KHSE - HALSA - GREMLIN Contacts

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KHSE - Homoserine kinase

UniProt:	Q9HP55	Sequences: MVVTVRAPATSANLGSGFDVFGVALSKPADVVRVERADTTTITVTGAGAQYVPTDPQENTAGVVAAALDAPATIHINKGVRPSSGLGSSAASAAAATVALAELYDRPLDDDALVRAAAQGEAAASGVAHADNVAPAILGGFTIVREDGIEHVDASLALAVCLPETTVSTRDARGVVPESAAMEAVVSTVESAATLTLGMCENDPQRVGRGVEDALVTPARARLMDGYEAASAAARDAGATGVTISGSGPGVVAVCRRRDRKRVAAALVDGFDSAGVAASAYQTRIGDGATRLAADGDDRAP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (257)
Sequences:	7154 (5292)
Seq/√Len:	330.1

ECOLI - KHSE ISPE GAL1
BACSU - KHSE ISPE
HALSA - KHSE Q9HQI6
SULSO - KHSE Q980I6 MVK PMK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
13_N	16_S	3.979	1.00
35_E	73_T	3.748	1.00
109_D	112_A	3.479	1.00
6_R	28_P	3.235	1.00
43_T	73_T	3.205	1.00
7_A	92_S	3.144	1.00
255_C	263_V	3.137	1.00
31_V	77_N	2.949	1.00
34_V	99_A	2.648	1.00
97_T	113_L	2.594	1.00
217_T	231_S	2.477	1.00
45_T	75_H	2.459	1.00
4_T	33_R	2.446	1.00
37_A	73_T	2.421	1.00
66_A	119_Q	2.407	1.00
101_A	107_P	2.288	1.00
221_A	228_E	2.168	1.00
114_V	138_L	2.154	1.00
56_P	65_A	2.113	1.00
160_V	250_G	2.106	1.00
33_R	75_H	2.077	1.00
203_D	206_R	2.060	1.00
227_Y	251_V	2.055	1.00
170_R	174_G	1.965	1.00
258_R	261_K	1.955	1.00
172_A	215_L	1.910	1.00
159_A	255_C	1.910	1.00
67_A	106_R	1.873	1.00
33_R	77_N	1.864	1.00
233_A	237_A	1.821	1.00
101_A	108_L	1.804	1.00
66_A	116_A	1.800	1.00
23_V	141_F	1.784	1.00
158_L	254_V	1.783	1.00
211_V	241_G	1.754	1.00
228_E	232_A	1.747	1.00
61_A	65_A	1.737	1.00
242_V	253_A	1.682	1.00
35_E	75_H	1.648	1.00
157_A	258_R	1.642	1.00
20_V	144_V	1.632	1.00
101_A	106_R	1.632	1.00
175_V	223_L	1.628	1.00
167_V	172_A	1.584	1.00
6_R	31_V	1.583	1.00
232_A	236_D	1.563	1.00
65_A	68_L	1.557	1.00
5_V	99_A	1.541	1.00
37_A	71_P	1.538	1.00
112_A	115_R	1.511	1.00
168_S	171_D	1.505	1.00
31_V	79_G	1.498	1.00
34_V	74_I	1.472	1.00
4_T	31_V	1.465	1.00
208_G	241_G	1.462	1.00
67_A	97_T	1.456	1.00
5_V	98_V	1.454	1.00
43_T	75_H	1.442	1.00
171_D	174_G	1.432	1.00
227_Y	244_I	1.417	1.00
32_V	95_A	1.399	1.00
226_G	229_A	1.397	1.00
36_R	70_A	1.394	1.00
41_T	73_T	1.381	1.00
231_S	251_V	1.376	1.00
145_R	150_E	1.374	1.00
175_V	178_E	1.369	1.00
64_V	68_L	1.352	1.00
67_A	104_Y	1.349	1.00
237_A	266_A	1.347	1.00
167_V	220_R	1.343	1.00
265_A	269_D	1.336	1.00
100_L	104_Y	1.319	1.00
162_L	250_G	1.296	1.00
234_A	253_A	1.290	1.00
42_I	61_A	1.279	1.00
7_A	95_A	1.275	1.00
32_V	96_A	1.274	1.00
264_A	268_V	1.271	1.00
243_T	252_V	1.265	1.00
