GREMLIN Database
KHSE - Homoserine kinase
UniProt: Q9HP55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (257)
Sequences: 7154 (5292)
Seq/√Len: 330.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_N16_S3.9791.00
35_E73_T3.7481.00
109_D112_A3.4791.00
6_R28_P3.2351.00
43_T73_T3.2051.00
7_A92_S3.1441.00
255_C263_V3.1371.00
31_V77_N2.9491.00
34_V99_A2.6481.00
97_T113_L2.5941.00
217_T231_S2.4771.00
45_T75_H2.4591.00
4_T33_R2.4461.00
37_A73_T2.4211.00
66_A119_Q2.4071.00
101_A107_P2.2881.00
221_A228_E2.1681.00
114_V138_L2.1541.00
56_P65_A2.1131.00
160_V250_G2.1061.00
33_R75_H2.0771.00
203_D206_R2.0601.00
227_Y251_V2.0551.00
170_R174_G1.9651.00
258_R261_K1.9551.00
172_A215_L1.9101.00
159_A255_C1.9101.00
67_A106_R1.8731.00
33_R77_N1.8641.00
233_A237_A1.8211.00
101_A108_L1.8041.00
66_A116_A1.8001.00
23_V141_F1.7841.00
158_L254_V1.7831.00
211_V241_G1.7541.00
228_E232_A1.7471.00
61_A65_A1.7371.00
242_V253_A1.6821.00
35_E75_H1.6481.00
157_A258_R1.6421.00
20_V144_V1.6321.00
101_A106_R1.6321.00
175_V223_L1.6281.00
167_V172_A1.5841.00
6_R31_V1.5831.00
232_A236_D1.5631.00
65_A68_L1.5571.00
5_V99_A1.5411.00
37_A71_P1.5381.00
112_A115_R1.5111.00
168_S171_D1.5051.00
31_V79_G1.4981.00
34_V74_I1.4721.00
4_T31_V1.4651.00
208_G241_G1.4621.00
67_A97_T1.4561.00
5_V98_V1.4541.00
43_T75_H1.4421.00
171_D174_G1.4321.00
227_Y244_I1.4171.00
32_V95_A1.3991.00
226_G229_A1.3971.00
36_R70_A1.3941.00
41_T73_T1.3811.00
231_S251_V1.3761.00
145_R150_E1.3741.00
175_V178_E1.3691.00
64_V68_L1.3521.00
67_A104_Y1.3491.00
237_A266_A1.3471.00
167_V220_R1.3431.00
265_A269_D1.3361.00
100_L104_Y1.3191.00
162_L250_G1.2961.00
234_A253_A1.2901.00
42_I61_A1.2791.00
7_A95_A1.2751.00
32_V96_A1.2741.00
264_A268_V1.2711.00
243_T252_V1.2651.00
217_T221_A1.2531.00
83_S166_T1.2431.00
205_Q256_R1.2391.00
160_V252_V1.2321.00
101_A113_L1.2261.00
157_A260_R1.2251.00
212_E215_L1.2201.00
5_V102_E1.2081.00
37_A40_T1.2061.00
239_A253_A1.2011.00
165_T226_G1.2001.00
22_G144_V1.2001.00
159_A260_R1.1971.00
101_A110_D1.1771.00
198_G207_V1.1611.00
53_P57_Q1.1581.00
194_T210_G1.1471.00
96_A100_L1.1401.00
72_A104_Y1.1361.00
74_I96_A1.1351.00
221_A227_Y1.1321.00
161_C230_A1.1291.00
10_T136_A1.1281.00
60_T96_A1.1241.00
97_T117_A1.1211.00
110_D138_L1.1201.00
11_S23_V1.1151.00
197_L201_E1.1131.00
56_P61_A1.1071.00
37_A41_T1.0961.00
39_T71_P1.0961.00
45_T73_T1.0941.00
24_A141_F1.0901.00
24_A140_G1.0891.00
25_L28_P1.0821.00
94_A137_I1.0691.00
32_V60_T1.0681.00
60_T76_I1.0671.00
9_A80_V1.0601.00
229_A232_A1.0441.00
198_G206_R1.0431.00
159_A263_V1.0361.00
221_A231_S1.0361.00
108_L116_A1.0361.00
176_V180_A1.0251.00
172_A220_R1.0201.00
40_T46_G1.0201.00
245_S250_G1.0181.00
29_A80_V1.0161.00
197_L200_C1.0151.00
