GREMLIN Database
Q9HP48 - NADH oxidase
UniProt: Q9HP48 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (369)
Sequences: 28715 (19797)
Seq/√Len: 1030.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D79_L4.1771.00
147_V232_A4.1741.00
4_S29_D3.3541.00
145_T168_D3.3081.00
262_D266_R3.1331.00
170_K203_V3.1221.00
88_H271_D3.0801.00
89_T97_E3.0041.00
192_H196_R2.8641.00
168_D201_E2.7091.00
372_G384_Y2.7091.00
221_A229_R2.6951.00
210_H223_V2.6681.00
212_E223_V2.6631.00
84_N87_A2.6281.00
203_V228_V2.6071.00
254_T260_H2.5721.00
17_A104_L2.5181.00
112_N242_D2.4871.00
85_P269_V2.4751.00
31_T75_Q2.3411.00
117_E210_H2.3331.00
174_R207_G2.3151.00
102_K271_D2.3081.00
4_S31_T2.3031.00
100_Y103_L2.2971.00
33_L98_I2.2531.00
110_T244_N2.2381.00
223_V229_R2.1281.00
4_S101_D2.1091.00
212_E221_A2.0841.00
176_N205_E2.0471.00
29_D73_D2.0381.00
110_T246_E2.0331.00
5_Y21_I2.0081.00
91_E97_E1.9991.00
147_V172_L1.9711.00
13_A275_A1.9601.00
346_G365_K1.9581.00
147_V222_A1.9211.00
170_K201_E1.9181.00
6_V98_I1.8931.00
6_V33_L1.8761.00
206_S226_N1.8631.00
368_Q391_E1.8551.00
110_T242_D1.8371.00
145_T233_D1.8341.00
221_A231_D1.8171.00
104_L309_M1.8051.00
209_D223_V1.7881.00
273_Y308_T1.7721.00
177_R188_A1.7631.00
131_E134_R1.7601.00
207_G225_G1.7591.00
102_K273_Y1.7341.00
145_T170_K1.6971.00
89_T99_E1.6901.00
305_A309_M1.6801.00
82_R91_E1.6651.00
121_A213_V1.6461.00
185_E338_L1.6401.00
146_G162_C1.6291.00
337_F341_G1.6271.00
6_V90_V1.6181.00
203_V206_S1.6121.00
107_A278_I1.6081.00
266_R270_D1.5961.00
185_E189_E1.5811.00
254_T268_E1.5801.00
163_G168_D1.5551.00
7_I18_A1.5521.00
156_I171_Y1.5341.00
125_H139_H1.5121.00
85_P272_I1.5081.00
194_G197_E1.5021.00
306_G310_L1.4871.00
163_G200_V1.4751.00
20_A307_R1.4751.00
146_G167_V1.4741.00
374_L379_A1.4651.00
212_E229_R1.4581.00
102_K309_M1.4581.00
213_V220_A1.4561.00
82_R250_D1.4531.00
6_V31_T1.4521.00
10_D34_T1.4481.00
81_T91_E1.4471.00
302_G306_G1.4291.00
79_L93_H1.4161.00
6_V100_Y1.4111.00
104_L275_A1.4111.00
5_Y28_A1.3961.00
193_E196_R1.3941.00
192_H204_F1.3901.00
362_L372_G1.3761.00
335_F343_P1.3711.00
146_G234_F1.3691.00
206_S225_G1.3581.00
151_A173_M1.3491.00
24_E307_R1.3251.00
264_Y308_T1.3241.00
31_T98_I1.3211.00
172_L230_H1.3161.00
64_P68_D1.3151.00
164_G198_K1.3141.00
177_R185_E1.3111.00
173_M204_F1.3101.00
304_L308_T1.3061.00
206_S228_V1.3001.00
130_F134_R1.2981.00
192_H202_P1.2941.00
84_N89_T1.2931.00
259_V274_A1.2901.00
194_G198_K1.2891.00
66_W70_R1.2851.00
5_Y104_L1.2751.00
338_L342_F1.2601.00
144_D233_D1.2531.00
193_E197_E1.2511.00
336_P339_S1.2501.00
142_A167_V1.2441.00
8_I80_V1.2411.00
109_G241_L1.2401.00
13_A298_A1.2341.00
124_V211_F1.2311.00
75_Q98_I1.2291.00
151_A178_W1.2111.00
33_L80_V1.2081.00
92_T98_I1.2071.00
145_T231_D1.1931.00
127_F130_F1.1901.00
265_M305_A1.1891.00
128_W131_E1.1791.00
189_E192_H1.1761.00
87_A97_E1.1711.00
335_F340_F1.1701.00
184_S361_R1.1631.00
