GREMLIN Database
Q9HP66 - Uncharacterized protein
UniProt: Q9HP66 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (266)
Sequences: 241 (159)
Seq/√Len: 9.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
284_A309_T4.1280.99
141_G213_L4.0630.99
217_V220_L3.5700.97
214_S242_T3.2440.95
226_L233_V3.0390.93
90_A145_T2.9450.91
119_G162_D2.9400.91
214_S249_G2.9140.91
64_V67_W2.7680.89
224_P281_G2.6870.87
112_M115_G2.6250.86
174_S204_S2.4720.82
246_E283_T2.4630.82
213_L252_G2.3520.79
141_G144_A2.3470.78
233_V237_T2.3400.78
208_A307_T2.2620.76
227_V240_A2.1800.73
107_T293_E2.1220.71
172_G210_A2.1180.71
47_R56_P2.0940.70
59_L136_A2.0180.67
175_A279_V1.9510.64
225_R235_P1.8740.61
144_A213_L1.8440.59
229_T250_V1.8260.59
136_A263_V1.8170.58
133_V174_S1.8080.58
225_R252_G1.7530.55
307_T311_A1.7450.55
223_T232_R1.7300.54
53_R56_P1.7260.54
173_N285_D1.7210.54
130_W310_G1.7150.54
312_A316_A1.7050.53
135_V162_D1.7020.53
137_F173_N1.6650.51
52_L63_V1.6540.51
278_G285_D1.6410.50
165_R216_E1.6310.50
250_V275_V1.6120.49
101_S146_K1.6100.49
117_F284_A1.5990.48
173_N281_G1.5730.47
157_V310_G1.5670.47
181_L214_S1.5470.46
281_G285_D1.5350.46
47_R53_R1.5310.45
219_G222_D1.5200.45
60_G64_V1.5070.44
47_R238_D1.4950.44
108_S227_V1.4920.44
148_K242_T1.4810.43
96_A262_A1.4760.43
258_V261_V1.4700.43
207_T310_G1.4580.42
74_P287_L1.4170.40
255_I317_L1.4150.40
95_T135_V1.4020.40
147_F205_V1.3980.39
114_T171_L1.3870.39
105_G255_I1.3720.38
260_S284_A1.3660.38
137_F285_D1.3660.38
200_A222_D1.3640.38
55_A207_T1.3570.38
217_V248_A1.3550.38
254_T262_A1.3240.36
96_A272_G1.3220.36
166_G169_N1.3200.36
169_N307_T1.3200.36
137_F278_G1.3160.36
60_G63_V1.3150.36
194_D297_L1.3130.36
204_S230_F1.2980.35
152_K163_G1.2960.35
96_A247_L1.2960.35
200_A297_L1.2880.35
111_G176_A1.2790.34
232_R311_A1.2780.34
115_G248_A1.2780.34
148_K304_F1.2770.34
112_M164_A1.2690.34
137_F206_A1.2650.34
251_V276_A1.2620.34
130_W201_Y1.2570.34
197_F240_A1.2540.33
84_W295_R1.2440.33
244_Q247_L1.2400.33
277_A314_G1.2300.32
207_T240_A1.2290.32
120_L238_D1.2280.32
57_L207_T1.2230.32
133_V172_G1.2210.32
96_A119_G1.2170.32
130_W203_G1.2170.32
134_L288_A1.2010.31
132_V288_A1.2010.31
111_G226_L1.1990.31
173_N206_A1.1970.31
107_T144_A1.1970.31
208_A281_G1.1920.31
137_F281_G1.1920.31
210_A257_A1.1870.31
273_V313_V1.1850.31
108_S301_G1.1830.31
230_F283_T1.1560.30
203_G224_P1.1470.29
262_A265_G1.1450.29
133_V157_V1.1430.29
306_A310_G1.1240.28
63_V67_W1.1160.28
52_L55_A1.1120.28
173_N278_G1.1090.28
93_V140_V1.1050.28
99_W135_V1.1050.28
249_G282_M1.1010.28
95_T115_G1.0990.28
142_S276_A1.0980.27
254_T275_V1.0960.27
50_F55_A1.0930.27
116_V182_V1.0870.27
115_G181_L1.0760.27
140_V213_L1.0760.27
131_F186_A1.0760.27
108_S171_L1.0670.26
101_S181_L1.0650.26
106_A288_A1.0640.26
299_N303_N1.0570.26
234_D237_T1.0450.26
107_T142_S1.0420.26
282_M293_E1.0400.25
147_F159_E1.0390.25