217_T	221_A	1.253	1.00
83_S	166_T	1.243	1.00
205_Q	256_R	1.239	1.00
160_V	252_V	1.232	1.00
101_A	113_L	1.226	1.00
157_A	260_R	1.225	1.00
212_E	215_L	1.220	1.00
5_V	102_E	1.208	1.00
37_A	40_T	1.206	1.00
239_A	253_A	1.201	1.00
165_T	226_G	1.200	1.00
22_G	144_V	1.200	1.00
159_A	260_R	1.197	1.00
101_A	110_D	1.177	1.00
198_G	207_V	1.161	1.00
53_P	57_Q	1.158	1.00
194_T	210_G	1.147	1.00
96_A	100_L	1.140	1.00
72_A	104_Y	1.136	1.00
74_I	96_A	1.135	1.00
221_A	227_Y	1.132	1.00
161_C	230_A	1.129	1.00
10_T	136_A	1.128	1.00
60_T	96_A	1.124	1.00
97_T	117_A	1.121	1.00
110_D	138_L	1.120	1.00
11_S	23_V	1.115	1.00
197_L	201_E	1.113	1.00
56_P	61_A	1.107	1.00
37_A	41_T	1.096	1.00
39_T	71_P	1.096	1.00
45_T	73_T	1.094	1.00
24_A	141_F	1.090	1.00
24_A	140_G	1.089	1.00
25_L	28_P	1.082	1.00
94_A	137_I	1.069	1.00
32_V	60_T	1.068	1.00
60_T	76_I	1.067	1.00
9_A	80_V	1.060	1.00
229_A	232_A	1.044	1.00
198_G	206_R	1.043	1.00
159_A	263_V	1.036	1.00
221_A	231_S	1.036	1.00
108_L	116_A	1.036	1.00
176_V	180_A	1.025	1.00
172_A	220_R	1.020	1.00
40_T	46_G	1.020	1.00
245_S	250_G	1.018	1.00
29_A	80_V	1.016	1.00
197_L	200_C	1.015	1.00
235_R	242_V	1.014	1.00
171_D	223_L	1.010	1.00
231_S	242_V	1.009	1.00
229_A	233_A	1.006	1.00
83_S	249_P	1.006	1.00
101_A	109_D	1.001	1.00
171_D	175_V	0.999	1.00
59_N	62_G	0.998	1.00
84_S	162_L	0.992	1.00
234_A	239_A	0.990	1.00
233_A	270_G	0.989	1.00
34_V	72_A	0.987	1.00
233_A	236_D	0.987	1.00
80_V	86_L	0.979	1.00
45_T	77_N	0.961	1.00
266_A	270_G	0.959	1.00
24_A	139_G	0.957	1.00
10_T	135_P	0.956	1.00
63_V	66_A	0.946	1.00
111_D	115_R	0.941	1.00
68_L	104_Y	0.933	1.00
110_D	114_V	0.930	1.00
22_G	135_P	0.926	1.00
70_A	104_Y	0.926	1.00
211_V	243_T	0.922	1.00
40_T	71_P	0.919	1.00
162_L	166_T	0.914	1.00
167_V	247_S	0.912	1.00
27_K	86_L	0.911	1.00
237_A	263_V	0.910	1.00
59_N	93_A	0.905	1.00
205_Q	209_R	0.903	1.00
60_T	63_V	0.899	1.00
261_K	264_A	0.899	1.00
261_K	265_A	0.898	1.00
215_L	220_R	0.897	1.00
64_V	74_I	0.895	1.00
53_P	56_P	0.887	1.00
80_V	91_A	0.884	1.00
40_T	44_V	0.883	1.00
159_A	264_A	0.875	1.00
44_V	47_A	0.875	1.00
83_S	250_G	0.871	1.00
208_G	240_T	0.869	1.00
165_T	224_M	0.868	1.00
108_L	112_A	0.867	1.00
231_S	235_R	0.861	1.00
157_A	257_R	0.861	1.00
266_A	269_D	0.859	1.00
208_G	211_V	0.845	1.00
40_T	68_L	0.845	1.00
63_V	120_G	0.845	1.00
206_R	209_R	0.844	1.00
191_S	194_T	0.842	1.00
114_V	117_A	0.840	1.00
184_A	214_A	0.835	1.00
42_I	46_G	0.833	1.00
102_E	106_R	0.824	1.00
11_S	158_L	0.823	1.00
