Q9HP58 - HALSA - GREMLIN Contacts

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Q9HP58 - Uncharacterized protein

UniProt:	Q9HP58	Sequences: MRRPRDRRHVPMPTRDAAETTPDDTLPWYVAPLPTRLEDLALRLAWVIAAINVAGTVFGFWYYRIQLADTPLAAWIFVPDSPTATLFIAASLVAYKLDWDADWLHALAFFGCLKLGLWTPFVQLVVNGQGALWWGMYWFLVLSHFGMAVEAFIVHRYATFSVPAVGVALAWYGINDLLDYFLGVLGGPHHTLLRAELGAEAPHALYAHDIAAACAVALTMLATYLALATHIHATEHRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	238 (181)
Sequences:	247 (177)
Seq/√Len:	13.2

BACSU - YPJA
HALSA - Q9HP58

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_V	89_A	4.858	1.00
94_A	101_A	4.310	1.00
49_A	53_V	4.118	1.00
49_A	89_A	3.717	0.99
103_W	167_V	3.094	0.97
107_L	168_A	3.090	0.97
51_I	146_G	2.837	0.95
160_F	217_A	2.741	0.94
200_E	204_A	2.640	0.93
70_T	78_V	2.547	0.92
110_F	165_V	2.531	0.92
49_A	93_V	2.452	0.90
91_S	154_V	2.380	0.89
174_I	200_E	2.169	0.84
154_V	157_Y	2.158	0.83
76_I	177_L	2.129	0.82
91_S	94_A	2.100	0.82
71_P	92_L	2.014	0.79
73_A	76_I	1.873	0.73
110_F	210_I	1.763	0.69
91_S	157_Y	1.757	0.68
133_W	173_G	1.708	0.66
91_S	105_H	1.685	0.65
61_W	64_R	1.668	0.64
200_E	203_H	1.648	0.63
50_A	54_A	1.643	0.63
109_F	151_A	1.611	0.61
71_P	184_V	1.573	0.59
165_V	214_C	1.542	0.58
166_G	210_I	1.535	0.57
103_W	163_P	1.522	0.57
111_G	171_W	1.510	0.56
117_L	145_F	1.510	0.56
57_V	104_L	1.504	0.56
89_A	93_V	1.502	0.56
66_Q	147_M	1.470	0.54
64_R	68_A	1.445	0.53
109_F	212_A	1.444	0.53
66_Q	78_V	1.434	0.52
57_V	61_W	1.432	0.52
94_A	102_D	1.430	0.52
174_I	204_A	1.423	0.52
123_Q	137_Y	1.408	0.51
69_D	187_G	1.387	0.50
90_A	104_L	1.345	0.47
152_F	212_A	1.325	0.46
56_T	86_L	1.325	0.46
40_L	157_Y	1.322	0.46
52_N	150_E	1.308	0.46
174_I	184_V	1.305	0.45
94_A	163_P	1.291	0.45
108_A	114_K	1.278	0.44
181_F	200_E	1.271	0.44
124_L	161_S	1.271	0.44
55_G	140_L	1.262	0.43
112_C	150_E	1.261	0.43
146_G	213_A	1.250	0.43
81_S	175_N	1.237	0.42
109_F	213_A	1.218	0.41
111_G	172_Y	1.191	0.40
124_L	216_V	1.185	0.39
53_V	93_V	1.182	0.39
178_L	182_L	1.180	0.39
73_A	150_E	1.155	0.38
91_S	95_Y	1.121	0.36
93_V	100_D	1.118	0.36
161_S	194_R	1.114	0.36
105_H	154_V	1.110	0.36
104_L	176_D	1.103	0.35
114_K	176_D	1.100	0.35
49_A	97_L	1.089	0.35
89_A	97_L	1.088	0.34
79_P	140_L	1.080	0.34
158_A	172_Y	1.079	0.34
107_L	123_Q	1.078	0.34
61_W	120_P	1.073	0.34
211_A	215_A	1.072	0.34
47_V	216_V	1.071	0.34
76_I	96_K	1.069	0.34
60_F	113_L	1.068	0.34
91_S	102_D	1.059	0.33
