Q9HP66 - HALSA - GREMLIN Contacts

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Q9HP66 - Uncharacterized protein

UniProt:	Q9HP66	Sequences: MCGFVVAAAGAAFAGQAVVAASAGAPVGQPQFVFLAVSGALLAGIMRTLFALRDAPLVLGSVVVVLWVVTALAPLAGVPTVAAWERVLVALAVTTAFGWVSRALGATSIAGMLTGVFLGLLAVVLGGYGWFVVLVAFFAVGSLATKFKYELKADRGVAEPNDGARGTANVLGNSAAALIALVLYAAHAHVPFADTAFLFAYAGSVATALADTLSSEVGGLFDTPRLVTTFERVDPGTDGAVTWQGELAGVVGATIIAVLSVAVFGVTLRGGGVVVAAGVAGMTADSLAGATIEGRVLTNQGVNFLATLTGAAVGGALALAVGVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	324 (266)
Sequences:	241 (159)
Seq/√Len:	9.7

HALSA - Q9HP66

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
284_A	309_T	4.128	0.99
141_G	213_L	4.063	0.99
217_V	220_L	3.570	0.97
214_S	242_T	3.244	0.95
226_L	233_V	3.039	0.93
90_A	145_T	2.945	0.91
119_G	162_D	2.940	0.91
214_S	249_G	2.914	0.91
64_V	67_W	2.768	0.89
224_P	281_G	2.687	0.87
112_M	115_G	2.625	0.86
174_S	204_S	2.472	0.82
246_E	283_T	2.463	0.82
213_L	252_G	2.352	0.79
141_G	144_A	2.347	0.78
233_V	237_T	2.340	0.78
208_A	307_T	2.262	0.76
227_V	240_A	2.180	0.73
107_T	293_E	2.122	0.71
172_G	210_A	2.118	0.71
47_R	56_P	2.094	0.70
59_L	136_A	2.018	0.67
175_A	279_V	1.951	0.64
225_R	235_P	1.874	0.61
144_A	213_L	1.844	0.59
229_T	250_V	1.826	0.59
136_A	263_V	1.817	0.58
133_V	174_S	1.808	0.58
225_R	252_G	1.753	0.55
307_T	311_A	1.745	0.55
223_T	232_R	1.730	0.54
53_R	56_P	1.726	0.54
173_N	285_D	1.721	0.54
130_W	310_G	1.715	0.54
312_A	316_A	1.705	0.53
135_V	162_D	1.702	0.53
137_F	173_N	1.665	0.51
52_L	63_V	1.654	0.51
278_G	285_D	1.641	0.50
165_R	216_E	1.631	0.50
250_V	275_V	1.612	0.49
101_S	146_K	1.610	0.49
117_F	284_A	1.599	0.48
173_N	281_G	1.573	0.47
157_V	310_G	1.567	0.47
181_L	214_S	1.547	0.46
281_G	285_D	1.535	0.46
47_R	53_R	1.531	0.45
219_G	222_D	1.520	0.45
60_G	64_V	1.507	0.44
47_R	238_D	1.495	0.44
108_S	227_V	1.492	0.44
148_K	242_T	1.481	0.43
96_A	262_A	1.476	0.43
258_V	261_V	1.470	0.43
207_T	310_G	1.458	0.42
74_P	287_L	1.417	0.40
255_I	317_L	1.415	0.40
95_T	135_V	1.402	0.40
147_F	205_V	1.398	0.39
114_T	171_L	1.387	0.39
105_G	255_I	1.372	0.38
260_S	284_A	1.366	0.38
137_F	285_D	1.366	0.38
200_A	222_D	1.364	0.38
55_A	207_T	1.357	0.38
217_V	248_A	1.355	0.38
254_T	262_A	1.324	0.36
96_A	272_G	1.322	0.36
166_G	169_N	1.320	0.36
169_N	307_T	1.320	0.36
137_F	278_G	1.316	0.36
60_G	63_V	1.315	0.36
194_D	297_L	1.313	0.36
204_S	230_F	1.298	0.35
152_K	163_G	1.296	0.35
96_A	247_L	1.296	0.35
200_A	297_L	1.288	0.35
111_G	176_A	1.279	0.34
232_R	311_A	1.278	0.34
115_G	248_A	1.278	0.34
148_K	304_F	1.277	0.34
112_M	164_A	1.269	0.34
137_F	206_A	1.265	0.34
