GREMLIN Database
Q9HP54 - Uncharacterized protein
UniProt: Q9HP54 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 438 (402)
Sequences: 15646 (12446)
Seq/√Len: 620.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_A254_A3.9821.00
26_R222_E3.7531.00
30_A226_R3.7181.00
34_V223_T3.5061.00
229_A242_T3.4711.00
245_S250_E3.4361.00
14_A258_I3.1651.00
28_F252_V3.0261.00
3_A28_F2.9381.00
34_V213_V2.9251.00
32_A224_G2.7781.00
242_T251_R2.7501.00
427_G431_A2.7421.00
259_V266_L2.7211.00
3_A252_V2.7111.00
7_G34_V2.7071.00
231_Q242_T2.6671.00
206_G210_D2.5871.00
3_A241_V2.5791.00
24_D220_H2.5691.00
225_A243_V2.5431.00
344_S347_E2.5041.00
228_T244_D2.4991.00
226_R244_D2.4951.00
231_Q240_G2.4791.00
207_R210_D2.3791.00
243_V252_V2.3301.00
5_V259_V2.3261.00
260_A407_A2.2671.00
28_F222_E2.2021.00
243_V249_T2.2001.00
213_V217_G2.1991.00
5_V261_A2.1751.00
240_G251_R2.1611.00
141_V149_E2.1511.00
222_E225_A2.1291.00
17_R428_N2.1131.00
222_E250_E2.1131.00
28_F254_A2.1101.00
213_V221_I2.1031.00
40_T47_P2.0171.00
373_T376_N2.0081.00
144_E148_C1.9981.00
10_A260_A1.9971.00
42_E47_P1.9951.00
256_G405_Y1.9681.00
107_L110_T1.9331.00
17_R20_Q1.9121.00
9_I420_L1.9121.00
211_A214_E1.8441.00
33_T39_A1.8301.00
243_V250_E1.8281.00
16_R215_D1.8081.00
349_R371_V1.8051.00
13_S424_I1.7901.00
350_E354_S1.7851.00
298_L301_A1.7801.00
258_I434_I1.7571.00
289_D367_S1.7461.00
142_G145_Q1.7461.00
240_G253_D1.7421.00
357_E362_D1.7371.00
228_T242_T1.6991.00
222_E252_V1.6741.00
225_A245_S1.6651.00
17_R432_D1.6641.00
365_R368_V1.6491.00
346_E350_E1.6301.00
217_G220_H1.5991.00
15_A27_V1.5971.00
20_Q68_E1.5931.00
231_Q251_R1.5891.00
289_D369_N1.5561.00
144_E173_D1.5451.00
3_A26_R1.5401.00
103_P107_L1.5291.00
324_E369_N1.5241.00
106_S110_T1.5161.00
225_A250_E1.4951.00
34_V209_L1.4851.00
215_D219_E1.4841.00
72_G202_D1.4751.00
227_V241_V1.4631.00
19_Q219_E1.4621.00
26_R220_H1.4601.00
261_A266_L1.4581.00
407_A430_A1.4491.00
26_R254_A1.4441.00
148_C157_E1.4431.00
110_T113_L1.4421.00
153_R157_E1.4241.00
34_V221_I1.4221.00
345_D375_R1.4211.00
107_L111_A1.4171.00
37_L409_M1.4161.00
103_P110_T1.4131.00
357_E364_D1.4081.00
4_I15_A1.4071.00
110_T114_A1.4051.00
38_A209_L1.3871.00
141_V145_Q1.3711.00
328_Y332_Y1.3691.00
296_Y300_I1.3671.00
28_F227_V1.3531.00
74_D202_D1.3521.00
205_F420_L1.3501.00
391_V394_Y1.3341.00
103_P106_S1.3271.00
405_Y430_A1.3261.00
26_R252_V1.3211.00
42_E45_G1.3201.00
214_E217_G1.3131.00
11_G260_A1.3121.00
46_D287_S1.3011.00
28_F243_V1.2991.00
16_R20_Q1.2971.00
111_A117_T1.2921.00
