GREMLIN Database
Q9HP44 - Succinoglycan biosynthesis
UniProt: Q9HP44 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 434 (382)
Sequences: 1120 (840)
Seq/√Len: 43.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
274_E315_R4.3571.00
46_T78_L3.8331.00
73_F77_A3.7201.00
96_D100_V3.7061.00
133_F137_R3.3991.00
84_A148_V3.3661.00
274_E316_H3.3031.00
50_F316_H3.3001.00
326_A420_L3.2661.00
363_D424_P3.1921.00
328_A353_P3.1191.00
323_I419_A3.1041.00
130_L143_V3.0611.00
294_I322_A3.0371.00
49_R319_D3.0031.00
81_R141_D2.9791.00
71_V286_P2.9241.00
273_A287_V2.7801.00
69_R72_R2.7441.00
51_V80_C2.7441.00
358_I413_Y2.7401.00
266_D269_M2.6931.00
273_A312_L2.6391.00
49_R277_R2.6161.00
360_T364_D2.5891.00
336_D346_I2.5291.00
39_D73_F2.5121.00
52_G320_Y2.4561.00
50_F277_R2.4551.00
329_R425_E2.4201.00
42_R73_F2.3851.00
148_V308_L2.3791.00
296_R313_A2.3631.00
61_R65_Q2.3211.00
45_L78_L2.2611.00
100_V142_R2.2331.00
123_V145_F2.2151.00
105_D108_E2.1911.00
71_V83_F2.1881.00
310_Q314_A2.1531.00
289_A308_L2.1371.00
53_L126_L2.1300.99
72_R76_D2.1150.99
98_Y128_E2.0940.99
358_I414_T2.0930.99
58_H86_E2.0580.99
61_R122_S2.0570.99
82_A285_L2.0360.99
85_L145_F2.0170.99
137_R142_R1.9880.99
42_R78_L1.9760.99
75_V143_V1.9450.99
82_A280_T1.9060.99
203_D207_P1.8980.99
362_L420_L1.8450.99
57_T63_C1.7800.98
126_L130_L1.7700.98
86_E149_D1.7560.98
146_F276_V1.7390.98
139_V142_R1.7290.98
73_F78_L1.7210.98
58_H265_R1.7070.97
271_E315_R1.7070.97
390_R413_Y1.6870.97
60_T63_C1.6850.97
163_F232_A1.6840.97
76_D133_F1.6790.97
326_A422_F1.6540.97
369_P424_P1.6290.97
95_I127_V1.6280.97
71_V130_L1.6250.97
95_I145_F1.6250.97
333_Q345_L1.6160.96
86_E265_R1.6110.96
132_A135_A1.5860.96
48_A321_W1.5820.96
58_H149_D1.5800.96
53_L421_A1.5790.96
82_A146_F1.5770.96
328_A363_D1.5750.96
38_L69_R1.5580.96
350_L395_T1.5410.95
265_R269_M1.5370.95
106_P124_L1.5320.95
37_D69_R1.5270.95
65_Q122_S1.5220.95
80_C284_I1.5200.95
321_W371_V1.5180.95
51_V74_L1.4860.94
51_V286_P1.4850.94
38_L66_F1.4790.94
133_F136_D1.4760.94
238_V271_E1.4630.94
78_L284_I1.4540.94
52_G312_L1.4420.93
394_Q409_V1.4400.93
96_D146_F1.4320.93
58_H290_H1.4300.93
149_D290_H1.4280.93
56_V413_Y1.4260.93
163_F229_V1.4240.93
55_E58_H1.4230.93
270_A308_L1.4160.93
277_R285_L1.4100.93
290_H294_I1.3930.92
149_D265_R1.3830.92
60_T426_T1.3690.91
321_W419_A1.3680.91
392_H411_Y1.3640.91
63_C327_F1.3580.91
211_N214_D1.3480.91
