GREMLIN Database
DNAG - DNA primase DnaG
UniProt: Q9HP65 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 406 (393)
Sequences: 161 (120)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_A227_L4.0400.94
324_T362_D3.4340.87
169_V225_R3.1810.82
176_A252_T2.9800.78
323_D362_D2.9410.77
327_A345_V2.8810.75
214_L221_D2.8150.73
13_F58_V2.7720.72
24_V193_E2.7540.72
171_I197_I2.7090.70
366_T383_G2.5210.65
317_H328_R2.4900.64
211_T260_K2.4250.61
40_L113_R2.4200.61
16_D145_S2.3330.58
116_V156_G2.2880.57
370_L396_T2.2650.56
61_E99_D2.2300.55
19_V191_A2.2000.54
105_I189_A2.1950.53
243_E252_T2.1910.53
314_L330_L2.1540.52
10_H147_R2.1430.52
19_V157_Y2.1420.51
193_E224_L2.1410.51
135_A142_V2.1010.50
224_L236_V2.0890.50
19_V224_L2.0750.49
371_D393_P2.0700.49
74_S139_L2.0530.48
98_A151_I2.0260.47
361_V381_L1.9750.46
67_G86_A1.9730.45
64_Q72_A1.9700.45
367_Q393_P1.9670.45
163_V183_K1.9630.45
210_A214_L1.9360.44
128_F244_C1.8970.43
11_A233_L1.8950.43
363_A368_R1.8600.41
147_R218_R1.8490.41
235_F243_E1.8470.41
159_A224_L1.8440.41
78_V383_G1.8400.41
367_Q371_D1.8390.41
193_E227_L1.8370.41
65_S77_R1.8350.41
195_T229_Q1.7860.39
323_D344_E1.7800.39
24_V159_A1.7620.38
30_G182_L1.7590.38
83_L197_I1.7540.38
137_D235_F1.7490.38
314_L339_E1.7440.38
100_V327_A1.7440.38
168_A211_T1.7420.37
252_T264_S1.7380.37
81_A155_D1.7270.37
117_V236_V1.7220.37
349_V373_A1.7170.37
99_D249_S1.7090.36
251_R255_S1.7050.36
102_V398_V1.6940.36
39_D243_E1.6910.36
171_I225_R1.6760.35
203_A236_V1.6600.35
98_A221_D1.6590.35
69_I134_N1.6540.35
373_A387_D1.6500.34
154_Y190_V1.6490.34
19_V193_E1.6100.33
197_I324_T1.6060.33
148_V154_Y1.6020.33
325_E343_A1.5870.32
8_L117_V1.5860.32
343_A361_V1.5830.32
212_A224_L1.5820.32
208_K251_R1.5650.32
121_K149_D1.5420.31
55_D99_D1.5380.31
330_L339_E1.5150.30
134_N208_K1.5130.30
83_L229_Q1.4900.29
212_A233_L1.4890.29
265_A383_G1.4860.29
345_V365_I1.4800.29
123_L376_R1.4600.29
159_A191_A1.4570.29
195_T211_T1.4430.28
171_I233_L1.4310.28
74_S96_C1.4210.27
180_T251_R1.4200.27
343_A366_T1.4170.27
138_I166_S1.4130.27
327_A340_V1.4100.27
39_D121_K1.4090.27
16_D248_L1.4080.27
149_D196_N1.4030.27
365_I383_G1.4010.27
42_I170_V1.4010.27
331_D335_A1.3980.27
323_D376_R1.3930.27
203_A207_E1.3910.27
142_V261_T1.3900.27
239_A248_L1.3800.26
85_A178_V1.3690.26
16_D221_D1.3590.26
275_E286_A1.3570.26
96_C195_T1.3500.25
37_G105_I1.3440.25
201_I273_Q1.3420.25
190_V368_R1.3340.25
331_D342_A1.3220.25
13_F100_V1.3220.25