235_R242_V1.0141.00
171_D223_L1.0101.00
231_S242_V1.0091.00
229_A233_A1.0061.00
83_S249_P1.0061.00
101_A109_D1.0011.00
171_D175_V0.9991.00
59_N62_G0.9981.00
84_S162_L0.9921.00
234_A239_A0.9901.00
233_A270_G0.9891.00
34_V72_A0.9871.00
233_A236_D0.9871.00
80_V86_L0.9791.00
45_T77_N0.9611.00
266_A270_G0.9591.00
24_A139_G0.9571.00
10_T135_P0.9561.00
63_V66_A0.9461.00
111_D115_R0.9411.00
68_L104_Y0.9331.00
110_D114_V0.9301.00
22_G135_P0.9261.00
70_A104_Y0.9261.00
211_V243_T0.9221.00
40_T71_P0.9191.00
162_L166_T0.9141.00
167_V247_S0.9121.00
27_K86_L0.9111.00
237_A263_V0.9101.00
59_N93_A0.9051.00
205_Q209_R0.9031.00
60_T63_V0.8991.00
261_K264_A0.8991.00
261_K265_A0.8981.00
215_L220_R0.8971.00
64_V74_I0.8951.00
53_P56_P0.8871.00
80_V91_A0.8841.00
40_T44_V0.8831.00
159_A264_A0.8751.00
44_V47_A0.8751.00
83_S250_G0.8711.00
208_G240_T0.8691.00
165_T224_M0.8681.00
108_L112_A0.8671.00
231_S235_R0.8611.00
157_A257_R0.8611.00
266_A269_D0.8591.00
208_G211_V0.8451.00
40_T68_L0.8451.00
63_V120_G0.8451.00
206_R209_R0.8441.00
191_S194_T0.8421.00
114_V117_A0.8401.00
184_A214_A0.8351.00
42_I46_G0.8331.00
102_E106_R0.8241.00
11_S158_L0.8231.00
234_A242_V0.8231.00
91_A136_A0.8191.00
48_G51_Y0.8171.00
144_V149_I0.8171.00
59_N120_G0.8161.00
34_V96_A0.8151.00
142_T149_I0.8151.00
148_G151_H0.8131.00
9_A25_L0.8131.00
262_R266_A0.8091.00
117_A133_V0.8081.00
5_V32_V0.8071.00
253_A263_V0.8021.00
72_A100_L0.8001.00
195_L207_V0.7961.00
66_A120_G0.7911.00
7_A136_A0.7901.00
116_A119_Q0.7891.00
59_N63_V0.7881.00
11_S252_V0.7861.00
255_C260_R0.7851.00
97_T116_A0.7821.00
242_V251_V0.7781.00
114_V137_I0.7761.00
265_A268_V0.7761.00
64_V100_L0.7731.00
29_A78_K0.7671.00
114_V134_A0.7661.00
115_R119_Q0.7631.00
226_G230_A0.7631.00
267_L271_F0.7571.00
98_V110_D0.7571.00
44_V52_V0.7571.00
52_V82_P0.7561.00
177_P181_A0.7520.99
198_G210_G0.7490.99
63_V97_T0.7490.99
167_V249_P0.7490.99
196_T200_C0.7470.99
99_A103_L0.7470.99
189_V192_A0.7470.99
52_V55_D0.7460.99
111_D138_L0.7450.99
108_L113_L0.7440.99
98_V137_I0.7400.99
259_D262_R0.7350.99
8_P139_G0.7340.99
178_E181_A0.7330.99
93_A120_G0.7330.99
98_V113_L0.7320.99
135_P144_V0.7300.99
87_G136_A0.7290.99
173_R176_V0.7240.99
50_Q54_T0.7200.99
235_R241_G0.7200.99
26_S29_A0.7160.99
25_L160_V0.7160.99
8_P24_A0.7130.99
239_A242_V0.7120.99
176_V179_S0.7090.99
161_C253_A0.7060.99
167_V224_M0.7050.99
224_M244_I0.7040.99
240_T256_R0.7010.99
263_V266_A0.6990.99
188_T191_S0.6940.99
177_P180_A0.6930.99
34_V103_L0.6920.99
178_E182_M0.6920.99
64_V71_P0.6920.99
260_R264_A0.6900.99
32_V76_I0.6900.99
104_Y107_P0.6790.99
239_A255_C0.6790.99
237_A255_C0.6780.99
5_V95_A0.6770.99
117_A137_I0.6740.99
90_A136_A0.6730.99
230_A251_V0.6730.99
175_V222_R0.6730.99
24_A135_P0.6690.99
