GREMLIN Database
Q9HP70 - Heme biosynthesis protein
UniProt: Q9HP70 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (320)
Sequences: 292 (212)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_D52_R7.5101.00
151_F264_D5.9411.00
28_R205_T3.6160.99
9_D52_R3.4100.98
83_M97_V3.3690.98
108_E336_L3.3250.98
90_F116_M3.2570.97
79_S144_N3.1920.97
108_E334_R3.0520.96
195_A213_D3.0380.96
278_H338_K2.9750.95
283_P294_F2.5570.90
89_R92_E2.5040.89
9_D12_D2.4490.87
203_V209_A2.4090.87
104_A341_I2.3010.84
338_K341_I2.2380.82
67_A237_V2.2020.81
116_M336_L2.2000.81
55_T59_N2.1870.81
79_S131_L2.1750.80
299_G305_S2.1690.80
27_Q218_P2.1450.79
260_D284_R2.1380.79
252_G329_T2.1380.79
189_E224_T2.0960.78
157_F277_T2.0800.77
155_A278_H2.0560.76
91_D336_L2.0200.75
100_I137_E2.0150.75
154_E338_K1.9950.74
243_H280_Y1.9420.72
244_Y335_I1.9340.71
119_V199_G1.8850.69
147_K278_H1.8750.69
28_R46_A1.8650.69
278_H341_I1.8190.67
15_V49_L1.7940.65
335_I338_K1.7900.65
257_N284_R1.7880.65
284_R292_N1.7590.64
64_R340_G1.7570.64
62_L266_V1.7440.63
34_A181_G1.7440.63
90_F336_L1.7270.62
104_A278_H1.7230.62
85_A93_I1.7180.62
272_G290_E1.7110.62
31_E46_A1.6820.60
236_R280_Y1.6780.60
67_A196_V1.6550.59
121_S341_I1.6340.58
88_H219_E1.5960.56
104_A340_G1.5720.55
119_V150_E1.5710.55
106_N235_R1.5580.54
154_E278_H1.5510.54
108_E299_G1.5330.53
78_A153_V1.5200.52
146_P283_P1.5090.52
34_A55_T1.5000.51
59_N314_S1.4830.50
87_E214_I1.4830.50
205_T218_P1.4650.50
98_N106_N1.4510.49
135_E241_P1.4380.48
90_F108_E1.4310.48
34_A45_S1.4250.48
236_R243_H1.4230.47
105_H251_N1.4180.47
71_A121_S1.4060.47
122_V127_V1.4060.47
85_A97_V1.4050.47
106_N118_F1.3950.46
135_E142_T1.3930.46
68_L238_G1.3900.46
111_H294_F1.3810.45
195_A210_V1.3790.45
191_D223_A1.3770.45
261_D265_D1.3740.45
147_K338_K1.3730.45
58_E272_G1.3680.45
99_D212_D1.3680.45
208_C218_P1.3590.44
54_R58_E1.3540.44
74_I193_V1.3520.44
197_Q294_F1.3510.44
155_A338_K1.3380.43
104_A338_K1.3290.43
240_I336_L1.3270.43
72_E158_L1.3220.42
68_L104_A1.3070.42
69_I193_V1.2970.41
111_H328_D1.2960.41
226_R303_A1.2910.41
24_P206_P1.2880.41
23_F234_V1.2870.41
100_I344_D1.2760.40
112_P151_F1.2730.40
301_S305_S1.2720.40
243_H279_C1.2700.40
236_R279_C1.2590.39
23_F238_G1.2540.39
276_V279_C1.2500.39
125_R128_A1.2470.39
110_E331_F1.2440.39
35_E261_D1.2440.39
50_R202_V1.2300.38
104_A121_S1.2280.38
85_A151_F1.2160.37
256_W279_C1.2050.37
104_A154_E1.1980.37
63_T335_I1.1930.36
226_R261_D1.1830.36
236_R267_G1.1790.36
278_H335_I1.1710.35
94_A116_M1.1610.35
47_T230_E1.1530.35
35_E87_E1.1490.34