251_V	276_A	1.262	0.34
130_W	201_Y	1.257	0.34
197_F	240_A	1.254	0.33
84_W	295_R	1.244	0.33
244_Q	247_L	1.240	0.33
277_A	314_G	1.230	0.32
207_T	240_A	1.229	0.32
120_L	238_D	1.228	0.32
57_L	207_T	1.223	0.32
133_V	172_G	1.221	0.32
96_A	119_G	1.217	0.32
130_W	203_G	1.217	0.32
134_L	288_A	1.201	0.31
132_V	288_A	1.201	0.31
111_G	226_L	1.199	0.31
173_N	206_A	1.197	0.31
107_T	144_A	1.197	0.31
208_A	281_G	1.192	0.31
137_F	281_G	1.192	0.31
210_A	257_A	1.187	0.31
273_V	313_V	1.185	0.31
108_S	301_G	1.183	0.31
230_F	283_T	1.156	0.30
203_G	224_P	1.147	0.29
262_A	265_G	1.145	0.29
133_V	157_V	1.143	0.29
306_A	310_G	1.124	0.28
63_V	67_W	1.116	0.28
52_L	55_A	1.112	0.28
173_N	278_G	1.109	0.28
93_V	140_V	1.105	0.28
99_W	135_V	1.105	0.28
249_G	282_M	1.101	0.28
95_T	115_G	1.099	0.28
142_S	276_A	1.098	0.27
254_T	275_V	1.096	0.27
50_F	55_A	1.093	0.27
116_V	182_V	1.087	0.27
115_G	181_L	1.076	0.27
140_V	213_L	1.076	0.27
131_F	186_A	1.076	0.27
108_S	171_L	1.067	0.26
101_S	181_L	1.065	0.26
106_A	288_A	1.064	0.26
299_N	303_N	1.057	0.26
234_D	237_T	1.045	0.26
107_T	142_S	1.042	0.26
282_M	293_E	1.040	0.25
147_F	159_E	1.039	0.25
156_G	159_E	1.032	0.25
158_A	169_N	1.029	0.25
50_F	58_V	1.028	0.25
60_G	67_W	1.025	0.25
61_S	64_V	1.024	0.25
145_T	215_S	1.024	0.25
97_F	148_K	1.019	0.25
53_R	128_Y	1.016	0.25
170_V	215_S	1.015	0.25
232_R	242_T	1.012	0.24
134_L	177_A	1.005	0.24
47_R	242_T	1.000	0.24
262_A	313_V	0.991	0.24
127_G	271_G	0.991	0.24
184_Y	206_A	0.985	0.24
95_T	254_T	0.985	0.24
236_G	239_G	0.981	0.23
236_G	245_G	0.981	0.23
239_G	245_G	0.981	0.23
310_G	314_G	0.981	0.23
233_V	259_L	0.978	0.23
149_Y	169_N	0.970	0.23
259_L	280_A	0.970	0.23
149_Y	291_T	0.966	0.23
140_V	217_V	0.963	0.23
52_L	277_A	0.963	0.23
127_G	186_A	0.956	0.23
59_L	240_A	0.953	0.23
83_A	256_I	0.940	0.22
224_P	238_D	0.939	0.22
147_F	232_R	0.937	0.22
53_R	297_L	0.936	0.22
188_A	192_F	0.934	0.22
59_L	154_D	0.929	0.22
207_T	210_A	0.927	0.22
149_Y	158_A	0.925	0.22
280_A	304_F	0.924	0.22
62_V	122_A	0.912	0.21
133_V	263_V	0.911	0.21
88_L	276_A	0.900	0.21
97_F	157_V	0.894	0.21
93_V	97_F	0.893	0.21
155_R	240_A	0.893	0.21
235_P	287_L	0.884	0.20
164_A	169_N	0.883	0.20
145_T	199_F	0.879	0.20
154_D	250_V	0.875	0.20
293_E	298_T	0.873	0.20
213_L	238_D	0.852	0.20
224_P	278_G	0.851	0.20
251_V	261_V	0.846	0.19
176_A	194_D	0.844	0.19
156_G	307_T	0.839	0.19
159_E	204_S	0.839	0.19
117_F	229_T	0.838	0.19
126_G	210_A	0.836	0.19
93_V	177_A	0.835	0.19
138_F	241_V	0.830	0.19
252_G	302_V	0.830	0.19
184_Y	292_I	0.827	0.19
278_G	281_G	0.826	0.19
186_A	242_T	0.824	0.19
229_T	267_T	0.824	0.19