96_C186_I1.3210.25
73_S78_V1.3200.25
279_T285_P1.3140.25
91_E374_A1.3140.25
82_T106_E1.2990.24
62_G398_V1.2860.24
255_S259_N1.2860.24
56_V226_E1.2830.24
44_D149_D1.2830.24
359_V372_V1.2750.24
128_F250_R1.2730.23
83_L144_E1.2590.23
60_S151_I1.2560.23
235_F385_D1.2530.23
164_D208_K1.2500.23
291_P297_P1.2460.23
265_A361_V1.2460.23
64_Q69_I1.2280.22
22_S48_S1.2260.22
382_I400_T1.2170.22
154_Y164_D1.2160.22
123_L243_E1.2160.22
326_T369_L1.2110.22
147_R381_L1.2070.22
367_Q391_K1.2060.22
38_D252_T1.1960.22
50_K345_V1.1920.21
137_D252_T1.1920.21
193_E259_N1.1900.21
11_A159_A1.1890.21
272_T276_T1.1870.21
93_I116_V1.1840.21
34_G166_S1.1820.21
191_A224_L1.1810.21
34_G167_D1.1790.21
222_M226_E1.1740.21
145_S381_L1.1720.21
197_I295_T1.1710.21
179_V196_N1.1670.21
19_V249_S1.1660.21
70_T153_D1.1640.21
34_G138_I1.1640.21
16_D77_R1.1580.21
25_V86_A1.1580.21
113_R260_K1.1490.20
77_R97_R1.1410.20
58_V71_I1.1360.20
132_A137_D1.1350.20
368_R400_T1.1320.20
77_R132_A1.1310.20
68_D81_A1.1290.20
98_A122_E1.1260.20
331_D400_T1.1250.20
253_V389_F1.1220.20
123_L225_R1.1090.20
36_L218_R1.1000.19
46_Q73_S1.1000.19
12_D183_K1.0960.19
186_I192_V1.0940.19
328_R339_E1.0900.19
238_R383_G1.0830.19
37_G142_V1.0800.19
345_V361_V1.0720.19
371_D391_K1.0710.19
235_F361_V1.0690.19
102_V375_Q1.0660.19
40_L135_A1.0610.18
63_G187_K1.0590.18
86_A383_G1.0580.18
368_R373_A1.0580.18
292_A296_A1.0570.18
167_D233_L1.0500.18
221_D304_D1.0480.18
25_V58_V1.0420.18
113_R229_Q1.0400.18
200_A401_L1.0360.18
157_Y249_S1.0310.18
50_K150_D1.0270.18
37_G146_V1.0260.18
49_A180_T1.0260.18
48_S59_D1.0240.18
203_A206_R1.0220.18
205_S253_V1.0180.18
323_D361_V1.0170.18
202_A247_D1.0130.17
91_E138_I1.0130.17
55_D113_R1.0130.17
344_E381_L1.0070.17
90_V222_M1.0020.17
141_E153_D0.9980.17
21_R235_F0.9980.17
368_R387_D0.9960.17
339_E390_V0.9960.17
39_D278_A0.9940.17
12_D115_E0.9930.17
75_L135_A0.9910.17
25_V67_G0.9900.17
178_V189_A0.9900.17
22_S231_G0.9880.17
85_A377_G0.9870.17
28_A201_I0.9800.17
150_D265_A0.9780.17
363_A385_D0.9780.17
40_L48_S0.9770.17
138_I237_A0.9770.17
47_D91_E0.9730.17
224_L227_L0.9730.17
158_P198_P0.9710.17
274_S282_S0.9690.17
203_A360_V0.9670.17
44_D129_D0.9660.17
219_G235_F0.9660.17
155_D319_R0.9640.16
24_V191_A0.9640.16
164_D189_A0.9610.16
8_L214_L0.9590.16
330_L334_L0.9540.16
92_R260_K0.9510.16
58_V230_V0.9490.16
82_T127_A0.9470.16
128_F147_R0.9470.16
66_F247_D0.9460.16
349_V387_D0.9440.16
96_C229_Q0.9410.16
