GTPC1 - HALSA - GREMLIN Contacts

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GTPC1 - Putative GTP cyclohydrolase 1 type 2

UniProt:	Q9HP80	Sequences: MDVSDVTSRYNDRLRVTDYADAATNGLQVGPGDRSVERIAFAVDAAAATISDAVEWGADLLVVHHGVAWGGLDAVTGREYDRIAALVDGECALYAAHLPLDGHPELGNAAHVADVLGLTQRSPFGDHSGEQIGLQGQLPDPTSAPALSKSLAAALPTGDQPVQVLDVGPAELTDVAVVTGSGADWLREAEANGVDALVTGEGKGKLYHEAREAGVSVFLAGHYATETGGVRALEAVADDWGVETRFISHPTGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	253 (241)
Sequences:	3756 (2809)
Seq/√Len:	180.9

ECOLI - GTPC1
BACSU - GTPC1
HALSA - GTPC1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
220_A	225_T	3.598	1.00
51_S	85_A	3.371	1.00
176_A	194_V	2.867	1.00
137_Q	174_D	2.663	1.00
142_T	150_S	2.583	1.00
137_Q	173_T	2.563	1.00
147_L	196_A	2.525	1.00
42_A	63_V	2.470	1.00
150_S	154_A	2.433	1.00
143_S	146_A	2.245	1.00
19_Y	25_N	2.241	1.00
86_L	93_L	2.194	1.00
37_E	59_D	2.144	1.00
112_V	155_L	2.099	1.00
40_A	58_A	2.060	1.00
54_V	89_G	2.050	1.00
199_T	217_V	2.040	1.00
6_V	60_L	2.004	1.00
141_P	171_E	1.965	1.00
38_R	59_D	1.927	1.00
119_T	139_P	1.924	1.00
172_L	196_A	1.908	1.00
47_A	81_D	1.891	1.00
11_N	16_V	1.876	1.00
52_D	56_W	1.870	1.00
38_R	243_E	1.858	1.00
54_V	85_A	1.856	1.00
120_Q	137_Q	1.844	1.00
38_R	245_R	1.844	1.00
42_A	49_T	1.820	1.00
201_E	219_L	1.787	1.00
56_W	245_R	1.749	1.00
9_R	240_W	1.731	1.00
19_Y	102_G	1.700	1.00
51_S	55_E	1.693	1.00
3_V	92_A	1.689	1.00
196_A	218_F	1.684	1.00
141_P	173_T	1.681	1.00
13_R	235_A	1.670	1.00
86_L	91_C	1.667	1.00
110_A	134_L	1.630	1.00
42_A	61_L	1.621	1.00
50_I	61_L	1.616	1.00
151_L	198_V	1.612	1.00
7_T	94_Y	1.608	1.00
9_R	235_A	1.605	1.00
50_I	86_L	1.599	1.00
115_V	231_R	1.596	1.00
145_P	169_P	1.574	1.00
84_A	88_D	1.574	1.00
50_I	85_A	1.557	1.00
47_A	85_A	1.529	1.00
45_A	63_V	1.502	1.00
178_V	185_W	1.494	1.00
109_A	179_T	1.488	1.00
63_V	95_A	1.480	1.00
3_V	36_V	1.474	1.00
40_A	61_L	1.454	1.00
123_P	131_Q	1.444	1.00
199_T	202_G	1.437	1.00
12_D	239_D	1.426	1.00
151_L	218_F	1.412	1.00
144_A	216_S	1.400	1.00
200_G	221_G	1.385	1.00
124_F	192_N	1.373	1.00
106_L	110_A	1.366	1.00
125_G	188_E	1.363	1.00
68_A	72_L	1.363	1.00
202_G	217_V	1.356	1.00
3_V	60_L	1.356	1.00
38_R	57_G	1.349	1.00
40_A	56_W	1.347	1.00
189_A	194_V	1.346	1.00
135_Q	194_V	1.340	1.00
6_V	36_V	1.334	1.00
147_L	198_V	1.327	1.00