196_V225_L1.1440.34
155_A327_W1.1400.34
27_Q222_V1.1360.34
46_A204_E1.1340.34
121_S340_G1.1340.34
62_L241_P1.1280.33
68_L147_K1.1230.33
121_S338_K1.1140.33
119_V340_G1.1090.33
267_G280_Y1.1090.33
63_T152_R1.1080.33
157_F238_G1.1030.32
26_V88_H1.1000.32
104_A241_P1.0950.32
51_D261_D1.0820.31
156_K338_K1.0730.31
119_V155_A1.0660.31
114_L310_E1.0650.31
71_A81_V1.0620.31
91_D334_R1.0580.30
199_G340_G1.0570.30
27_Q208_C1.0530.30
156_K278_H1.0530.30
207_Y237_V1.0470.30
50_R111_H1.0470.30
51_D93_I1.0460.30
124_D340_G1.0340.29
256_W280_Y1.0100.28
262_A265_D1.0100.28
153_V294_F1.0090.28
33_A57_D1.0090.28
26_V32_P1.0060.28
33_A311_R1.0040.28
155_A158_L1.0030.28
275_F336_L1.0020.28
63_T119_V1.0010.28
44_F216_R0.9980.28
134_I142_T0.9980.28
121_S154_E0.9970.28
195_A226_R0.9950.28
71_A278_H0.9860.27
151_F281_Q0.9820.27
255_V332_S0.9790.27
155_A199_G0.9680.27
240_I314_S0.9670.27
71_A78_A0.9660.27
64_R134_I0.9650.27
19_F104_A0.9590.26
119_V335_I0.9570.26
258_V294_F0.9550.26
32_P35_E0.9540.26
81_V155_A0.9490.26
72_E127_V0.9490.26
153_V343_L0.9430.26
236_R256_W0.9420.26
52_R300_R0.9380.26
89_R249_T0.9370.26
101_Q217_D0.9370.26
217_D220_W0.9360.25
64_R124_D0.9360.25
153_V237_V0.9320.25
53_V70_N0.9290.25
228_F231_S0.9250.25
119_V238_G0.9240.25
87_E211_A0.9210.25
47_T55_T0.9140.25
228_F254_T0.9100.25
47_T213_D0.9080.24
22_G304_E0.9020.24
104_A153_V0.9010.24
70_N336_L0.9010.24
23_F192_L0.9010.24
94_A255_V0.8970.24
45_S225_L0.8970.24
69_I343_L0.8930.24
261_D311_R0.8920.24
234_V237_V0.8910.24
32_P202_V0.8890.24
239_V277_T0.8850.24
23_F207_Y0.8840.24
127_V131_L0.8830.24
147_K155_A0.8820.23
150_E235_R0.8820.23
254_T295_A0.8780.23
62_L78_A0.8740.23
243_H267_G0.8740.23
274_D301_S0.8720.23
60_G322_V0.8700.23
64_R341_I0.8690.23
71_A147_K0.8680.23
187_P204_E0.8680.23
267_G276_V0.8630.23
64_R104_A0.8600.23
190_R212_D0.8570.23
90_F252_G0.8560.23
25_V159_V0.8550.23
197_Q337_K0.8520.22
251_N296_M0.8510.22
105_H296_M0.8510.22
258_V263_V0.8450.22
158_L205_T0.8430.22
152_R335_I0.8350.22
35_E213_D0.8310.22
145_L297_T0.8290.22
146_P293_F0.8250.22
51_D54_R0.8220.21
71_A341_I0.8200.21
18_A36_A0.8190.21
41_G132_A0.8160.21
8_L16_L0.8140.21
51_D314_S0.8140.21
146_P236_R0.8130.21
93_I97_V0.8080.21
22_G339_T0.8030.21
267_G279_C0.8000.21
50_R270_V0.7960.21
30_F50_R0.7940.20
105_H298_H0.7930.20
251_N298_H0.7930.20
98_N326_D0.7880.20
146_P267_G0.7870.20
62_L92_E0.7850.20
270_V273_L0.7820.20
103_V221_V0.7820.20
83_M93_I0.7780.20
66_G238_G0.7760.20
84_H136_A0.7690.20
208_C212_D0.7660.20
257_N260_D0.7660.20