19_Q216_V1.2901.00
228_T249_T1.2831.00
100_L103_P1.2821.00
378_R381_P1.2681.00
330_P333_V1.2611.00
216_V221_I1.2571.00
19_Q25_A1.2561.00
368_V371_V1.2521.00
64_D68_E1.2511.00
289_D324_E1.2491.00
245_S249_T1.2441.00
239_T403_G1.2431.00
27_V221_I1.2421.00
42_E206_G1.2401.00
104_H107_L1.2371.00
254_A257_V1.2371.00
381_P384_E1.2371.00
256_G434_I1.2351.00
26_R255_D1.2321.00
7_G27_V1.2241.00
411_S429_E1.2231.00
64_D428_N1.2211.00
284_S373_T1.2201.00
244_D249_T1.2121.00
340_V343_M1.2031.00
430_A433_R1.2021.00
379_T382_V1.1991.00
349_R353_L1.1981.00
10_A426_A1.1961.00
210_D214_E1.1931.00
10_A407_A1.1861.00
288_M353_L1.1841.00
91_H96_P1.1741.00
286_V353_L1.1691.00
101_A107_L1.1681.00
114_A118_Q1.1521.00
384_E390_M1.1431.00
28_F225_A1.1421.00
288_M368_V1.1401.00
17_R427_G1.1401.00
330_P334_Q1.1351.00
24_D255_D1.1341.00
112_R115_M1.1331.00
392_V395_D1.1331.00
411_S426_A1.1301.00
67_E72_G1.1271.00
16_R212_L1.1261.00
101_A108_Y1.1201.00
429_E433_R1.1141.00
103_P108_Y1.1071.00
233_D253_D1.1071.00
328_Y333_V1.1041.00
108_Y111_A1.1001.00
104_H110_T1.1001.00
262_M265_V1.1001.00
171_R174_D1.1001.00
343_M347_E1.1001.00
103_P117_T1.0901.00
23_V26_R1.0871.00
381_P385_R1.0841.00
361_P364_D1.0831.00
351_H354_S1.0721.00
201_L208_L1.0711.00
290_E367_S1.0711.00
270_T274_C1.0681.00
386_G390_M1.0661.00
4_I25_A1.0631.00
328_Y331_K1.0591.00
225_A252_V1.0581.00
213_V223_T1.0501.00
378_R386_G1.0431.00
110_T118_Q1.0431.00
386_G389_D1.0421.00
295_T300_I1.0381.00
63_I67_E1.0371.00
203_G207_R1.0361.00
43_T372_E1.0351.00
23_V255_D1.0341.00
61_T428_N1.0291.00
103_P111_A1.0241.00
230_I257_V1.0221.00
297_W301_A1.0221.00
16_R216_V1.0201.00
7_G223_T1.0201.00
308_A311_E1.0161.00
401_H404_V1.0121.00
354_S358_A1.0061.00
347_E350_E1.0041.00
265_V268_S1.0011.00
311_E314_N0.9991.00
210_D213_V0.9961.00
355_G358_A0.9951.00
106_S109_D0.9921.00
232_R239_T0.9891.00
112_R116_L0.9891.00
41_H50_A0.9841.00
207_R211_A0.9841.00
76_R202_D0.9831.00
18_L431_A0.9831.00
353_L357_E0.9821.00
405_Y433_R0.9771.00
350_E364_D0.9721.00
9_I38_A0.9641.00
64_D67_E0.9621.00
297_W300_I0.9611.00
295_T298_L0.9521.00
405_Y434_I0.9471.00
328_Y334_Q0.9471.00
263_P410_A0.9441.00
209_L213_V0.9411.00
304_A358_A0.9331.00
230_I241_V0.9321.00
102_F110_T0.9301.00
161_E172_M0.9261.00
101_A110_T0.9231.00
428_N432_D0.9211.00
118_Q121_D0.9191.00
15_A216_V0.9181.00
295_T299_N0.9141.00
383_Y387_Y0.9141.00
233_D239_T0.9091.00
105_L110_T0.9061.00
331_K334_Q0.9001.00
230_I259_V0.8981.00
62_I424_I0.8951.00
329_V333_V0.8931.00
291_A294_D0.8911.00
326_L329_V0.8911.00