114_D	121_R	1.323	1.00
11_N	94_Y	1.304	1.00
124_F	133_G	1.293	1.00
111_H	232_A	1.291	1.00
5_D	8_S	1.286	1.00
47_A	51_S	1.278	1.00
184_D	205_K	1.274	1.00
144_A	164_V	1.266	1.00
84_A	87_V	1.257	1.00
100_L	229_G	1.253	1.00
145_P	149_K	1.251	1.00
41_F	62_V	1.250	1.00
144_A	218_F	1.225	1.00
163_Q	219_L	1.213	1.00
173_T	195_D	1.205	1.00
38_R	56_W	1.200	1.00
108_N	179_T	1.200	1.00
167_V	170_A	1.198	1.00
113_A	177_V	1.197	1.00
190_E	213_A	1.195	1.00
34_R	90_E	1.194	1.00
10_Y	62_V	1.181	1.00
45_A	61_L	1.176	1.00
24_T	73_D	1.173	1.00
4_S	33_D	1.164	1.00
7_T	11_N	1.163	1.00
40_A	52_D	1.160	1.00
144_A	196_A	1.153	1.00
80_Y	87_V	1.151	1.00
234_E	238_D	1.149	1.00
196_A	216_S	1.146	1.00
203_K	206_L	1.145	1.00
13_R	106_L	1.142	1.00
41_F	236_V	1.138	1.00
46_A	208_H	1.136	1.00
142_T	146_A	1.130	1.00
183_A	203_K	1.129	1.00
111_H	114_D	1.119	1.00
60_L	92_A	1.109	1.00
117_G	150_S	1.104	1.00
114_D	232_A	1.084	1.00
122_S	192_N	1.083	1.00
187_R	209_E	1.083	1.00
25_N	99_P	1.082	1.00
118_L	136_G	1.081	1.00
41_F	230_V	1.079	1.00
170_A	216_S	1.067	1.00
168_G	171_E	1.064	1.00
152_A	160_Q	1.055	1.00
50_I	82_R	1.049	1.00
122_S	174_D	1.042	1.00
187_R	191_A	1.023	0.99
60_L	94_Y	1.011	0.99
15_R	18_D	1.005	0.99
29_V	86_L	0.999	0.99
181_S	203_K	0.997	0.99
41_F	244_T	0.993	0.99
149_K	153_A	0.993	0.99
186_L	215_V	0.988	0.99
44_D	204_G	0.987	0.99
10_Y	96_A	0.984	0.99
159_D	162_V	0.976	0.99
168_G	216_S	0.972	0.99
77_G	80_Y	0.968	0.99
34_R	59_D	0.965	0.99
188_E	191_A	0.962	0.99
118_L	147_L	0.960	0.99
204_G	223_Y	0.947	0.99
235_A	239_D	0.942	0.99
174_D	193_G	0.940	0.99
135_Q	192_N	0.936	0.99
52_D	55_E	0.932	0.99
100_L	233_L	0.926	0.99
51_S	54_V	0.920	0.99
111_H	115_V	0.917	0.99
117_G	139_P	0.917	0.99
49_T	61_L	0.914	0.99
14_L	100_L	0.912	0.99
183_A	206_L	0.910	0.99
146_A	149_K	0.905	0.99
80_Y	84_A	0.904	0.99
147_L	175_V	0.901	0.99
188_E	192_N	0.899	0.99
6_V	39_I	0.895	0.99
102_G	132_I	0.893	0.99
81_D	85_A	0.893	0.99
178_V	197_L	0.891	0.99
113_A	121_R	0.888	0.99
116_L	151_L	0.883	0.98
138_L	175_V	0.883	0.98
47_A	212_E	0.881	0.98
189_A	193_G	0.871	0.98
148_S	164_V	0.870	0.98
27_L	92_A	0.867	0.98
18_D	130_E	0.865	0.98
204_G	208_H	0.862	0.98
80_Y	83_I	0.858	0.98
113_A	136_G	0.856	0.98
9_R	12_D	0.855	0.98
198_V	218_F	0.853	0.98
178_V	182_G	0.851	0.98
108_N	229_G	0.849	0.98
116_L	198_V	0.848	0.98