65_I	69_D	1.051	0.33
56_T	85_T	1.029	0.32
40_L	43_R	1.013	0.31
129_Q	141_V	1.010	0.31
62_Y	186_G	1.008	0.31
72_L	152_F	1.001	0.30
154_V	158_A	0.993	0.30
46_W	54_A	0.991	0.30
124_L	128_G	0.985	0.30
121_F	125_V	0.984	0.30
66_Q	143_S	0.983	0.30
138_W	141_V	0.975	0.29
50_A	170_A	0.975	0.29
123_Q	126_V	0.974	0.29
173_G	207_A	0.973	0.29
129_Q	194_R	0.967	0.29
96_K	146_G	0.963	0.29
90_A	97_L	0.960	0.29
110_F	172_Y	0.958	0.29
199_A	203_H	0.953	0.28
74_A	178_L	0.953	0.28
121_F	201_A	0.949	0.28
123_Q	127_N	0.940	0.28
188_P	194_R	0.926	0.27
140_L	147_M	0.920	0.27
51_I	75_W	0.918	0.27
56_T	143_S	0.912	0.27
68_A	132_L	0.910	0.27
146_G	207_A	0.909	0.27
77_F	198_G	0.907	0.26
50_A	142_L	0.903	0.26
55_G	79_P	0.902	0.26
104_L	154_V	0.892	0.26
90_A	135_G	0.880	0.25
134_W	138_W	0.879	0.25
104_L	166_G	0.878	0.25
127_N	151_A	0.871	0.25
113_L	209_D	0.869	0.25
75_W	184_V	0.867	0.25
69_D	208_H	0.864	0.25
181_F	204_A	0.861	0.25
93_V	124_L	0.859	0.25
78_V	147_M	0.851	0.24
109_F	152_F	0.847	0.24
191_T	194_R	0.846	0.24
79_P	171_W	0.841	0.24
202_P	209_D	0.839	0.24
183_G	196_E	0.823	0.23
159_T	169_L	0.818	0.23
57_V	74_A	0.814	0.23
89_A	217_A	0.814	0.23
54_A	215_A	0.812	0.23
154_V	205_L	0.811	0.23
65_I	190_H	0.809	0.23
54_A	216_V	0.809	0.23
166_G	169_L	0.805	0.22
162_V	166_G	0.804	0.22
152_F	208_H	0.803	0.22
166_G	197_L	0.795	0.22
96_K	127_N	0.788	0.22
162_V	170_A	0.786	0.22
142_L	183_G	0.786	0.22
145_F	149_V	0.783	0.22
149_V	172_Y	0.779	0.22
40_L	64_R	0.778	0.22
44_L	61_W	0.772	0.21
68_A	99_W	0.768	0.21
93_V	104_L	0.762	0.21
135_G	216_V	0.759	0.21
148_A	201_A	0.758	0.21
55_G	147_M	0.758	0.21
117_L	121_F	0.757	0.21
125_V	188_P	0.755	0.21
185_L	196_E	0.755	0.21
66_Q	140_L	0.755	0.21
126_V	134_W	0.754	0.21
169_L	210_I	0.751	0.21
138_W	176_D	0.751	0.21
58_F	119_T	0.750	0.21
85_T	111_G	0.747	0.20
58_F	139_F	0.744	0.20
48_I	146_G	0.744	0.20
66_Q	70_T	0.740	0.20
44_L	165_V	0.737	0.20
174_I	181_F	0.737	0.20
58_F	62_Y	0.736	0.20
89_A	94_A	0.736	0.20
66_Q	79_P	0.735	0.20
119_T	123_Q	0.735	0.20
203_H	206_Y	0.727	0.20
102_D	155_H	0.724	0.20
102_D	105_H	0.718	0.19
125_V	130_G	0.717	0.19
113_L	152_F	0.707	0.19
182_L	203_H	0.691	0.19
188_P	196_E	0.689	0.19
92_L	170_A	0.688	0.18
167_V	170_A	0.680	0.18
127_N	191_T	0.671	0.18
154_V	202_P	0.666	0.18
145_F	160_F	0.658	0.18
53_V	217_A	0.657	0.18
60_F	83_T	0.656	0.17
91_S	187_G	0.655	0.17
138_W	214_C	0.647	0.17
55_G	66_Q	0.646	0.17
46_W	73_A	0.644	0.17