156_G159_E1.0320.25
158_A169_N1.0290.25
50_F58_V1.0280.25
60_G67_W1.0250.25
61_S64_V1.0240.25
145_T215_S1.0240.25
97_F148_K1.0190.25
53_R128_Y1.0160.25
170_V215_S1.0150.25
232_R242_T1.0120.24
134_L177_A1.0050.24
47_R242_T1.0000.24
262_A313_V0.9910.24
127_G271_G0.9910.24
184_Y206_A0.9850.24
95_T254_T0.9850.24
236_G239_G0.9810.23
236_G245_G0.9810.23
239_G245_G0.9810.23
310_G314_G0.9810.23
233_V259_L0.9780.23
149_Y169_N0.9700.23
259_L280_A0.9700.23
149_Y291_T0.9660.23
140_V217_V0.9630.23
52_L277_A0.9630.23
127_G186_A0.9560.23
59_L240_A0.9530.23
83_A256_I0.9400.22
224_P238_D0.9390.22
147_F232_R0.9370.22
53_R297_L0.9360.22
188_A192_F0.9340.22
59_L154_D0.9290.22
207_T210_A0.9270.22
149_Y158_A0.9250.22
280_A304_F0.9240.22
62_V122_A0.9120.21
133_V263_V0.9110.21
88_L276_A0.9000.21
97_F157_V0.8940.21
93_V97_F0.8930.21
155_R240_A0.8930.21
235_P287_L0.8840.20
164_A169_N0.8830.20
145_T199_F0.8790.20
154_D250_V0.8750.20
293_E298_T0.8730.20
213_L238_D0.8520.20
224_P278_G0.8510.20
251_V261_V0.8460.19
176_A194_D0.8440.19
156_G307_T0.8390.19
159_E204_S0.8390.19
117_F229_T0.8380.19
126_G210_A0.8360.19
93_V177_A0.8350.19
138_F241_V0.8300.19
252_G302_V0.8300.19
184_Y292_I0.8270.19
278_G281_G0.8260.19
186_A242_T0.8240.19
229_T267_T0.8240.19
50_F56_P0.8220.19
105_G153_A0.8150.19
138_F309_T0.8150.19
174_S205_V0.8100.18
211_D216_E0.8080.18
165_R211_D0.8080.18
51_A58_V0.8080.18
92_A126_G0.8070.18
108_S210_A0.8070.18
87_V140_V0.7970.18
96_A136_A0.7960.18
225_R292_I0.7950.18
256_I292_I0.7950.18
88_L231_E0.7910.18
68_V71_A0.7900.18
87_V172_G0.7870.18
275_V308_L0.7860.18
228_T290_A0.7850.18
145_T172_G0.7830.18
305_L308_L0.7780.18
256_I267_T0.7770.17
61_S67_W0.7740.17
172_G315_G0.7730.17
93_V174_S0.7710.17
134_L302_V0.7700.17
112_M214_S0.7690.17
203_G258_V0.7670.17
202_A311_A0.7660.17
182_V316_A0.7650.17
45_I284_A0.7590.17
138_F224_P0.7590.17
66_L311_A0.7550.17
173_N224_P0.7520.17
175_A183_L0.7500.17
203_G310_G0.7500.17
265_G295_R0.7410.17
113_L153_A0.7410.17
176_A237_T0.7360.16
171_L214_S0.7330.16
240_A274_V0.7300.16
98_G162_D0.7260.16
111_G233_V0.7240.16
125_L135_V0.7210.16
47_R50_F0.7210.16
279_V292_I0.7200.16
224_P285_D0.7200.16
136_A196_A0.7190.16
65_V287_L0.7180.16
158_A166_G0.7170.16
211_D218_G0.7140.16
184_Y304_F0.7120.16
58_V61_S0.7100.16
102_R149_Y0.7090.16
62_V65_V0.7040.16
93_V252_G0.7030.16
108_S228_T0.7020.16
162_D223_T0.7020.16
119_G273_V0.7020.16
178_L238_D0.7010.16
171_L281_G0.7000.16
95_T301_G0.6970.15
126_G249_G0.6950.15
55_A58_V0.6950.15
256_I259_L0.6950.15
246_E310_G0.6950.15
210_A253_A0.6930.15
134_L173_N0.6930.15
206_A232_R0.6910.15
172_G300_Q0.6880.15
227_V279_V0.6870.15
150_E247_L0.6850.15
255_I262_A0.6830.15
132_V143_L0.6830.15
257_A274_V0.6820.15
104_L249_G0.6810.15
254_T316_A0.6790.15
136_A313_V0.6760.15
169_N173_N0.6760.15
211_D303_N0.6750.15
176_A312_A0.6740.15
172_G310_G0.6710.15
142_S233_V0.6700.15