408_G426_A0.8901.00
65_R69_L0.8901.00
89_T155_V0.8881.00
368_V376_N0.8881.00
16_R68_E0.8831.00
80_G83_A0.8821.00
17_R68_E0.8781.00
14_A427_G0.8781.00
378_R382_V0.8771.00
227_V243_V0.8771.00
109_D113_L0.8751.00
388_L391_V0.8731.00
111_A114_A0.8721.00
347_E351_H0.8701.00
17_R21_H0.8691.00
357_E365_R0.8661.00
271_G274_C0.8661.00
233_D240_G0.8651.00
259_V404_V0.8651.00
383_Y389_D0.8641.00
31_S39_A0.8631.00
73_D77_W0.8631.00
10_A423_G0.8531.00
232_R403_G0.8511.00
37_L51_F0.8501.00
146_F150_H0.8501.00
108_Y117_T0.8451.00
79_I82_N0.8401.00
105_L109_D0.8371.00
13_S427_G0.8371.00
148_C153_R0.8361.00
349_R352_W0.8351.00
232_R401_H0.8341.00
146_F177_A0.8321.00
100_L104_H0.8321.00
296_Y299_N0.8291.00
287_S370_W0.8291.00
40_T206_G0.8271.00
113_L117_T0.8231.00
256_G403_G0.8231.00
66_I71_L0.8201.00
103_P113_L0.8191.00
384_E388_L0.8171.00
115_M119_E0.8141.00
20_Q215_D0.8131.00
215_D218_R0.8121.00
141_V146_F0.8081.00
100_L107_L0.8061.00
100_L110_T0.8051.00
111_A118_Q0.8021.00
116_L119_E0.8011.00
113_L116_L0.8001.00
261_A269_L0.7981.00
107_L114_A0.7981.00
384_E389_D0.7941.00
391_V395_D0.7941.00
9_I423_G0.7941.00
59_E421_N0.7941.00
380_A383_Y0.7941.00
43_T370_W0.7931.00
66_I69_L0.7921.00
228_T245_S0.7911.00
46_D321_Y0.7901.00
354_S357_E0.7891.00
98_E101_A0.7891.00
356_I363_F0.7881.00
307_G312_H0.7871.00
384_E387_Y0.7841.00
382_V386_G0.7841.00
107_L118_Q0.7811.00
13_S17_R0.7811.00
305_P355_G0.7771.00
102_F105_L0.7761.00
102_F106_S0.7761.00
168_F175_V0.7751.00
57_A60_E0.7731.00
9_I13_S0.7721.00
73_D76_R0.7681.00
423_G427_G0.7631.00
114_A117_T0.7621.00
153_R156_Y0.7621.00
240_G243_V0.7601.00
101_A104_H0.7601.00
154_G158_Q0.7591.00
239_T257_V0.7591.00
354_S364_D0.7581.00
65_R424_I0.7541.00
379_T384_E0.7521.00
327_L331_K0.7511.00
385_R389_D0.7511.00
380_A384_E0.7491.00
113_L120_L0.7471.00
271_G275_D0.7451.00
241_V257_V0.7441.00
387_Y390_M0.7421.00
82_N88_G0.7411.00
104_H108_Y0.7411.00
356_I360_F0.7401.00
407_A427_G0.7391.00
383_Y386_G0.7361.00
101_A106_S0.7351.00
263_P267_E0.7331.00
372_E376_N0.7301.00
346_E349_R0.7301.00
286_V368_V0.7281.00
9_I209_L0.7281.00
49_E205_F0.7271.00
22_G25_A0.7261.00
12_L209_L0.7251.00
19_Q220_H0.7251.00
320_R324_E0.7241.00
103_P114_A0.7221.00
104_H111_A0.7201.00
38_A52_Y0.7161.00
331_K352_W0.7161.00
369_N373_T0.7151.00
353_L368_V0.7141.00
326_L332_Y0.7121.00
16_R219_E0.7111.00
172_M175_V0.7091.00
5_V227_V0.7081.00
116_L120_L0.7071.00
257_V403_G0.7061.00
430_A434_I0.7051.00
169_G281_T0.7051.00
28_F241_V0.7051.00
83_A86_V0.7031.00
201_L207_R0.7011.00