76_I	90_A	0.642	0.17
76_I	102_D	0.640	0.17
94_A	187_G	0.634	0.17
88_I	148_A	0.632	0.17
110_F	176_D	0.631	0.17
90_A	212_A	0.628	0.17
113_L	117_L	0.627	0.17
165_V	210_I	0.625	0.17
72_L	173_G	0.620	0.16
79_P	147_M	0.615	0.16
177_L	203_H	0.615	0.16
81_S	108_A	0.614	0.16
74_A	99_W	0.613	0.16
102_D	177_L	0.613	0.16
48_I	88_I	0.612	0.16
71_P	209_D	0.612	0.16
45_A	96_K	0.611	0.16
185_L	188_P	0.610	0.16
113_L	212_A	0.607	0.16
68_A	104_L	0.606	0.16
109_F	177_L	0.605	0.16
75_W	85_T	0.605	0.16
137_Y	189_H	0.605	0.16
47_V	57_V	0.599	0.16
113_L	208_H	0.597	0.16
70_T	79_P	0.595	0.16
113_L	125_V	0.593	0.16
76_I	145_F	0.592	0.16
124_L	141_V	0.591	0.16
199_A	204_A	0.590	0.16
89_A	155_H	0.589	0.16
50_A	67_L	0.586	0.15
76_I	132_L	0.580	0.15
188_P	191_T	0.580	0.15
133_W	138_W	0.579	0.15
72_L	75_W	0.577	0.15
67_L	75_W	0.576	0.15
46_W	171_W	0.575	0.15
64_R	157_Y	0.572	0.15
114_K	175_N	0.568	0.15
110_F	197_L	0.568	0.15
174_I	203_H	0.565	0.15
138_W	161_S	0.563	0.15
78_V	140_L	0.563	0.15
178_L	184_V	0.561	0.15
51_I	150_E	0.560	0.15
168_A	172_Y	0.559	0.15
88_I	154_V	0.559	0.15
72_L	100_D	0.558	0.15
201_A	206_Y	0.556	0.15
42_L	151_A	0.555	0.15
119_T	198_G	0.554	0.15
45_A	111_G	0.549	0.14
128_G	166_G	0.548	0.14
135_G	138_W	0.546	0.14
112_C	123_Q	0.546	0.14
83_T	205_L	0.541	0.14
60_F	86_L	0.540	0.14
87_F	139_F	0.539	0.14
54_A	124_L	0.538	0.14
215_A	218_L	0.535	0.14
114_K	205_L	0.533	0.14
113_L	151_A	0.533	0.14
57_V	110_F	0.531	0.14
50_A	64_R	0.530	0.14
98_D	165_V	0.529	0.14
40_L	54_A	0.526	0.14
114_K	206_Y	0.526	0.14
139_F	143_S	0.526	0.14
177_L	217_A	0.524	0.14
136_M	195_A	0.524	0.14
55_G	143_S	0.520	0.14
94_A	103_W	0.515	0.14
77_F	86_L	0.512	0.14
56_T	147_M	0.511	0.14
202_P	210_I	0.510	0.13
142_L	161_S	0.508	0.13
149_V	168_A	0.508	0.13
104_L	210_I	0.505	0.13
40_L	190_H	0.505	0.13
130_G	194_R	0.503	0.13
97_L	190_H	0.502	0.13
138_W	160_F	0.501	0.13
104_L	211_A	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tx3A	2	0.3824	10.9	0.971	Contact Map
4v3iA	2	0.0882	10	0.971	Contact Map
4ev6A	3	0.4118	7.4	0.973	Contact Map
2m20A	2	0.1218	5	0.975	Contact Map
4i0uA	4	0.3992	4.8	0.975	Contact Map
3s8fA	1	0.2773	3.8	0.976	Contact Map
2hg6A	1	0.1807	2.6	0.978	Contact Map
2py8A	2	0.1092	2.2	0.979	Contact Map
2zxjA	1	0.1303	2.2	0.979	Contact Map
3j21h	1	0.063	2.1	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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