24_V65_S0.9380.16
4_T147_R0.9330.16
86_A211_T0.9320.16
15_V96_C0.9320.16
18_V60_S0.9280.16
24_V190_V0.9260.16
61_E66_F0.9230.16
57_S243_E0.9160.16
342_A348_A0.9090.15
171_I258_R0.9080.15
133_I137_D0.9080.15
368_R383_G0.9070.15
25_V186_I0.9030.15
128_F218_R0.9010.15
25_V208_K0.8990.15
83_L371_D0.8960.15
41_A229_Q0.8930.15
64_Q115_E0.8920.15
238_R381_L0.8890.15
169_V252_T0.8860.15
78_V398_V0.8850.15
259_N345_V0.8850.15
74_S186_I0.8840.15
15_V74_S0.8830.15
13_F222_M0.8800.15
331_D368_R0.8780.15
130_E176_A0.8770.15
77_R171_I0.8760.15
280_D287_P0.8730.15
9_I167_D0.8700.15
338_R389_F0.8700.15
367_Q377_G0.8660.15
106_E187_K0.8650.15
44_D48_S0.8650.15
147_R195_T0.8650.15
20_E83_L0.8610.15
186_I254_D0.8610.15
82_T90_V0.8590.15
363_A387_D0.8590.15
192_V229_Q0.8550.14
199_D255_S0.8540.14
86_A209_T0.8520.14
162_N241_M0.8510.14
102_V197_I0.8510.14
34_G218_R0.8480.14
244_C247_D0.8470.14
330_L400_T0.8470.14
5_A254_D0.8460.14
128_F230_V0.8450.14
36_L40_L0.8440.14
51_L163_V0.8430.14
57_S130_E0.8420.14
325_E366_T0.8400.14
18_V341_P0.8400.14
48_S74_S0.8360.14
28_A233_L0.8350.14
159_A205_S0.8330.14
228_G263_A0.8310.14
253_V259_N0.8310.14
365_I389_F0.8260.14
137_D176_A0.8260.14
211_T229_Q0.8240.14
383_G389_F0.8230.14
25_V136_D0.8230.14
219_G260_K0.8210.14
49_A267_A0.8160.14
144_E250_R0.8160.14
163_V352_A0.8150.14
91_E237_A0.8150.14
363_A400_T0.8150.14
302_D360_V0.8140.14
324_T366_T0.8140.14
299_P309_A0.8130.14
314_L381_L0.8120.14
72_A363_A0.8120.14
243_E339_E0.8070.14
327_A349_V0.8060.14
320_A346_V0.8060.14
322_A391_K0.8030.14
55_D250_R0.8030.14
50_K206_R0.8020.14
77_R176_A0.8020.14
68_D125_A0.8010.14
68_D214_L0.8010.14
96_C187_K0.8000.13
113_R258_R0.7990.13
275_E278_A0.7970.13
72_A244_C0.7960.13
155_D191_A0.7950.13
30_G78_V0.7950.13
39_D199_D0.7930.13
47_D55_D0.7880.13
96_C334_L0.7860.13
16_D61_E0.7860.13
86_A96_C0.7840.13
72_A238_R0.7830.13
77_R252_T0.7820.13
343_A349_V0.7800.13
70_T83_L0.7740.13
51_L369_L0.7740.13
321_V385_D0.7710.13
366_T400_T0.7690.13
321_V340_V0.7690.13
159_A200_A0.7690.13
18_V67_G0.7680.13
74_S311_P0.7670.13
129_D184_Y0.7670.13
92_R96_C0.7660.13
152_T261_T0.7640.13
19_V159_A0.7610.13
83_L148_V0.7600.13
209_T260_K0.7590.13
113_R135_A0.7590.13
28_A54_I0.7580.13
5_A61_E0.7570.13
118_D298_S0.7550.13
138_I144_E0.7550.13
197_I348_A0.7550.13
48_S69_I0.7540.13
116_V401_L0.7520.13
108_V398_V0.7510.13
154_Y189_A0.7510.13
130_E259_N0.7490.13
40_L187_K0.7470.13
36_L123_L0.7460.13
