GREMLIN Database
PDXS - Pyridoxal biosynthesis lyase PdxS
UniProt: Q9HP57 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (290)
Sequences: 894 (253)
Seq/√Len: 14.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_I272_L5.8091.00
137_A175_I4.6041.00
99_E234_H4.1001.00
76_T277_S3.9971.00
148_D191_D3.8481.00
70_A74_S3.8311.00
160_A297_M3.5400.99
164_D288_N3.2900.99
172_Q237_C3.1760.99
216_V239_G3.1700.98
125_D128_E3.1230.98
250_E284_Q3.0630.98
206_E210_M2.9270.97
182_L204_V2.8410.97
139_N178_A2.8280.97
36_R77_G2.8250.97
156_T217_N2.8250.97
14_S18_K2.7280.96
296_R299_D2.6760.96
182_L208_A2.5950.95
73_A278_N2.4640.93
70_A298_Q2.4430.93
44_D253_E2.4410.93
15_E19_R2.3900.92
272_L275_I2.3430.91
164_D287_P2.2800.90
35_N77_G2.2310.89
191_D201_R2.1510.87
73_A277_S2.1440.87
193_W197_H2.1380.87
21_F25_Q2.1080.86
120_D166_N2.0770.85
79_I105_G2.0600.84
167_Q170_H1.9390.80
271_R275_I1.9370.80
172_Q232_M1.9220.80
165_V223_I1.8920.79
293_E299_D1.8500.77
96_K230_A1.8470.77
185_M193_W1.8410.77
102_Q130_T1.8380.77
250_E281_E1.8370.77
240_I263_V1.8320.76
164_D167_Q1.8160.76
261_D274_E1.7950.75
212_R238_D1.7940.75
21_F108_M1.7930.75
164_D170_H1.7380.72
144_L203_L1.7160.71
284_Q287_P1.7090.71
270_E274_E1.6930.70
223_I263_V1.6820.70
13_G17_V1.6630.69
148_D201_R1.6460.68
79_I106_A1.6400.68
216_V237_C1.6270.67
95_R234_H1.6240.67
59_D248_G1.5410.63
73_A77_G1.5360.63
120_D164_D1.5320.62
182_L193_W1.5240.62
95_R99_E1.5200.62
261_D265_N1.5120.61
20_G24_M1.4990.61
71_D279_I1.4970.61
207_T210_M1.4740.59
25_Q108_M1.4630.59
139_N174_N1.4390.57
14_S20_G1.4140.56
60_I65_G1.4050.56
156_T219_A1.3790.54
18_K152_A1.3760.54
23_K108_M1.3660.53
148_D199_A1.3380.52
120_D170_H1.3290.51
216_V238_D1.3260.51
250_E287_P1.3120.50
180_R189_E1.3050.50
138_R217_N1.3040.50
23_K239_G1.2970.50
96_K99_E1.2920.49
147_I154_I1.2900.49
144_L207_T1.2810.49
206_E209_E1.2730.48
167_Q288_N1.2670.48
121_E177_S1.2570.47
139_N198_E1.2430.47
174_N178_A1.2290.46
273_A277_S1.2250.46
255_M281_E1.2240.45
15_E152_A1.2240.45
254_A278_N1.2230.45
148_D200_P1.2190.45
13_G18_K1.2080.45
176_K180_R1.2080.45
199_A204_V1.1890.44
187_Y205_H1.1850.43
58_A284_Q1.1820.43
125_D137_A1.1810.43
216_V219_A1.1810.43
201_R205_H1.1770.43
189_E195_R1.1550.42
24_M264_N1.1540.42
189_E199_A1.1440.41
40_R43_E1.1420.41
19_R152_A1.1400.41
219_A237_C1.1320.40
100_I227_A1.1310.40
138_R156_T1.1270.40
174_N298_Q1.1180.40
207_T212_R1.0830.38
191_D195_R1.0790.38
193_W208_A1.0790.38
287_P290_D1.0780.38
154_I165_V1.0680.37
183_E211_G1.0550.36
58_A250_E1.0460.36
90_S124_I1.0440.36
95_R124_I1.0430.36
34_V38_Q1.0420.36
17_V20_G1.0340.35
138_R231_L1.0080.34
249_A252_P1.0030.34
58_A62_K1.0000.34
13_G19_R1.0000.34
67_A167_Q0.9990.34
56_V60_I0.9990.34
55_A70_A0.9980.33
153_M216_V0.9960.33
34_V138_R0.9940.33
75_L160_A0.9930.33
206_E212_R0.9930.33
185_M195_R0.9920.33
210_M238_D0.9860.33
74_S77_G0.9790.33
95_R255_M0.9750.32
187_Y208_A0.9750.32
14_S17_V0.9750.32
178_A185_M0.9730.32
104_V273_A0.9680.32
164_D286_D0.9670.32
60_I67_A0.9630.32
76_T80_E0.9620.32
63_R70_A0.9610.32
40_R44_D0.9580.31
73_A76_T0.9550.31