209_D225_G1.1631.00
224_D230_H1.1581.00
82_R88_H1.1571.00
129_T132_D1.1551.00
211_F235_A1.1491.00
65_E69_E1.1421.00
265_M279_T1.1351.00
203_V230_H1.1341.00
8_I107_A1.1321.00
33_L75_Q1.1261.00
197_E357_N1.1251.00
24_E310_L1.1221.00
8_I105_V1.1171.00
105_V278_I1.1161.00
20_A24_E1.1131.00
134_R137_R1.1061.00
84_N88_H1.0961.00
347_D363_A1.0931.00
246_E249_Q1.0931.00
106_A275_A1.0921.00
307_R312_D1.0921.00
266_R271_D1.0891.00
275_A305_A1.0881.00
59_I62_H1.0851.00
269_V272_I1.0841.00
329_S380_P1.0841.00
33_L92_T1.0841.00
206_S224_D1.0741.00
56_E60_S1.0671.00
149_V235_A1.0661.00
81_T93_H1.0661.00
45_L48_E1.0641.00
178_W204_F1.0631.00
62_H66_W1.0611.00
190_I375_I1.0591.00
63_D66_W1.0501.00
31_T73_D1.0451.00
123_G213_V1.0431.00
339_S342_F1.0351.00
360_R374_L1.0351.00
339_S343_P1.0291.00
177_R192_H1.0261.00
92_T96_T1.0241.00
88_H92_T1.0221.00
260_H268_E1.0091.00
149_V237_V1.0011.00
345_I370_V0.9931.00
190_I194_G0.9921.00
103_L272_I0.9811.00
63_D67_Y0.9791.00
156_I326_S0.9781.00
82_R85_P0.9721.00
305_A308_T0.9701.00
362_L384_Y0.9681.00
246_E250_D0.9631.00
335_F339_S0.9631.00
17_A275_A0.9631.00
20_A303_A0.9621.00
77_N94_E0.9611.00
256_E260_H0.9611.00
255_I260_H0.9591.00
261_V274_A0.9551.00
144_D168_D0.9551.00
75_Q96_T0.9541.00
17_A305_A0.9531.00
172_L224_D0.9511.00
22_H72_I0.9511.00
57_A61_I0.9501.00
147_V230_H0.9461.00
163_G198_K0.9441.00
64_P76_L0.9431.00
4_S99_E0.9411.00
196_R201_E0.9391.00
172_L203_V0.9381.00
217_G220_A0.9361.00
274_A278_I0.9361.00
189_E193_E0.9361.00
18_A72_I0.9351.00
132_D135_R0.9341.00
201_E228_V0.9311.00
337_F361_R0.9281.00
267_T274_A0.9261.00
126_H129_T0.9131.00
58_P62_H0.9111.00
17_A302_G0.9101.00
190_I193_E0.9081.00
173_M180_R0.9081.00
245_V255_I0.9071.00
21_I306_G0.8971.00
125_H234_F0.8881.00
261_V279_T0.8871.00
130_F133_A0.8851.00
340_F347_D0.8851.00
60_S64_P0.8831.00
259_V278_I0.8831.00
14_G18_A0.8821.00
257_N280_Q0.8821.00
7_I14_G0.8821.00
82_R86_D0.8771.00
338_L341_G0.8761.00
264_Y313_S0.8761.00
383_K386_Q0.8731.00
183_L322_F0.8701.00
20_A23_E0.8681.00
148_V155_G0.8681.00
60_S63_D0.8671.00
89_T92_T0.8661.00
115_P119_A0.8631.00
266_R308_T0.8611.00
156_I195_L0.8581.00
67_Y70_R0.8551.00
28_A101_D0.8541.00
84_N91_E0.8521.00
80_V88_H0.8501.00
273_Y309_M0.8501.00
266_R273_Y0.8481.00
159_A171_Y0.8481.00
145_T167_V0.8461.00
19_E23_E0.8421.00
175_G180_R0.8391.00
127_F131_E0.8391.00
56_E59_I0.8381.00
221_A224_D0.8371.00
386_Q390_E0.8371.00
353_S356_D0.8351.00
25_A28_A0.8321.00
113_D126_H0.8301.00
37_G77_N0.8281.00
131_E135_R0.8281.00
149_V208_V0.8221.00
187_G359_W0.8221.00
176_N185_E0.8211.00
17_A306_G0.8181.00
172_L206_S0.8171.00
128_W132_D0.8161.00
137_R165_Q0.8151.00
80_V84_N0.8141.00
273_Y305_A0.8131.00
7_I17_A0.8131.00
173_M176_N0.8091.00
256_E280_Q0.8081.00
20_A306_G0.8071.00
104_L305_A0.8071.00
5_Y309_M0.8041.00
61_I65_E0.8041.00
21_I309_M0.8041.00
133_A137_R0.8021.00
340_F345_I0.8021.00
127_F133_A0.8001.00
