GREMLIN Database
Q9HP71 - Uncharacterized protein
UniProt: Q9HP71 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (199)
Sequences: 2209 (1716)
Seq/√Len: 121.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_D68_A4.9621.00
63_A91_A4.9521.00
14_L72_P3.8541.00
15_V26_A3.4671.00
26_A47_E3.1441.00
23_A44_G3.0911.00
43_F58_P2.8711.00
197_G200_N2.8241.00
70_V95_A2.6061.00
134_R161_G2.4801.00
12_S37_V2.4691.00
131_T139_S2.3941.00
48_F60_P2.3011.00
11_A73_A2.1371.00
79_T85_N2.0971.00
150_F153_A2.0681.00
61_D64_A2.0301.00
87_A91_A1.9631.00
104_V111_S1.9271.00
23_A46_R1.9221.00
76_V116_V1.9041.00
12_S35_R1.8681.00
37_V72_P1.8591.00
93_R113_D1.8301.00
37_V57_A1.7981.00
5_L128_A1.7821.00
2_I116_V1.7741.00
143_R147_D1.7111.00
43_F47_E1.7091.00
84_V87_A1.6991.00
84_V88_F1.6981.00
15_V36_V1.6621.00
125_V157_A1.6501.00
162_R202_R1.6481.00
64_A67_V1.6391.00
173_S176_E1.6291.00
51_A58_P1.6261.00
145_R149_E1.5651.00
6_H98_L1.5631.00
127_I150_F1.5341.00
65_D87_A1.5231.00
48_F52_D1.5161.00
73_A98_L1.5131.00
120_A147_D1.4991.00
86_A90_A1.4881.00
89_A93_R1.4831.00
41_P62_G1.4681.00
120_A129_V1.4481.00
171_G177_R1.4401.00
122_D147_D1.4321.00
49_G53_R1.4071.00
16_V88_F1.4051.00
15_V29_F1.3931.00
141_H186_R1.3881.00
63_A88_F1.3871.00
97_A113_D1.3591.00
81_D84_V1.3491.00
21_V24_R1.3241.00
103_D112_G1.3151.00
43_F51_A1.3121.00
189_P193_A1.2991.00
39_V68_A1.2661.00
4_L114_V1.2611.00
77_A88_F1.2581.00
73_A96_G1.2240.99
35_R57_A1.2180.99
10_G35_R1.1970.99
80_S85_N1.1880.99
127_I146_I1.1730.99
82_S104_V1.1720.99
141_H145_R1.1650.99
18_G43_F1.1510.99
125_V142_L1.1440.99
131_T157_A1.1380.99
75_V92_A1.1380.99
100_N112_G1.1370.99
129_V142_L1.1280.99
124_P134_R1.1150.99
13_V29_F1.0970.99
9_H33_A1.0930.99
64_A68_A1.0920.99
196_T201_P1.0810.98
12_S72_P1.0770.98
89_A101_R1.0750.98
77_A85_N1.0570.98
118_A143_R1.0570.98
43_F60_P1.0550.98
104_V112_G1.0450.98
14_L39_V1.0440.98
31_A121_G1.0420.98
89_A112_G1.0420.98
98_L113_D1.0400.98
138_L157_A1.0340.98
8_F13_V1.0290.98
86_A111_S1.0260.98
11_A113_D1.0230.98
192_K197_G1.0190.98
16_V63_A1.0180.98
44_G47_E0.9980.97
199_A203_V0.9970.97
18_G22_G0.9820.97
160_T185_V0.9690.97
27_R46_R0.9680.97
49_G52_D0.9660.97
166_D206_E0.9630.97
101_R111_S0.9630.97
50_D55_R0.9610.97
51_A56_A0.9600.97
137_A182_R0.9570.97
2_I28_R0.9570.97
30_A55_R0.9510.97
68_A71_D0.9500.97
92_A97_A0.9470.96
136_P164_R0.9340.96
90_A94_D0.9330.96
7_D115_V0.9250.96
41_P58_P0.9220.96
91_A95_A0.9210.96
75_V97_A0.9200.96
154_G157_A0.9160.96
171_G180_A0.9150.96
76_V114_V0.9140.96
165_D169_S0.8990.95
126_T132_G0.8990.95
37_V59_D0.8880.95
45_D48_F0.8870.95
124_P158_V0.8870.95
105_A112_G0.8840.95
23_A50_D0.8760.95
67_V91_A0.8670.94
18_G40_S0.8630.94
123_P126_T0.8610.94
47_E51_A0.8580.94
122_D154_G0.8560.94
89_A111_S0.8480.94
32_E36_V0.8460.94
41_P84_V0.8450.93
172_L177_R0.8430.93
193_A201_P0.8420.93
192_K200_N0.8350.93
171_G176_E0.8300.93
23_A27_R0.8290.93
187_S190_V0.8220.93
46_R50_D0.8200.92
160_T181_V0.8140.92
191_W194_L0.8110.92
36_V56_A0.8040.92
25_K102_A0.7950.91
199_A202_R0.7900.91
89_A113_D0.7880.91
142_L150_F0.7880.91
28_R119_T0.7870.91
67_V70_V0.7860.91
202_R206_E0.7800.90
144_E186_R0.7780.90
117_P128_A0.7770.90
193_A196_T0.7750.90