23_K216_V0.9520.31
44_D83_S0.9510.31
96_K234_H0.9430.31
208_A212_R0.9350.30
211_G268_D0.9340.30
137_A154_I0.9340.30
16_L19_R0.9310.30
20_G106_A0.9180.30
166_N173_R0.9180.30
265_N268_D0.9130.29
250_E286_D0.9100.29
20_G38_Q0.9090.29
177_S185_M0.9060.29
200_P203_L0.9020.29
153_M239_G0.8980.29
229_A259_V0.8980.29
116_T295_E0.8980.29
177_S204_V0.8970.29
96_K255_M0.8920.28
176_K184_G0.8900.28
78_I152_A0.8870.28
108_M216_V0.8830.28
18_K106_A0.8750.28
177_S186_D0.8660.27
281_E284_Q0.8650.27
251_N295_E0.8640.27
192_M198_E0.8640.27
232_M273_A0.8600.27
98_A124_I0.8600.27
96_K272_L0.8590.27
36_R74_S0.8570.27
128_E187_Y0.8550.27
263_V275_I0.8540.27
172_Q176_K0.8500.27
124_I129_F0.8470.26
95_R129_F0.8460.26
182_L207_T0.8460.26
294_D299_D0.8450.26
71_D275_I0.8430.26
54_E60_I0.8430.26
15_E25_Q0.8390.26
292_P295_E0.8380.26
180_R199_A0.8350.26
13_G20_G0.8350.26
175_I219_A0.8290.26
183_E208_A0.8200.25
144_L204_V0.8180.25
290_D294_D0.8090.25
271_R274_E0.8070.25
288_N291_L0.8020.24
19_R25_Q0.8010.24
74_S298_Q0.8010.24
238_D291_L0.7990.24
100_I275_I0.7990.24
18_K24_M0.7980.24
56_V104_V0.7980.24
129_F133_F0.7950.24
255_M284_Q0.7940.24
36_R104_V0.7910.24
204_V208_A0.7890.24
182_L185_M0.7880.24
144_L199_A0.7860.24
295_E299_D0.7850.24
67_A116_T0.7850.24
276_A279_I0.7840.24
96_K238_D0.7840.24
19_R127_R0.7800.24
34_V156_T0.7700.23
234_H266_H0.7620.23
23_K76_T0.7600.23
75_L298_Q0.7590.23
44_D270_E0.7590.23
15_E20_G0.7560.23
19_R216_V0.7550.23
22_A26_K0.7540.23
58_A234_H0.7540.23
167_Q289_A0.7530.23
184_G188_E0.7510.22
162_T165_V0.7460.22
63_R298_Q0.7390.22
237_C296_R0.7370.22
290_D296_R0.7370.22
165_V255_M0.7350.22
185_M197_H0.7350.22
219_A238_D0.7270.22
31_M53_L0.7270.22
284_Q289_A0.7260.21
192_M199_A0.7260.21
31_M51_M0.7250.21
160_A175_I0.7250.21
240_I253_E0.7220.21
193_W237_C0.7210.21
274_E277_S0.7170.21
182_L190_R0.7100.21
66_V162_T0.7060.21
219_A233_M0.7050.21
212_R261_D0.7030.21
261_D275_I0.7020.21
181_K184_G0.7000.21
138_R219_A0.6990.20
79_I265_N0.6920.20
52_N60_I0.6910.20
40_R83_S0.6900.20
181_K197_H0.6880.20
34_V70_A0.6860.20
79_I104_V0.6840.20
34_V217_N0.6840.20
55_A60_I0.6820.20
90_S273_A0.6810.20
180_R211_G0.6800.20
27_G30_I0.6760.20
164_D290_D0.6750.20
44_D265_N0.6740.20
48_V264_N0.6720.20
185_M212_R0.6700.19
185_M208_A0.6670.19
99_E269_P0.6630.19
90_S138_R0.6620.19
15_E18_K0.6610.19
99_E124_I0.6590.19
122_Y198_E0.6590.19
195_R199_A0.6580.19
52_N56_V0.6570.19
63_R288_N0.6560.19
195_R198_E0.6510.19
191_D199_A0.6500.19
223_I229_A0.6500.19
90_S125_D0.6490.19
164_D175_I0.6480.19
18_K22_A0.6470.19
99_E266_H0.6450.19
178_A181_K0.6420.18
40_R254_A0.6420.18
58_A122_Y0.6410.18
14_S131_A0.6410.18
67_A164_D0.6410.18
70_A75_L0.6380.18
29_V229_A0.6360.18
144_L200_P0.6360.18
77_G295_E0.6340.18
182_L197_H0.6330.18
135_C276_A0.6320.18
198_E265_N0.6320.18
250_E278_N0.6280.18
83_S288_N0.6250.18
17_V24_M0.6250.18
233_M238_D0.6220.18
19_R239_G0.6210.18
204_V211_G0.6200.18
223_I230_A0.6200.18
165_V232_M0.6200.18
169_V231_L0.6190.18
66_V116_T0.6150.18
105_G270_E0.6140.18
174_N200_P0.6140.18
193_W204_V0.6120.17
63_R160_A0.6120.17
54_E135_C0.6100.17
