GREMLIN Database
Q9HP63 - Pantothenate permease
UniProt: Q9HP63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 482 (445)
Sequences: 11589 (7309)
Seq/√Len: 346.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
414_G456_L5.8991.00
346_T349_R4.1921.00
403_T457_T3.9051.00
250_S253_T3.8951.00
342_N349_R3.6231.00
6_A10_V3.4591.00
190_V194_A3.3091.00
414_G452_L3.2411.00
159_V362_A3.2181.00
458_V462_A3.1751.00
192_V278_W3.0181.00
337_Y345_A3.0111.00
411_G457_T3.0031.00
410_A460_V2.9821.00
456_L460_V2.9701.00
404_T464_T2.8981.00
460_V464_T2.8241.00
102_G111_R2.7701.00
146_P149_A2.7501.00
348_R352_T2.7441.00
418_F452_L2.7121.00
406_A464_T2.6941.00
352_T356_V2.6851.00
396_L457_T2.6001.00
407_G461_S2.5921.00
155_T366_F2.5431.00
197_A200_T2.4781.00
29_L171_A2.4181.00
356_V360_A2.3881.00
20_E27_R2.3761.00
167_M247_V2.3641.00
279_A292_I2.3621.00
249_D253_T2.2631.00
204_A208_P2.2611.00
203_L206_A2.2521.00
205_G208_P2.2201.00
203_L207_L2.1801.00
406_A410_A2.0781.00
21_D26_G2.0731.00
109_G409_F2.0711.00
345_A349_R2.0581.00
410_A456_L2.0471.00
53_N290_E2.0111.00
186_W190_V2.0101.00
400_W403_T2.0091.00
100_M397_A2.0061.00
393_P408_M2.0031.00
212_R215_G2.0001.00
24_L27_R1.9731.00
404_T407_G1.9701.00
152_G156_L1.9681.00
204_A207_L1.9671.00
252_R256_R1.9111.00
105_F403_T1.8971.00
334_R338_R1.8921.00
253_T256_R1.8891.00
363_V367_G1.8851.00
455_V459_G1.8751.00
106_G109_G1.8711.00
45_A132_G1.8571.00
338_R350_E1.8531.00
396_L454_V1.8501.00
295_I299_E1.8121.00
184_I312_G1.8001.00
407_G460_V1.7811.00
198_G201_G1.7801.00
342_N345_A1.7761.00
33_V175_T1.7751.00
417_A421_A1.7721.00
94_Y103_D1.7721.00
158_M321_S1.7621.00
402_R462_A1.7441.00
337_Y353_L1.7391.00
252_R255_K1.6891.00
307_A311_A1.6881.00
404_T461_S1.6851.00
352_T355_R1.6791.00
206_A209_A1.6731.00
400_W462_A1.6631.00
31_T253_T1.6511.00
165_S169_G1.6411.00
407_G411_G1.6321.00
213_A216_G1.6231.00
332_F336_I1.6191.00
78_W82_G1.6111.00
410_A414_G1.6061.00
400_W458_V1.5461.00
349_R352_T1.5191.00
332_F357_G1.5151.00
325_L362_A1.4971.00
36_F175_T1.4951.00
337_Y342_N1.4951.00
414_G418_F1.4891.00
207_L210_E1.4891.00
99_E335_D1.4801.00
148_W370_L1.4631.00
156_L160_V1.4491.00
18_D21_D1.4391.00
134_G151_A1.4331.00
135_E288_D1.4301.00
402_R465_A1.4291.00
211_F214_L1.4221.00
78_W83_Y1.4061.00
34_L248_A1.3901.00
116_G336_I1.3821.00
99_E334_R1.3821.00
451_P455_V1.3821.00
149_A152_G1.3721.00
106_G405_K1.3691.00
295_I298_S1.3681.00
197_A201_G1.3681.00
337_Y349_R1.3681.00
174_D244_R1.3651.00
8_G11_A1.3521.00
113_L409_F1.3491.00
158_M318_M1.3471.00
351_D355_R1.3341.00
328_G361_F1.3321.00
117_V416_Q1.3121.00
67_G70_D1.3041.00
79_Y83_Y1.3001.00
421_A425_G1.2941.00
454_V458_V1.2921.00
151_A366_F1.2851.00
23_Y354_G1.2791.00
341_V345_A1.2771.00
110_L409_F1.2731.00
102_G107_S1.2631.00
