GREMLIN Database
Q9HP74 - 3-phosphoglycerate kinase
UniProt: Q9HP74 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (200)
Sequences: 28773 (23074)
Seq/√Len: 1631.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_D162_A4.1491.00
121_D126_A3.2281.00
140_G144_D2.9541.00
150_V154_G2.8631.00
176_A183_A2.6251.00
113_S117_D2.6061.00
158_Q161_A2.5431.00
167_G172_D2.5121.00
10_V157_A2.4871.00
8_Y182_D2.3781.00
106_G131_V2.3581.00
104_P130_D2.2901.00
113_S137_D2.2691.00
140_G146_Q2.2641.00
150_V153_G2.2501.00
13_F105_T2.1971.00
131_V154_G2.1741.00
108_V147_P2.1311.00
152_L163_G2.1051.00
177_K201_D2.0611.00
205_S209_D2.0501.00
173_V183_A2.0371.00
109_T116_T2.0011.00
174_G178_N1.9841.00
182_D201_D1.8851.00
11_W103_A1.8801.00
99_G128_W1.8321.00
165_Y176_A1.7741.00
158_Q162_A1.7581.00
152_L181_L1.7261.00
164_V184_V1.6981.00
117_D126_A1.6971.00
10_V155_L1.6131.00
105_T129_F1.6001.00
95_A207_F1.5971.00
12_L151_A1.5961.00
157_A163_G1.5631.00
8_Y164_V1.5551.00
37_R78_A1.5471.00
12_L165_Y1.5381.00
12_L108_V1.5381.00
187_E205_S1.5381.00
152_L159_P1.5071.00
106_G155_L1.4361.00
33_Q82_P1.4211.00
11_W166_A1.4161.00
99_G130_D1.3731.00
184_V202_H1.3621.00
76_F80_E1.3521.00
184_V204_V1.3481.00
187_E203_R1.3451.00
170_V174_G1.3441.00
18_T166_A1.3341.00
15_L107_V1.3061.00
117_D121_D1.2851.00
92_Y188_R1.2751.00
15_L116_T1.2741.00
145_P149_R1.2731.00
206_S209_D1.2601.00
15_L20_V1.2531.00
74_P78_A1.2471.00
19_L95_A1.2411.00
133_V154_G1.2321.00
78_A82_P1.2171.00
148_L165_Y1.2161.00
91_L125_I1.1931.00
71_A74_P1.1871.00
78_A81_D1.1741.00
148_L175_A1.1641.00
133_V151_A1.1581.00
76_F79_V1.1581.00
52_H55_G1.1571.00
68_D71_A1.1491.00
34_V38_L1.1451.00
12_L163_G1.1411.00
33_Q37_R1.1391.00
193_K197_C1.1381.00
94_D97_P1.1191.00
10_V163_G1.1161.00
38_L78_A1.1151.00
148_L181_L1.1121.00
10_V104_P1.1041.00
16_D22_T1.1001.00
146_Q150_V1.0871.00
77_H81_D1.0861.00
116_T134_S1.0851.00
108_V151_A1.0821.00
60_H63_R1.0761.00
43_T46_H1.0721.00
48_E51_W1.0701.00
75_A79_V1.0651.00
163_G181_L1.0601.00
97_P208_A1.0571.00
15_L111_C1.0541.00
99_G105_T1.0531.00
149_R153_G1.0351.00
124_D127_D1.0261.00
165_Y181_L1.0181.00
96_R128_W1.0161.00
118_P122_H1.0151.00
54_I57_T1.0141.00
131_V155_L1.0131.00
151_A155_L1.0121.00
10_V106_G1.0121.00
182_D202_H1.0121.00
32_D36_D1.0091.00
146_Q149_R1.0061.00
59_D63_R0.9991.00
149_R179_A0.9981.00
28_R33_Q0.9921.00
58_R61_Y0.9861.00
107_V129_F0.9851.00
53_G57_T0.9851.00
91_L96_R0.9841.00
177_K183_A0.9801.00
33_Q36_D0.9791.00
113_S134_S0.9681.00
36_D42_F0.9601.00
118_P121_D0.9571.00
73_W77_H0.9571.00
75_A78_A0.9561.00
11_W98_L0.9351.00
171_S174_G0.9321.00
57_T60_H0.9301.00
92_Y95_A0.9191.00
58_R62_L0.9161.00
173_V200_G0.9131.00
37_R82_P0.9031.00
177_K199_L0.8981.00
183_A201_D0.8951.00
79_V82_P0.8921.00
138_D150_V0.8901.00
133_V150_V0.8831.00
148_L167_G0.8831.00
45_Q49_R0.8781.00
16_D111_C0.8781.00
113_S136_T0.8761.00
166_A184_V0.8711.00
109_T134_S0.8691.00
15_L119_V0.8681.00
12_L181_L0.8621.00
47_A52_H0.8591.00
175_A179_A0.8501.00
98_L101_L0.8471.00
164_V182_D0.8431.00
60_H64_A0.8431.00
72_F75_A0.8371.00
12_L155_L0.8331.00
116_T119_V0.8281.00
94_D206_S0.8141.00
204_V210_V0.8111.00
20_V119_V0.8071.00
134_S137_D0.8061.00
92_Y186_V0.8031.00
72_F76_F0.8001.00
139_T146_Q0.7991.00
106_G151_A0.7941.00
