GREMLIN Database
Q9HP76 - Uncharacterized protein
UniProt: Q9HP76 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 537 (450)
Sequences: 3015 (1956)
Seq/√Len: 92.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_A92_D4.9581.00
64_E187_R4.5701.00
206_E212_R4.3541.00
75_F100_V4.3351.00
52_A57_A4.1211.00
167_N230_D4.0511.00
86_G154_Y3.7961.00
162_T181_E3.7071.00
243_A253_Y3.4921.00
213_S364_D3.3621.00
90_T193_Y3.3221.00
58_Q69_D3.2781.00
90_T97_Q3.1171.00
62_E67_P2.9581.00
100_V188_V2.9531.00
201_D204_T2.9321.00
179_V191_M2.9231.00
96_Q178_T2.9151.00
158_G181_E2.8941.00
97_Q195_E2.8651.00
96_Q180_Y2.7951.00
58_Q62_E2.7781.00
197_T208_R2.7441.00
214_Q218_T2.7421.00
62_E68_V2.7241.00
163_E260_R2.7151.00
10_L41_E2.7111.00
80_I99_A2.6831.00
161_L179_V2.6481.00
75_F91_A2.6181.00
225_Q230_D2.6081.00
92_D97_Q2.6031.00
64_E185_S2.5881.00
119_R145_A2.5871.00
61_I102_V2.5781.00
181_E184_S2.5571.00
53_D56_E2.5521.00
282_D304_A2.5331.00
245_Q249_S2.5031.00
245_Q251_V2.4991.00
119_R142_D2.4851.00
112_E149_R2.4541.00
58_Q77_R2.4261.00
31_P34_L2.4251.00
194_I251_V2.3471.00
36_T40_E2.3081.00
6_A38_Y2.2921.00
175_V192_Q2.2821.00
99_A193_Y2.2641.00
262_D265_I2.2251.00
72_F190_T2.1501.00
54_W57_A2.1051.00
173_D218_T2.0881.00
91_A100_V2.0841.00
41_E44_E2.0831.00
103_R187_R2.0471.00
76_N90_T2.0431.00
368_D371_T2.0211.00
202_V206_E2.0111.00
108_E186_D1.9551.00
158_G184_S1.9401.00
7_R41_E1.9381.00
219_L360_C1.9131.00
73_D92_D1.9121.00
320_E366_E1.8901.00
271_E283_A1.8631.00
306_V338_F1.8541.00
129_V132_G1.8521.00
299_D302_V1.8501.00
63_D187_R1.8481.00
108_E112_E1.8381.00
47_D198_K1.8191.00
275_G284_I1.8171.00
180_Y183_Y1.7921.00
235_A257_M1.7801.00
54_W77_R1.7781.00
438_D441_A1.7671.00
145_A149_R1.7621.00
59_R63_D1.7451.00
225_Q229_E1.7311.00
103_R154_Y1.7201.00
54_W58_Q1.7151.00
204_T208_R1.6901.00
136_S139_N1.6811.00
10_L14_L1.6651.00
71_V183_Y1.6581.00
233_F259_G1.6561.00
61_I65_L1.6551.00
175_V249_S1.6491.00
176_I258_S1.6381.00
286_D300_R1.6161.00
56_E59_R1.6101.00
222_A252_F1.6031.00
180_Y192_Q1.5961.00
91_A98_V1.5941.00
61_I71_V1.5851.00
242_L252_F1.5821.00
65_L190_T1.5771.00
126_V138_E1.5691.00
57_A89_Y1.5621.00
158_G189_L1.5561.00
202_V212_R1.5301.00
165_R175_V1.5281.00
122_I138_E1.5201.00
28_S46_Q1.5151.00
67_P70_D1.5141.00
122_I141_A1.4941.00
65_L72_F1.4831.00
216_S364_D1.4751.00
158_G179_V1.4541.00
61_I68_V1.4370.99
61_I75_F1.4220.99
9_L42_L1.4210.99
199_I244_V1.4200.99
165_R178_T1.4190.99
414_R420_E1.4190.99
275_G283_A1.4140.99
367_F372_V1.4130.99
40_E43_A1.4110.99
52_A104_R1.4060.99
204_T207_R1.4030.99
215_V244_V1.3800.99
98_V190_T1.3750.99
205_L209_G1.3600.99
153_D186_D1.3540.99
284_I307_M1.3360.99
171_E225_Q1.3340.99
140_L347_A1.3120.99
123_P138_E1.3020.99
374_T378_A1.2770.99
205_L211_D1.2760.99
195_E246_D1.2760.99
