GREMLIN Database
HEM1 - Glutamyl-tRNA reductase
UniProt: Q9HP72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 436 (399)
Sequences: 2489 (1658)
Seq/√Len: 83.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_V276_V6.5531.00
98_R313_E6.4821.00
147_R151_E4.7151.00
271_A275_D3.9531.00
148_A312_V3.8251.00
179_R203_E3.7571.00
179_R205_V3.6431.00
48_F138_V3.5421.00
46_E131_D3.4931.00
203_E226_E3.4481.00
245_T275_D3.4351.00
366_S369_E3.0081.00
245_T276_V2.9171.00
12_R85_I2.8951.00
94_R317_E2.8421.00
308_A311_E2.7941.00
232_D235_G2.7861.00
347_K377_A2.7511.00
344_D347_K2.7201.00
183_V254_L2.6641.00
19_S83_G2.6261.00
147_R319_E2.5451.00
259_F267_V2.5201.00
207_A228_T2.4911.00
256_A279_G2.3581.00
236_R239_A2.2361.00
256_A260_A2.2311.00
181_V207_A2.2221.00
211_P229_T2.2031.00
96_L117_L2.1811.00
170_E199_A2.1771.00
211_P215_V2.1761.00
267_V286_V2.1671.00
215_V219_D2.1491.00
147_R318_T2.1451.00
343_A384_L2.0831.00
211_P227_A2.0651.00
180_A201_V2.0401.00
98_R104_E2.0371.00
303_E306_E1.9771.00
90_E324_L1.9731.00
252_H277_A1.9681.00
319_E322_R1.9661.00
137_A323_L1.9601.00
276_V280_A1.9461.00
400_D403_T1.8901.00
340_Y382_S1.8881.00
245_T271_A1.8541.00
194_K220_M1.8521.00
259_F262_A1.8481.00
22_E274_R1.8301.00
255_P258_A1.8291.00
112_Q191_L1.8251.00
350_E353_T1.7901.00
125_K135_R1.7691.00
228_T236_R1.7631.00
153_A156_E1.7621.00
34_A49_V1.7511.00
59_Y138_V1.7401.00
205_V228_T1.7391.00
340_Y389_T1.7321.00
35_L129_G1.7291.00
247_T275_D1.7201.00
185_A208_N1.7011.00
256_A282_G1.6961.00
344_D348_S1.6911.00
10_G59_Y1.6841.00
124_A129_G1.6721.00
39_L129_G1.6461.00
91_D94_R1.6161.00
101_A148_A1.6121.00
350_E379_A1.6091.00
114_L145_G1.5851.00
257_S260_A1.5631.00
259_F280_A1.5621.00
142_M145_G1.5210.99
354_A372_V1.4980.99
355_V370_R1.4970.99
279_G282_G1.4900.99
234_R258_A1.4860.99
121_Y135_R1.4610.99
26_A34_A1.4600.99
272_Q291_L1.4590.99
50_L117_L1.4490.99
177_D202_A1.4470.99
13_V24_A1.4370.99
237_L243_V1.4160.99
76_G79_P1.4150.99
190_A220_M1.4080.99
289_H293_D1.4010.99
59_Y99_V1.3880.99
158_A163_T1.3860.99
350_E383_Q1.3790.99
310_R313_E1.3580.99
93_L137_A1.3560.99
46_E61_V1.3560.99
343_A385_L1.3520.99
259_F265_T1.3500.99
93_L320_F1.3490.99
144_V316_I1.3320.99
56_V102_G1.3280.99
158_A164_A1.3270.99
258_A277_A1.3260.99
207_A233_A1.3180.99
347_K378_D1.3120.98
342_S387_A1.3060.98
180_A196_F1.3050.98
165_A268_V1.3040.98
295_E299_A1.2950.98
121_Y125_K1.2930.98
181_V236_R1.2900.98
226_E236_R1.2900.98
101_A312_V1.2880.98
99_V104_E1.2880.98
207_A230_L1.2870.98
347_K374_E1.2850.98
