G0.5910.87
22_A25_N0.5890.87
201_E207_Y0.5850.86
227_T230_V0.5830.86
144_A166_D0.5790.86
125_G197_L0.5790.86
164_V168_G0.5780.86
189_A192_N0.5750.86
109_A134_L0.5740.85
10_Y14_L0.5680.85
65_H101_D0.5660.85
229_G233_L0.5660.85
199_T206_L0.5650.85
45_A93_L0.5640.84
204_G224_A0.5630.84
208_H211_R0.5630.84
144_A170_A0.5550.83
36_V92_A0.5550.83
174_D195_D0.5540.83
222_H226_E0.5530.83
145_P167_V0.5520.83
197_L210_A0.5520.83
51_S81_D0.5510.83
45_A82_R0.5480.83
155_L220_A0.5470.83
200_G220_A0.5470.83
148_S162_V0.5460.82
53_A61_L0.5460.82
177_V198_V0.5440.82
134_L177_V0.5430.82
241_G244_T0.5430.82
38_R58_A0.5410.82
64_H99_P0.5410.82
163_Q221_G0.5400.82
85_A88_D0.5400.82
103_H106_L0.5390.82
243_E246_F0.5390.82
23_A205_K0.5380.82
24_T69_W0.5360.81
162_V220_A0.5350.81
29_V75_V0.5340.81
81_D84_A0.5320.81
67_V93_L0.5320.81
112_V179_T0.5310.81
13_R233_L0.5290.80
127_H130_E0.5240.80
68_A83_I0.5240.80
72_L83_I0.5240.80
36_V60_L0.5230.80
22_A69_W0.5220.80
45_A67_V0.5220.80
152_A159_D0.5200.79
100_L108_N0.5200.79
48_A212_E0.5190.79
28_Q67_V0.5180.79
6_V62_V0.5170.79
177_V197_L0.5170.79
42_A45_A0.5130.78
62_V233_L0.5130.78
131_Q134_L0.5110.78
22_A208_H0.5090.78
186_L210_A0.5060.78
165_L202_G0.5060.78
29_V93_L0.5060.78
113_A134_L0.5050.77
210_A215_V0.5040.77
179_T225_T0.5040.77
170_A173_T0.5030.77
23_A95_A0.5030.77
112_V177_V0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gx8A 5 0.9842 100 0.079 Contact Map
2nydA 5 0.9842 100 0.085 Contact Map
2fywA 3 0.9802 100 0.104 Contact Map
1nmoA 4 0.9684 100 0.109 Contact Map
3wsfA 3 0.9447 100 0.132 Contact Map
2yybA 3 0.9486 100 0.133 Contact Map
3rxyA 4 0.9091 100 0.249 Contact Map
4djdC 2 0.8617 74.2 0.942 Contact Map
4nirA 3 0.7866 68.9 0.944 Contact Map
1f6yA 2 0.83 62.1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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