28_P80_V0.6670.99
32_V74_I0.6660.99
67_A100_L0.6660.99
24_A136_A0.6650.99
55_D58_E0.6650.99
169_T173_R0.6640.99
162_L165_T0.6560.99
9_A29_A0.6560.99
143_I196_T0.6550.99
61_A67_A0.6550.99
215_L247_S0.6550.99
8_P28_P0.6490.98
63_V67_A0.6450.98
13_N176_V0.6430.98
223_L226_G0.6430.98
114_V118_A0.6410.98
96_A99_A0.6410.98
220_R223_L0.6400.98
153_D156_L0.6390.98
37_A43_T0.6390.98
138_L142_T0.6350.98
172_A175_V0.6350.98
94_A117_A0.6330.98
130_A144_V0.6320.98
195_L199_M0.6250.98
235_R239_A0.6230.98
162_L249_P0.6210.98
86_L160_V0.6200.98
198_G203_D0.6170.98
44_V58_E0.6130.98
60_T64_V0.6100.98
62_G66_A0.6100.98
230_A271_F0.6090.98
174_G178_E0.6070.98
181_A184_A0.6060.98
8_P91_A0.6050.98
67_A116_A0.6010.98
145_R148_G0.5970.97
64_V96_A0.5970.97
121_E173_R0.5960.97
270_G273_S0.5900.97
190_E193_A0.5900.97
208_G235_R0.5870.97
217_T243_T0.5870.97
21_F141_F0.5770.97
40_T72_A0.5770.97
18_F131_D0.5750.97
41_T44_V0.5730.97
136_A139_G0.5730.97
40_T43_T0.5730.97
189_V193_A0.5700.97
194_T197_L0.5700.97
40_T64_V0.5700.97
204_P240_T0.5690.97
134_A137_I0.5670.96
84_S250_G0.5640.96
232_A235_R0.5620.96
220_R224_M0.5610.96
227_Y231_S0.5600.96
32_V91_A0.5590.96
218_P228_E0.5580.96
196_T199_M0.5580.96
91_A139_G0.5580.96
36_R103_L0.5580.96
36_R104_Y0.5580.96
61_A74_I0.5550.96
180_A183_E0.5520.96
267_L270_G0.5500.96
225_D229_A0.5450.96
167_V223_L0.5450.96
161_C271_F0.5450.96
58_E76_I0.5440.96
59_N67_A0.5410.95
257_R260_R0.5400.95
52_V58_E0.5400.95
207_V211_V0.5390.95
269_D273_S0.5390.95
19_D173_R0.5390.95
229_A273_S0.5380.95
102_E105_D0.5380.95
98_V102_E0.5380.95
135_P173_R0.5350.95
55_D59_N0.5350.95
180_A185_V0.5340.95
130_A146_E0.5330.95
21_F192_A0.5310.95
97_T120_G0.5300.95
130_A133_V0.5290.95
7_A91_A0.5250.95
60_T65_A0.5240.95
43_T54_T0.5220.94
52_V59_N0.5220.94
163_P249_P0.5220.94
83_S162_L0.5210.94
173_R177_P0.5210.94
173_R180_A0.5210.94
111_D114_V0.5200.94
41_T46_G0.5200.94
159_A253_A0.5190.94
41_T47_A0.5180.94
233_A267_L0.5170.94
61_A64_V0.5170.94
101_A105_D0.5160.94
262_R265_A0.5160.94
82_P166_T0.5150.94
220_R227_Y0.5150.94
27_K81_R0.5090.94
149_I152_V0.5080.94
76_I92_S0.5070.94
205_Q240_T0.5060.94
22_G173_R0.5060.94
58_E63_V0.5050.93
25_L158_L0.5050.93
112_A116_A0.5050.93
157_A255_C0.5030.93
175_V179_S0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p52A 2 0.9701 100 0.264 Contact Map
4rpfA 2 0.9668 100 0.286 Contact Map
1h72C 2 0.9336 100 0.286 Contact Map
3hulA 4 0.897 100 0.293 Contact Map
3pyfA 1 0.9169 100 0.323 Contact Map
4hacA 2 0.9369 100 0.355 Contact Map
2hfsA 1 0.9402 100 0.377 Contact Map
3k85A 3 0.8605 100 0.382 Contact Map
1kkhA 1 0.9103 100 0.386 Contact Map
1pieA 1 0.9668 100 0.387 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.