347_D351_E0.8001.00
248_L251_T0.7941.00
322_F332_H0.7931.00
55_P58_P0.7931.00
160_A164_G0.7851.00
251_T269_V0.7841.00
232_A235_A0.7831.00
348_E351_E0.7821.00
220_A223_V0.7811.00
143_A167_V0.7801.00
36_E47_K0.7791.00
183_L332_H0.7781.00
265_M304_L0.7781.00
112_N239_I0.7741.00
378_L381_Q0.7731.00
187_G373_V0.7731.00
341_G347_D0.7711.00
82_R103_L0.7691.00
178_W192_H0.7691.00
62_H67_Y0.7691.00
186_A351_E0.7661.00
148_V236_G0.7651.00
114_L237_V0.7631.00
194_G357_N0.7621.00
266_R269_V0.7611.00
251_T255_I0.7601.00
65_E68_D0.7571.00
58_P61_I0.7571.00
49_Y134_R0.7561.00
171_Y202_P0.7551.00
125_H129_T0.7491.00
341_G346_G0.7441.00
297_S301_Q0.7441.00
62_H65_E0.7421.00
149_V239_I0.7411.00
10_D32_V0.7371.00
37_G76_L0.7361.00
34_T74_I0.7361.00
56_E62_H0.7361.00
263_E315_H0.7361.00
300_Q303_A0.7351.00
158_L236_G0.7331.00
112_N115_P0.7321.00
6_V103_L0.7311.00
85_P88_H0.7301.00
347_D350_C0.7291.00
100_Y271_D0.7271.00
303_A307_R0.7271.00
116_V119_A0.7261.00
118_N210_H0.7251.00
135_R138_E0.7231.00
24_E312_D0.7221.00
155_G173_M0.7161.00
137_R141_E0.7161.00
16_S299_K0.7151.00
125_H128_W0.7141.00
83_I97_E0.7051.00
39_T74_I0.7041.00
56_E63_D0.7041.00
319_I388_I0.7021.00
21_I28_A0.6981.00
348_E367_G0.6961.00
80_V90_V0.6941.00
177_R189_E0.6921.00
21_I30_I0.6921.00
351_E359_W0.6911.00
85_P100_Y0.6911.00
154_L238_A0.6901.00
195_L200_V0.6901.00
113_D119_A0.6891.00
349_T363_A0.6891.00
337_F349_T0.6871.00
35_D244_N0.6861.00
140_A162_C0.6851.00
4_S28_A0.6851.00
186_A361_R0.6831.00
340_F363_A0.6831.00
329_S334_D0.6821.00
114_L119_A0.6821.00
21_I310_L0.6821.00
56_E134_R0.6811.00
369_L384_Y0.6811.00
146_G236_G0.6801.00
19_E70_R0.6801.00
385_K389_K0.6791.00
211_F222_A0.6781.00
265_M308_T0.6781.00
344_T347_D0.6781.00
28_A310_L0.6771.00
59_I63_D0.6761.00
136_I234_F0.6761.00
372_G388_I0.6751.00
307_R311_A0.6741.00
29_D101_D0.6731.00
117_E120_D0.6731.00
145_T232_A0.6721.00
345_I363_A0.6721.00
253_A259_V0.6711.00
184_S373_V0.6691.00
224_D228_V0.6671.00
134_R138_E0.6661.00
170_K232_A0.6651.00
178_W188_A0.6651.00
48_E51_K0.6631.00
325_V328_Y0.6631.00
369_L388_I0.6631.00
125_H130_F0.6621.00
158_L161_I0.6611.00
248_L253_A0.6601.00
159_A200_V0.6601.00
58_P63_D0.6601.00
57_A60_S0.6581.00
14_G106_A0.6581.00
119_A237_V0.6581.00
212_E220_A0.6571.00
209_D227_G0.6561.00
22_H71_D0.6561.00
16_S302_G0.6551.00
67_Y72_I0.6531.00
128_W134_R0.6531.00
133_A136_I0.6521.00
334_D339_S0.6511.00
85_P271_D0.6501.00
38_E131_E0.6501.00
28_A309_M0.6491.00
77_N93_H0.6471.00
148_V159_A0.6471.00
259_V267_T0.6461.00
267_T272_I0.6451.00
86_D269_V0.6441.00
113_D237_V0.6431.00
160_A198_K0.6421.00
14_G32_V0.6421.00
92_T95_G0.6411.00
80_V83_I0.6351.00
187_G375_I0.6341.00
191_I375_I0.6341.00
245_V249_Q0.6331.00
275_A302_G0.6311.00
170_K230_H0.6291.00
330_I375_I0.6281.00
364_F369_L0.6251.00
188_A192_H0.6231.00
208_V222_A0.6221.00
362_L369_L0.6221.00
4_S98_I0.6211.00
177_R338_L0.6211.00
