Q9HP79 - HALSA - GREMLIN Contacts

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Q9HP79 - Agmatinase

UniProt:	Q9HP79	Sequences: MFPGASTADESNPGADADYVVVGAPLDVSTSFQPGTRFGPGELRTYAATFEDYHHRTGTHFSALSVTDYGDVRAWNDVPAYLEYLNGVVTDISWNDATPLLVGGEHTVTVAAVRALNPDVFVALDAHLDLRAALDGDPLSHSTVTRHALDVADEAIVVGARAGSEEEWERAADSDVTVIEPSAVADWTPAFGDADVYLSVDIDAADPGYAPGTGTPEPFGMSPRELRAAVRAVAPHAVGFDVVEVNDRDDGQAPTLGAKLLREFVHTHHADG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	272 (252)
Sequences:	5137 (3275)
Seq/√Len:	206.3

ECOLI - SPEB
BACSU - SPEB HUTG ARGI
HALSA - Q9HP79 HUTG
SULSO - Q97ZX8 Q97VA3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
43_L	102_V	3.883	1.00
200_V	226_L	3.721	1.00
86_N	114_R	3.368	1.00
113_V	148_A	3.291	1.00
205_A	256_L	3.053	1.00
210_A	253_A	2.669	1.00
202_I	213_T	2.578	1.00
41_G	71_D	2.528	1.00
23_G	44_R	2.474	1.00
240_F	264_F	2.287	1.00
120_V	194_A	2.242	1.00
169_E	173_D	2.160	1.00
118_P	194_A	2.132	1.00
202_I	245_V	2.076	1.00
205_A	226_L	2.027	1.00
157_V	160_A	2.015	1.00
20_V	97_A	2.008	1.00
22_V	92_I	2.005	1.00
83_E	87_G	1.977	1.00
223_P	256_L	1.950	1.00
86_N	115_A	1.933	1.00
41_G	45_T	1.933	1.00
198_L	237_A	1.900	1.00
93_S	115_A	1.886	1.00
124_L	229_A	1.865	1.00
89_V	112_A	1.863	1.00
124_L	204_A	1.861	1.00
80_A	84_Y	1.856	1.00
89_V	101_L	1.828	1.00
24_A	101_L	1.791	1.00
110_V	114_R	1.787	1.00
27_D	37_R	1.776	1.00
90_T	94_W	1.769	1.00
146_R	150_D	1.767	1.00
204_A	221_M	1.755	1.00
24_A	85_L	1.739	1.00
102_V	261_L	1.720	1.00
43_L	257_G	1.720	1.00
242_V	261_L	1.693	1.00
101_L	112_A	1.678	1.00
187_W	190_A	1.669	1.00
185_A	224_R	1.624	1.00
156_I	177_T	1.592	1.00
209_Y	223_P	1.579	1.00
86_N	90_T	1.572	1.00
170_R	174_S	1.563	1.00
222_S	225_E	1.549	1.00
197_Y	239_G	1.544	1.00
24_A	81_Y	1.543	1.00
20_V	92_I	1.539	1.00
165_E	169_E	1.532	1.00
93_S	116_L	1.515	1.00
77_D	80_A	1.514	1.00
117_N	195_D	1.505	1.00
100_L	240_F	1.500	1.00
18_D	65_S	1.494	1.00
160_A	178_V	1.487	1.00
231_R	263_E	1.437	1.00
204_A	226_L	1.428	1.00
202_I	242_V	1.428	1.00
180_E	183_A	1.423	1.00
108_V	243_V	1.422	1.00
202_I	210_A	1.417	1.00
245_V	257_G	1.414	1.00
177_T	190_A	1.387	1.00
154_E	194_A	1.385	1.00
122_V	233_V	1.383	1.00
82_L	107_T	1.380	1.00
123_A	157_V	1.378	1.00
118_P	154_E	1.376	1.00
88_V	91_D	1.372	1.00
195_D	236_H	1.371	1.00
212_G	250_D	1.367	1.00
53_Y	58_G	1.365	1.00
106_H	199_S	1.360	1.00
42_E	45_T	1.348	1.00
43_L	245_V	1.329	1.00
19_Y	265_V	1.328	1.00