60_I282_G0.6100.17
204_V289_A0.6090.17
81_E90_S0.6080.17
76_T206_E0.6080.17
120_D200_P0.6080.17
138_R160_A0.6070.17
191_D198_E0.6050.17
38_Q62_K0.6030.17
223_I259_V0.6030.17
19_R206_E0.6020.17
15_E21_F0.6010.17
253_E257_R0.5990.17
63_R297_M0.5980.17
125_D175_I0.5970.17
32_D53_L0.5960.17
16_L198_E0.5950.17
27_G36_R0.5940.17
58_A148_D0.5930.17
172_Q175_I0.5920.17
277_S294_D0.5910.17
176_K210_M0.5900.17
223_I289_A0.5870.17
297_M300_R0.5840.17
186_D191_D0.5780.16
82_V118_A0.5770.16
288_N296_R0.5770.16
120_D203_L0.5760.16
172_Q223_I0.5750.16
252_P279_I0.5730.16
165_V193_W0.5720.16
16_L20_G0.5700.16
190_R200_P0.5670.16
290_D299_D0.5650.16
98_A252_P0.5640.16
167_Q290_D0.5640.16
156_T175_I0.5630.16
58_A223_I0.5620.16
69_M231_L0.5620.16
29_V230_A0.5600.16
90_S109_I0.5590.16
288_N297_M0.5590.16
96_K278_N0.5550.16
20_G152_A0.5550.16
248_G281_E0.5540.16
169_V219_A0.5540.16
25_Q99_E0.5540.16
181_K193_W0.5540.16
179_I207_T0.5520.16
15_E108_M0.5520.16
249_A279_I0.5520.16
40_R253_E0.5520.16
106_A131_A0.5500.16
289_A296_R0.5490.16
193_W198_E0.5490.16
154_I213_L0.5490.16
120_D138_R0.5490.16
117_P190_R0.5450.15
165_V288_N0.5450.15
121_E200_P0.5450.15
125_D188_E0.5440.15
201_R204_V0.5430.15
138_R169_V0.5420.15
23_K26_K0.5410.15
181_K185_M0.5390.15
90_S263_V0.5390.15
122_Y188_E0.5370.15
175_I232_M0.5370.15
12_R19_R0.5370.15
13_G216_V0.5360.15
174_N203_L0.5350.15
71_D280_G0.5350.15
175_I237_C0.5330.15
29_V223_I0.5330.15
35_N193_W0.5330.15
17_V37_E0.5320.15
79_I109_I0.5280.15
175_I266_H0.5270.15
104_V137_A0.5270.15
173_R198_E0.5270.15
16_L108_M0.5260.15
250_E253_E0.5260.15
173_R199_A0.5250.15
17_V127_R0.5250.15
291_L299_D0.5240.15
63_R79_I0.5240.15
29_V259_V0.5240.15
234_H269_P0.5230.15
69_M131_A0.5230.15
74_S104_V0.5220.15
167_Q252_P0.5210.15
100_I263_V0.5200.15
74_S177_S0.5200.15
157_K168_A0.5190.15
290_D295_E0.5190.15
168_A245_G0.5190.15
32_D51_M0.5190.15
125_D186_D0.5170.15
193_W207_T0.5170.15
195_R235_H0.5170.15
44_D76_T0.5160.15
79_I297_M0.5160.15
223_I253_E0.5150.15
21_F130_T0.5150.15
255_M286_D0.5150.15
275_I279_I0.5140.15
212_R239_G0.5140.15
71_D254_A0.5140.15
183_E207_T0.5130.15
21_F212_R0.5130.15
127_R176_K0.5130.15
71_D239_G0.5120.14
36_R52_N0.5110.14
53_L157_K0.5110.14
58_A179_I0.5100.14
166_N170_H0.5100.14
108_M254_A0.5100.14
249_A256_G0.5090.14
188_E266_H0.5080.14
129_F255_M0.5070.14
40_R73_A0.5050.14
58_A267_D0.5050.14
157_K245_G0.5040.14
116_T123_H0.5030.14
89_K157_K0.5030.14
16_L21_F0.5030.14
278_N292_P0.5020.14
26_K264_N0.5010.14
230_A259_V0.5010.14
36_R81_E0.5000.14
56_V65_G0.5000.14
257_R261_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yzrA 5 0.904 100 0.697 Contact Map
2nv1A 5 0.8576 100 0.769 Contact Map
2zbtA 5 0.9205 100 0.774 Contact Map
3o07A 3 0.8543 100 0.791 Contact Map
4adtA 5 0.904 100 0.796 Contact Map
4qccA 6 0.7318 99.6 0.898 Contact Map
2htmA 3 0.649 99.5 0.901 Contact Map
3qjaA 1 0.7517 99.5 0.903 Contact Map
1wv2A 3 0.6159 99.5 0.905 Contact Map
1xm3A 4 0.6788 99.5 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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