81_T84_N0.6211.00
333_F388_I0.6171.00
178_W202_P0.6171.00
311_A314_G0.6151.00
13_A106_A0.6141.00
195_L202_P0.6131.00
261_V265_M0.6121.00
128_W133_A0.6111.00
62_H70_R0.6101.00
260_H280_Q0.6101.00
255_I259_V0.6091.00
253_A269_V0.6081.00
129_T133_A0.6071.00
32_V67_Y0.6071.00
28_A102_K0.6061.00
16_S20_A0.6061.00
279_T301_Q0.6031.00
274_A279_T0.6021.00
46_I49_Y0.6011.00
280_Q283_D0.5991.00
348_E364_F0.5991.00
337_F363_A0.5991.00
251_T272_I0.5991.00
66_W69_E0.5991.00
18_A32_V0.5981.00
384_Y388_I0.5971.00
144_D167_V0.5961.00
220_A224_D0.5931.00
323_R380_P0.5911.00
174_R180_R0.5901.00
86_D271_D0.5901.00
186_A189_E0.5891.00
60_S67_Y0.5881.00
159_A169_A0.5881.00
364_F367_G0.5871.00
24_E306_G0.5841.00
44_I49_Y0.5831.00
16_S303_A0.5821.00
277_D298_A0.5821.00
61_I64_P0.5791.00
154_L157_D0.5781.00
56_E67_Y0.5781.00
211_F237_V0.5771.00
337_F347_D0.5761.00
366_D391_E0.5751.00
48_E53_K0.5731.00
83_I105_V0.5731.00
263_E282_W0.5721.00
100_Y269_V0.5701.00
194_G375_I0.5701.00
61_I66_W0.5661.00
316_D389_K0.5631.00
245_V278_I0.5611.00
124_V235_A0.5611.00
203_V224_D0.5611.00
160_A195_L0.5571.00
10_D39_T0.5561.00
139_H143_A0.5551.00
64_P67_Y0.5551.00
316_D319_I0.5531.00
82_R87_A0.5531.00
126_H132_D0.5531.00
22_H30_I0.5521.00
307_R314_G0.5501.00
12_I295_W0.5501.00
153_L324_W0.5491.00
128_W136_I0.5471.00
249_Q255_I0.5461.00
155_G238_A0.5431.00
224_D227_G0.5421.00
161_I165_Q0.5411.00
191_I330_I0.5401.00
252_D269_V0.5391.00
19_E66_W0.5391.00
107_A247_I0.5381.00
127_F132_D0.5371.00
356_D377_N0.5361.00
253_A267_T0.5361.00
116_V208_V0.5351.00
252_D255_I0.5341.00
87_A99_E0.5291.00
179_W191_I0.5281.00
143_A233_D0.5261.00
111_P126_H0.5261.00
156_I202_P0.5251.00
17_A309_M0.5251.00
73_D76_L0.5251.00
17_A21_I0.5241.00
355_G377_N0.5241.00
59_I66_W0.5231.00
156_I178_W0.5231.00
12_I16_S0.5231.00
30_I72_I0.5231.00
139_H234_F0.5221.00
127_F134_R0.5201.00
118_N121_A0.5171.00
85_P251_T0.5161.00
162_C167_V0.5161.00
196_R202_P0.5161.00
122_D213_V0.5161.00
321_P328_Y0.5151.00
308_T314_G0.5141.00
275_A309_M0.5131.00
15_S32_V0.5121.00
85_P252_D0.5111.00
185_E188_A0.5111.00
93_H96_T0.5091.00
113_D120_D0.5091.00
351_E361_R0.5071.00
336_P373_V0.5061.00
223_V227_G0.5051.00
263_E281_Y0.5041.00
5_Y17_A0.5031.00
253_A268_E0.5031.00
331_T379_A0.5021.00
213_V217_G0.5021.00
220_A231_D0.5021.00
340_F343_P0.5011.00
350_C364_F0.5001.00
135_R139_H0.5001.00
138_E141_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iwaA 2 0.8801 100 0.266 Contact Map
1q1rA 1 0.9832 100 0.269 Contact Map
3kljA 1 0.9017 100 0.273 Contact Map
3oc4A 2 0.9424 100 0.273 Contact Map
4fx9A 2 0.9832 100 0.276 Contact Map
3l8kA 3 0.9448 100 0.281 Contact Map
1ojtA 2 0.9424 100 0.282 Contact Map
2cduA 2 0.9856 100 0.284 Contact Map
3icsA 2 0.988 100 0.285 Contact Map
3ntdA 2 0.9904 100 0.29 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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