141_H	215_T	1.325	1.00
245_V	253_A	1.323	1.00
22_V	101_L	1.321	1.00
100_L	261_L	1.312	1.00
146_R	170_R	1.307	1.00
42_E	254_P	1.303	1.00
141_H	214_G	1.303	1.00
116_L	119_D	1.301	1.00
198_L	240_F	1.283	1.00
212_G	253_A	1.265	1.00
38_F	248_R	1.263	1.00
128_L	163_G	1.262	1.00
181_P	185_A	1.261	1.00
188_T	232_A	1.258	1.00
20_V	69_Y	1.256	1.00
33_Q	249_D	1.253	1.00
121_F	145_T	1.245	1.00
145_T	157_V	1.245	1.00
147_H	150_D	1.234	1.00
22_V	89_V	1.228	1.00
112_A	241_D	1.222	1.00
92_I	99_P	1.218	1.00
85_L	101_L	1.202	1.00
22_V	88_V	1.188	1.00
227_R	263_E	1.185	1.00
81_Y	85_L	1.171	1.00
34_P	38_F	1.170	1.00
195_D	238_V	1.154	1.00
90_T	115_A	1.150	1.00
30_T	36_T	1.148	1.00
185_A	225_E	1.148	1.00
19_Y	98_T	1.147	1.00
89_V	99_P	1.136	1.00
132_A	147_H	1.134	1.00
109_T	113_V	1.126	1.00
187_W	191_F	1.117	1.00
186_D	228_A	1.106	1.00
82_L	111_A	1.103	1.00
253_A	257_G	1.103	1.00
140_S	143_T	1.094	1.00
127_H	203_D	1.087	1.00
124_L	221_M	1.083	1.00
198_L	230_V	1.083	1.00
44_R	71_D	1.077	1.00
202_I	257_G	1.076	1.00
21_V	102_V	1.076	1.00
42_E	46_Y	1.066	1.00
24_A	108_V	1.063	1.00
221_M	229_A	1.058	1.00
80_A	83_E	1.050	1.00
112_A	197_Y	1.049	1.00
246_N	249_D	1.041	1.00
34_P	37_R	1.027	1.00
125_D	129_D	1.027	1.00
98_T	240_F	1.023	1.00
130_L	171_A	1.022	1.00
171_A	176_V	1.007	1.00
68_D	71_D	1.002	1.00
87_G	91_D	0.998	1.00
123_A	199_S	0.994	1.00
151_V	154_E	0.994	1.00
128_L	157_V	0.991	1.00
141_H	213_T	0.988	1.00
247_D	250_D	0.987	1.00
118_P	151_V	0.978	1.00
145_T	155_A	0.976	1.00
91_D	94_W	0.968	1.00
226_L	260_L	0.961	1.00
142_S	215_T	0.960	1.00
113_V	121_F	0.955	0.99
232_A	235_P	0.955	0.99
162_A	217_E	0.954	0.99
131_R	167_E	0.950	0.99
130_L	149_L	0.940	0.99
27_D	35_G	0.940	0.99
119_D	238_V	0.932	0.99
210_A	256_L	0.929	0.99
205_A	223_P	0.928	0.99
87_G	90_T	0.927	0.99
128_L	178_V	0.920	0.99
89_V	115_A	0.916	0.99
132_A	146_R	0.915	0.99
182_S	228_A	0.914	0.99
161_R	206_D	0.910	0.99
92_I	97_A	0.909	0.99
83_E	86_N	0.906	0.99
19_Y	64_L	0.906	0.99
185_A	228_A	0.903	0.99
116_L	239_G	0.902	0.99
54_H	57_T	0.902	0.99
120_V	154_E	0.900	0.99
141_H	244_E	0.899	0.99
36_T	246_N	0.897	0.99
128_L	160_A	0.894	0.99
106_H	241_D	0.893	0.99
109_T	241_D	0.888	0.99
172_A	178_V	0.886	0.99
120_V	156_I	0.886	0.99
229_A	232_A	0.884	0.99
106_H	141_H	0.881	0.99
109_T	144_V	0.875	0.99
200_V	260_L	0.873	0.99
91_D	95_N	0.866	0.99
213_T	216_P	0.852	0.99
126_A	161_R	0.849	0.99
196_V	236_H	0.839	0.99
221_M	226_L	0.838	0.99