86_A137_D0.7420.13
182_L247_D0.7420.13
197_I309_A0.7420.13
210_A387_D0.7400.13
46_Q82_T0.7380.12
92_R211_T0.7370.12
116_V366_T0.7370.12
22_S67_G0.7360.12
96_C143_R0.7360.12
72_A180_T0.7340.12
47_D146_V0.7320.12
38_D208_K0.7320.12
205_S353_D0.7310.12
96_C162_N0.7300.12
102_V166_S0.7280.12
107_D234_D0.7270.12
93_I367_Q0.7260.12
55_D81_A0.7250.12
123_L127_A0.7230.12
61_E70_T0.7220.12
19_V122_E0.7180.12
15_V222_M0.7180.12
21_R244_C0.7180.12
133_I136_D0.7160.12
196_N360_V0.7150.12
169_V258_R0.7140.12
156_G360_V0.7110.12
148_V374_A0.7110.12
221_D268_P0.7100.12
28_A182_L0.7070.12
65_S140_D0.7060.12
105_I163_V0.7040.12
74_S330_L0.7030.12
235_F364_T0.7020.12
171_I333_A0.7020.12
138_I264_S0.7000.12
192_V195_T0.7000.12
55_D70_T0.6990.12
86_A135_A0.6980.12
325_E362_D0.6960.12
70_T141_E0.6960.12
71_I163_V0.6950.12
40_L196_N0.6940.12
93_I227_L0.6940.12
8_L19_V0.6930.12
20_E193_E0.6920.12
168_A260_K0.6890.12
143_R370_L0.6860.12
115_E214_L0.6860.12
86_A380_S0.6850.12
22_S91_E0.6850.12
358_V378_V0.6840.12
28_A346_V0.6840.12
51_L133_I0.6830.12
364_T385_D0.6810.12
162_N168_A0.6780.12
49_A207_E0.6750.12
11_A100_V0.6740.12
62_G262_P0.6720.12
129_D147_R0.6710.11
57_S221_D0.6680.11
351_D378_V0.6670.11
91_E153_D0.6650.11
74_S121_K0.6640.11
63_G96_C0.6630.11
155_D381_L0.6630.11
327_A361_V0.6600.11
51_L238_R0.6570.11
282_S286_A0.6570.11
138_I167_D0.6550.11
47_D150_D0.6540.11
343_A383_G0.6540.11
86_A184_Y0.6530.11
47_D383_G0.6530.11
210_A233_L0.6520.11
374_A378_V0.6510.11
162_N208_K0.6500.11
22_S127_A0.6490.11
92_R186_I0.6480.11
211_T230_V0.6480.11
314_L334_L0.6450.11
50_K123_L0.6450.11
40_L96_C0.6440.11
41_A391_K0.6410.11
63_G166_S0.6400.11
118_D163_V0.6400.11
227_L349_V0.6380.11
327_A381_L0.6380.11
20_E197_I0.6360.11
171_I210_A0.6360.11
208_K252_T0.6350.11
51_L370_L0.6320.11
90_V143_R0.6320.11
208_K345_V0.6320.11
130_E384_A0.6280.11
317_H329_L0.6260.11
379_A401_L0.6230.11
106_E229_Q0.6220.11
36_L113_R0.6220.11
209_T391_K0.6180.11
311_P334_L0.6170.11
91_E375_Q0.6160.11
117_V261_T0.6150.11
39_D104_R0.6140.11
122_E159_A0.6140.11
274_S285_P0.6140.11
153_D396_T0.6110.11
146_V150_D0.6100.11
106_E113_R0.6090.11
96_C192_V0.6080.11
18_V143_R0.6070.11
4_T77_R0.6050.11
60_S247_D0.6050.11
40_L195_T0.6050.11
354_S379_A0.6050.11
386_T399_R0.6040.11
369_L377_G0.6010.11
304_D377_G0.6010.11
59_D209_T0.6000.10
113_R195_T0.6000.10
176_A366_T0.5990.10
116_V249_S0.5980.10
82_T142_V0.5970.10
143_R229_Q0.5970.10
158_P213_F0.5960.10