234_A	242_V	0.823	1.00
91_A	136_A	0.819	1.00
48_G	51_Y	0.817	1.00
144_V	149_I	0.817	1.00
59_N	120_G	0.816	1.00
34_V	96_A	0.815	1.00
142_T	149_I	0.815	1.00
148_G	151_H	0.813	1.00
9_A	25_L	0.813	1.00
262_R	266_A	0.809	1.00
117_A	133_V	0.808	1.00
5_V	32_V	0.807	1.00
253_A	263_V	0.802	1.00
72_A	100_L	0.800	1.00
195_L	207_V	0.796	1.00
66_A	120_G	0.791	1.00
7_A	136_A	0.790	1.00
116_A	119_Q	0.789	1.00
59_N	63_V	0.788	1.00
11_S	252_V	0.786	1.00
255_C	260_R	0.785	1.00
97_T	116_A	0.782	1.00
242_V	251_V	0.778	1.00
114_V	137_I	0.776	1.00
265_A	268_V	0.776	1.00
64_V	100_L	0.773	1.00
29_A	78_K	0.767	1.00
114_V	134_A	0.766	1.00
115_R	119_Q	0.763	1.00
226_G	230_A	0.763	1.00
267_L	271_F	0.757	1.00
98_V	110_D	0.757	1.00
44_V	52_V	0.757	1.00
52_V	82_P	0.756	1.00
177_P	181_A	0.752	0.99
198_G	210_G	0.749	0.99
63_V	97_T	0.749	0.99
167_V	249_P	0.749	0.99
196_T	200_C	0.747	0.99
99_A	103_L	0.747	0.99
189_V	192_A	0.747	0.99
52_V	55_D	0.746	0.99
111_D	138_L	0.745	0.99
108_L	113_L	0.744	0.99
98_V	137_I	0.740	0.99
259_D	262_R	0.735	0.99
8_P	139_G	0.734	0.99
178_E	181_A	0.733	0.99
93_A	120_G	0.733	0.99
98_V	113_L	0.732	0.99
135_P	144_V	0.730	0.99
87_G	136_A	0.729	0.99
173_R	176_V	0.724	0.99
50_Q	54_T	0.720	0.99
235_R	241_G	0.720	0.99
26_S	29_A	0.716	0.99
25_L	160_V	0.716	0.99
8_P	24_A	0.713	0.99
239_A	242_V	0.712	0.99
176_V	179_S	0.709	0.99
161_C	253_A	0.706	0.99
167_V	224_M	0.705	0.99
224_M	244_I	0.704	0.99
240_T	256_R	0.701	0.99
263_V	266_A	0.699	0.99
188_T	191_S	0.694	0.99
177_P	180_A	0.693	0.99
34_V	103_L	0.692	0.99
178_E	182_M	0.692	0.99
64_V	71_P	0.692	0.99
260_R	264_A	0.690	0.99
32_V	76_I	0.690	0.99
104_Y	107_P	0.679	0.99
239_A	255_C	0.679	0.99
237_A	255_C	0.678	0.99
5_V	95_A	0.677	0.99
117_A	137_I	0.674	0.99
90_A	136_A	0.673	0.99
230_A	251_V	0.673	0.99
175_V	222_R	0.673	0.99
24_A	135_P	0.669	0.99
28_P	80_V	0.667	0.99
32_V	74_I	0.666	0.99
67_A	100_L	0.666	0.99
24_A	136_A	0.665	0.99
55_D	58_E	0.665	0.99
169_T	173_R	0.664	0.99
162_L	165_T	0.656	0.99
9_A	29_A	0.656	0.99
143_I	196_T	0.655	0.99
61_A	67_A	0.655	0.99
215_L	247_S	0.655	0.99
8_P	28_P	0.649	0.98
63_V	67_A	0.645	0.98
13_N	176_V	0.643	0.98
223_L	226_G	0.643	0.98
114_V	118_A	0.641	0.98
96_A	99_A	0.641	0.98
220_R	223_L	0.640	0.98
153_D	156_L	0.639	0.98
37_A	43_T	0.639	0.98
138_L	142_T	0.635	0.98
172_A	175_V	0.635	0.98
94_A	117_A	0.633	0.98
130_A	144_V	0.632	0.98
195_L	199_M	0.625	0.98
235_R	239_A	0.623	0.98
162_L	249_P	0.621	0.98
86_L	160_V	0.620	0.98
198_G	203_D	0.617	0.98