149_A153_F1.2591.00
104_R397_A1.2571.00
404_T465_A1.2571.00
206_A210_E1.2481.00
345_A350_E1.2461.00
100_M104_R1.2461.00
81_L85_Q1.2391.00
402_R466_P1.2361.00
25_A29_L1.2341.00
67_G73_L1.2281.00
201_G205_G1.2221.00
81_L395_A1.2151.00
7_V176_L1.2131.00
452_L456_L1.2111.00
138_V147_Y1.2071.00
451_P454_V1.2061.00
173_T322_D1.2011.00
211_F215_G1.1951.00
155_T362_A1.1941.00
96_T330_S1.1901.00
152_G366_F1.1881.00
220_S223_W1.1871.00
367_G371_L1.1801.00
332_F337_Y1.1751.00
152_G370_L1.1711.00
4_A8_G1.1701.00
3_V176_L1.1621.00
349_R353_L1.1611.00
116_G120_F1.1571.00
121_W386_G1.1551.00
83_Y255_K1.1541.00
405_K409_F1.1531.00
41_T323_S1.1531.00
205_G209_A1.1521.00
35_L260_I1.1511.00
333_T354_G1.1461.00
91_A251_K1.1461.00
112_G340_F1.1451.00
179_V183_G1.1401.00
133_A154_I1.1391.00
107_S405_K1.1381.00
174_D322_D1.1321.00
25_A167_M1.1311.00
448_V451_P1.1291.00
354_G358_V1.1251.00
353_L357_G1.1231.00
130_Q155_T1.1231.00
4_A176_L1.1221.00
404_T460_V1.1171.00
111_R335_D1.1131.00
3_V7_V1.1111.00
418_F456_L1.1081.00
195_E282_V1.1071.00
31_T35_L1.0991.00
183_G187_V1.0961.00
55_A62_W1.0951.00
411_G453_G1.0931.00
102_G339_P1.0901.00
288_D291_N1.0851.00
113_L412_V1.0801.00
333_T353_L1.0781.00
114_V412_V1.0781.00
37_T323_S1.0701.00
39_F264_L1.0631.00
446_Q450_L1.0611.00
15_T21_D1.0561.00
145_V150_G1.0541.00
379_V383_A1.0531.00
69_M73_L1.0521.00
5_L8_G1.0471.00
286_L289_G1.0451.00
110_L408_M1.0441.00
406_A463_V1.0441.00
393_P412_V1.0371.00
406_A460_V1.0341.00
375_S378_E1.0341.00
187_V305_F1.0321.00
347_A350_E1.0321.00
161_Y322_D1.0301.00
69_M72_V1.0291.00
5_L9_L1.0291.00
297_L309_V1.0281.00
126_V365_A1.0241.00
357_G360_A1.0191.00
148_W152_G1.0181.00
177_Q322_D1.0081.00
456_L459_G1.0081.00
158_M322_D1.0041.00
67_G71_G1.0011.00
119_I332_F1.0001.00
109_G113_L0.9991.00
396_L403_T0.9981.00
101_L110_L0.9981.00
278_W282_V0.9911.00
37_T40_A0.9891.00
389_Q453_G0.9871.00
239_P327_S0.9861.00
57_A289_G0.9691.00
127_M368_G0.9671.00
161_Y318_M0.9661.00
326_L329_S0.9651.00
130_Q151_A0.9641.00
337_Y341_V0.9641.00
163_A359_A0.9631.00
411_G415_T0.9621.00
173_T177_Q0.9591.00
141_T145_V0.9571.00
196_I199_T0.9541.00
68_L72_V0.9531.00
23_Y330_S0.9521.00
294_P297_L0.9521.00
403_T461_S0.9501.00
7_V11_A0.9431.00
66_M70_D0.9421.00
105_F397_A0.9401.00
117_V412_V0.9401.00
382_T423_V0.9381.00
33_V171_A0.9371.00
31_T256_R0.9361.00
332_F361_F0.9341.00
191_W195_E0.9311.00
92_N103_D0.9301.00
54_I58_N0.9271.00
187_V191_W0.9241.00
402_R467_S0.9201.00
6_A9_L0.9121.00
204_A209_A0.9121.00
20_E93_G0.9111.00
248_A254_L0.9081.00
397_A408_M0.9081.00
3_V6_A0.9071.00
297_L306_A0.9051.00
109_G405_K0.9041.00
101_L114_V0.9031.00
174_D323_S0.8981.00
145_V153_F0.8971.00
396_L458_V0.8961.00
239_P243_Q0.8961.00
450_L453_G0.8931.00
393_P453_G0.8871.00
360_A364_A0.8851.00
452_L455_V0.8821.00