58_Q68_V1.2720.99
436_V452_T1.2710.99
14_L44_E1.2710.99
68_V75_F1.2660.99
164_I255_F1.2590.99
231_G266_Q1.2570.99
162_T165_R1.2550.99
160_M258_S1.2480.99
437_I440_L1.2420.98
54_W68_V1.2400.98
205_L212_R1.2330.98
44_E48_R1.2270.98
227_I349_V1.2240.98
126_V136_S1.2240.98
411_K417_D1.2210.98
232_V258_S1.2150.98
449_V454_V1.2130.98
155_S184_S1.2110.98
93_V183_Y1.2110.98
115_L149_R1.1930.98
205_L210_V1.1920.98
158_G162_T1.1900.98
210_V215_V1.1810.98
203_D206_E1.1790.98
115_L145_A1.1770.98
184_S190_T1.1710.98
272_F284_I1.1690.98
82_G104_R1.1680.98
184_S189_L1.1610.98
437_I441_A1.1600.98
229_E376_Y1.1570.98
203_D207_R1.1570.98
161_L255_F1.1550.98
71_V190_T1.1450.97
423_D427_R1.1420.97
167_N232_V1.1380.97
55_A77_R1.1300.97
173_D249_S1.1270.97
60_V64_E1.1230.97
57_A102_V1.1220.97
404_S409_P1.1170.97
18_P357_E1.1130.97
252_F258_S1.1130.97
166_A169_A1.1070.97
379_E383_R1.1030.97
310_A334_T1.1010.97
7_R44_E1.0950.97
221_R372_V1.0920.97
52_A60_V1.0910.96
451_A454_V1.0780.96
10_L44_E1.0710.96
175_V245_Q1.0650.96
34_L39_I1.0640.96
419_V424_L1.0640.96
9_L38_Y1.0610.96
411_K420_E1.0590.96
54_W75_F1.0580.96
212_R215_V1.0510.96
164_I226_M1.0510.96
93_V98_V1.0420.95
292_G340_L1.0380.95
313_D330_K1.0350.95
183_Y190_T1.0330.95
150_E156_R1.0290.95
56_E60_V1.0280.95
46_Q198_K1.0240.95
286_D290_D1.0190.95
213_S366_E1.0190.95
288_L307_M1.0130.95
142_D145_A1.0130.95
265_I291_M1.0110.95
191_M253_Y1.0110.95
448_L451_A1.0100.95
175_V251_V1.0090.95
175_V194_I1.0070.94
161_L191_M1.0030.94
111_V363_L0.9980.94
80_I89_Y0.9970.94
68_V71_V0.9890.94
406_L409_P0.9880.94
351_R355_V0.9870.94
73_D94_D0.9670.93
427_R431_E0.9660.93
450_L453_S0.9650.93
159_R181_E0.9630.93
222_A226_M0.9620.93
61_I188_V0.9570.93
214_Q248_G0.9570.93
213_S217_E0.9540.93
194_I243_A0.9510.93
22_K25_Q0.9450.92
168_F171_E0.9450.92
97_Q193_Y0.9410.92
103_R108_E0.9390.92
111_V148_I0.9270.92
93_V180_Y0.9250.92
427_R430_L0.9230.91
168_F222_A0.9210.91
67_P71_V0.9200.91
72_F91_A0.9140.91
35_P38_Y0.9110.91
425_Y429_D0.9100.91
163_E166_A0.9090.91
52_A105_P0.9060.91
106_G110_L0.9010.90
52_A82_G0.8920.90
325_Q328_V0.8910.90
118_I141_A0.8880.90
58_Q75_F0.8870.90
11_D41_E0.8840.90
194_I253_Y0.8830.90
314_A330_K0.8790.89
168_F252_F0.8770.89
261_V349_V0.8750.89
35_P39_I0.8680.89
7_R11_D0.8660.89
266_Q376_Y0.8640.89
285_L304_A0.8600.88
164_I168_F0.8590.88
90_T99_A0.8550.88
7_R10_L0.8470.88
416_L419_V0.8450.87
53_D77_R0.8440.87
99_A231_G0.8420.87
194_I245_Q0.8410.87
386_S389_Q0.8400.87
285_L307_M0.8400.87
303_M340_L0.8380.87
197_T204_T0.8340.87
174_I252_F0.8300.87
265_I345_N0.8300.87
12_A15_T0.8300.87
444_V448_L0.8290.86
205_L244_V0.8260.86
96_Q192_Q0.8240.86
34_L42_L0.8230.86
71_V188_V0.8210.86
447_G450_L0.8210.86
356_V368_D0.8150.85
418_K423_D0.8130.85
80_I90_T0.8120.85
281_I285_L0.8060.85
442_R448_L0.8060.85