45_E63_A1.2850.98
381_V384_L1.2820.98
61_V131_D1.2800.98
193_A221_V1.2790.98
403_T407_A1.2760.98
339_M413_P1.2720.98
243_V267_V1.2660.98
375_S379_A1.2650.98
370_R374_E1.2530.98
172_K287_A1.2520.98
117_L138_V1.2470.98
371_E375_S1.2460.98
391_S394_D1.2260.98
165_A270_L1.2250.98
252_H278_P1.2220.98
236_R240_A1.2180.97
130_I135_R1.2140.97
93_L324_L1.2040.97
323_L326_Q1.2020.97
161_L188_M1.2000.97
237_L262_A1.1990.97
189_G217_V1.1850.97
136_E326_Q1.1820.97
335_V413_P1.1810.97
387_A412_N1.1810.97
179_R239_A1.1740.97
85_I104_E1.1730.97
13_V84_A1.1720.97
257_S279_G1.1670.97
212_A216_R1.1630.97
174_Q177_D1.1590.97
9_S60_V1.1580.97
59_Y102_G1.1540.97
101_A144_V1.1530.97
161_L270_L1.1520.96
144_V315_M1.1400.96
196_F201_V1.1300.96
205_V226_E1.1300.96
247_T253_V1.1270.96
255_P277_A1.1260.96
181_V240_A1.1240.96
182_V196_F1.1230.96
145_G157_G1.1230.96
16_E104_E1.1220.96
167_R199_A1.1220.96
205_V240_A1.1210.96
395_A399_D1.1110.96
97_L320_F1.1100.96
49_V58_A1.1000.95
102_G108_V1.0890.95
140_K144_V1.0870.95
228_T232_D1.0860.95
8_V133_V1.0850.95
317_E321_E1.0820.95
14_S104_E1.0820.95
235_G239_A1.0790.95
254_L267_V1.0760.95
251_E255_P1.0690.95
253_V275_D1.0610.94
24_A80_A1.0590.94
277_A281_G1.0570.94
205_V236_R1.0510.94
181_V228_T1.0460.94
20_L272_Q1.0410.94
50_L120_A1.0340.94
251_E257_S1.0320.94
135_R139_T1.0310.94
267_V288_V1.0310.94
39_L47_A1.0230.93
158_A167_R1.0180.93
281_G288_V1.0180.93
367_A370_R1.0180.93
216_R219_D1.0170.93
32_E127_A1.0150.93
178_A242_V1.0130.93
140_K319_E1.0100.93
207_A229_T1.0050.93
174_Q399_D1.0010.93
257_S261_D0.9990.92
249_S275_D0.9950.92
124_A130_I0.9940.92
123_A127_A0.9930.92
140_K143_H0.9930.92
94_R320_F0.9910.92
290_D293_D0.9900.92
368_D371_E0.9830.92
348_S374_E0.9820.92
350_E375_S0.9770.92
228_T233_A0.9760.92
339_M385_L0.9700.91
107_V296_A0.9680.91
377_A380_L0.9600.91
122_D126_D0.9540.91
122_D125_K0.9530.91
15_H106_L0.9520.91
48_F130_I0.9510.90
209_R273_P0.9510.90
182_V193_A0.9500.90
394_D398_E0.9490.90
330_K333_D0.9470.90
172_K242_V0.9460.90
373_V376_M0.9410.90
251_E277_A0.9370.90
139_T143_H0.9290.89
314_A317_E0.9250.89
36_D127_A0.9200.89
191_L195_A0.9180.89
368_D372_V0.9130.89
214_A218_A0.9120.89
354_A358_L0.9110.88
211_P230_L0.9090.88
229_T232_D0.9070.88
179_R202_A0.9050.88
202_A226_E0.9010.88
101_A315_M0.9000.88
247_T271_A0.8970.88
351_V373_V0.8920.87
403_T406_T0.8920.87
168_L289_H0.8870.87
402_S406_T0.8770.87
90_E321_E0.8770.87
314_A318_T0.8760.86
123_A126_D0.8750.86
351_V374_E0.8750.86
204_I225_A0.8750.86
33_A36_D0.8710.86