98_Y127_V1.3450.91
121_E430_R1.3410.91
137_R141_D1.3280.90
26_L77_A1.3100.90
97_D228_R1.3020.89
42_R45_L1.2940.89
158_D162_A1.2850.89
167_V219_E1.2810.89
75_V129_W1.2760.88
148_V272_N1.2750.88
326_A359_E1.2690.88
63_C290_H1.2540.87
55_E86_E1.2520.87
317_G320_Y1.2430.87
55_E325_S1.2420.87
133_F141_D1.2400.87
294_I307_S1.2310.86
59_G324_G1.2230.86
135_A142_R1.2210.86
136_D372_L1.2150.86
85_L123_V1.2110.86
96_D189_P1.2060.85
86_E293_H1.1950.85
166_T228_R1.1940.85
45_L48_A1.1870.84
37_D41_L1.1790.84
371_V419_A1.1760.84
81_R283_D1.1720.84
336_D348_H1.1440.82
58_H293_H1.1410.82
133_F143_V1.1380.82
92_T145_F1.1350.82
273_A285_L1.1340.81
121_E125_A1.1310.81
328_A360_T1.1270.81
270_A312_L1.1220.81
57_T327_F1.1170.80
140_G319_D1.1040.80
28_G37_D1.0930.79
66_F423_L1.0860.79
206_A342_E1.0840.78
86_E269_M1.0750.78
110_L113_I1.0740.78
93_L231_L1.0670.77
116_W334_A1.0540.76
44_H321_W1.0480.76
83_F130_L1.0400.75
54_G58_H1.0300.75
102_G105_D1.0300.75
96_D144_R1.0280.75
409_V417_F1.0280.75
373_S376_Q1.0270.75
47_D78_L1.0250.74
143_V188_P1.0230.74
234_R237_R1.0210.74
125_A229_V1.0200.74
62_E122_S1.0110.73
325_S421_A1.0060.73
395_T399_F1.0060.73
88_N91_E1.0010.73
75_V126_L0.9990.72
58_H269_M0.9990.72
357_T408_L0.9900.72
73_F321_W0.9880.72
26_L369_P0.9840.71
159_A162_A0.9830.71
165_D176_R0.9820.71
355_D360_T0.9790.71
324_G417_F0.9700.70
68_H72_R0.9630.70
303_E415_V0.9610.70
67_K151_Q0.9580.69
52_G75_V0.9570.69
28_G286_P0.9430.68
67_K288_W0.9420.68
412_D415_V0.9420.68
290_H324_G0.9410.68
270_A316_H0.9390.68
142_R284_I0.9260.67
153_T272_N0.9260.67
146_F280_T0.9250.67
96_D142_R0.9210.66
298_G306_P0.9180.66
98_Y101_H0.9170.66
118_W288_W0.9160.66
60_T334_A0.9160.66
86_E290_H0.9130.66
180_D184_D0.9070.65
216_H219_E0.9070.65
42_R77_A0.9060.65
117_T397_A0.9040.65
82_A276_V0.9010.64
312_L320_Y0.8980.64
152_Y245_R0.8980.64
83_F126_L0.8950.64
363_D370_A0.8910.64
53_L325_S0.8880.63
322_A417_F0.8860.63
41_L69_R0.8850.63
41_L77_A0.8780.62
149_D269_M0.8760.62
213_L343_N0.8750.62
50_F317_G0.8720.62
353_P360_T0.8700.62
108_E228_R0.8700.62
59_G182_A0.8690.62
98_Y104_G0.8650.61
62_E90_S0.8650.61
219_E229_V0.8650.61
149_D289_A0.8630.61
237_R375_R0.8620.61
162_A170_A0.8610.61
62_E417_F0.8610.61
138_P319_D0.8590.61
96_D134_N0.8530.60
59_G396_G0.8470.60
211_N215_A0.8460.60
45_L321_W0.8400.59
69_R76_D0.8390.59
276_V280_T0.8370.59
38_L42_R0.8340.58
117_T357_T0.8320.58
71_V75_V0.8300.58