119_I328_G0.8821.00
142_G146_P0.8821.00
279_A296_L0.8811.00
71_G74_F0.8791.00
403_T407_G0.8791.00
453_G457_T0.8741.00
41_T174_D0.8721.00
37_T244_R0.8711.00
413_L417_A0.8691.00
204_A210_E0.8691.00
363_V366_F0.8661.00
392_P454_V0.8641.00
454_V457_T0.8631.00
45_A317_M0.8621.00
345_A353_L0.8591.00
25_A247_V0.8581.00
67_G72_V0.8561.00
415_T419_Y0.8561.00
259_A263_L0.8551.00
172_W175_T0.8551.00
188_A192_V0.8521.00
263_L267_L0.8501.00
113_L413_L0.8491.00
138_V142_G0.8471.00
189_F271_P0.8461.00
4_A11_A0.8461.00
329_S333_T0.8421.00
5_L160_V0.8401.00
60_P277_A0.8351.00
77_L83_Y0.8351.00
284_L287_P0.8341.00
421_A424_F0.8301.00
406_A465_A0.8271.00
82_G85_Q0.8251.00
356_V359_A0.8251.00
83_Y251_K0.8231.00
36_F178_G0.8231.00
380_G384_F0.8211.00
196_I201_G0.8211.00
211_F216_G0.8211.00
68_L71_G0.8171.00
177_Q315_A0.8171.00
212_R216_G0.8161.00
459_G462_A0.8161.00
221_P224_M0.8161.00
438_S441_F0.8151.00
66_M72_V0.8121.00
409_F413_L0.8121.00
11_A15_T0.8121.00
30_G253_T0.8111.00
55_A277_A0.8111.00
358_V362_A0.8041.00
319_S322_D0.8041.00
418_F422_T0.8041.00
151_A369_S0.8021.00
192_V195_E0.8011.00
135_E138_V0.8001.00
445_A449_G0.8001.00
147_Y151_A0.7981.00
422_T448_V0.7961.00
201_G204_A0.7921.00
195_E300_Y0.7921.00
465_A468_D0.7921.00
4_A9_L0.7921.00
350_E354_G0.7911.00
418_F421_A0.7911.00
8_G12_Y0.7851.00
106_G468_D0.7841.00
188_A293_V0.7831.00
440_Y443_W0.7831.00
404_T466_P0.7831.00
161_Y177_Q0.7831.00
414_G460_V0.7811.00
200_T205_G0.7801.00
291_N295_I0.7781.00
337_Y340_F0.7781.00
191_W194_A0.7771.00
79_Y82_G0.7761.00
301_T305_F0.7761.00
150_G154_I0.7751.00
67_G74_F0.7751.00
37_T41_T0.7741.00
31_T260_I0.7731.00
112_G336_I0.7711.00
304_W308_L0.7711.00
459_G463_V0.7691.00
14_V168_R0.7681.00
40_A244_R0.7671.00
61_E64_L0.7671.00
196_I281_G0.7621.00
416_Q420_L0.7621.00
458_V461_S0.7621.00
114_V390_L0.7601.00
78_W85_Q0.7581.00
37_T171_A0.7571.00
280_N292_I0.7551.00
449_G453_G0.7551.00
275_M296_L0.7541.00
15_T351_D0.7531.00
98_G114_V0.7501.00
99_E103_D0.7491.00
206_A281_G0.7491.00
70_D73_L0.7481.00
417_A420_L0.7461.00
104_R400_W0.7461.00
14_V17_R0.7451.00
400_W461_S0.7421.00
161_Y319_S0.7401.00
17_R21_D0.7391.00
170_V173_T0.7391.00
403_T411_G0.7371.00
329_S357_G0.7340.99
450_L454_V0.7340.99
463_V466_P0.7330.99
80_V83_Y0.7320.99
42_L384_F0.7310.99
415_T453_G0.7310.99
400_W404_T0.7310.99
182_L186_W0.7290.99
22_Y358_V0.7280.99
105_F457_T0.7270.99
177_Q318_M0.7270.99
112_G115_A0.7250.99
77_L82_G0.7230.99
9_L164_I0.7200.99
9_L13_R0.7190.99
44_S125_Y0.7190.99
142_G145_V0.7150.99
444_F448_V0.7150.99
407_G410_A0.7140.99
233_V391_A0.7110.99
248_A253_T0.7090.99
29_L34_L0.7080.99
329_S358_V0.7070.99
129_Q320_S0.7070.99
464_T467_S0.7060.99
296_L300_Y0.7060.99
410_A413_L0.7060.99
9_L12_Y0.7050.99
134_G147_Y0.7050.99
213_A217_G0.7010.99
96_T335_D0.6990.99
