GREMLIN Database
PHS - Putative pterin-4-alpha-carbinolamine dehydratase
UniProt: Q9HP73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 91 (84)
Sequences: 2027 (1391)
Seq/√Len: 151.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_A77_T2.6311.00
38_V45_G2.5261.00
44_V87_T2.1731.00
78_S82_E2.1281.00
66_V87_T2.0791.00
28_T65_E1.9821.00
27_R88_D1.9691.00
17_D27_R1.9111.00
13_R81_I1.9111.00
38_V42_S1.8881.00
6_D9_T1.8771.00
41_A59_I1.7311.00
68_F87_T1.7061.00
47_L86_R1.7021.00
56_E60_R1.6621.00
31_F40_F1.6121.00
24_A67_R1.5681.00
41_A57_I1.5111.00
20_H76_V1.5061.00
33_E36_D1.4851.00
51_A79_Q1.4591.00
51_A82_E1.4511.00
70_D79_Q1.4441.00
38_V41_A1.4111.00
47_L51_A1.3991.00
29_Y87_T1.3781.00
35_L43_E1.3721.00
17_D88_D1.3721.00
34_Y37_G1.3461.00
26_T67_R1.3151.00
79_Q82_E1.3051.00
68_F83_L1.2881.00
40_F64_V1.2411.00
38_V59_I1.2001.00
32_E36_D1.1871.00
7_D11_S1.1771.00
28_T63_E1.1631.00
81_I85_R1.1511.00
39_A42_S1.1210.99
29_Y88_D1.1030.99
39_A46_D1.0900.99
37_G64_V1.0830.99
7_D20_H1.0810.99
8_D12_D1.0750.99
46_D50_E1.0660.99
13_R16_D1.0630.99
10_I20_H1.0360.99
57_I66_V1.0340.99
30_T62_D0.9970.99
10_I81_I0.9620.98
9_T78_S0.9580.98
76_V81_I0.9530.98
26_T65_E0.9490.98
5_L10_I0.9330.98
12_D16_D0.9310.98
16_D85_R0.9070.98
31_F37_G0.9030.98
75_G81_I0.9000.98
51_A86_R0.8860.97
19_I26_T0.8810.97
47_L50_E0.8580.97
40_F44_V0.8500.97
42_S46_D0.8430.96
20_H25_I0.8360.96
49_D52_F0.8180.96
82_E85_R0.8100.96
61_Y72_E0.8080.95
58_T65_E0.7980.95
83_L87_T0.7920.95
29_Y66_V0.7750.94
36_D39_A0.7630.94
35_L49_D0.7630.94
35_L46_D0.7630.94
12_D15_P0.7410.93
48_A55_P0.7300.92
41_A45_G0.7290.92
8_D11_S0.7280.92
56_E69_T0.7280.92
24_A69_T0.7180.92
72_E79_Q0.7070.91
23_D69_T0.7070.91
58_T67_R0.7050.91
35_L39_A0.7010.91
21_D26_T0.6820.90
37_G49_D0.6770.89
13_R85_R0.6730.89
39_A49_D0.6720.89
9_T12_D0.6700.89
36_D43_E0.6690.89
38_V57_I0.6680.89
45_G59_I0.6670.89
40_F66_V0.6650.88
50_E86_R0.6430.87
20_H23_D0.6360.86
52_F79_Q0.6300.86
25_I76_V0.6250.85
70_D74_G0.6200.85
25_I88_D0.6190.85
37_G62_D0.6170.84
57_I60_R0.6170.84
82_E86_R0.5940.82
54_H71_H0.5860.81
39_A43_E0.5790.80
37_G59_I0.5740.80
8_D15_P0.5740.80
41_A64_V0.5730.80
43_E46_D0.5610.78
59_I64_V0.5610.78
34_Y68_F0.5600.78
41_A60_R0.5580.78
79_Q83_L0.5560.78
19_I32_E0.5420.76
14_L20_H0.5400.76
46_D49_D0.5400.76
10_I76_V0.5390.76
51_A83_L0.5380.75
60_R63_E0.5330.75
35_L38_V0.5320.75
56_E71_H0.5290.74
13_R78_S0.5280.74
33_E62_D0.5210.73
60_R69_T0.5200.73
78_S81_I0.5050.71
8_D78_S0.5040.71
9_T13_R0.5010.70
44_V66_V0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jstA 1 1 100 0.195 Contact Map
4wilA 4 1 100 0.199 Contact Map
3hxaA 5 1 100 0.199 Contact Map
2ebbA 2 0.978 100 0.205 Contact Map
2v6uA 4 1 100 0.222 Contact Map
1usmA 2 0.8132 99.9 0.277 Contact Map
4lowA 2 0.8791 99.9 0.317 Contact Map
1mdcA 1 0.7692 27.2 0.911 Contact Map
3pptA 1 0.8132 26.9 0.912 Contact Map
2g7bA 1 0.8242 26.5 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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