GREMLIN Database
Q9HP58 - Uncharacterized protein
UniProt: Q9HP58 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (181)
Sequences: 247 (177)
Seq/√Len: 13.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_V89_A4.8581.00
94_A101_A4.3101.00
49_A53_V4.1181.00
49_A89_A3.7170.99
103_W167_V3.0940.97
107_L168_A3.0900.97
51_I146_G2.8370.95
160_F217_A2.7410.94
200_E204_A2.6400.93
70_T78_V2.5470.92
110_F165_V2.5310.92
49_A93_V2.4520.90
91_S154_V2.3800.89
174_I200_E2.1690.84
154_V157_Y2.1580.83
76_I177_L2.1290.82
91_S94_A2.1000.82
71_P92_L2.0140.79
73_A76_I1.8730.73
110_F210_I1.7630.69
91_S157_Y1.7570.68
133_W173_G1.7080.66
91_S105_H1.6850.65
61_W64_R1.6680.64
200_E203_H1.6480.63
50_A54_A1.6430.63
109_F151_A1.6110.61
71_P184_V1.5730.59
165_V214_C1.5420.58
166_G210_I1.5350.57
103_W163_P1.5220.57
111_G171_W1.5100.56
117_L145_F1.5100.56
57_V104_L1.5040.56
89_A93_V1.5020.56
66_Q147_M1.4700.54
64_R68_A1.4450.53
109_F212_A1.4440.53
66_Q78_V1.4340.52
57_V61_W1.4320.52
94_A102_D1.4300.52
174_I204_A1.4230.52
123_Q137_Y1.4080.51
69_D187_G1.3870.50
90_A104_L1.3450.47
152_F212_A1.3250.46
56_T86_L1.3250.46
40_L157_Y1.3220.46
52_N150_E1.3080.46
174_I184_V1.3050.45
94_A163_P1.2910.45
108_A114_K1.2780.44
181_F200_E1.2710.44
124_L161_S1.2710.44
55_G140_L1.2620.43
112_C150_E1.2610.43
146_G213_A1.2500.43
81_S175_N1.2370.42
109_F213_A1.2180.41
111_G172_Y1.1910.40
124_L216_V1.1850.39
53_V93_V1.1820.39
178_L182_L1.1800.39
73_A150_E1.1550.38
91_S95_Y1.1210.36
93_V100_D1.1180.36
161_S194_R1.1140.36
105_H154_V1.1100.36
104_L176_D1.1030.35
114_K176_D1.1000.35
49_A97_L1.0890.35
89_A97_L1.0880.34
79_P140_L1.0800.34
158_A172_Y1.0790.34
107_L123_Q1.0780.34
61_W120_P1.0730.34
211_A215_A1.0720.34
47_V216_V1.0710.34
76_I96_K1.0690.34
60_F113_L1.0680.34
91_S102_D1.0590.33
65_I69_D1.0510.33
56_T85_T1.0290.32
40_L43_R1.0130.31
129_Q141_V1.0100.31
62_Y186_G1.0080.31
72_L152_F1.0010.30
154_V158_A0.9930.30
46_W54_A0.9910.30
124_L128_G0.9850.30
121_F125_V0.9840.30
66_Q143_S0.9830.30
138_W141_V0.9750.29
50_A170_A0.9750.29
123_Q126_V0.9740.29
173_G207_A0.9730.29
129_Q194_R0.9670.29
96_K146_G0.9630.29
90_A97_L0.9600.29
110_F172_Y0.9580.29
199_A203_H0.9530.28
74_A178_L0.9530.28
121_F201_A0.9490.28
123_Q127_N0.9400.28
188_P194_R0.9260.27
140_L147_M0.9200.27
51_I75_W0.9180.27
56_T143_S0.9120.27
68_A132_L0.9100.27
146_G207_A0.9090.27
77_F198_G0.9070.26
50_A142_L0.9030.26
55_G79_P0.9020.26
104_L154_V0.8920.26
90_A135_G0.8800.25
134_W138_W0.8790.25
104_L166_G0.8780.25
127_N151_A0.8710.25
113_L209_D0.8690.25
75_W184_V0.8670.25
69_D208_H0.8640.25
181_F204_A0.8610.25
93_V124_L0.8590.25
78_V147_M0.8510.24
109_F152_F0.8470.24
191_T194_R0.8460.24
79_P171_W0.8410.24
202_P209_D0.8390.24
183_G196_E0.8230.23
159_T169_L0.8180.23
57_V74_A0.8140.23
89_A217_A0.8140.23
54_A215_A0.8120.23
154_V205_L0.8110.23
65_I190_H0.8090.23
54_A216_V0.8090.23
166_G169_L0.8050.22
162_V166_G0.8040.22
152_F208_H0.8030.22
166_G197_L0.7950.22
96_K127_N0.7880.22
162_V170_A0.7860.22
142_L183_G0.7860.22