187_S201_P0.7730.90
141_H144_E0.7690.90
21_V85_N0.7690.90
13_V34_D0.7670.90
177_R181_V0.7660.90
124_P161_G0.7660.90
15_V18_G0.7610.89
26_A56_A0.7520.89
30_A56_A0.7510.89
92_A99_V0.7510.89
201_P205_A0.7480.89
65_D91_A0.7480.89
167_L180_A0.7470.88
40_S43_F0.7430.88
21_V102_A0.7430.88
155_G198_D0.7370.88
115_V132_G0.7370.88
41_P61_D0.7340.88
85_N168_R0.7330.88
2_I32_E0.7320.87
59_D68_A0.7250.87
125_V131_T0.7130.86
144_E147_D0.7120.86
5_L126_T0.7090.86
21_V80_S0.7070.86
198_D202_R0.6930.84
69_R97_A0.6930.84
46_R49_G0.6920.84
193_A197_G0.6780.83
26_A36_V0.6770.83
124_P154_G0.6770.83
138_L142_L0.6730.83
13_V36_V0.6710.83
21_V101_R0.6700.82
140_K144_E0.6690.82
166_D170_T0.6680.82
137_A178_R0.6670.82
112_G115_V0.6630.82
166_D202_R0.6480.80
38_V56_A0.6430.80
15_V22_G0.6400.79
71_D96_G0.6390.79
22_G78_A0.6390.79
69_R75_V0.6380.79
43_F48_F0.6350.79
27_R50_D0.6350.79
122_D153_A0.6330.79
146_I150_F0.6310.78
124_P157_A0.6270.78
123_P154_G0.6270.78
198_D205_A0.6240.78
200_N203_V0.6220.78
53_R90_A0.6190.77
19_G78_A0.6140.77
100_N118_A0.6130.76
112_G118_A0.6110.76
134_R158_V0.6040.75
140_K182_R0.6040.75
85_N104_V0.6040.75
134_R185_V0.6030.75
172_L176_E0.6010.75
111_S115_V0.6010.75
89_A99_V0.6000.75
184_V189_P0.6000.75
67_V71_D0.6000.75
6_H114_V0.5990.75
192_K201_P0.5970.75
137_A181_V0.5970.75
193_A198_D0.5960.74
103_D118_A0.5950.74
84_V157_A0.5940.74
39_V72_P0.5940.74
4_L74_L0.5920.74
47_E50_D0.5920.74
101_R112_G0.5890.74
76_V113_D0.5840.73
199_A206_E0.5820.73
27_R49_G0.5800.72
145_R150_F0.5790.72
18_G47_E0.5770.72
76_V102_A0.5770.72
75_V88_F0.5740.72
190_V193_A0.5700.71
129_V146_I0.5700.71
160_T180_A0.5680.71
2_I25_K0.5680.71
79_T84_V0.5660.71
102_A116_V0.5660.71
25_K77_A0.5640.70
200_N204_R0.5610.70
7_D105_A0.5590.70
125_V150_F0.5590.70
48_F58_P0.5580.70
38_V43_F0.5560.69
67_V75_V0.5540.69
91_A94_D0.5510.69
10_G94_D0.5480.68
78_A102_A0.5460.68
189_P201_P0.5450.68
74_L78_A0.5440.68
21_V79_T0.5440.68
135_S140_K0.5430.68
119_T126_T0.5410.67
181_V184_V0.5400.67
142_L146_I0.5390.67
117_P132_G0.5370.67
163_I205_A0.5340.66
4_L116_V0.5340.66
28_R121_G0.5340.66
19_G85_N0.5330.66
22_G40_S0.5320.66
116_V128_A0.5280.65
146_I149_E0.5260.65
39_V61_D0.5240.65
65_D95_A0.5230.65
18_G41_P0.5200.64
19_G79_T0.5190.64
52_D82_S0.5180.64
187_S192_K0.5180.64
178_R182_R0.5170.64
155_G158_V0.5170.64
77_A118_A0.5160.64
13_V74_L0.5160.64
179_D186_R0.5140.63
29_F36_V0.5140.63
26_A30_A0.5120.63
6_H113_D0.5110.63
24_R79_T0.5100.63
183_A187_S0.5100.63
71_D97_A0.5100.63
187_S196_T0.5090.63
39_V63_A0.5080.62
69_R72_P0.5080.62
79_T88_F0.5060.62
30_A50_D0.5050.62
194_L197_G0.5050.62
118_A164_R0.5040.62
26_A29_F0.5020.62
24_R117_P0.5010.61
137_A185_V0.5010.61
150_F156_M0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjqA 2 0.9773 100 0.222 Contact Map
1kyqA 2 0.9773 100 0.253 Contact Map
3dfzA 2 0.9045 100 0.288 Contact Map
4d79A 2 0.8545 98.5 0.832 Contact Map
3d4oA 4 0.6545 98.3 0.843 Contact Map
3c85A 2 0.6545 98.3 0.843 Contact Map
2rirA 4 0.6727 98.2 0.848 Contact Map
2g1uA 2 0.5864 98.1 0.85 Contact Map
4b4uA 2 0.5818 98.1 0.851 Contact Map
1id1A 2 0.6455 98 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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