161_R	217_E	0.829	0.99
252_Q	256_L	0.826	0.98
251_G	254_P	0.824	0.98
23_G	71_D	0.822	0.98
121_F	148_A	0.822	0.98
116_L	238_V	0.821	0.98
112_A	239_G	0.820	0.98
119_D	195_D	0.817	0.98
44_R	70_G	0.816	0.98
188_T	235_P	0.815	0.98
161_R	207_P	0.813	0.98
26_L	78_V	0.811	0.98
106_H	244_E	0.807	0.98
223_P	227_R	0.805	0.98
27_D	34_P	0.798	0.98
158_V	187_W	0.798	0.98
111_A	115_A	0.797	0.98
122_V	158_V	0.795	0.98
149_L	152_A	0.789	0.98
99_P	116_L	0.789	0.98
18_D	97_A	0.786	0.98
23_G	70_G	0.786	0.98
133_A	147_H	0.784	0.98
27_D	36_T	0.782	0.98
22_V	99_P	0.772	0.98
182_S	231_R	0.758	0.97
72_V	84_Y	0.753	0.97
156_I	190_A	0.752	0.97
27_D	33_Q	0.748	0.97
33_Q	216_P	0.748	0.97
130_L	170_R	0.748	0.97
205_A	209_Y	0.744	0.97
74_A	81_Y	0.742	0.97
39_G	214_G	0.742	0.97
85_L	111_A	0.741	0.97
39_G	42_E	0.741	0.97
113_V	119_D	0.740	0.97
149_L	155_A	0.731	0.97
198_L	264_F	0.729	0.97
114_R	148_A	0.725	0.97
209_Y	222_S	0.723	0.97
183_A	186_D	0.722	0.96
122_V	156_I	0.721	0.96
31_S	141_H	0.719	0.96
170_R	173_D	0.713	0.96
129_D	244_E	0.712	0.96
84_Y	88_V	0.706	0.96
45_T	251_G	0.705	0.96
132_A	138_P	0.705	0.96
149_L	153_D	0.701	0.96
69_Y	92_I	0.697	0.96
21_V	100_L	0.696	0.96
101_L	108_V	0.694	0.96
227_R	260_L	0.691	0.96
124_L	198_L	0.690	0.95
107_T	139_L	0.687	0.95
56_R	59_T	0.686	0.95
213_T	246_N	0.683	0.95
228_A	232_A	0.682	0.95
196_V	237_A	0.681	0.95
42_E	247_D	0.678	0.95
199_S	243_V	0.677	0.95
181_P	221_M	0.676	0.95
158_V	221_M	0.676	0.95
39_G	246_N	0.675	0.95
122_V	196_V	0.673	0.95
29_S	78_V	0.670	0.95
75_W	84_Y	0.670	0.95
29_S	105_E	0.669	0.95
124_L	158_V	0.664	0.94
224_R	228_A	0.663	0.94
210_A	245_V	0.661	0.94
46_Y	254_P	0.660	0.94
125_D	203_D	0.660	0.94
184_V	225_E	0.659	0.94
93_S	96_D	0.657	0.94
179_I	184_V	0.656	0.94
112_A	116_L	0.655	0.94
72_V	88_V	0.655	0.94
28_V	81_Y	0.653	0.94
171_A	175_D	0.652	0.94
100_L	265_V	0.650	0.94
25_P	71_D	0.648	0.94
84_Y	87_G	0.647	0.94
261_L	264_F	0.640	0.93
109_T	145_T	0.638	0.93
199_S	241_D	0.638	0.93
58_G	165_E	0.637	0.93
26_L	81_Y	0.637	0.93
169_E	172_A	0.636	0.93
212_G	245_V	0.636	0.93
245_V	254_P	0.636	0.93
117_N	194_A	0.634	0.93
263_E	266_H	0.628	0.93
55_H	58_G	0.628	0.93
103_G	108_V	0.627	0.93
197_Y	241_D	0.627	0.93
129_D	203_D	0.627	0.93
38_F	41_G	0.627	0.93
88_V	92_I	0.626	0.93
39_G	247_D	0.626	0.93
207_P	210_A	0.624	0.92
159_G	204_A	0.624	0.92
177_T	180_E	0.622	0.92
128_L	171_A	0.619	0.92
110_V	147_H	0.618	0.92
120_V	195_D	0.617	0.92