147_L	151_L	0.843	0.98
108_N	111_H	0.840	0.98
140_D	146_A	0.835	0.98
20_A	102_G	0.834	0.98
34_R	92_A	0.832	0.98
202_G	207_Y	0.832	0.98
234_E	237_A	0.827	0.98
147_L	218_F	0.823	0.98
204_G	221_G	0.815	0.97
31_P	34_R	0.815	0.97
150_S	153_A	0.813	0.97
187_R	213_A	0.812	0.97
223_Y	227_T	0.811	0.97
28_Q	95_A	0.802	0.97
10_Y	94_Y	0.800	0.97
9_R	239_D	0.792	0.97
14_L	103_H	0.792	0.97
207_Y	217_V	0.789	0.97
48_A	211_R	0.787	0.97
110_A	114_D	0.787	0.97
124_F	131_Q	0.786	0.97
46_A	49_T	0.785	0.97
16_V	94_Y	0.785	0.97
142_T	147_L	0.785	0.97
4_S	32_G	0.783	0.97
10_Y	233_L	0.780	0.97
102_G	127_H	0.773	0.97
121_R	137_Q	0.772	0.96
117_G	154_A	0.771	0.96
39_I	60_L	0.770	0.96
9_R	13_R	0.769	0.96
172_L	218_F	0.769	0.96
29_V	83_I	0.767	0.96
54_V	91_C	0.767	0.96
115_V	154_A	0.763	0.96
7_T	16_V	0.759	0.96
118_L	121_R	0.756	0.96
135_Q	174_D	0.755	0.96
143_S	171_E	0.753	0.96
4_S	8_S	0.751	0.96
148_S	218_F	0.748	0.96
115_V	119_T	0.747	0.96
40_A	91_C	0.747	0.96
145_P	168_G	0.745	0.96
170_A	195_D	0.744	0.96
37_E	57_G	0.735	0.95
108_N	228_G	0.734	0.95
123_P	126_D	0.723	0.95
49_T	52_D	0.719	0.95
174_D	194_V	0.718	0.95
75_V	83_I	0.717	0.95
27_L	30_G	0.714	0.95
45_A	50_I	0.707	0.94
136_G	189_A	0.704	0.94
96_A	99_P	0.702	0.94
67_V	79_E	0.701	0.94
100_L	232_A	0.700	0.94
142_T	196_A	0.696	0.94
7_T	60_L	0.691	0.94
122_S	137_Q	0.687	0.93
122_S	135_Q	0.687	0.93
119_T	137_Q	0.686	0.93
220_A	224_A	0.685	0.93
106_L	235_A	0.682	0.93
138_L	142_T	0.682	0.93
47_A	82_R	0.678	0.93
20_A	185_W	0.678	0.93
165_L	207_Y	0.678	0.93
111_H	229_G	0.677	0.93
85_A	89_G	0.674	0.93
103_H	110_A	0.671	0.93
8_S	12_D	0.671	0.93
155_L	225_T	0.671	0.93
3_V	94_Y	0.666	0.92
18_D	102_G	0.664	0.92
206_L	209_E	0.663	0.92
23_A	207_Y	0.661	0.92
190_E	215_V	0.660	0.92
144_A	148_S	0.657	0.92
75_V	87_V	0.655	0.92
242_V	245_R	0.655	0.92
111_H	228_G	0.653	0.92
22_A	66_G	0.653	0.92
209_E	213_A	0.650	0.91
54_V	57_G	0.642	0.91
25_N	28_Q	0.642	0.91
202_G	219_L	0.641	0.91
166_D	216_S	0.640	0.91
186_L	190_E	0.640	0.91
138_L	141_P	0.638	0.91
147_L	195_D	0.637	0.91
165_L	217_V	0.632	0.90
184_D	203_K	0.632	0.90
24_T	28_Q	0.631	0.90
3_V	34_R	0.630	0.90
79_E	82_R	0.628	0.90
31_P	88_D	0.626	0.90
66_G	95_A	0.623	0.90
182_G	197_L	0.621	0.89
115_V	228_G	0.621	0.89
143_S	148_S	0.620	0.89
138_L	147_L	0.618	0.89
186_L	213_A	0.614	0.89
