GREMLIN Database
Q9HP50 - Small heat shock protein
UniProt: Q9HP50 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (134)
Sequences: 2279 (1878)
Seq/√Len: 162.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_D143_E4.6761.00
81_I102_V3.5331.00
104_A129_L2.7061.00
87_S150_D2.6741.00
68_V81_I2.5441.00
73_S76_E2.5181.00
72_E159_K2.4541.00
76_E156_T2.3921.00
92_T167_E2.3631.00
139_I157_V2.2621.00
105_E128_R2.1591.00
82_E152_V2.0771.00
43_Q47_D2.0511.00
83_V91_I2.0401.00
124_E131_R1.9711.00
68_V133_I1.9481.00
92_T103_T1.8561.00
69_D125_C1.8261.00
91_I148_H1.7961.00
78_V154_H1.7871.00
161_E164_R1.7841.00
73_S78_V1.7331.00
66_P129_L1.7131.00
87_S90_E1.6841.00
35_Q38_Q1.6191.00
45_V48_G1.5631.00
72_E121_L1.5381.00
101_Y132_A1.5141.00
100_L155_V1.4861.00
88_K150_D1.4851.00
143_E158_P1.4751.00
103_T130_E1.4671.00
71_I78_V1.4611.00
83_V148_H1.4571.00
86_F104_A1.3981.00
77_V137_N1.3751.00
95_A135_L1.3591.00
100_L144_A1.3381.00
43_Q46_Q1.3351.00
82_E125_C1.3181.00
40_P43_Q1.3171.00
44_P47_D1.3161.00
69_D123_R1.2881.00
43_Q49_A1.2681.00
88_K92_T1.2521.00
80_M154_H1.2421.00
108_N126_P1.2421.00
69_D80_M1.2381.00
68_V102_V1.2231.00
104_A127_D1.2121.00
77_V144_A1.1881.00
70_V79_V1.1691.00
95_A144_A1.1351.00
99_N132_A1.1301.00
47_D50_S1.1231.00
82_E106_R1.1231.00
103_T128_R1.1161.00
140_D160_D1.1101.00
138_Y160_D1.1051.00
66_P104_A1.0971.00
144_A168_I1.0760.99
77_V138_Y1.0520.99
70_V77_V1.0370.99
48_G51_Q1.0100.99
38_Q41_Q1.0100.99
95_A100_L0.9930.99
98_S141_P0.9870.99
41_Q45_V0.9800.99
125_C152_V0.9780.99
94_Q101_Y0.9690.99
36_Q40_P0.9680.99
79_V157_V0.9620.99
141_P158_P0.9610.99
136_P139_I0.9580.99
79_V123_R0.9320.98
138_Y159_K0.9270.98
110_P115_E0.9250.98
94_Q165_Q0.9240.98
99_N134_T0.9170.98
38_Q45_V0.9110.98
46_Q50_S0.8980.98
65_T69_D0.8900.98
46_Q49_A0.8840.98
79_V133_I0.8770.98
137_N160_D0.8760.98
90_E107_S0.8700.98
64_A104_A0.8690.98
135_L157_V0.8580.97
147_E156_T0.8580.97
38_Q43_Q0.8560.97
37_P40_P0.8510.97
91_I125_C0.8430.97
87_S149_V0.8360.97
115_E118_D0.8280.97
75_A164_R0.8260.97
108_N123_R0.8250.97
77_V159_K0.8150.96
71_I80_M0.8140.96
95_A139_I0.8110.96
38_Q47_D0.8040.96
140_D161_E0.8020.96
87_S148_H0.7970.96
69_D82_E0.7970.96
122_L166_H0.7890.96
101_Y130_E0.7880.96
145_T156_T0.7820.96
39_M43_Q0.7750.95
34_R38_Q0.7740.95
66_P83_V0.7700.95
77_V121_L0.7640.95
100_L168_I0.7600.95
114_I121_L0.7550.95
120_V123_R0.7510.94
95_A141_P0.7470.94
106_R127_D0.7450.94
42_Q47_D0.7450.94
163_E169_A0.7340.94
76_E159_K0.7270.93
94_Q167_E0.7230.93
120_V124_E0.7130.93
34_R37_P0.7080.93
42_Q50_S0.7030.92
42_Q45_V0.6960.92
52_R55_A0.6870.91
115_E119_N0.6860.91
86_F125_C0.6830.91
86_F106_R0.6810.91
44_P48_G0.6790.91
36_Q39_M0.6770.91
98_S137_N0.6670.90
80_M152_V0.6610.90
124_E133_I0.6610.90
88_K169_A0.6590.90
91_I155_V0.6540.89
49_A52_R0.6540.89
80_M125_C0.6530.89
107_S166_H0.6520.89
96_D99_N0.6480.89
45_V52_R0.6470.89
96_D100_L0.6420.88
92_T169_A0.6400.88
83_V104_A0.6330.88
39_M42_Q0.6330.88
66_P124_E0.6320.88
36_Q46_Q0.6300.87
144_A166_H0.6300.87
66_P82_E0.6280.87
127_D148_H0.6270.87
100_L138_Y0.6140.86
129_L144_A0.6110.86
72_E137_N0.6110.86
58_D62_P0.6110.86
144_A158_P0.6100.86
71_I118_D0.6090.86
93_V146_A0.6030.85
75_A156_T0.6020.85
80_M109_D0.6010.85
71_I77_V0.5970.84
78_V156_T0.5960.84
135_L139_I0.5960.84
37_P41_Q0.5880.84
121_L132_A0.5840.83
77_V149_V0.5830.83
81_I148_H0.5790.83
70_V133_I0.5780.83
42_Q46_Q0.5740.82
109_D116_G0.5730.82
40_P44_P0.5710.82
55_A60_Q0.5690.82
35_Q39_M0.5560.80
54_A58_D0.5520.80
137_N169_A0.5500.79
149_V154_H0.5490.79
78_V81_I0.5460.79
45_V49_A0.5460.79
91_I126_P0.5420.78
94_Q103_T0.5390.78
59_Q63_A0.5340.77
90_E118_D0.5330.77
44_P53_Q0.5310.77
50_S118_D0.5310.77
40_P47_D0.5280.77
106_R124_E0.5260.76
96_D165_Q0.5240.76
41_Q44_P0.5240.76
145_T149_V0.5230.76
86_F127_D0.5220.76
39_M49_A0.5150.75
124_E127_D0.5140.75
83_V96_D0.5130.74
71_I120_V0.5110.74
79_V100_L0.5090.74
69_D122_L0.5080.74
43_Q50_S0.5080.74
71_I76_E0.5070.74
86_F129_L0.5050.73
58_D79_V0.5050.73
41_Q52_R0.5020.73
86_F91_I0.5020.73
160_D164_R0.5010.73
47_D51_Q0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eldA 4 0.655 100 0.292 Contact Map
3w1zA 7 0.7895 100 0.336 Contact Map
3aabA 2 0.6608 100 0.359 Contact Map
1gmeA 6 0.8246 100 0.36 Contact Map
3glaA 2 0.5789 99.9 0.42 Contact Map
4ydzA 4 0.6901 99.9 0.439 Contact Map
4jutA 4 0.5205 99.9 0.448 Contact Map
2bolA 2 0.924 99.9 0.45 Contact Map
2klrA 2 0.4737 99.9 0.454 Contact Map
3l1eA 2 0.5731 99.9 0.454 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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