139_T142_M0.8700.86
38_L47_A0.8680.86
87_M91_D0.8640.86
169_A266_V0.8620.86
132_H330_K0.8610.86
374_E378_D0.8600.85
26_A73_G0.8600.85
339_M411_F0.8590.85
136_E330_K0.8580.85
212_A215_V0.8550.85
146_E150_T0.8530.85
47_A58_A0.8430.84
111_D149_R0.8410.84
64_D68_G0.8400.84
354_A376_M0.8390.84
48_F120_A0.8380.84
255_P279_G0.8380.84
30_S73_G0.8360.84
161_L291_L0.8360.84
264_D287_A0.8310.83
267_V280_A0.8290.83
232_D257_S0.8220.83
254_L258_A0.8220.83
183_V276_V0.8220.83
335_V338_R0.8200.83
12_R146_E0.8200.83
277_A280_A0.8190.83
107_V164_A0.8170.82
106_L291_L0.8170.82
44_V47_A0.8160.82
118_R146_E0.8140.82
181_V230_L0.8080.82
148_A315_M0.8060.82
102_G155_N0.8050.81
306_E310_R0.8050.81
17_T85_I0.8000.81
36_D40_E0.7990.81
342_S345_R0.7990.81
304_R307_D0.7980.81
7_V10_G0.7950.81
316_I342_S0.7940.81
173_T177_D0.7940.81
154_I294_L0.7920.80
246_A270_L0.7840.80
266_V287_A0.7830.80
349_R352_Q0.7810.79
183_V243_V0.7800.79
28_A119_D0.7770.79
404_I410_L0.7750.79
141_A145_G0.7730.79
95_H104_E0.7720.79
395_A404_I0.7710.79
31_T123_A0.7660.78
193_A225_A0.7660.78
59_Y117_L0.7650.78
405_A408_L0.7650.78
178_A241_D0.7620.78
353_T379_A0.7610.78
234_R251_E0.7580.77
44_V62_T0.7580.77
107_V161_L0.7570.77
100_A117_L0.7560.77
152_T315_M0.7560.77
340_Y386_A0.7550.77
326_Q329_R0.7530.77
162_G192_A0.7530.77
192_A244_V0.7530.77
103_L313_E0.7520.77
137_A326_Q0.7510.77
95_H99_V0.7470.76
280_A283_H0.7470.76
158_A301_T0.7460.76
389_T393_R0.7440.76
241_D263_G0.7430.76
274_R292_D0.7410.76
210_T214_A0.7390.76
111_D145_G0.7380.76
119_D243_V0.7360.75
354_A377_A0.7330.75
237_L254_L0.7330.75
244_V270_L0.7320.75
19_S22_E0.7320.75
37_A286_V0.7310.75
374_E377_A0.7290.75
256_A277_A0.7270.74
152_T169_A0.7260.74
154_I343_A0.7260.74
316_I320_F0.7260.74
339_M388_P0.7250.74
368_D373_V0.7250.74
185_A213_R0.7240.74
216_R220_M0.7220.74
54_H292_D0.7220.74
249_S271_A0.7200.74
151_E315_M0.7190.74
8_V92_S0.7170.73
35_L47_A0.7160.73
14_S108_V0.7160.73
345_R349_R0.7150.73
261_D279_G0.7150.73
133_V326_Q0.7130.73
12_R17_T0.7130.73
381_V385_L0.7110.73
335_V392_L0.7080.72
309_A312_V0.7080.72
185_A206_I0.7080.72
24_A73_G0.7070.72
30_S33_A0.7060.72
158_A309_A0.7050.72
10_G92_S0.7040.72
171_R300_A0.7000.72
192_A210_T0.6980.71
243_V265_T0.6980.71
210_T213_R0.6980.71
112_Q274_R0.6970.71
65_Q68_G0.6940.71
376_M380_L0.6940.71
326_Q333_D0.6920.71
346_L376_M0.6920.71
114_L142_M0.6920.71
14_S85_I0.6910.71
345_R348_S0.6900.71
181_V336_I0.6890.70
97_L334_E0.6880.70
12_R104_E0.6870.70
185_A217_V0.6860.70
162_G166_V0.6860.70