5_A186_I0.5960.10
63_G192_V0.5960.10
57_S99_D0.5950.10
77_R251_R0.5950.10
221_D333_A0.5930.10
60_S230_V0.5920.10
146_V197_I0.5920.10
59_D66_F0.5920.10
67_G143_R0.5910.10
345_V350_A0.5890.10
15_V229_Q0.5870.10
130_E366_T0.5870.10
21_R269_I0.5860.10
83_L128_F0.5860.10
186_I195_T0.5860.10
123_L319_R0.5860.10
263_A336_R0.5850.10
193_E359_V0.5850.10
209_T375_Q0.5840.10
326_T339_E0.5840.10
96_C211_T0.5810.10
141_E365_I0.5800.10
239_A400_T0.5800.10
25_V87_L0.5800.10
15_V25_V0.5800.10
117_V383_G0.5780.10
235_F359_V0.5770.10
229_Q258_R0.5760.10
154_Y248_L0.5730.10
103_D123_L0.5730.10
275_E282_S0.5730.10
48_S381_L0.5720.10
4_T10_H0.5720.10
85_A213_F0.5710.10
214_L263_A0.5710.10
38_D65_S0.5700.10
256_A274_S0.5700.10
47_D81_A0.5700.10
53_R158_P0.5690.10
285_P291_P0.5680.10
300_D304_D0.5680.10
370_L392_Q0.5670.10
48_S113_R0.5660.10
63_G113_R0.5660.10
11_A388_E0.5650.10
118_D353_D0.5640.10
92_R196_N0.5640.10
116_V310_A0.5640.10
92_R166_S0.5630.10
67_G184_Y0.5630.10
281_G287_P0.5600.10
48_S123_L0.5590.10
124_L189_A0.5550.10
42_I82_T0.5550.10
78_V368_R0.5520.10
92_R385_D0.5520.10
37_G163_V0.5510.10
93_I193_E0.5510.10
28_A247_D0.5500.10
233_L324_T0.5450.10
147_R176_A0.5430.10
91_E193_E0.5430.10
18_V25_V0.5430.10
150_D267_A0.5430.10
311_P324_T0.5430.10
50_K231_G0.5430.10
106_E142_V0.5420.10
60_S258_R0.5410.10
65_S78_V0.5390.10
369_L379_A0.5390.10
197_I356_P0.5380.10
40_L229_Q0.5370.10
214_L359_V0.5350.10
90_V147_R0.5330.10
292_A295_T0.5330.10
140_D157_Y0.5320.10
47_D74_S0.5300.10
201_I308_A0.5280.10
130_E235_F0.5280.10
50_K376_R0.5250.10
81_A335_A0.5250.10
10_H128_F0.5210.09
40_L89_A0.5200.09
230_V377_G0.5200.09
92_R195_T0.5170.09
28_A236_V0.5160.09
365_I370_L0.5160.09
143_R262_P0.5140.09
331_D373_A0.5140.09
139_L155_D0.5140.09
60_S149_D0.5110.09
15_V90_V0.5110.09
266_A320_A0.5100.09
39_D207_E0.5080.09
60_S260_K0.5070.09
76_D226_E0.5060.09
151_I179_V0.5040.09
218_R378_V0.5040.09
362_D382_I0.5020.09
9_I154_Y0.5010.09
237_A383_G0.5010.09
101_E233_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fcjA 2 0.2734 99.8 0.882 Contact Map
1t6t1 2 0.266 99.2 0.924 Contact Map
4edgA 1 0.601 98.2 0.947 Contact Map
2au3A 1 0.6355 98 0.95 Contact Map
1dd9A 1 0.6502 98 0.95 Contact Map
1nuiA 1 0.4187 69.9 0.977 Contact Map
1vddA 7 0.4261 57.9 0.978 Contact Map
1y02A 1 0.0837 51.3 0.979 Contact Map
2v2fA 1 0.0369 14.8 0.984 Contact Map
1q57A 3 0.67 11 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.