208_R246_D0.8040.85
63_D109_S0.8030.85
103_R186_D0.8020.85
275_G287_A0.8010.85
60_V187_R0.8000.84
100_V190_T0.7980.84
99_A191_M0.7980.84
161_L181_E0.7970.84
176_I255_F0.7960.84
47_D243_A0.7960.84
214_Q217_E0.7930.84
289_I300_R0.7920.84
13_L24_G0.7920.84
65_L68_V0.7920.84
69_D73_D0.7910.84
81_S375_D0.7910.84
80_I193_Y0.7850.83
89_Y275_G0.7830.83
168_F226_M0.7810.83
428_A434_N0.7800.83
9_L13_L0.7740.82
432_D436_V0.7720.82
407_R413_E0.7720.82
28_S198_K0.7690.82
283_A287_A0.7660.82
99_A253_Y0.7650.82
76_N89_Y0.7630.82
202_V362_T0.7630.82
74_A97_Q0.7620.81
216_S363_L0.7610.81
266_Q335_I0.7610.81
178_T192_Q0.7600.81
445_V449_V0.7600.81
83_A151_E0.7590.81
11_D14_L0.7590.81
107_I110_L0.7570.81
9_L148_I0.7550.81
39_I43_A0.7540.81
179_V184_S0.7510.80
391_A395_A0.7510.80
82_G85_L0.7510.80
391_A394_T0.7490.80
80_I235_A0.7490.80
220_E372_V0.7470.80
65_L71_V0.7450.80
267_D389_Q0.7450.80
21_I50_P0.7440.80
219_L242_L0.7400.80
306_V337_E0.7390.79
280_D283_A0.7390.79
433_S436_V0.7380.79
144_F255_F0.7360.79
164_I258_S0.7360.79
70_D73_D0.7350.79
287_A291_M0.7300.79
369_F372_V0.7300.79
173_D250_I0.7300.79
404_S413_E0.7280.78
190_T198_K0.7250.78
163_E232_V0.7240.78
284_I288_L0.7200.78
294_L340_L0.7190.78
143_E226_M0.7170.77
6_A37_E0.7170.77
27_L34_L0.7160.77
268_K291_M0.7160.77
281_I308_E0.7150.77
71_V93_V0.7130.77
136_S341_R0.7130.77
197_T205_L0.7120.77
334_T338_F0.7110.77
93_V96_Q0.7110.77
52_A89_Y0.7100.77
62_E69_D0.7090.77
430_L433_S0.7090.77
268_K287_A0.7080.76
70_D182_E0.7050.76
59_R62_E0.7050.76
61_I89_Y0.7030.76
126_V133_Q0.7030.76
193_Y243_A0.7030.76
384_E387_I0.7030.76
103_R343_P0.7030.76
118_I121_S0.7020.76
57_A60_V0.7000.76
137_L261_V0.7000.76
303_M306_V0.6980.75
428_A435_R0.6980.75
155_S186_D0.6950.75
401_A404_S0.6950.75
80_I326_Q0.6940.75
235_A348_L0.6900.75
119_R138_E0.6890.75
13_L20_F0.6890.75
202_V205_L0.6890.75
218_T250_I0.6880.74
290_D327_I0.6880.74
26_L144_F0.6860.74
411_K415_A0.6860.74
21_I49_V0.6850.74
197_T209_G0.6840.74
168_F219_L0.6830.74
88_V99_A0.6800.74
452_T455_P0.6780.73
173_D221_R0.6770.73
323_R326_Q0.6760.73
371_T374_T0.6760.73
340_L344_P0.6760.73
30_R357_E0.6760.73
63_D366_E0.6730.73
191_M255_F0.6730.73
152_M261_V0.6720.73
297_E339_P0.6710.73
267_D271_E0.6710.73
263_S266_Q0.6700.72
168_F173_D0.6660.72
207_R211_D0.6660.72
70_D394_T0.6660.72
288_L340_L0.6660.72
11_D15_T0.6650.72
106_G109_S0.6650.72
86_G291_M0.6640.72
430_L438_D0.6640.72
197_T201_D0.6640.72
415_A419_V0.6630.72
229_E379_E0.6590.71
197_T211_D0.6580.71
224_L364_D0.6550.71
56_E106_G0.6550.71
64_E186_D0.6540.71
242_L250_I0.6520.70
35_P366_E0.6510.70
429_D434_N0.6500.70
226_M258_S0.6470.70
163_E258_S0.6460.70
201_D205_L0.6460.70
134_A137_L0.6460.70
442_R454_V0.6440.69
257_M352_V0.6440.69
143_E273_Y0.6410.69
217_E364_D0.6390.69
167_N225_Q0.6390.69