11_W164_V0.7931.00
8_Y103_A0.7921.00
105_T128_W0.7901.00
94_D208_A0.7901.00
28_R32_D0.7871.00
166_A210_V0.7811.00
28_R88_A0.7811.00
46_H49_R0.7801.00
59_D65_W0.7781.00
35_G40_V0.7661.00
188_R207_F0.7641.00
16_D109_T0.7631.00
137_D154_G0.7621.00
149_R159_P0.7611.00
184_V210_V0.7601.00
99_G102_D0.7581.00
111_C116_T0.7571.00
50_L53_G0.7491.00
9_D103_A0.7471.00
20_V123_L0.7451.00
77_H80_E0.7441.00
117_D132_V0.7431.00
48_E52_H0.7381.00
98_L103_A0.7331.00
159_P181_L0.7321.00
185_H203_R0.7321.00
131_V151_A0.7311.00
110_H141_W0.7271.00
37_R75_A0.7271.00
185_H196_H0.7261.00
157_A162_A0.7261.00
61_Y65_W0.7241.00
194_R197_C0.7141.00
173_V185_H0.7121.00
27_T32_D0.7111.00
69_P73_W0.7101.00
193_K205_S0.7091.00
16_D168_D0.7031.00
120_L126_A0.7031.00
74_P77_H0.6991.00
96_R124_D0.6951.00
47_A51_W0.6941.00
116_T132_V0.6931.00
62_L65_W0.6931.00
186_V207_F0.6911.00
174_G177_K0.6901.00
12_L106_G0.6881.00
9_D157_A0.6841.00
110_H143_P0.6831.00
104_P157_A0.6831.00
47_A50_L0.6821.00
145_P178_N0.6791.00
159_P163_G0.6751.00
56_G60_H0.6721.00
16_D119_V0.6661.00
208_A211_F0.6661.00
9_D104_P0.6651.00
204_V207_F0.6631.00
45_Q48_E0.6621.00
8_Y162_A0.6621.00
51_W54_I0.6611.00
152_L157_A0.6591.00
32_D43_T0.6591.00
207_F211_F0.6571.00
71_A75_A0.6571.00
32_D42_F0.6571.00
17_G23_E0.6561.00
18_T172_D0.6531.00
32_D44_D0.6491.00
21_D90_Y0.6471.00
67_I71_A0.6441.00
51_W55_G0.6421.00
105_T130_D0.6421.00
133_V147_P0.6361.00
148_L172_D0.6331.00
116_T120_L0.6331.00
204_V211_F0.6331.00
36_D41_E0.6281.00
165_Y172_D0.6281.00
70_E74_P0.6261.00
93_E208_A0.6251.00
91_L123_L0.6231.00
24_W90_Y0.6211.00
165_Y175_A0.6181.00
26_Y30_V0.6171.00
147_P151_A0.6161.00
149_R152_L0.6081.00
18_T186_V0.6001.00
110_H135_C0.6001.00
108_V165_Y0.6001.00
129_F132_V0.5991.00
75_A80_E0.5811.00
22_T111_C0.5741.00
138_D147_P0.5741.00
70_E73_W0.5731.00
131_V134_S0.5691.00
59_D69_P0.5681.00
39_G42_F0.5651.00
21_D24_W0.5641.00
86_A118_P0.5601.00
26_Y111_C0.5541.00
147_P175_A0.5531.00
135_C147_P0.5521.00
46_H50_L0.5511.00
8_Y11_W0.5501.00
174_G199_L0.5491.00
20_V89_T0.5481.00
152_L158_Q0.5481.00
99_G127_D0.5471.00
185_H200_G0.5451.00
98_L105_T0.5411.00
111_C167_G0.5381.00
108_V133_V0.5371.00
148_L176_A0.5361.00
73_W76_F0.5351.00
98_L102_D0.5351.00
93_E206_S0.5351.00
110_H171_S0.5331.00
12_L148_L0.5331.00
49_R52_H0.5311.00
46_H51_W0.5291.00
152_L179_A0.5291.00
133_V155_L0.5281.00
66_G69_P0.5261.00
111_C115_L0.5261.00
114_F118_P0.5241.00
25_S89_T0.5231.00
49_R53_G0.5211.00
38_L75_A0.5191.00
34_V37_R0.5171.00
114_F117_D0.5161.00
29_S34_V0.5161.00
59_D62_L0.5131.00
121_D127_D0.5101.00
112_Q115_L0.5101.00
120_L125_I0.5091.00
61_Y64_A0.5071.00
191_P194_R0.5041.00
19_L107_V0.5041.00
86_A89_T0.5031.00
173_V177_K0.5011.00
174_G198_V0.5011.00
171_S175_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uw9A 1 0.8991 100 0.31 Contact Map
3qxgA 3 0.9679 100 0.317 Contact Map
3s6jA 2 0.9633 100 0.321 Contact Map
1te2A 2 0.9587 100 0.323 Contact Map
1swvA 2 0.9679 100 0.329 Contact Map
4eekA 2 0.9495 100 0.329 Contact Map
3umbA 2 0.9312 100 0.33 Contact Map
3dv9A 1 0.9725 100 0.33 Contact Map
2hdoA 1 0.9266 100 0.331 Contact Map
3l5kA 1 0.9817 100 0.334 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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