376_Q415_V0.8270.58
60_T288_W0.8270.58
297_T310_Q0.8270.58
76_D95_I0.8270.58
96_D226_A0.8250.58
56_V131_R0.8240.58
108_E111_D0.8230.57
365_A370_A0.8230.57
306_P310_Q0.8200.57
265_R290_H0.8200.57
366_V424_P0.8180.57
174_T177_G0.8150.57
98_Y131_R0.8140.57
53_L286_P0.8140.57
75_V130_L0.8130.57
87_A299_L0.8120.56
136_D142_R0.8120.56
38_L41_L0.8090.56
41_L323_I0.8070.56
58_H289_A0.8050.56
41_L44_H0.8050.56
288_W330_G0.8020.55
234_R275_W0.8010.55
67_K291_D0.8000.55
108_E167_V0.7970.55
166_T315_R0.7950.55
427_T430_R0.7950.55
202_V252_A0.7940.55
120_V292_A0.7940.55
304_R394_Q0.7920.55
53_L356_D0.7910.54
67_K249_F0.7910.54
66_F421_A0.7900.54
312_L322_A0.7900.54
330_G396_G0.7900.54
323_I410_T0.7890.54
219_E226_A0.7870.54
411_Y417_F0.7850.54
377_A380_D0.7830.54
393_F399_F0.7820.54
132_A415_V0.7810.53
45_L80_C0.7790.53
288_W325_S0.7790.53
137_R276_V0.7780.53
143_V166_T0.7750.53
116_W397_A0.7730.53
331_G428_R0.7700.52
129_W133_F0.7700.52
25_E28_G0.7690.52
117_T120_V0.7670.52
294_I324_G0.7670.52
110_L127_V0.7660.52
211_N425_E0.7630.52
360_T415_V0.7620.52
148_V273_A0.7610.52
125_A206_A0.7610.52
88_N153_T0.7600.52
195_I420_L0.7590.51
331_G349_E0.7530.51
244_E285_L0.7530.51
265_R293_H0.7510.51
270_A285_L0.7500.51
245_R262_A0.7500.51
317_G375_R0.7500.51
53_L228_R0.7480.50
218_T428_R0.7480.50
68_H126_L0.7480.50
70_I364_D0.7430.50
114_Y117_T0.7420.50
72_R378_R0.7410.50
237_R271_E0.7390.50
76_D136_D0.7380.49
123_V126_L0.7370.49
57_T396_G0.7360.49
70_I157_V0.7350.49
28_G38_L0.7350.49
132_A318_D0.7310.49
64_F118_W0.7310.49
290_H417_F0.7300.49
105_D316_H0.7270.48
64_F67_K0.7260.48
64_F71_V0.7250.48
161_R165_D0.7240.48
169_P236_C0.7230.48
35_I38_L0.7220.48
333_Q347_G0.7210.48
47_D238_V0.7210.48
105_D109_A0.7210.48
130_L145_F0.7200.48
225_S354_L0.7140.47
52_G277_R0.7130.47
362_L370_A0.7130.47
213_L216_H0.7110.47
84_A273_A0.7110.47
47_D140_G0.7100.47
201_A205_L0.7100.47
183_A186_G0.7090.47
159_A371_V0.7050.46
61_R94_A0.7040.46
90_S152_Y0.7040.46
75_V331_G0.7020.46
359_E393_F0.7010.46
177_G372_L0.6980.46
39_D42_R0.6980.46
290_H396_G0.6970.46
261_H307_S0.6970.46
132_A162_A0.6960.45
49_R106_P0.6950.45
123_V137_R0.6930.45
157_V186_G0.6930.45
111_D158_D0.6930.45
114_Y152_Y0.6910.45
37_D40_A0.6910.45
89_F275_W0.6910.45
59_G333_Q0.6870.45
151_Q288_W0.6840.44
177_G316_H0.6830.44
207_P379_A0.6820.44
123_V345_L0.6820.44
211_N354_L0.6800.44
106_P127_V0.6790.44