113_A	118_L	0.611	0.89
11_N	17_T	0.611	0.89
10_Y	13_R	0.608	0.88
164_V	218_F	0.604	0.88
78_R	213_A	0.604	0.88
124_F	189_A	0.599	0.88
207_Y	211_R	0.598	0.88
22_A	181_S	0.595	0.87
144_A	169_P	0.593	0.87
16_V	25_N	0.592	0.87
120_Q	136_G	0.591	0.87
22_A	25_N	0.589	0.87
201_E	207_Y	0.585	0.86
227_T	230_V	0.583	0.86
144_A	166_D	0.579	0.86
125_G	197_L	0.579	0.86
164_V	168_G	0.578	0.86
189_A	192_N	0.575	0.86
109_A	134_L	0.574	0.85
10_Y	14_L	0.568	0.85
65_H	101_D	0.566	0.85
229_G	233_L	0.566	0.85
199_T	206_L	0.565	0.85
45_A	93_L	0.564	0.84
204_G	224_A	0.563	0.84
208_H	211_R	0.563	0.84
144_A	170_A	0.555	0.83
36_V	92_A	0.555	0.83
174_D	195_D	0.554	0.83
222_H	226_E	0.553	0.83
145_P	167_V	0.552	0.83
197_L	210_A	0.552	0.83
51_S	81_D	0.551	0.83
45_A	82_R	0.548	0.83
155_L	220_A	0.547	0.83
200_G	220_A	0.547	0.83
148_S	162_V	0.546	0.82
53_A	61_L	0.546	0.82
177_V	198_V	0.544	0.82
134_L	177_V	0.543	0.82
241_G	244_T	0.543	0.82
38_R	58_A	0.541	0.82
64_H	99_P	0.541	0.82
163_Q	221_G	0.540	0.82
85_A	88_D	0.540	0.82
103_H	106_L	0.539	0.82
243_E	246_F	0.539	0.82
23_A	205_K	0.538	0.82
24_T	69_W	0.536	0.81
162_V	220_A	0.535	0.81
29_V	75_V	0.534	0.81
81_D	84_A	0.532	0.81
67_V	93_L	0.532	0.81
112_V	179_T	0.531	0.81
13_R	233_L	0.529	0.80
127_H	130_E	0.524	0.80
68_A	83_I	0.524	0.80
72_L	83_I	0.524	0.80
36_V	60_L	0.523	0.80
22_A	69_W	0.522	0.80
45_A	67_V	0.522	0.80
152_A	159_D	0.520	0.79
100_L	108_N	0.520	0.79
48_A	212_E	0.519	0.79
28_Q	67_V	0.518	0.79
6_V	62_V	0.517	0.79
177_V	197_L	0.517	0.79
42_A	45_A	0.513	0.78
62_V	233_L	0.513	0.78
131_Q	134_L	0.511	0.78
22_A	208_H	0.509	0.78
186_L	210_A	0.506	0.78
165_L	202_G	0.506	0.78
29_V	93_L	0.506	0.78
113_A	134_L	0.505	0.77
210_A	215_V	0.504	0.77
179_T	225_T	0.504	0.77
170_A	173_T	0.503	0.77
23_A	95_A	0.503	0.77
112_V	177_V	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gx8A	5	0.9842	100	0.079	Contact Map
2nydA	5	0.9842	100	0.085	Contact Map
2fywA	3	0.9802	100	0.104	Contact Map
1nmoA	4	0.9684	100	0.109	Contact Map
3wsfA	3	0.9447	100	0.132	Contact Map
2yybA	3	0.9486	100	0.133	Contact Map
3rxyA	4	0.9091	100	0.249	Contact Map
4djdC	2	0.8617	74.2	0.942	Contact Map
4nirA	3	0.7866	68.9	0.944	Contact Map
1f6yA	2	0.83	62.1	0.946	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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