54_H	263_E	0.616	0.92
184_V	229_A	0.614	0.92
74_A	85_L	0.613	0.92
23_G	68_D	0.612	0.92
230_V	267_T	0.611	0.92
209_Y	256_L	0.609	0.91
155_A	176_V	0.608	0.91
131_R	142_S	0.606	0.91
46_Y	258_A	0.605	0.91
28_V	31_S	0.603	0.91
189_P	192_G	0.602	0.91
145_T	160_A	0.602	0.91
123_A	215_T	0.601	0.91
157_V	176_V	0.600	0.91
20_V	67_T	0.598	0.91
17_A	97_A	0.597	0.91
54_H	58_G	0.595	0.91
69_Y	88_V	0.592	0.90
106_H	197_Y	0.592	0.90
28_V	78_V	0.591	0.90
123_A	145_T	0.590	0.90
219_F	227_R	0.589	0.90
193_D	236_H	0.588	0.90
42_E	251_G	0.586	0.90
158_V	184_V	0.586	0.90
50_F	54_H	0.584	0.90
59_T	63_A	0.579	0.89
46_Y	251_G	0.577	0.89
71_D	74_A	0.574	0.89
30_T	34_P	0.573	0.89
194_A	236_H	0.572	0.89
130_L	174_S	0.572	0.89
158_V	179_I	0.572	0.89
228_A	231_R	0.567	0.88
19_Y	100_L	0.567	0.88
106_H	243_V	0.567	0.88
24_A	112_A	0.567	0.88
120_V	191_F	0.566	0.88
180_E	184_V	0.562	0.88
44_R	68_D	0.561	0.88
121_F	155_A	0.556	0.87
53_Y	57_T	0.553	0.87
79_P	83_E	0.553	0.87
81_Y	84_Y	0.552	0.87
109_T	197_Y	0.551	0.87
123_A	144_V	0.549	0.87
52_D	55_H	0.549	0.87
128_L	131_R	0.549	0.87
106_H	127_H	0.547	0.87
41_G	251_G	0.546	0.86
89_V	111_A	0.541	0.86
109_T	243_V	0.537	0.86
22_V	85_L	0.535	0.85
211_P	253_A	0.534	0.85
23_G	103_G	0.533	0.85
156_I	187_W	0.533	0.85
251_G	255_T	0.529	0.85
166_E	170_R	0.528	0.85
210_A	213_T	0.526	0.84
89_V	93_S	0.526	0.84
52_D	56_R	0.524	0.84
118_P	195_D	0.524	0.84
21_V	66_V	0.523	0.84
255_T	258_A	0.523	0.84
135_D	142_S	0.522	0.84
77_D	137_D	0.522	0.84
240_F	261_L	0.521	0.84
142_S	203_D	0.521	0.84
214_G	244_E	0.521	0.84
208_G	223_P	0.520	0.84
128_L	168_W	0.520	0.84
164_S	167_E	0.519	0.84
131_R	215_T	0.519	0.84
186_D	231_R	0.518	0.83
68_D	72_V	0.512	0.83
106_H	214_G	0.512	0.83
128_L	162_A	0.510	0.82
107_T	110_V	0.510	0.82
105_E	141_H	0.510	0.82
133_A	138_P	0.510	0.82
124_L	226_L	0.506	0.82
96_D	99_P	0.505	0.82
29_S	162_A	0.503	0.82
149_L	176_V	0.502	0.82
68_D	74_A	0.501	0.81
72_V	75_W	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pzlA	5	1	100	0.149	Contact Map
3nioA	5	0.9816	100	0.165	Contact Map
3niqA	5	1	100	0.17	Contact Map
3lhlA	3	0.9559	100	0.173	Contact Map
1wohA	5	0.9963	100	0.173	Contact Map
1gq6A	5	0.989	100	0.174	Contact Map
4mykA	3	0.9485	100	0.177	Contact Map
3m1rA	5	0.9816	100	0.178	Contact Map
4dz4A	5	0.9596	100	0.196	Contact Map
4q40A	5	0.9228	100	0.204	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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