50_F	56_P	0.822	0.19
105_G	153_A	0.815	0.19
138_F	309_T	0.815	0.19
174_S	205_V	0.810	0.18
211_D	216_E	0.808	0.18
165_R	211_D	0.808	0.18
51_A	58_V	0.808	0.18
92_A	126_G	0.807	0.18
108_S	210_A	0.807	0.18
87_V	140_V	0.797	0.18
96_A	136_A	0.796	0.18
225_R	292_I	0.795	0.18
256_I	292_I	0.795	0.18
88_L	231_E	0.791	0.18
68_V	71_A	0.790	0.18
87_V	172_G	0.787	0.18
275_V	308_L	0.786	0.18
228_T	290_A	0.785	0.18
145_T	172_G	0.783	0.18
305_L	308_L	0.778	0.18
256_I	267_T	0.777	0.17
61_S	67_W	0.774	0.17
172_G	315_G	0.773	0.17
93_V	174_S	0.771	0.17
134_L	302_V	0.770	0.17
112_M	214_S	0.769	0.17
203_G	258_V	0.767	0.17
202_A	311_A	0.766	0.17
182_V	316_A	0.765	0.17
45_I	284_A	0.759	0.17
138_F	224_P	0.759	0.17
66_L	311_A	0.755	0.17
173_N	224_P	0.752	0.17
175_A	183_L	0.750	0.17
203_G	310_G	0.750	0.17
265_G	295_R	0.741	0.17
113_L	153_A	0.741	0.17
176_A	237_T	0.736	0.16
171_L	214_S	0.733	0.16
240_A	274_V	0.730	0.16
98_G	162_D	0.726	0.16
111_G	233_V	0.724	0.16
125_L	135_V	0.721	0.16
47_R	50_F	0.721	0.16
279_V	292_I	0.720	0.16
224_P	285_D	0.720	0.16
136_A	196_A	0.719	0.16
65_V	287_L	0.718	0.16
158_A	166_G	0.717	0.16
211_D	218_G	0.714	0.16
184_Y	304_F	0.712	0.16
58_V	61_S	0.710	0.16
102_R	149_Y	0.709	0.16
62_V	65_V	0.704	0.16
93_V	252_G	0.703	0.16
108_S	228_T	0.702	0.16
162_D	223_T	0.702	0.16
119_G	273_V	0.702	0.16
178_L	238_D	0.701	0.16
171_L	281_G	0.700	0.16
95_T	301_G	0.697	0.15
126_G	249_G	0.695	0.15
55_A	58_V	0.695	0.15
256_I	259_L	0.695	0.15
246_E	310_G	0.695	0.15
210_A	253_A	0.693	0.15
134_L	173_N	0.693	0.15
206_A	232_R	0.691	0.15
172_G	300_Q	0.688	0.15
227_V	279_V	0.687	0.15
150_E	247_L	0.685	0.15
255_I	262_A	0.683	0.15
132_V	143_L	0.683	0.15
257_A	274_V	0.682	0.15
104_L	249_G	0.681	0.15
254_T	316_A	0.679	0.15
136_A	313_V	0.676	0.15
169_N	173_N	0.676	0.15
211_D	303_N	0.675	0.15
176_A	312_A	0.674	0.15
172_G	310_G	0.671	0.15
142_S	233_V	0.670	0.15
90_A	305_L	0.670	0.15
140_V	316_A	0.668	0.15
85_E	276_A	0.667	0.15
124_V	304_F	0.665	0.15
71_A	280_A	0.664	0.15
297_L	302_V	0.664	0.15
285_D	306_A	0.663	0.15
308_L	316_A	0.658	0.15
206_A	252_G	0.658	0.15
185_A	205_V	0.655	0.15
140_V	282_M	0.652	0.14
210_A	227_V	0.651	0.14
250_V	312_A	0.648	0.14
277_A	318_A	0.647	0.14
176_A	235_P	0.644	0.14
198_L	257_A	0.644	0.14
230_F	311_A	0.644	0.14
159_E	282_M	0.644	0.14
138_F	251_V	0.644	0.14
268_L	304_F	0.643	0.14
169_N	213_L	0.643	0.14
44_G	238_D	0.642	0.14
232_R	318_A	0.639	0.14
53_R	58_V	0.639	0.14
154_D	261_V	0.637	0.14
52_L	292_I	0.637	0.14
175_A	205_V	0.635	0.14
205_V	296_V	0.634	0.14
252_G	285_D	0.634	0.14
56_P	59_L	0.633	0.14
205_V	301_G	0.631	0.14