166_A169_G0.6991.00
348_V373_T0.6981.00
165_E171_R0.6971.00
378_R384_E0.6971.00
108_Y112_R0.6961.00
151_T160_F0.6951.00
111_A115_M0.6941.00
425_V429_E0.6941.00
157_E161_E0.6931.00
20_Q219_E0.6931.00
308_A312_H0.6931.00
21_H432_D0.6901.00
4_I11_G0.6901.00
12_L216_V0.6891.00
228_T231_Q0.6881.00
85_Y90_V0.6871.00
329_V332_Y0.6861.00
85_Y89_T0.6851.00
350_E371_V0.6841.00
387_Y391_V0.6831.00
282_V285_I0.6811.00
373_T377_P0.6811.00
110_T116_L0.6801.00
355_G359_L0.6801.00
349_R373_T0.6801.00
29_E223_T0.6791.00
110_T115_M0.6791.00
105_L111_A0.6781.00
383_Y388_L0.6771.00
110_T117_T0.6761.00
67_E70_G0.6751.00
256_G259_V0.6751.00
306_F312_H0.6741.00
154_G157_E0.6731.00
69_L212_L0.6731.00
41_H372_E0.6721.00
267_E274_C0.6711.00
100_L106_S0.6691.00
99_I107_L0.6691.00
232_R240_G0.6681.00
310_I315_F0.6591.00
79_I84_Y0.6591.00
386_G392_V0.6581.00
296_Y301_A0.6581.00
61_T425_V0.6531.00
105_L108_Y0.6531.00
63_I199_G0.6511.00
13_S212_L0.6511.00
371_V376_N0.6491.00
9_I424_I0.6481.00
46_D324_E0.6471.00
108_Y113_L0.6471.00
108_Y115_M0.6461.00
52_Y56_S0.6461.00
287_S369_N0.6451.00
307_G311_E0.6431.00
239_T243_V0.6421.00
228_T243_V0.6421.00
265_V269_L0.6411.00
306_F309_L0.6411.00
214_E218_R0.6401.00
148_C173_D0.6391.00
115_M121_D0.6381.00
106_S117_T0.6371.00
99_I103_P0.6361.00
44_A370_W0.6361.00
19_Q217_G0.6351.00
258_I430_A0.6351.00
66_I201_L0.6351.00
84_Y90_V0.6351.00
399_E406_Y0.6331.00
100_L118_Q0.6331.00
357_E363_F0.6331.00
108_Y119_E0.6311.00
108_Y114_A0.6311.00
431_A434_I0.6291.00
305_P308_A0.6281.00
369_N372_E0.6271.00
388_L392_V0.6251.00
72_G75_L0.6241.00
370_W376_N0.6241.00
4_I258_I0.6241.00
378_R389_D0.6231.00
143_V180_L0.6211.00
264_T268_S0.6201.00
282_V375_R0.6201.00
306_F311_E0.6201.00
259_V406_Y0.6191.00
106_S113_L0.6181.00
378_R383_Y0.6171.00
389_D392_V0.6171.00
382_V390_M0.6131.00
109_D117_T0.6131.00
84_Y88_G0.6121.00
101_A117_T0.6121.00
211_A215_D0.6121.00
52_Y205_F0.6111.00
54_H167_K0.6111.00
49_E54_H0.6101.00
341_W345_D0.6071.00
82_N85_Y0.6071.00
62_I420_L0.6071.00
4_I8_G0.6051.00
326_L330_P0.6021.00
233_D236_G0.6011.00
81_K86_V0.6001.00
390_M393_P0.6001.00
288_M292_L0.6001.00
12_L27_V0.5991.00
103_P118_Q0.5981.00
115_M118_Q0.5971.00
368_V374_N0.5971.00
114_A120_L0.5961.00
390_M394_Y0.5961.00
107_L115_M0.5961.00
299_N302_D0.5951.00
14_A430_A0.5941.00
23_V256_G0.5931.00
106_S118_Q0.5931.00
288_M293_T0.5911.00
327_L330_P0.5901.00
329_V334_Q0.5891.00
79_I83_A0.5891.00
106_S114_A0.5881.00
261_A265_V0.5881.00
258_I405_Y0.5861.00
158_Q162_P0.5821.00
107_L121_D0.5821.00