26_A31_T0.6860.70
14_S335_V0.6850.70
197_A221_V0.6820.70
136_E142_M0.6790.69
149_R354_A0.6790.69
7_V11_V0.6770.69
132_H135_R0.6740.69
152_T308_A0.6740.69
404_I408_L0.6730.69
118_R142_M0.6730.69
248_G252_H0.6730.69
208_N214_A0.6710.68
37_A50_L0.6700.68
8_V61_V0.6700.68
29_A32_E0.6690.68
106_L161_L0.6680.68
256_A283_H0.6660.68
168_L294_L0.6650.68
254_L259_F0.6630.67
311_E314_A0.6630.67
384_L389_T0.6620.67
167_R270_L0.6620.67
335_V339_M0.6620.67
179_R240_A0.6620.67
64_D67_S0.6610.67
30_S37_A0.6600.67
52_T55_R0.6600.67
164_A298_T0.6600.67
60_V72_L0.6600.67
245_T280_A0.6580.67
237_L240_A0.6580.67
226_E239_A0.6550.67
396_A399_D0.6550.67
347_K380_L0.6540.66
152_T312_V0.6530.66
32_E36_D0.6530.66
358_L372_V0.6490.66
12_R87_M0.6480.66
201_V204_I0.6470.66
407_A410_L0.6450.65
250_P271_A0.6450.65
168_L171_R0.6440.65
100_A141_A0.6420.65
274_R288_V0.6410.65
90_E384_L0.6400.65
340_Y388_P0.6390.65
23_L79_P0.6370.64
183_V192_A0.6360.64
145_G149_R0.6350.64
346_L380_L0.6330.64
233_A240_A0.6330.64
217_V220_M0.6320.64
180_A266_V0.6320.64
343_A381_V0.6310.64
159_T305_R0.6300.64
162_G270_L0.6270.63
11_V69_R0.6270.63
121_Y139_T0.6260.63
125_K139_T0.6240.63
247_T273_P0.6230.63
403_T408_L0.6230.63
210_T393_R0.6210.62
234_R261_D0.6210.62
97_L339_M0.6190.62
179_R403_T0.6190.62
120_A124_A0.6160.62
305_R308_A0.6150.62
341_E345_R0.6140.62
75_A80_A0.6140.62
69_R72_L0.6140.62
37_A74_G0.6130.61
195_A312_V0.6130.61
112_Q188_M0.6110.61
48_F117_L0.6100.61
201_V242_V0.6080.61
115_G338_R0.6060.61
177_D180_A0.6050.60
100_A130_I0.6040.60
106_L110_E0.6040.60
10_G85_I0.6020.60
303_E316_I0.6000.60
370_R373_V0.5990.60
225_A266_V0.5990.60
208_N213_R0.5980.60
190_A246_A0.5970.59
96_L138_V0.5950.59
274_R291_L0.5940.59
315_M330_K0.5940.59
172_K266_V0.5930.59
195_A291_L0.5900.59
181_V233_A0.5890.58
121_Y142_M0.5880.58
408_L412_N0.5870.58
290_D369_E0.5870.58
270_L297_V0.5860.58
258_A279_G0.5860.58
316_I350_E0.5850.58
26_A49_V0.5840.58
190_A194_K0.5820.57
244_V275_D0.5820.57
40_E44_V0.5820.57
262_A265_T0.5810.57
250_P275_D0.5810.57
11_V86_S0.5800.57
48_F96_L0.5800.57
35_L39_L0.5790.57
12_R18_A0.5790.57
169_A242_V0.5790.57
404_I407_A0.5790.57
144_V312_V0.5780.57
13_V18_A0.5780.57
119_D122_D0.5760.57
169_A175_L0.5750.57
188_M294_L0.5750.57
376_M379_A0.5740.56
244_V268_V0.5730.56
32_E123_A0.5730.56
208_N294_L0.5730.56
178_A285_G0.5730.56
378_D393_R0.5720.56
75_A219_D0.5720.56
97_L106_L0.5720.56
13_V83_G0.5710.56
164_A297_V0.5710.56
117_L242_V0.5700.56
367_A371_E0.5690.56
76_G127_A0.5640.55
48_F59_Y0.5630.55