274_V278_N0.6380.69
216_S365_P0.6370.69
194_I217_E0.6360.69
174_I319_I0.6330.68
83_A88_V0.6320.68
9_L452_T0.6320.68
408_V412_L0.6320.68
215_V218_T0.6320.68
191_M231_G0.6310.68
446_L452_T0.6300.68
238_H241_N0.6300.68
219_L250_I0.6300.68
111_V137_L0.6300.68
419_V422_E0.6300.68
397_E410_P0.6290.68
147_T348_L0.6290.68
442_R450_L0.6290.68
181_E351_R0.6280.68
199_I329_G0.6280.68
102_V188_V0.6260.67
197_T210_V0.6260.67
228_I231_G0.6240.67
148_I311_I0.6240.67
448_L455_P0.6240.67
111_V152_M0.6230.67
398_F402_A0.6230.67
143_E256_G0.6230.67
112_E412_L0.6220.67
378_A382_Y0.6220.67
64_E190_T0.6210.67
23_L144_F0.6210.67
351_R380_Q0.6200.67
73_D76_N0.6200.67
434_N438_D0.6180.66
199_I250_I0.6180.66
40_E59_R0.6170.66
303_M314_A0.6160.66
165_R449_V0.6150.66
17_G20_F0.6150.66
429_D432_D0.6140.66
54_W89_Y0.6130.66
279_Q312_Q0.6120.66
111_V144_F0.6120.66
443_R454_V0.6110.65
86_G367_F0.6110.65
428_A443_R0.6110.65
6_A292_G0.6100.65
222_A250_I0.6100.65
447_G452_T0.6100.65
179_V189_L0.6100.65
206_E210_V0.6080.65
255_F258_S0.6080.65
135_F346_L0.6060.65
21_I84_S0.6060.65
20_F357_E0.6060.65
211_D214_Q0.6050.65
55_A58_Q0.6050.65
125_V132_G0.6050.65
35_P353_A0.6040.65
78_E203_D0.6030.64
22_K238_H0.6020.64
351_R443_R0.6010.64
18_P270_V0.6000.64
223_Y356_V0.6000.64
134_A339_P0.6000.64
121_S142_D0.5980.64
444_V447_G0.5980.64
144_F360_C0.5980.64
445_V448_L0.5980.64
253_Y303_M0.5970.64
126_V137_L0.5960.64
224_L373_A0.5960.64
257_M351_R0.5950.63
252_F255_F0.5950.63
51_P104_R0.5950.63
442_R445_V0.5950.63
352_V355_V0.5940.63
264_F290_D0.5940.63
150_E309_L0.5940.63
158_G161_L0.5930.63
245_Q248_G0.5920.63
151_E351_R0.5920.63
288_L343_P0.5920.63
52_A81_S0.5890.63
14_L17_G0.5890.63
277_A377_L0.5890.63
288_L350_L0.5880.62
401_A405_V0.5870.62
68_V77_R0.5870.62
117_A121_S0.5870.62
59_R106_G0.5870.62
6_A9_L0.5870.62
169_A206_E0.5870.62
109_S382_Y0.5860.62
414_R418_K0.5850.62
306_V358_G0.5840.62
443_R452_T0.5820.62
115_L420_E0.5820.62
237_P284_I0.5810.62
69_D77_R0.5810.62
91_A190_T0.5780.61
283_A286_D0.5780.61
235_A359_V0.5780.61
285_L293_T0.5770.61
31_P43_A0.5760.61
342_L359_V0.5740.61
319_I360_C0.5730.61
84_S238_H0.5730.61
112_E116_R0.5710.60
29_T239_P0.5710.60
13_L357_E0.5710.60
236_D241_N0.5710.60
433_S437_I0.5710.60
96_Q182_E0.5700.60
151_E241_N0.5700.60
282_D286_D0.5690.60
235_A259_G0.5680.60
318_N351_R0.5680.60
47_D83_A0.5680.60
430_L441_A0.5680.60
155_S159_R0.5680.60
130_G137_L0.5660.60
263_S393_G0.5660.60
262_D301_A0.5660.60
172_P215_V0.5650.59
22_K241_N0.5650.59
342_L354_T0.5640.59
390_F394_T0.5630.59
278_N374_T0.5630.59
224_L228_I0.5630.59
271_E290_D0.5630.59
124_I128_F0.5620.59
441_A446_L0.5620.59
101_K157_E0.5610.59
27_L137_L0.5610.59
235_A441_A0.5600.59
189_L396_E0.5590.59
219_L367_F0.5580.58
236_D254_D0.5580.58
450_L454_V0.5570.58
122_I285_L0.5570.58
418_K422_E0.5550.58