145_Q148_C0.5791.00
170_S174_D0.5781.00
326_L334_Q0.5781.00
382_V388_L0.5771.00
399_E402_D0.5751.00
109_D116_L0.5741.00
388_L394_Y0.5731.00
216_V219_E0.5731.00
381_P386_G0.5731.00
25_A216_V0.5711.00
304_A355_G0.5711.00
52_Y420_L0.5711.00
295_T301_A0.5701.00
386_G394_Y0.5701.00
104_H117_T0.5691.00
107_L113_L0.5681.00
139_E142_G0.5681.00
340_V344_S0.5671.00
297_W302_D0.5671.00
101_A105_L0.5671.00
99_I104_H0.5661.00
38_A420_L0.5651.00
103_P121_D0.5641.00
33_T206_G0.5621.00
134_D137_D0.5621.00
398_S433_R0.5621.00
372_E375_R0.5621.00
345_D349_R0.5611.00
389_D394_Y0.5611.00
16_R69_L0.5591.00
272_Y276_I0.5591.00
286_V371_V0.5581.00
81_K85_Y0.5571.00
385_R390_M0.5561.00
8_G11_G0.5541.00
163_L166_A0.5541.00
231_Q239_T0.5541.00
3_A257_V0.5521.00
353_L371_V0.5521.00
213_V216_V0.5511.00
103_P120_L0.5491.00
103_P109_D0.5481.00
242_T249_T0.5481.00
63_I73_D0.5471.00
351_H355_G0.5471.00
110_T121_D0.5450.99
81_K84_Y0.5450.99
367_S376_N0.5450.99
232_R404_V0.5440.99
381_P389_D0.5440.99
382_V385_R0.5430.99
429_E432_D0.5420.99
262_M410_A0.5420.99
38_A205_F0.5410.99
379_T386_G0.5410.99
104_H109_D0.5400.99
3_A255_D0.5400.99
52_Y421_N0.5400.99
350_E353_L0.5390.99
360_F363_F0.5380.99
113_L118_Q0.5360.99
63_I66_I0.5360.99
312_H315_F0.5360.99
80_G84_Y0.5310.99
255_D403_G0.5300.99
200_Y205_F0.5280.99
83_A90_V0.5270.99
313_T325_H0.5270.99
56_S198_L0.5270.99
101_A111_A0.5220.99
102_F108_Y0.5210.99
79_I85_Y0.5210.99
43_T48_I0.5200.99
345_D373_T0.5170.99
286_V329_V0.5160.99
104_H113_L0.5160.99
368_V372_E0.5150.99
320_R323_G0.5150.99
296_Y302_D0.5130.99
381_P387_Y0.5120.99
133_E136_T0.5110.99
86_V89_T0.5100.99
101_A109_D0.5100.99
113_L119_E0.5090.99
40_T49_E0.5090.99
32_A39_A0.5070.99
311_E360_F0.5070.99
7_G29_E0.5060.99
49_E206_G0.5050.99
162_P165_E0.5050.99
386_G391_V0.5050.99
329_V356_I0.5050.99
7_G12_L0.5050.99
266_L269_L0.5040.99
17_R65_R0.5040.99
7_G11_G0.5040.99
143_V147_L0.5030.99
282_V373_T0.5030.99
100_L111_A0.5030.99
27_V216_V0.5020.99
378_R385_R0.5000.99
367_S370_W0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i59A 1 0.9566 100 0.323 Contact Map
2yg5A 2 0.9566 100 0.328 Contact Map
1sezA 3 0.9429 100 0.329 Contact Map
3i6dA 1 0.9018 100 0.329 Contact Map
2ivdA 1 0.9452 100 0.337 Contact Map
1s3eA 2 0.9589 100 0.339 Contact Map
3lovA 1 0.9475 100 0.351 Contact Map
4dsgA 1 0.9361 100 0.372 Contact Map
3nksA 2 0.9384 100 0.382 Contact Map
2vvmA 2 0.9406 100 0.382 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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