159_A369_P0.6790.44
115_F151_Q0.6780.44
104_G129_W0.6780.44
231_L275_W0.6770.44
132_A389_E0.6740.43
26_L38_L0.6730.43
158_D187_T0.6730.43
269_M396_G0.6730.43
147_G293_H0.6730.43
356_D360_T0.6720.43
36_D323_I0.6710.43
336_D373_S0.6700.43
102_G106_P0.6690.43
87_A116_W0.6680.43
92_T342_E0.6660.43
287_V390_R0.6610.42
57_T123_V0.6610.42
88_N307_S0.6600.42
297_T350_L0.6590.42
160_L179_L0.6590.42
64_F120_V0.6580.42
230_A279_F0.6560.42
394_Q397_A0.6520.41
206_A210_R0.6520.41
61_R98_Y0.6500.41
210_R214_D0.6470.41
202_V205_L0.6460.41
149_D291_D0.6420.40
102_G128_E0.6410.40
60_T330_G0.6400.40
68_H83_F0.6380.40
50_F82_A0.6360.40
127_V292_A0.6360.40
76_D336_D0.6350.40
107_R121_E0.6350.40
171_F174_T0.6350.40
175_V297_T0.6340.40
126_L423_L0.6330.40
67_K408_L0.6320.39
262_A300_Q0.6300.39
159_A170_A0.6280.39
232_A247_R0.6280.39
90_S235_H0.6280.39
101_H142_R0.6280.39
116_W288_W0.6250.39
241_Q272_N0.6240.39
83_F145_F0.6240.39
196_D200_A0.6220.39
333_Q429_A0.6220.39
48_A80_C0.6220.39
214_D237_R0.6200.38
128_E135_A0.6180.38
156_A334_A0.6180.38
163_F224_T0.6170.38
240_E271_E0.6160.38
218_T226_A0.6150.38
190_Q204_R0.6150.38
57_T60_T0.6140.38
36_D40_A0.6130.38
58_H291_D0.6120.38
46_T80_C0.6120.38
292_A416_A0.6110.38
59_G332_F0.6070.37
55_E266_D0.6050.37
160_L229_V0.6040.37
55_E149_D0.6040.37
165_D410_T0.6040.37
23_A28_G0.6040.37
356_D392_H0.6020.37
119_N292_A0.6020.37
61_R430_R0.6010.37
124_L423_L0.6000.37
125_A430_R0.5980.36
107_R111_D0.5970.36
122_S128_E0.5960.36
109_A112_G0.5950.36
219_E223_E0.5940.36
209_I249_F0.5930.36
114_Y245_R0.5930.36
154_Q157_V0.5910.36
351_D410_T0.5910.36
323_I421_A0.5910.36
212_R215_A0.5910.36
297_T313_A0.5900.36
60_T399_F0.5890.36
146_F359_E0.5880.36
419_A422_F0.5870.35
164_F175_V0.5870.35
188_P191_Q0.5860.35
277_R316_H0.5860.35
69_R374_L0.5850.35
48_A52_G0.5850.35
55_E269_M0.5850.35
50_F81_R0.5850.35
244_E248_H0.5850.35
244_E267_E0.5840.35
233_R278_E0.5840.35
62_E65_Q0.5820.35
56_V124_L0.5820.35
71_V288_W0.5820.35
180_D183_A0.5820.35
361_A366_V0.5810.35
267_E271_E0.5800.35
107_R133_F0.5780.35
77_A374_L0.5770.35
129_W320_Y0.5750.34
263_R304_R0.5750.34
99_V145_F0.5740.34
120_V151_Q0.5740.34
327_F332_F0.5740.34
182_A292_A0.5720.34
26_L73_F0.5700.34
24_T44_H0.5700.34
252_A258_T0.5690.34
95_I106_P0.5690.34
111_D314_A0.5680.34
406_A409_V0.5650.34
179_L239_L0.5630.33
53_L279_F0.5620.33
93_L99_V0.5610.33
159_A211_N0.5600.33
219_E225_S0.5580.33