392_L404_I0.5620.55
292_D326_Q0.5620.55
161_L294_L0.5620.55
56_V333_D0.5610.55
130_I139_T0.5610.55
101_A114_L0.5600.55
47_A60_V0.5600.55
68_G216_R0.5550.54
94_R98_R0.5530.54
317_E320_F0.5530.54
153_A308_A0.5510.53
270_L379_A0.5490.53
161_L315_M0.5480.53
118_R268_V0.5480.53
106_L295_E0.5470.53
228_T254_L0.5460.53
387_A391_S0.5460.53
151_E319_E0.5450.53
353_T357_R0.5450.53
189_G290_D0.5450.53
377_A384_L0.5440.53
353_T386_A0.5440.53
215_V229_T0.5440.53
24_A51_Q0.5430.52
210_T227_A0.5430.52
107_V136_E0.5420.52
42_P45_E0.5410.52
94_R313_E0.5410.52
136_E323_L0.5410.52
111_D187_E0.5410.52
234_R257_S0.5400.52
91_D317_E0.5380.52
240_A265_T0.5360.51
335_V411_F0.5360.51
208_N217_V0.5350.51
145_G312_V0.5340.51
104_E159_T0.5330.51
124_A151_E0.5330.51
369_E373_V0.5320.51
47_A215_V0.5320.51
209_R247_T0.5320.51
117_L122_D0.5310.51
124_A127_A0.5310.51
183_V233_A0.5310.51
247_T250_P0.5310.51
111_D182_V0.5310.51
328_K396_A0.5310.51
243_V401_W0.5300.51
325_T397_A0.5300.51
108_V137_A0.5300.51
237_L259_F0.5300.51
145_G148_A0.5290.51
320_F323_L0.5290.51
230_L233_A0.5290.51
321_E325_T0.5280.50
215_V227_A0.5240.50
174_Q306_E0.5240.50
187_E292_D0.5240.50
394_D397_A0.5240.50
23_L27_S0.5230.50
306_E313_E0.5230.50
100_A104_E0.5220.50
236_R381_V0.5210.49
391_S409_E0.5210.49
403_T410_L0.5210.49
237_L265_T0.5200.49
53_C116_Q0.5190.49
12_R191_L0.5190.49
168_L309_A0.5190.49
56_V138_V0.5180.49
162_G187_E0.5180.49
373_V383_Q0.5170.49
354_A357_R0.5160.49
11_V72_L0.5150.49
274_R290_D0.5150.49
33_A37_A0.5140.49
406_T412_N0.5130.48
162_G167_R0.5130.48
173_T178_A0.5120.48
30_S36_D0.5100.48
7_V89_H0.5090.48
395_A400_D0.5090.48
62_T65_Q0.5080.48
56_V288_V0.5080.48
300_A304_R0.5080.48
160_S288_V0.5080.48
10_G33_A0.5070.48
245_T267_V0.5070.48
97_L140_K0.5070.48
377_A383_Q0.5060.48
111_D142_M0.5060.48
128_G307_D0.5060.48
96_L196_F0.5050.47
243_V314_A0.5040.47
149_R273_P0.5040.47
167_R170_E0.5030.47
332_A393_R0.5020.47
371_E374_E0.5020.47
108_V374_E0.5020.47
253_V271_A0.5010.47
142_M155_N0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n7rA 2 0.8784 100 0.348 Contact Map
1gpjA 2 0.8853 100 0.448 Contact Map
4ppmA 2 0.1583 99.9 0.799 Contact Map
1edzA 2 0.6583 99.9 0.808 Contact Map
3u62A 1 0.5344 99.9 0.819 Contact Map
1p77A 1 0.5665 99.9 0.829 Contact Map
3oj0A 1 0.3165 99.8 0.84 Contact Map
1nytA 6 0.5803 99.8 0.842 Contact Map
3fbtA 2 0.5757 99.8 0.843 Contact Map
2eggA 5 0.5872 99.8 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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