185_T272_A0.6990.99
68_L73_L0.6990.99
131_I135_E0.6980.99
273_F277_A0.6980.99
177_Q319_S0.6970.99
366_F370_L0.6960.99
109_G112_G0.6960.99
170_V323_S0.6940.99
240_Q243_Q0.6940.99
366_F369_S0.6940.99
455_V458_V0.6920.99
341_V344_D0.6920.99
332_F353_L0.6850.99
320_S324_M0.6840.99
400_W407_G0.6830.99
177_Q320_S0.6820.99
441_F444_F0.6820.99
19_A23_Y0.6800.99
275_M293_V0.6800.99
367_G370_L0.6790.99
440_Y448_V0.6790.99
48_F185_T0.6780.99
171_A174_D0.6760.99
324_M327_S0.6730.99
95_V99_E0.6710.99
133_A317_M0.6700.99
112_G116_G0.6700.99
74_F78_W0.6700.99
337_Y343_A0.6670.99
283_G299_E0.6660.99
194_A199_T0.6660.99
22_Y355_R0.6620.99
32_G36_F0.6620.99
54_I57_A0.6580.99
228_A232_A0.6560.99
107_S110_L0.6560.99
44_S48_F0.6540.99
460_V463_V0.6520.99
40_A178_G0.6490.99
10_V13_R0.6490.99
3_V9_L0.6490.99
333_T350_E0.6480.99
152_G363_V0.6480.99
4_A12_Y0.6470.99
286_L295_I0.6470.99
441_F448_V0.6460.99
447_V451_P0.6440.99
13_R17_R0.6430.99
12_Y164_I0.6420.99
18_D26_G0.6420.99
159_V359_A0.6410.99
56_Y292_I0.6410.99
388_A392_P0.6410.99
129_Q321_S0.6400.99
47_T269_F0.6400.99
162_V322_D0.6390.99
221_P225_L0.6390.99
333_T337_Y0.6390.99
418_F449_G0.6380.99
8_G13_R0.6380.99
107_S339_P0.6370.99
338_R347_A0.6340.99
396_L400_W0.6330.98
262_P266_V0.6330.98
404_T408_M0.6310.98
406_A409_F0.6310.98
30_G33_V0.6310.98
118_S331_Y0.6300.98
338_R343_A0.6280.98
40_A177_Q0.6270.98
125_Y324_M0.6250.98
415_T418_F0.6240.98
10_V14_V0.6230.98
408_M415_T0.6230.98
298_S306_A0.6220.98
291_N294_P0.6220.98
110_L405_K0.6190.98
35_L39_F0.6190.98
234_G238_F0.6180.98
81_L84_R0.6180.98
249_D252_R0.6170.98
56_Y286_L0.6170.98
195_E199_T0.6170.98
125_Y238_F0.6160.98
447_V450_L0.6130.98
325_L358_V0.6120.98
286_L291_N0.6110.98
48_F309_V0.6110.98
168_R172_W0.6090.98
189_F274_L0.6090.98
402_R406_A0.6080.98
214_L218_A0.6080.98
167_M171_A0.6080.98
196_I203_L0.6080.98
126_V321_S0.6060.98
256_R260_I0.6050.98
135_E290_E0.6040.98
377_L381_S0.6040.98
152_G155_T0.6030.98
105_F396_L0.6030.98
186_W189_F0.6030.98
283_G295_I0.6020.98
105_F408_M0.6010.98
245_F258_F0.6000.98
443_W447_V0.5980.98
19_A350_E0.5970.98
193_A198_G0.5960.98
199_T204_A0.5960.98
107_S111_R0.5960.98
462_A465_A0.5960.98
223_W226_S0.5950.98
32_G175_T0.5950.98
161_Y169_G0.5930.98
84_R399_Y0.5930.98
193_A274_L0.5920.98
203_L208_P0.5900.98
225_L228_A0.5890.98
443_W446_Q0.5890.98
283_G286_L0.5880.98
155_T369_S0.5860.98
282_V296_L0.5860.98
333_T357_G0.5850.97
420_L424_F0.5850.97
402_R405_K0.5830.97
135_E139_G0.5820.97
60_P63_I0.5810.97
294_P313_A0.5810.97
442_G446_Q0.5800.97
111_R339_P0.5800.97
187_V190_V0.5790.97
106_G110_L0.5790.97
446_Q453_G0.5790.97
230_G238_F0.5790.97
457_T460_V0.5790.97
174_D319_S0.5790.97
37_T174_D0.5770.97
303_G306_A0.5760.97
124_P383_A0.5760.97
54_I62_W0.5760.97
318_M322_D0.5760.97