178_L	208_A	0.628	0.14
63_V	102_R	0.626	0.14
199_F	271_G	0.623	0.14
245_G	286_S	0.623	0.14
239_G	286_S	0.623	0.14
236_G	286_S	0.623	0.14
107_T	242_T	0.622	0.14
200_A	315_G	0.622	0.14
166_G	172_G	0.622	0.14
107_T	156_G	0.620	0.14
90_A	124_V	0.620	0.14
210_A	304_F	0.617	0.14
159_E	169_N	0.616	0.14
97_F	174_S	0.616	0.14
262_A	266_V	0.614	0.14
184_Y	269_R	0.612	0.14
212_T	286_S	0.611	0.14
125_L	171_L	0.608	0.14
181_L	185_A	0.599	0.13
240_A	285_D	0.597	0.13
87_V	195_T	0.596	0.13
203_G	276_A	0.596	0.13
144_A	300_Q	0.595	0.13
142_S	183_L	0.594	0.13
107_T	149_Y	0.594	0.13
234_D	315_G	0.594	0.13
148_K	151_L	0.593	0.13
127_G	229_T	0.591	0.13
145_T	160_P	0.591	0.13
97_F	210_A	0.586	0.13
234_D	271_G	0.586	0.13
52_L	250_V	0.585	0.13
169_N	282_M	0.584	0.13
234_D	312_A	0.582	0.13
156_G	169_N	0.578	0.13
84_W	269_R	0.578	0.13
49_L	318_A	0.578	0.13
105_G	227_V	0.578	0.13
95_T	284_A	0.576	0.13
109_I	151_L	0.572	0.13
238_D	285_D	0.572	0.13
176_A	248_A	0.572	0.13
171_L	278_G	0.567	0.13
227_V	261_V	0.565	0.13
167_T	172_G	0.564	0.13
305_L	309_T	0.563	0.13
47_R	237_T	0.563	0.13
208_A	306_A	0.562	0.13
100_V	188_A	0.561	0.13
107_T	205_V	0.561	0.13
203_G	228_T	0.561	0.13
103_A	219_G	0.558	0.12
122_A	201_Y	0.556	0.12
248_A	313_V	0.555	0.12
46_M	51_A	0.554	0.12
95_T	229_T	0.553	0.12
162_D	276_A	0.552	0.12
204_S	255_I	0.552	0.12
118_L	240_A	0.551	0.12
234_D	256_I	0.550	0.12
134_L	174_S	0.548	0.12
158_A	238_D	0.547	0.12
105_G	200_A	0.544	0.12
68_V	242_T	0.541	0.12
107_T	115_G	0.534	0.12
91_L	105_G	0.531	0.12
98_G	174_S	0.530	0.12
60_G	117_F	0.527	0.12
104_L	107_T	0.523	0.12
288_A	304_F	0.523	0.12
50_F	53_R	0.521	0.12
53_R	238_D	0.520	0.12
225_R	256_I	0.516	0.12
44_G	60_G	0.514	0.12
115_G	120_L	0.514	0.12
57_L	296_V	0.513	0.12
169_N	300_Q	0.509	0.12
230_F	312_A	0.509	0.12
57_L	292_I	0.508	0.12
73_A	280_A	0.507	0.12
145_T	233_V	0.505	0.11
131_F	221_F	0.505	0.11
194_D	231_E	0.505	0.11
85_E	311_A	0.503	0.11
240_A	263_V	0.502	0.11
71_A	292_I	0.502	0.11
243_W	272_G	0.502	0.11
56_P	293_E	0.502	0.11
188_A	316_A	0.501	0.11
252_G	305_L	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dh4A	3	0.5216	82.2	0.953	Contact Map
2xq2A	2	0.6173	68.1	0.958	Contact Map
4q2eA	2	0.7438	14.2	0.972	Contact Map
1pw4A	1	0.4938	11	0.973	Contact Map
3qnqA	2	0.4784	9.7	0.974	Contact Map
2kncA	1	0.1667	9.7	0.974	Contact Map
4w6vA	1	0.4444	8.3	0.974	Contact Map
4j05A	3	0.466	7.4	0.975	Contact Map
3wdoA	1	0.9506	6.9	0.975	Contact Map
2jwaA	2	0.1358	6.8	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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