GREMLIN Database
Q9HP79 - Agmatinase
UniProt: Q9HP79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (252)
Sequences: 5137 (3275)
Seq/√Len: 206.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_L102_V3.8831.00
200_V226_L3.7211.00
86_N114_R3.3681.00
113_V148_A3.2911.00
205_A256_L3.0531.00
210_A253_A2.6691.00
202_I213_T2.5781.00
41_G71_D2.5281.00
23_G44_R2.4741.00
240_F264_F2.2871.00
120_V194_A2.2421.00
169_E173_D2.1601.00
118_P194_A2.1321.00
202_I245_V2.0761.00
205_A226_L2.0271.00
157_V160_A2.0151.00
20_V97_A2.0081.00
22_V92_I2.0051.00
83_E87_G1.9771.00
223_P256_L1.9501.00
86_N115_A1.9331.00
41_G45_T1.9331.00
198_L237_A1.9001.00
93_S115_A1.8861.00
124_L229_A1.8651.00
89_V112_A1.8631.00
124_L204_A1.8611.00
80_A84_Y1.8561.00
89_V101_L1.8281.00
24_A101_L1.7911.00
110_V114_R1.7871.00
27_D37_R1.7761.00
90_T94_W1.7691.00
146_R150_D1.7671.00
204_A221_M1.7551.00
24_A85_L1.7391.00
102_V261_L1.7201.00
43_L257_G1.7201.00
242_V261_L1.6931.00
101_L112_A1.6781.00
187_W190_A1.6691.00
185_A224_R1.6241.00
156_I177_T1.5921.00
209_Y223_P1.5791.00
86_N90_T1.5721.00
170_R174_S1.5631.00
222_S225_E1.5491.00
197_Y239_G1.5441.00
24_A81_Y1.5431.00
20_V92_I1.5391.00
165_E169_E1.5321.00
93_S116_L1.5151.00
77_D80_A1.5141.00
117_N195_D1.5051.00
100_L240_F1.5001.00
18_D65_S1.4941.00
160_A178_V1.4871.00
231_R263_E1.4371.00
204_A226_L1.4281.00
202_I242_V1.4281.00
180_E183_A1.4231.00
108_V243_V1.4221.00
202_I210_A1.4171.00
245_V257_G1.4141.00
177_T190_A1.3871.00
154_E194_A1.3851.00
122_V233_V1.3831.00
82_L107_T1.3801.00
123_A157_V1.3781.00
118_P154_E1.3761.00
88_V91_D1.3721.00
195_D236_H1.3711.00
212_G250_D1.3671.00
53_Y58_G1.3651.00
106_H199_S1.3601.00
42_E45_T1.3481.00
43_L245_V1.3291.00
19_Y265_V1.3281.00
141_H215_T1.3251.00
245_V253_A1.3231.00
22_V101_L1.3211.00
100_L261_L1.3121.00
146_R170_R1.3071.00
42_E254_P1.3031.00
141_H214_G1.3031.00
116_L119_D1.3011.00
198_L240_F1.2831.00
212_G253_A1.2651.00
38_F248_R1.2631.00
128_L163_G1.2621.00
181_P185_A1.2611.00
188_T232_A1.2581.00
20_V69_Y1.2561.00
33_Q249_D1.2531.00
121_F145_T1.2451.00
145_T157_V1.2451.00
147_H150_D1.2341.00
22_V89_V1.2281.00
112_A241_D1.2221.00
92_I99_P1.2181.00
85_L101_L1.2021.00
22_V88_V1.1881.00
227_R263_E1.1851.00
81_Y85_L1.1711.00
34_P38_F1.1701.00
195_D238_V1.1541.00
90_T115_A1.1501.00
30_T36_T1.1481.00
185_A225_E1.1481.00
19_Y98_T1.1471.00
89_V99_P1.1361.00
132_A147_H1.1341.00
109_T113_V1.1261.00
187_W191_F1.1171.00
186_D228_A1.1061.00
82_L111_A1.1031.00
253_A257_G1.1031.00
140_S143_T1.0941.00
127_H203_D1.0871.00
124_L221_M1.0831.00
198_L230_V1.0831.00
44_R71_D1.0771.00
202_I257_G1.0761.00
21_V102_V1.0761.00
42_E46_Y1.0661.00
24_A108_V1.0631.00
221_M229_A1.0581.00
80_A83_E1.0501.00
