GREMLIN Database
IF5A - Translation initiation factor 5A
UniProt: Q9HP78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (121)
Sequences: 451 (239)
Seq/√Len: 21.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_M119_E5.2081.00
19_M46_A4.5511.00
11_L26_I4.2771.00
42_A61_V3.5211.00
39_S63_A3.0761.00
86_A124_I2.7420.99
11_L17_V2.7250.99
9_R62_D2.7090.99
22_A121_Q2.6300.99
27_N47_E2.5420.98
43_R58_S2.3120.97
17_V65_I2.2760.96
77_I111_E1.9550.92
115_Y124_I1.9150.91
9_R29_Y1.8790.90
75_G88_V1.8500.89
6_K10_D1.7940.88
6_K67_V1.7730.87
8_V26_I1.6560.83
48_G51_D1.6280.82
36_K41_K1.6210.82
8_V29_Y1.6050.81
37_H41_K1.5870.80
25_Q31_T1.4620.74
37_H40_A1.4490.74
70_V120_G1.4430.73
116_L125_L1.3830.70
48_G55_R1.3790.70
8_V17_V1.3760.70
33_K59_Q1.3400.68
36_K40_A1.3300.67
88_V113_I1.3120.66
4_E69_I1.2570.62
8_V11_L1.2330.61
51_D55_R1.2180.60
8_V61_V1.2150.60
103_G106_D1.1880.58
15_N67_V1.1270.54
89_M116_L1.1200.53
113_I124_I1.1060.53
28_A45_E1.1060.53
29_Y42_A1.1040.52
76_Q89_M1.0890.51
47_E119_E1.0730.50
26_I29_Y1.0690.50
43_R51_D1.0630.50
107_I110_D1.0360.48
88_V118_F1.0340.48
33_K40_A1.0340.48
73_K86_A1.0310.47
87_Q97_V1.0210.47
39_S57_L1.0150.46
87_Q96_T1.0040.46
79_S87_Q1.0030.46
73_K78_V0.9950.45
29_Y44_I0.9930.45
55_R73_K0.9830.44
108_Q111_E0.9710.43
13_E25_Q0.9700.43
17_V42_A0.9540.42
72_R116_L0.9540.42
23_A45_E0.9490.42
9_R61_V0.9350.41
18_M108_Q0.9300.41
112_N117_E0.9240.40
21_D66_W0.9070.39
77_I86_A0.9010.39
7_E64_K0.8980.39
90_D94_Y0.8760.37
70_V111_E0.8630.36
77_I80_K0.8620.36
33_K60_P0.8610.36
16_Y110_D0.8520.36
42_A123_K0.8510.36
27_N34_P0.8430.35
11_L29_Y0.8290.34
39_S64_K0.8250.34
47_E54_K0.8190.34
15_N93_T0.8160.34
8_V65_I0.8160.34
24_C45_E0.8140.33
34_P43_R0.8140.33
16_Y119_E0.8130.33
50_F56_S0.8070.33
79_S91_L0.8030.33
76_Q116_L0.8000.33
45_E119_E0.7960.32
15_N102_P0.7950.32
8_V42_A0.7910.32
7_E28_A0.7900.32
32_A35_G0.7860.32
21_D52_G0.7840.32
38_G41_K0.7730.31
39_S62_D0.7720.31
87_Q94_Y0.7700.31
11_L103_G0.7640.31
10_D17_V0.7600.30
118_F122_R0.7500.30
80_K101_I0.7450.29
76_Q91_L0.7350.29
86_A101_I0.7280.28
9_R33_K0.7230.28
9_R15_N0.7170.28
45_E116_L0.7160.28
61_V123_K0.7160.28
17_V99_M0.7150.28
99_M124_I0.7100.28
36_K39_S0.7040.27
5_Q45_E0.6990.27
21_D60_P0.6960.27
70_V95_E0.6920.27
78_V95_E0.6900.26
5_Q13_E0.6730.26
44_I61_V0.6640.25
73_K77_I0.6640.25
29_Y62_D0.6630.25
44_I65_I0.6570.25
17_V84_T0.6570.25
35_G41_K0.6560.25
74_Q114_E0.6500.24
40_A60_P0.6480.24
14_G112_N0.6420.24
96_T109_A0.6420.24
101_I106_D0.6390.24
67_V120_G0.6390.24
83_D101_I0.6250.23
79_S123_K0.6200.23
12_Q29_Y0.6060.22
75_G97_V0.6040.22
79_S85_V0.6030.22
81_E110_D0.6030.22
22_A48_G0.6030.22
9_R12_Q0.6030.22
60_P63_A0.5920.22
78_V89_M0.5920.22
117_E120_G0.5890.21
13_E20_E0.5870.21
10_D65_I0.5840.21
5_Q9_R0.5830.21
8_V44_I0.5820.21
114_E117_E0.5790.21
39_S59_Q0.5780.21
73_K90_D0.5780.21
27_N31_T0.5740.21
73_K79_S0.5730.21
78_V87_Q0.5650.20
6_K86_A0.5650.20
46_A55_R0.5640.20
77_I95_E0.5610.20
54_K96_T0.5600.20
77_I85_V0.5570.20
117_E122_R0.5560.20
5_Q64_K0.5530.20
108_Q115_Y0.5530.20
31_T64_K0.5520.20
54_K65_I0.5510.20
57_L63_A0.5510.20
73_K92_E0.5500.20
31_T63_A0.5490.20
32_A62_D0.5430.19
47_E52_G0.5340.19
76_Q79_S0.5300.19
10_D62_D0.5270.19
76_Q110_D0.5270.19
92_E113_I0.5270.19
69_I90_D0.5260.19
86_A102_P0.5220.19
42_A62_D0.5200.19
34_P59_Q0.5130.18
86_A104_E0.5130.18
75_G90_D0.5120.18
33_K54_K0.5110.18
23_A27_N0.5110.18
44_I57_L0.5090.18
73_K89_M0.5090.18
71_N76_Q0.5080.18
39_S78_V0.5080.18
77_I113_I0.5050.18
5_Q33_K0.5040.18
83_D90_D0.5010.18
46_A65_I0.5000.18
17_V46_A0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1khiA 1 0.937 100 0.329 Contact Map
1x6oA 1 0.9606 100 0.392 Contact Map
3er0A 1 0.9921 100 0.405 Contact Map
3hksA 1 1 100 0.407 Contact Map
3cpfA 1 0.9606 100 0.415 Contact Map
1bkbA 3 0.9921 100 0.42 Contact Map
1iz6A 1 0.9921 100 0.431 Contact Map
2eifA 1 0.9921 100 0.441 Contact Map
1ybyA 2 0.9449 99.9 0.568 Contact Map
3a5zB 1 0.9528 99.9 0.577 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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