97_V281_Q0.7660.20
121_S278_H0.7650.20
46_A286_D0.7630.19
119_V277_T0.7630.19
84_H112_P0.7620.19
244_Y336_L0.7600.19
245_A335_I0.7600.19
16_L196_V0.7590.19
185_L276_V0.7580.19
157_F252_G0.7580.19
243_H256_W0.7570.19
223_A261_D0.7560.19
129_D262_A0.7530.19
21_G155_A0.7530.19
271_A312_V0.7530.19
48_E219_E0.7510.19
62_L339_T0.7500.19
15_V215_G0.7490.19
53_V240_I0.7480.19
68_L153_V0.7450.19
83_M135_E0.7450.19
69_I290_E0.7450.19
152_R239_V0.7450.19
121_S147_K0.7410.19
68_L71_A0.7400.19
193_V197_Q0.7380.19
204_E227_R0.7380.19
302_E306_E0.7360.19
192_L215_G0.7350.19
30_F193_V0.7300.18
199_G246_L0.7300.18
122_V341_I0.7290.18
34_A214_I0.7290.18
63_T280_Y0.7280.18
150_E294_F0.7280.18
267_G293_F0.7270.18
104_A155_A0.7250.18
204_E249_T0.7240.18
234_V260_D0.7230.18
131_L134_I0.7210.18
149_Q235_R0.7210.18
35_E200_L0.7200.18
149_Q281_Q0.7200.18
106_N289_W0.7150.18
72_E143_Y0.7140.18
66_G340_G0.7110.18
78_A145_L0.7100.18
299_G332_S0.7080.18
218_P312_V0.7060.18
13_R149_Q0.7050.18
152_R248_Y0.7050.18
156_K341_I0.7020.18
132_A204_E0.6980.18
24_P289_W0.6960.17
88_H230_E0.6950.17
16_L47_T0.6930.17
20_Q153_V0.6880.17
49_L240_I0.6870.17
149_Q264_D0.6860.17
150_E312_V0.6860.17
213_D221_V0.6850.17
71_A338_K0.6830.17
84_H228_F0.6810.17
110_E315_V0.6810.17
119_V338_K0.6800.17
12_D56_L0.6800.17
154_E341_I0.6800.17
46_A78_A0.6800.17
190_R313_R0.6790.17
81_V122_V0.6780.17
34_A49_L0.6770.17
119_V278_H0.6760.17
74_I119_V0.6750.17
75_G197_Q0.6750.17
59_N223_A0.6750.17
81_V121_S0.6740.17
34_A44_F0.6710.17
191_D220_W0.6710.17
36_A50_R0.6700.17
30_F91_D0.6680.17
132_A136_A0.6680.17
32_P126_E0.6670.17
58_E101_Q0.6670.17
159_V242_N0.6660.17
45_S51_D0.6660.17
252_G332_S0.6660.17
272_G301_S0.6650.17
83_M339_T0.6630.17
212_D311_R0.6610.16
132_A334_R0.6600.16
55_T307_A0.6600.16
33_A299_G0.6590.16
243_H276_V0.6590.16
260_D342_R0.6580.16
34_A202_V0.6560.16
299_G304_E0.6510.16
26_V47_T0.6480.16
252_G278_H0.6430.16
98_N283_P0.6410.16
64_R119_V0.6410.16
74_I312_V0.6380.16
47_T54_R0.6370.16
155_A341_I0.6360.16
53_V60_G0.6320.16
78_A253_M0.6310.16
189_E228_F0.6310.16
78_A254_T0.6310.16
25_V205_T0.6310.16
41_G92_E0.6240.16
21_G338_K0.6240.16
151_F197_Q0.6240.16
222_V309_V0.6230.15
132_A208_C0.6230.15
32_P36_A0.6220.15
102_A235_R0.6220.15
32_P223_A0.6220.15
168_V215_G0.6210.15
210_V322_V0.6210.15
277_T338_K0.6210.15
131_L144_N0.6200.15
75_G284_R0.6200.15
198_D342_R0.6160.15
156_K252_G0.6130.15
94_A296_M0.6130.15
119_V273_L0.6120.15
187_P190_R0.6120.15
33_A301_S0.6120.15
118_F291_Y0.6090.15
30_F186_T0.6070.15
