GREMLIN Database
Q9HP77 - Uncharacterized protein
UniProt: Q9HP77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (158)
Sequences: 1985 (1497)
Seq/√Len: 119.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_D100_L4.0581.00
4_E14_S4.0071.00
148_E152_E3.6431.00
81_P146_T3.5541.00
89_Y148_E3.5211.00
7_V14_S3.3171.00
6_P10_D3.1561.00
17_R50_E3.1511.00
3_V11_Y2.9881.00
16_T47_L2.7441.00
88_Q97_D2.6891.00
13_A46_R2.6411.00
89_Y151_F2.5851.00
16_T27_V2.4971.00
90_L151_F2.4021.00
102_D138_D2.2841.00
13_A50_E2.2651.00
86_L151_F2.1071.00
85_A146_T2.0641.00
85_A143_T2.0561.00
89_Y144_A1.9981.00
155_S159_V1.9601.00
101_E133_N1.8501.00
7_V10_D1.7531.00
76_G80_G1.7411.00
144_A148_E1.7391.00
91_D94_H1.7361.00
81_P141_D1.6831.00
9_R43_V1.6521.00
152_E156_D1.6521.00
96_H99_R1.6391.00
56_V161_L1.6371.00
143_T146_T1.6331.00
160_Q163_E1.6281.00
16_T29_F1.6231.00
102_D139_Q1.6131.00
20_A53_L1.5681.00
10_D14_S1.5681.00
5_P39_H1.5631.00
4_E7_V1.5421.00
88_Q142_A1.5131.00
12_V40_L1.5031.00
85_A88_Q1.5031.00
17_R51_G1.5001.00
151_F155_S1.4961.00
9_R42_E1.4951.00
28_V162_C1.4191.00
96_H100_L1.4171.00
68_V150_L1.3241.00
159_V163_E1.3011.00
38_S41_R1.2801.00
72_F76_G1.2751.00
145_E148_E1.2100.99
92_G144_A1.1780.99
20_A25_D1.1570.99
88_Q95_V1.1120.99
156_D160_Q1.0980.99
2_W18_N1.0740.98
86_L150_L1.0690.98
9_R46_R1.0650.98
26_R54_Y1.0450.98
127_A131_T1.0300.98
61_D158_L1.0260.98
27_V53_L1.0230.98
19_L22_H0.9970.97
88_Q144_A0.9960.97
13_A43_V0.9960.97
160_Q164_W0.9940.97
33_H36_N0.9780.97
85_A142_A0.9750.97
32_A60_W0.9730.97
32_A61_D0.9640.97
34_G80_G0.9590.97
7_V18_N0.9580.97
28_V161_L0.9550.96
153_A157_Q0.9510.96
40_L57_E0.9410.96
14_S18_N0.9250.96
38_S45_R0.9170.96
97_D143_T0.9020.95
6_P46_R0.9000.95
18_N21_F0.8900.95
4_E17_R0.8870.95
3_V8_F0.8740.94
7_V11_Y0.8680.94
102_D140_T0.8680.94
79_G127_A0.8660.94
35_G137_G0.8640.94
161_L165_L0.8620.94
45_R49_D0.8610.94
6_P9_R0.8560.94
10_D13_A0.8470.93
81_P85_A0.8430.93
79_G135_V0.8280.92
100_L140_T0.8280.92
60_W76_G0.8250.92
44_G55_A0.8250.92
86_L158_L0.8120.92
76_G137_G0.8020.91
57_E60_W0.7940.91
27_V55_A0.7920.91
48_R125_Y0.7910.91
58_W88_Q0.7890.90
145_E149_R0.7850.90
81_P137_G0.7800.90
31_N36_N0.7760.90
17_R21_F0.7670.89
125_Y129_D0.7660.89
59_M62_E0.7550.88
5_P9_R0.7510.88
28_V165_L0.7450.88
84_T135_V0.7450.88
126_D129_D0.7400.87
46_R50_E0.7370.87
29_F44_G0.7340.87
64_I153_A0.7310.87
39_H42_E0.7180.86
35_G77_P0.7170.86
12_V43_V0.7090.85
20_A51_G0.7070.85
31_N40_L0.7060.85
19_L50_E0.7040.85
84_T95_V0.7020.85
36_N60_W0.6950.84
103_A135_V0.6930.84
88_Q100_L0.6880.83