90_A305_L0.6700.15
140_V316_A0.6680.15
85_E276_A0.6670.15
124_V304_F0.6650.15
71_A280_A0.6640.15
297_L302_V0.6640.15
285_D306_A0.6630.15
308_L316_A0.6580.15
206_A252_G0.6580.15
185_A205_V0.6550.15
140_V282_M0.6520.14
210_A227_V0.6510.14
250_V312_A0.6480.14
277_A318_A0.6470.14
176_A235_P0.6440.14
198_L257_A0.6440.14
230_F311_A0.6440.14
159_E282_M0.6440.14
138_F251_V0.6440.14
268_L304_F0.6430.14
169_N213_L0.6430.14
44_G238_D0.6420.14
232_R318_A0.6390.14
53_R58_V0.6390.14
154_D261_V0.6370.14
52_L292_I0.6370.14
175_A205_V0.6350.14
205_V296_V0.6340.14
252_G285_D0.6340.14
56_P59_L0.6330.14
205_V301_G0.6310.14
178_L208_A0.6280.14
63_V102_R0.6260.14
199_F271_G0.6230.14
245_G286_S0.6230.14
239_G286_S0.6230.14
236_G286_S0.6230.14
107_T242_T0.6220.14
200_A315_G0.6220.14
166_G172_G0.6220.14
107_T156_G0.6200.14
90_A124_V0.6200.14
210_A304_F0.6170.14
159_E169_N0.6160.14
97_F174_S0.6160.14
262_A266_V0.6140.14
184_Y269_R0.6120.14
212_T286_S0.6110.14
125_L171_L0.6080.14
181_L185_A0.5990.13
240_A285_D0.5970.13
87_V195_T0.5960.13
203_G276_A0.5960.13
144_A300_Q0.5950.13
142_S183_L0.5940.13
107_T149_Y0.5940.13
234_D315_G0.5940.13
148_K151_L0.5930.13
127_G229_T0.5910.13
145_T160_P0.5910.13
97_F210_A0.5860.13
234_D271_G0.5860.13
52_L250_V0.5850.13
169_N282_M0.5840.13
234_D312_A0.5820.13
156_G169_N0.5780.13
84_W269_R0.5780.13
49_L318_A0.5780.13
105_G227_V0.5780.13
95_T284_A0.5760.13
109_I151_L0.5720.13
238_D285_D0.5720.13
176_A248_A0.5720.13
171_L278_G0.5670.13
227_V261_V0.5650.13
167_T172_G0.5640.13
305_L309_T0.5630.13
47_R237_T0.5630.13
208_A306_A0.5620.13
100_V188_A0.5610.13
107_T205_V0.5610.13
203_G228_T0.5610.13
103_A219_G0.5580.12
122_A201_Y0.5560.12
248_A313_V0.5550.12
46_M51_A0.5540.12
95_T229_T0.5530.12
162_D276_A0.5520.12
204_S255_I0.5520.12
118_L240_A0.5510.12
234_D256_I0.5500.12
134_L174_S0.5480.12
158_A238_D0.5470.12
105_G200_A0.5440.12
68_V242_T0.5410.12
107_T115_G0.5340.12
91_L105_G0.5310.12
98_G174_S0.5300.12
60_G117_F0.5270.12
104_L107_T0.5230.12
288_A304_F0.5230.12
50_F53_R0.5210.12
53_R238_D0.5200.12
225_R256_I0.5160.12
44_G60_G0.5140.12
115_G120_L0.5140.12
57_L296_V0.5130.12
169_N300_Q0.5090.12
230_F312_A0.5090.12
57_L292_I0.5080.12
73_A280_A0.5070.12
145_T233_V0.5050.11
131_F221_F0.5050.11
194_D231_E0.5050.11
85_E311_A0.5030.11
240_A263_V0.5020.11
71_A292_I0.5020.11
243_W272_G0.5020.11
56_P293_E0.5020.11
188_A316_A0.5010.11
252_G305_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dh4A 3 0.5216 82.2 0.953 Contact Map
2xq2A 2 0.6173 68.1 0.958 Contact Map
4q2eA 2 0.7438 14.2 0.972 Contact Map
1pw4A 1 0.4938 11 0.973 Contact Map
3qnqA 2 0.4784 9.7 0.974 Contact Map
2kncA 1 0.1667 9.7 0.974 Contact Map
4w6vA 1 0.4444 8.3 0.974 Contact Map
4j05A 3 0.466 7.4 0.975 Contact Map
3wdoA 1 0.9506 6.9 0.975 Contact Map
2jwaA 2 0.1358 6.8 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.