160_L422_F0.5570.33
152_Y209_I0.5560.33
150_A238_V0.5560.33
28_G39_D0.5540.33
87_A397_A0.5540.33
287_V312_L0.5540.33
372_L375_R0.5540.33
86_E289_A0.5530.33
59_G290_H0.5520.33
28_G50_F0.5510.32
76_D303_E0.5510.32
95_I109_A0.5500.32
364_D376_Q0.5500.32
158_D342_E0.5490.32
136_D140_G0.5470.32
93_L380_D0.5450.32
237_R240_E0.5450.32
63_C332_F0.5440.32
115_F122_S0.5440.32
138_P223_E0.5440.32
102_G317_G0.5430.32
290_H413_Y0.5430.32
69_R78_L0.5430.32
62_E324_G0.5410.32
229_V355_D0.5410.32
191_Q195_I0.5400.32
203_D425_E0.5400.32
260_T267_E0.5400.32
66_F325_S0.5400.32
129_W142_R0.5400.32
202_V206_A0.5390.31
242_A246_K0.5380.31
114_Y118_W0.5360.31
62_E291_D0.5360.31
61_R72_R0.5350.31
108_E302_G0.5350.31
358_I392_H0.5340.31
64_F332_F0.5340.31
48_A375_R0.5340.31
164_F209_I0.5330.31
168_D424_P0.5330.31
243_T357_T0.5320.31
64_F288_W0.5320.31
355_D421_A0.5310.31
300_Q411_Y0.5300.31
52_G129_W0.5300.31
62_E413_Y0.5290.31
63_C276_V0.5280.31
24_T27_H0.5280.31
88_N151_Q0.5270.30
43_A317_G0.5270.30
250_P347_G0.5270.30
48_A51_V0.5270.30
106_P386_W0.5260.30
128_E349_E0.5250.30
396_G399_F0.5250.30
106_P110_L0.5240.30
44_H422_F0.5240.30
160_L163_F0.5230.30
294_I417_F0.5210.30
59_G292_A0.5210.30
393_F396_G0.5200.30
51_V330_G0.5200.30
75_V83_F0.5180.30
37_D374_L0.5180.30
116_W242_A0.5170.30
332_F399_F0.5160.30
199_V204_R0.5160.30
385_G388_A0.5150.29
246_K263_R0.5150.29
334_A393_F0.5140.29
140_G143_V0.5130.29
90_S156_A0.5130.29
149_D293_H0.5120.29
60_T90_S0.5120.29
388_A414_T0.5110.29
148_V312_L0.5110.29
334_A395_T0.5110.29
38_L122_S0.5100.29
426_T429_A0.5100.29
269_M287_V0.5100.29
50_F215_A0.5090.29
224_T227_D0.5090.29
36_D375_R0.5070.29
111_D140_G0.5060.29
166_T177_G0.5060.29
139_V173_G0.5060.29
85_L288_W0.5050.29
115_F139_V0.5050.29
75_V142_R0.5050.29
85_L308_L0.5050.29
64_F151_Q0.5030.29
60_T332_F0.5020.28
24_T37_D0.5010.28
107_R294_I0.5000.28
59_G88_N0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qgmA 1 0.8963 100 0.245 Contact Map
3b55A 1 0.9309 100 0.266 Contact Map
2g5gX 1 0.5645 98 0.915 Contact Map
1yzvA 6 0.2995 34.1 0.968 Contact Map
2ebfX 1 0.871 28.6 0.969 Contact Map
2o8bB 1 0.3525 26.9 0.97 Contact Map
2hhgA 2 0.2051 23.6 0.97 Contact Map
2i2wA 4 0.3986 19.6 0.972 Contact Map
3dfzA 2 0.2765 18.8 0.972 Contact Map
2i33A 2 0.2742 17.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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