60_W154_A0.6870.83
87_M91_D0.6850.83
28_V58_W0.6840.83
157_Q160_Q0.6820.83
127_A134_G0.6810.83
83_E95_V0.6790.83
37_V41_R0.6760.82
12_V29_F0.6730.82
27_V162_C0.6710.82
38_S42_E0.6690.82
63_S67_L0.6690.82
16_T20_A0.6660.81
87_M95_V0.6640.81
81_P100_L0.6640.81
39_H43_V0.6590.81
64_I154_A0.6550.80
36_N61_D0.6530.80
20_A27_V0.6520.80
84_T88_Q0.6520.80
80_G84_T0.6460.79
84_T87_M0.6400.79
86_L154_A0.6260.77
105_D108_V0.6260.77
58_W165_L0.6230.77
47_L50_E0.6160.76
32_A141_D0.6140.76
60_W82_K0.6120.76
11_Y47_L0.6100.75
142_A147_G0.6080.75
74_Q138_D0.6080.75
61_D64_I0.6070.75
66_E70_E0.6030.75
24_I44_G0.6010.74
63_S157_Q0.5990.74
36_N80_G0.5990.74
31_N83_E0.5970.74
3_V9_R0.5900.73
108_V111_V0.5900.73
138_D141_D0.5890.73
8_F39_H0.5890.73
98_D101_E0.5880.73
47_L51_G0.5870.73
86_L90_L0.5850.72
70_E156_D0.5830.72
23_G26_R0.5820.72
67_L71_V0.5810.72
4_E10_D0.5770.71
153_A156_D0.5760.71
60_W86_L0.5730.71
37_V61_D0.5720.71
48_R129_D0.5710.70
34_G137_G0.5690.70
59_M158_L0.5680.70
35_G76_G0.5670.70
48_R76_G0.5660.70
64_I130_N0.5650.70
71_V104_R0.5640.70
148_E155_S0.5610.69
19_L26_R0.5600.69
20_A46_R0.5600.69
154_A157_Q0.5590.69
124_F129_D0.5590.69
101_E104_R0.5540.68
65_P69_D0.5530.68
81_P142_A0.5520.68
121_S127_A0.5500.68
67_L70_E0.5460.67
31_N34_G0.5450.67
8_F11_Y0.5440.67
47_L53_L0.5430.67
33_H80_G0.5420.67
45_R79_G0.5420.67
16_T51_G0.5420.67
80_G165_L0.5390.66
73_D156_D0.5380.66
24_I121_S0.5370.66
56_V59_M0.5360.66
70_E149_R0.5360.66
75_N86_L0.5350.66
56_V165_L0.5340.65
64_I67_L0.5320.65
25_D99_R0.5310.65
45_R125_Y0.5270.64
84_T139_Q0.5260.64
53_L66_E0.5250.64
2_W21_F0.5250.64
30_V59_M0.5230.64
101_E160_Q0.5200.63
13_A107_G0.5200.63
28_V156_D0.5190.63
158_L162_C0.5170.63
79_G121_S0.5170.63
71_V145_E0.5160.63
6_P13_A0.5150.63
3_V10_D0.5140.62
9_R13_A0.5140.62
13_A17_R0.5120.62
79_G83_E0.5120.62
49_D55_A0.5110.62
29_F151_F0.5100.62
36_N147_G0.5080.62
31_N39_H0.5070.61
10_D152_E0.5070.61
79_G82_K0.5050.61
8_F42_E0.5040.61
5_P42_E0.5040.61
84_T142_A0.5040.61
90_L142_A0.5030.61
41_R45_R0.5010.61
31_N60_W0.5000.60
37_V154_A0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lubA 4 0.9116 100 0.226 Contact Map
3no4A 5 0.8729 100 0.251 Contact Map
1v7zA 5 0.8785 100 0.254 Contact Map
2lndA 1 0.4641 33.8 0.932 Contact Map
4od6A 1 0.4088 17.5 0.941 Contact Map
1un8A 2 0.8232 17.1 0.941 Contact Map
2zqeA 1 0.4088 15.9 0.942 Contact Map
1ae9A 4 0.5138 15.5 0.942 Contact Map
1yb1A 3 0.6298 13.1 0.944 Contact Map
3bq9A 3 0.9171 12.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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