145_F149_V0.7830.22
149_V172_Y0.7790.22
40_L64_R0.7780.22
44_L61_W0.7720.21
68_A99_W0.7680.21
93_V104_L0.7620.21
135_G216_V0.7590.21
148_A201_A0.7580.21
55_G147_M0.7580.21
117_L121_F0.7570.21
125_V188_P0.7550.21
185_L196_E0.7550.21
66_Q140_L0.7550.21
126_V134_W0.7540.21
169_L210_I0.7510.21
138_W176_D0.7510.21
58_F119_T0.7500.21
85_T111_G0.7470.20
58_F139_F0.7440.20
48_I146_G0.7440.20
66_Q70_T0.7400.20
44_L165_V0.7370.20
174_I181_F0.7370.20
58_F62_Y0.7360.20
89_A94_A0.7360.20
66_Q79_P0.7350.20
119_T123_Q0.7350.20
203_H206_Y0.7270.20
102_D155_H0.7240.20
102_D105_H0.7180.19
125_V130_G0.7170.19
113_L152_F0.7070.19
182_L203_H0.6910.19
188_P196_E0.6890.19
92_L170_A0.6880.18
167_V170_A0.6800.18
127_N191_T0.6710.18
154_V202_P0.6660.18
145_F160_F0.6580.18
53_V217_A0.6570.18
60_F83_T0.6560.17
91_S187_G0.6550.17
138_W214_C0.6470.17
55_G66_Q0.6460.17
46_W73_A0.6440.17
76_I90_A0.6420.17
76_I102_D0.6400.17
94_A187_G0.6340.17
88_I148_A0.6320.17
110_F176_D0.6310.17
90_A212_A0.6280.17
113_L117_L0.6270.17
165_V210_I0.6250.17
72_L173_G0.6200.16
79_P147_M0.6150.16
177_L203_H0.6150.16
81_S108_A0.6140.16
74_A99_W0.6130.16
102_D177_L0.6130.16
48_I88_I0.6120.16
71_P209_D0.6120.16
45_A96_K0.6110.16
185_L188_P0.6100.16
113_L212_A0.6070.16
68_A104_L0.6060.16
109_F177_L0.6050.16
75_W85_T0.6050.16
137_Y189_H0.6050.16
47_V57_V0.5990.16
113_L208_H0.5970.16
70_T79_P0.5950.16
113_L125_V0.5930.16
76_I145_F0.5920.16
124_L141_V0.5910.16
199_A204_A0.5900.16
89_A155_H0.5890.16
50_A67_L0.5860.15
76_I132_L0.5800.15
188_P191_T0.5800.15
133_W138_W0.5790.15
72_L75_W0.5770.15
67_L75_W0.5760.15
46_W171_W0.5750.15
64_R157_Y0.5720.15
114_K175_N0.5680.15
110_F197_L0.5680.15
174_I203_H0.5650.15
138_W161_S0.5630.15
78_V140_L0.5630.15
178_L184_V0.5610.15
51_I150_E0.5600.15
168_A172_Y0.5590.15
88_I154_V0.5590.15
72_L100_D0.5580.15
201_A206_Y0.5560.15
42_L151_A0.5550.15
119_T198_G0.5540.15
45_A111_G0.5490.14
128_G166_G0.5480.14
135_G138_W0.5460.14
112_C123_Q0.5460.14
83_T205_L0.5410.14
60_F86_L0.5400.14
87_F139_F0.5390.14
54_A124_L0.5380.14
215_A218_L0.5350.14
114_K205_L0.5330.14
113_L151_A0.5330.14
57_V110_F0.5310.14
50_A64_R0.5300.14
98_D165_V0.5290.14
40_L54_A0.5260.14
114_K206_Y0.5260.14
139_F143_S0.5260.14
177_L217_A0.5240.14
136_M195_A0.5240.14
55_G143_S0.5200.14
94_A103_W0.5150.14
77_F86_L0.5120.14
56_T147_M0.5110.14
202_P210_I0.5100.13
142_L161_S0.5080.13
149_V168_A0.5080.13
104_L210_I0.5050.13
40_L190_H0.5050.13
130_G194_R0.5030.13
97_L190_H0.5020.13
138_W160_F0.5010.13
104_L211_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx3A 2 0.3824 10.9 0.971 Contact Map
4v3iA 2 0.0882 10 0.971 Contact Map
4ev6A 3 0.4118 7.4 0.973 Contact Map
2m20A 2 0.1218 5 0.975 Contact Map
4i0uA 4 0.3992 4.8 0.975 Contact Map
3s8fA 1 0.2773 3.8 0.976 Contact Map
2hg6A 1 0.1807 2.6 0.978 Contact Map
2py8A 2 0.1092 2.2 0.979 Contact Map
2zxjA 1 0.1303 2.2 0.979 Contact Map
3j21h 1 0.063 2.1 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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