153_D284_I0.5550.58
388_R392_A0.5540.58
14_L48_R0.5540.58
235_A451_A0.5530.58
26_L107_I0.5530.58
442_R453_S0.5520.58
13_L42_L0.5520.58
274_V368_D0.5510.58
82_G273_Y0.5500.57
19_T117_A0.5490.57
206_E209_G0.5490.57
103_R149_R0.5490.57
206_E215_V0.5490.57
72_F75_F0.5490.57
208_R212_R0.5490.57
244_V252_F0.5470.57
131_Q377_L0.5460.57
13_L18_P0.5460.57
65_L316_G0.5450.57
431_E434_N0.5440.57
59_R94_D0.5440.57
172_P426_V0.5440.57
261_V367_F0.5410.56
85_L103_R0.5410.56
144_F347_A0.5410.56
176_I251_V0.5390.56
231_G248_G0.5390.56
319_I361_V0.5380.56
48_R297_E0.5380.56
65_L245_Q0.5380.56
64_E103_R0.5380.56
99_A445_V0.5370.56
20_F117_A0.5360.55
154_Y340_L0.5350.55
22_K101_K0.5350.55
81_S158_G0.5350.55
116_R436_V0.5350.55
157_E241_N0.5340.55
442_R447_G0.5330.55
86_G361_V0.5310.55
52_A56_E0.5310.55
63_D68_V0.5310.55
442_R446_L0.5300.55
61_I184_S0.5290.55
256_G276_V0.5290.55
217_E221_R0.5280.54
30_R104_R0.5280.54
93_V190_T0.5260.54
313_D326_Q0.5260.54
46_Q81_S0.5260.54
101_K254_D0.5220.54
448_L453_S0.5210.53
84_S151_E0.5200.53
359_V375_D0.5200.53
215_V228_I0.5200.53
269_I303_M0.5200.53
116_R119_R0.5190.53
62_E75_F0.5190.53
118_I261_V0.5190.53
65_L188_V0.5180.53
46_Q239_P0.5180.53
197_T244_V0.5180.53
23_L141_A0.5180.53
224_L376_Y0.5180.53
181_E190_T0.5180.53
219_L350_L0.5180.53
59_R78_E0.5170.53
217_E372_V0.5170.53
102_V455_P0.5170.53
427_R435_R0.5170.53
437_I444_V0.5160.53
441_A452_T0.5160.53
78_E440_L0.5150.53
445_V452_T0.5150.53
103_R422_E0.5150.53
198_K242_L0.5140.52
112_E115_L0.5140.52
105_P153_D0.5140.52
220_E331_V0.5140.52
432_D449_V0.5140.52
76_N80_I0.5140.52
14_L41_E0.5140.52
143_E146_K0.5130.52
174_I222_A0.5130.52
61_I190_T0.5130.52
67_P73_D0.5130.52
73_D93_V0.5130.52
272_F363_L0.5120.52
438_D446_L0.5120.52
104_R226_M0.5110.52
43_A239_P0.5100.52
69_D396_E0.5100.52
210_V249_S0.5090.52
40_E186_D0.5080.52
265_I268_K0.5070.51
195_E251_V0.5070.51
26_L257_M0.5070.51
220_E367_F0.5060.51
396_E405_V0.5060.51
52_A224_L0.5060.51
201_D243_A0.5050.51
33_V117_A0.5050.51
45_L259_G0.5040.51
101_K238_H0.5040.51
22_K151_E0.5040.51
138_E405_V0.5040.51
316_G450_L0.5030.51
325_Q354_T0.5030.51
42_L454_V0.5030.51
330_K333_D0.5030.51
28_S35_P0.5020.51
207_R366_E0.5020.51
111_V357_E0.5010.51
291_M343_P0.5010.51
78_E169_A0.5000.50
144_F390_F0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pedA 1 0.6983 100 0.497 Contact Map
2y7jA 3 0.4991 100 0.75 Contact Map
3byvA 1 0.594 100 0.753 Contact Map
4yhjA 2 0.6555 100 0.764 Contact Map
3v5wA 1 0.7523 100 0.81 Contact Map
1u5qA 2 0.5345 99.9 0.837 Contact Map
1zarA 1 0.4395 99.9 0.838 Contact Map
4otpA 1 0.3873 99.9 0.857 Contact Map
3dzoA 1 0.5866 99.9 0.863 Contact Map
3fegA 2 0.5773 99.9 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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