112_A197_Y1.0491.00
246_N249_D1.0411.00
34_P37_R1.0271.00
125_D129_D1.0271.00
98_T240_F1.0231.00
130_L171_A1.0221.00
171_A176_V1.0071.00
68_D71_D1.0021.00
87_G91_D0.9981.00
123_A199_S0.9941.00
151_V154_E0.9941.00
128_L157_V0.9911.00
141_H213_T0.9881.00
247_D250_D0.9871.00
118_P151_V0.9781.00
145_T155_A0.9761.00
91_D94_W0.9681.00
226_L260_L0.9611.00
142_S215_T0.9601.00
113_V121_F0.9550.99
232_A235_P0.9550.99
162_A217_E0.9540.99
131_R167_E0.9500.99
130_L149_L0.9400.99
27_D35_G0.9400.99
119_D238_V0.9320.99
210_A256_L0.9290.99
205_A223_P0.9280.99
87_G90_T0.9270.99
128_L178_V0.9200.99
89_V115_A0.9160.99
132_A146_R0.9150.99
182_S228_A0.9140.99
161_R206_D0.9100.99
92_I97_A0.9090.99
83_E86_N0.9060.99
19_Y64_L0.9060.99
185_A228_A0.9030.99
116_L239_G0.9020.99
54_H57_T0.9020.99
120_V154_E0.9000.99
141_H244_E0.8990.99
36_T246_N0.8970.99
128_L160_A0.8940.99
106_H241_D0.8930.99
109_T241_D0.8880.99
172_A178_V0.8860.99
120_V156_I0.8860.99
229_A232_A0.8840.99
106_H141_H0.8810.99
109_T144_V0.8750.99
200_V260_L0.8730.99
91_D95_N0.8660.99
213_T216_P0.8520.99
126_A161_R0.8490.99
196_V236_H0.8390.99
221_M226_L0.8380.99
161_R217_E0.8290.99
252_Q256_L0.8260.98
251_G254_P0.8240.98
23_G71_D0.8220.98
121_F148_A0.8220.98
116_L238_V0.8210.98
112_A239_G0.8200.98
119_D195_D0.8170.98
44_R70_G0.8160.98
188_T235_P0.8150.98
161_R207_P0.8130.98
26_L78_V0.8110.98
106_H244_E0.8070.98
223_P227_R0.8050.98
27_D34_P0.7980.98
158_V187_W0.7980.98
111_A115_A0.7970.98
122_V158_V0.7950.98
149_L152_A0.7890.98
99_P116_L0.7890.98
18_D97_A0.7860.98
23_G70_G0.7860.98
133_A147_H0.7840.98
27_D36_T0.7820.98
22_V99_P0.7720.98
182_S231_R0.7580.97
72_V84_Y0.7530.97
156_I190_A0.7520.97
27_D33_Q0.7480.97
33_Q216_P0.7480.97
130_L170_R0.7480.97
205_A209_Y0.7440.97
74_A81_Y0.7420.97
39_G214_G0.7420.97
85_L111_A0.7410.97
39_G42_E0.7410.97
113_V119_D0.7400.97
149_L155_A0.7310.97
198_L264_F0.7290.97
114_R148_A0.7250.97
209_Y222_S0.7230.97
183_A186_D0.7220.96
122_V156_I0.7210.96
31_S141_H0.7190.96
170_R173_D0.7130.96
129_D244_E0.7120.96
84_Y88_V0.7060.96
45_T251_G0.7050.96
132_A138_P0.7050.96
149_L153_D0.7010.96
69_Y92_I0.6970.96
21_V100_L0.6960.96
101_L108_V0.6940.96
227_R260_L0.6910.96
124_L198_L0.6900.95
107_T139_L0.6870.95
56_R59_T0.6860.95
213_T246_N0.6830.95
228_A232_A0.6820.95
196_V237_A0.6810.95
42_E247_D0.6780.95
199_S243_V0.6770.95
181_P221_M0.6760.95
158_V221_M0.6760.95
39_G246_N0.6750.95
122_V196_V0.6730.95
29_S78_V0.6700.95
75_W84_Y0.6700.95
29_S105_E0.6690.95
124_L158_V0.6640.94
224_R228_A0.6630.94
210_A245_V0.6610.94
46_Y254_P0.6600.94
125_D203_D0.6600.94
184_V225_E0.6590.94
93_S96_D0.6570.94
179_I184_V0.6560.94
112_A116_L0.6550.94
72_V88_V0.6550.94
28_V81_Y0.6530.94