52_R228_F0.6070.15
146_P279_C0.6000.15
104_A147_K0.6000.15
62_L320_W0.5980.15
65_F242_N0.5940.15
134_I340_G0.5930.15
8_L44_F0.5920.15
25_V157_F0.5920.15
146_P197_Q0.5920.15
62_L322_V0.5910.15
114_L321_D0.5900.15
49_L295_A0.5900.15
207_Y310_E0.5890.15
226_R230_E0.5870.15
74_I256_W0.5870.15
185_L256_W0.5870.15
129_D136_A0.5860.15
236_R293_F0.5850.15
31_E269_A0.5850.15
179_P310_E0.5840.14
129_D139_G0.5840.14
81_V340_G0.5840.14
11_R44_F0.5830.14
306_E331_F0.5820.14
81_V278_H0.5810.14
184_T204_E0.5810.14
35_E226_R0.5790.14
64_R199_G0.5770.14
96_T200_L0.5760.14
247_G298_H0.5730.14
214_I301_S0.5730.14
147_K341_I0.5710.14
258_V267_G0.5710.14
263_V281_Q0.5690.14
23_F337_K0.5680.14
99_D200_L0.5680.14
64_R68_L0.5660.14
151_F256_W0.5660.14
48_E184_T0.5650.14
189_E231_S0.5640.14
290_E339_T0.5630.14
63_T322_V0.5620.14
16_L223_A0.5610.14
260_D263_V0.5590.14
48_E203_V0.5590.14
85_A277_T0.5580.14
197_Q228_F0.5570.14
20_Q94_A0.5560.14
30_F304_E0.5550.14
81_V120_V0.5550.14
225_L245_A0.5540.14
33_A53_V0.5540.14
47_T59_N0.5540.14
110_E246_L0.5530.14
115_N296_M0.5510.14
276_V280_Y0.5500.14
219_E310_E0.5480.14
239_V278_H0.5460.14
78_A295_A0.5460.14
106_N248_Y0.5450.14
31_E204_E0.5430.14
147_K150_E0.5420.13
55_T136_A0.5420.13
45_S219_E0.5400.13
220_W223_A0.5380.13
147_K244_Y0.5380.13
15_V188_A0.5360.13
308_R333_T0.5350.13
21_G278_H0.5350.13
33_A306_E0.5330.13
187_P262_A0.5330.13
20_Q107_Y0.5310.13
119_V246_L0.5310.13
16_L61_V0.5310.13
102_A150_E0.5290.13
228_F233_M0.5290.13
154_E157_F0.5280.13
104_A335_I0.5270.13
48_E160_D0.5270.13
66_G119_V0.5270.13
78_A343_L0.5250.13
85_A321_D0.5250.13
137_E220_W0.5240.13
211_A222_V0.5230.13
118_F255_V0.5210.13
62_L221_V0.5210.13
279_C294_F0.5200.13
47_T51_D0.5190.13
193_V338_K0.5190.13
276_V283_P0.5170.13
108_E237_V0.5170.13
215_G304_E0.5170.13
211_A214_I0.5160.13
104_A199_G0.5140.13
258_V292_N0.5140.13
202_V293_F0.5090.13
235_R312_V0.5060.13
96_T230_E0.5060.13
62_L196_V0.5050.13
62_L95_D0.5050.13
17_N236_R0.5050.13
161_G166_G0.5040.13
122_V154_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.8438 100 0.528 Contact Map
4un1B 1 0.4517 100 0.768 Contact Map
4un1A 1 0.4091 99.9 0.808 Contact Map
2e1cA 1 0.4148 99.9 0.828 Contact Map
4pcqA 2 0.4176 99.9 0.832 Contact Map
2ia0A 2 0.4205 99.9 0.835 Contact Map
2cg4A 6 0.4176 99.8 0.841 Contact Map
2p5vA 5 0.4403 99.8 0.841 Contact Map
2pn6A 5 0.4148 99.8 0.845 Contact Map
2dbbA 4 0.4119 99.8 0.847 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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