44_V	58_E	0.613	0.98
60_T	64_V	0.610	0.98
62_G	66_A	0.610	0.98
230_A	271_F	0.609	0.98
174_G	178_E	0.607	0.98
181_A	184_A	0.606	0.98
8_P	91_A	0.605	0.98
67_A	116_A	0.601	0.98
145_R	148_G	0.597	0.97
64_V	96_A	0.597	0.97
121_E	173_R	0.596	0.97
270_G	273_S	0.590	0.97
190_E	193_A	0.590	0.97
208_G	235_R	0.587	0.97
217_T	243_T	0.587	0.97
21_F	141_F	0.577	0.97
40_T	72_A	0.577	0.97
18_F	131_D	0.575	0.97
41_T	44_V	0.573	0.97
136_A	139_G	0.573	0.97
40_T	43_T	0.573	0.97
189_V	193_A	0.570	0.97
194_T	197_L	0.570	0.97
40_T	64_V	0.570	0.97
204_P	240_T	0.569	0.97
134_A	137_I	0.567	0.96
84_S	250_G	0.564	0.96
232_A	235_R	0.562	0.96
220_R	224_M	0.561	0.96
227_Y	231_S	0.560	0.96
32_V	91_A	0.559	0.96
218_P	228_E	0.558	0.96
196_T	199_M	0.558	0.96
91_A	139_G	0.558	0.96
36_R	103_L	0.558	0.96
36_R	104_Y	0.558	0.96
61_A	74_I	0.555	0.96
180_A	183_E	0.552	0.96
267_L	270_G	0.550	0.96
225_D	229_A	0.545	0.96
167_V	223_L	0.545	0.96
161_C	271_F	0.545	0.96
58_E	76_I	0.544	0.96
59_N	67_A	0.541	0.95
257_R	260_R	0.540	0.95
52_V	58_E	0.540	0.95
207_V	211_V	0.539	0.95
269_D	273_S	0.539	0.95
19_D	173_R	0.539	0.95
229_A	273_S	0.538	0.95
102_E	105_D	0.538	0.95
98_V	102_E	0.538	0.95
135_P	173_R	0.535	0.95
55_D	59_N	0.535	0.95
180_A	185_V	0.534	0.95
130_A	146_E	0.533	0.95
21_F	192_A	0.531	0.95
97_T	120_G	0.530	0.95
130_A	133_V	0.529	0.95
7_A	91_A	0.525	0.95
60_T	65_A	0.524	0.95
43_T	54_T	0.522	0.94
52_V	59_N	0.522	0.94
163_P	249_P	0.522	0.94
83_S	162_L	0.521	0.94
173_R	177_P	0.521	0.94
173_R	180_A	0.521	0.94
111_D	114_V	0.520	0.94
41_T	46_G	0.520	0.94
159_A	253_A	0.519	0.94
41_T	47_A	0.518	0.94
233_A	267_L	0.517	0.94
61_A	64_V	0.517	0.94
101_A	105_D	0.516	0.94
262_R	265_A	0.516	0.94
82_P	166_T	0.515	0.94
220_R	227_Y	0.515	0.94
27_K	81_R	0.509	0.94
149_I	152_V	0.508	0.94
76_I	92_S	0.507	0.94
205_Q	240_T	0.506	0.94
22_G	173_R	0.506	0.94
58_E	63_V	0.505	0.93
25_L	158_L	0.505	0.93
112_A	116_A	0.505	0.93
157_A	255_C	0.503	0.93
175_V	179_S	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4p52A	2	0.9701	100	0.264	Contact Map
4rpfA	2	0.9668	100	0.286	Contact Map
1h72C	2	0.9336	100	0.286	Contact Map
3hulA	4	0.897	100	0.293	Contact Map
3pyfA	1	0.9169	100	0.323	Contact Map
4hacA	2	0.9369	100	0.355	Contact Map
2hfsA	1	0.9402	100	0.377	Contact Map
3k85A	3	0.8605	100	0.382	Contact Map
1kkhA	1	0.9103	100	0.386	Contact Map
1pieA	1	0.9668	100	0.387	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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