171_A175_D0.6520.94
100_L265_V0.6500.94
25_P71_D0.6480.94
84_Y87_G0.6470.94
261_L264_F0.6400.93
109_T145_T0.6380.93
199_S241_D0.6380.93
58_G165_E0.6370.93
26_L81_Y0.6370.93
169_E172_A0.6360.93
212_G245_V0.6360.93
245_V254_P0.6360.93
117_N194_A0.6340.93
263_E266_H0.6280.93
55_H58_G0.6280.93
103_G108_V0.6270.93
197_Y241_D0.6270.93
129_D203_D0.6270.93
38_F41_G0.6270.93
88_V92_I0.6260.93
39_G247_D0.6260.93
207_P210_A0.6240.92
159_G204_A0.6240.92
177_T180_E0.6220.92
128_L171_A0.6190.92
110_V147_H0.6180.92
120_V195_D0.6170.92
54_H263_E0.6160.92
184_V229_A0.6140.92
74_A85_L0.6130.92
23_G68_D0.6120.92
230_V267_T0.6110.92
209_Y256_L0.6090.91
155_A176_V0.6080.91
131_R142_S0.6060.91
46_Y258_A0.6050.91
28_V31_S0.6030.91
189_P192_G0.6020.91
145_T160_A0.6020.91
123_A215_T0.6010.91
157_V176_V0.6000.91
20_V67_T0.5980.91
17_A97_A0.5970.91
54_H58_G0.5950.91
69_Y88_V0.5920.90
106_H197_Y0.5920.90
28_V78_V0.5910.90
123_A145_T0.5900.90
219_F227_R0.5890.90
193_D236_H0.5880.90
42_E251_G0.5860.90
158_V184_V0.5860.90
50_F54_H0.5840.90
59_T63_A0.5790.89
46_Y251_G0.5770.89
71_D74_A0.5740.89
30_T34_P0.5730.89
194_A236_H0.5720.89
130_L174_S0.5720.89
158_V179_I0.5720.89
228_A231_R0.5670.88
19_Y100_L0.5670.88
106_H243_V0.5670.88
24_A112_A0.5670.88
120_V191_F0.5660.88
180_E184_V0.5620.88
44_R68_D0.5610.88
121_F155_A0.5560.87
53_Y57_T0.5530.87
79_P83_E0.5530.87
81_Y84_Y0.5520.87
109_T197_Y0.5510.87
123_A144_V0.5490.87
52_D55_H0.5490.87
128_L131_R0.5490.87
106_H127_H0.5470.87
41_G251_G0.5460.86
89_V111_A0.5410.86
109_T243_V0.5370.86
22_V85_L0.5350.85
211_P253_A0.5340.85
23_G103_G0.5330.85
156_I187_W0.5330.85
251_G255_T0.5290.85
166_E170_R0.5280.85
210_A213_T0.5260.84
89_V93_S0.5260.84
52_D56_R0.5240.84
118_P195_D0.5240.84
21_V66_V0.5230.84
255_T258_A0.5230.84
135_D142_S0.5220.84
77_D137_D0.5220.84
240_F261_L0.5210.84
142_S203_D0.5210.84
214_G244_E0.5210.84
208_G223_P0.5200.84
128_L168_W0.5200.84
164_S167_E0.5190.84
131_R215_T0.5190.84
186_D231_R0.5180.83
68_D72_V0.5120.83
106_H214_G0.5120.83
128_L162_A0.5100.82
107_T110_V0.5100.82
105_E141_H0.5100.82
133_A138_P0.5100.82
124_L226_L0.5060.82
96_D99_P0.5050.82
29_S162_A0.5030.82
149_L176_V0.5020.82
68_D74_A0.5010.81
72_V75_W0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pzlA 5 1 100 0.149 Contact Map
3nioA 5 0.9816 100 0.165 Contact Map
3niqA 5 1 100 0.17 Contact Map
3lhlA 3 0.9559 100 0.173 Contact Map
1wohA 5 0.9963 100 0.173 Contact Map
1gq6A 5 0.989 100 0.174 Contact Map
4mykA 3 0.9485 100 0.177 Contact Map
3m1rA 5 0.9816 100 0.178 Contact Map
4dz4A 5 0.9596 100 0.196 Contact Map
4q40A 5 0.9228 100 0.204 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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