21_D168_R0.5760.97
215_G218_A0.5730.97
139_G291_N0.5700.97
364_A367_G0.5700.97
46_F380_G0.5690.97
243_Q327_S0.5690.97
80_V84_R0.5680.97
39_F178_G0.5670.97
77_L85_Q0.5660.97
33_V172_W0.5650.97
68_L74_F0.5640.97
20_E347_A0.5640.97
69_M266_V0.5640.97
123_F368_G0.5640.97
355_R358_V0.5630.97
110_L114_V0.5630.97
5_L12_Y0.5620.97
302_P305_F0.5620.97
130_Q169_G0.5610.97
19_A22_Y0.5610.97
174_D177_Q0.5600.97
97_L394_V0.5600.97
159_V163_A0.5580.97
161_Y165_S0.5560.97
41_T244_R0.5560.97
131_I147_Y0.5550.97
444_F449_G0.5550.97
60_P64_L0.5540.97
408_M411_G0.5520.96
137_L150_G0.5520.96
29_L247_V0.5510.96
138_V146_P0.5500.96
137_L141_T0.5500.96
244_R323_S0.5470.96
101_L393_P0.5470.96
412_V415_T0.5460.96
170_V326_L0.5450.96
423_V445_A0.5450.96
39_F268_L0.5450.96
151_A370_L0.5450.96
414_G417_A0.5430.96
193_A197_A0.5430.96
256_R259_A0.5420.96
365_A369_S0.5420.96
234_G384_F0.5420.96
3_V11_A0.5410.96
196_I200_T0.5390.96
374_G378_E0.5390.96
410_A459_G0.5360.96
123_F364_A0.5350.96
34_L37_T0.5350.96
12_Y15_T0.5350.96
66_M73_L0.5340.96
115_A331_Y0.5340.96
125_Y240_Q0.5330.96
53_N289_G0.5330.96
301_T309_V0.5320.96
107_S112_G0.5310.96
193_A199_T0.5310.96
151_A155_T0.5300.96
216_G219_Y0.5290.95
11_A172_W0.5280.95
439_S444_F0.5280.95
188_A309_V0.5280.95
268_L272_A0.5270.95
170_V244_R0.5260.95
219_Y222_Q0.5260.95
30_G34_L0.5260.95
98_G118_S0.5220.95
425_G428_V0.5220.95
209_A280_N0.5220.95
392_P457_T0.5210.95
42_L235_V0.5210.95
201_G206_A0.5200.95
122_L383_A0.5200.95
129_Q132_G0.5200.95
381_S385_G0.5200.95
346_T352_T0.5200.95
192_V300_Y0.5190.95
237_M394_V0.5170.95
51_G55_A0.5170.95
66_M69_M0.5160.95
111_R115_A0.5160.95
4_A7_V0.5150.95
39_F261_W0.5150.95
134_G150_G0.5140.95
112_G339_P0.5140.95
43_L261_W0.5140.95
44_S129_Q0.5130.95
391_A395_A0.5120.95
265_V269_F0.5120.95
69_M224_M0.5120.95
403_T408_M0.5120.95
50_A125_Y0.5110.95
203_L209_A0.5100.95
259_A262_P0.5100.95
95_V334_R0.5100.95
301_T304_W0.5100.95
267_L271_P0.5090.94
289_G292_I0.5080.94
294_P309_V0.5080.94
359_A363_V0.5070.94
444_F447_V0.5060.94
212_R217_G0.5060.94
407_G453_G0.5060.94
234_G239_P0.5050.94
251_K255_K0.5050.94
407_G456_L0.5050.94
230_G234_G0.5040.94
125_Y129_Q0.5040.94
94_Y99_E0.5020.94
428_V440_Y0.5020.94
46_F384_F0.5020.94
39_F43_L0.5020.94
98_G115_A0.5020.94
42_L380_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9191 100 0.243 Contact Map
3dh4A 3 0.8963 100 0.26 Contact Map
3giaA 1 0.8755 99.2 0.854 Contact Map
3l1lA 2 0.8444 99.2 0.854 Contact Map
4wgvA 2 0.7676 98.9 0.874 Contact Map
4djkA 2 0.8361 98.7 0.88 Contact Map
2jlnA 1 0.8402 98.5 0.889 Contact Map
2a65A 2 0.888 94.2 0.936 Contact Map
4us3A 1 0.8195 93.5 0.938 Contact Map
4xp4A 1 0.9046 93.2 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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