CARB - HALSA - GREMLIN Contacts

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CARB - Carbamoyl-phosphate synthase large chain

UniProt:	Q9HP43	Sequences: MTEDSRTILLIGSGPIQIGQAAEFDYSGAQACRALQEEGARVVLVNSNPATIMTDPEMADAVYIEPIEPDAIAEVIEQEDPDGVIAGLGGQTGLNVTAALAEQGVLDEHDVDVMGTPLDTIYATEDRDLFRQRMADLGQPVPASTTIALGDDETATDIDEGALRERVDDAVEAVGGLPVIARTTYTLGGSGSGVVHDFEALVDRVRTGLRLSRNAEVLVTESITGWVELEYEVMRDAGDSCIIVCNMENIDPMGIHTGESTVVTPSQIIPDDGHQEMRNAAVAVIRELGIQGGCNIQFAWRDDGTPGGEYRVVEVNPRVSRSSALASKATGYPIARVTAKVALGKRLHEIDNEITGQTTAAFEPAIDYVVTKVPRWPNDKFPEVDFELSTAMKSTGEAMAIGRTFEESLLKALRSSEYDPSVDWATVSDDELAADYLQRPSPDRPYAVFEAFERGFTVGDVNDHTGFREWYLQRFQNVAAASAAASEGDVATPAALGYTNSAVAALASDGGDVAVDDVAATAPERTFKQVDTCAGEFAASTPYYYSARSQGSTGSDVRADRDAHSVVIVGGGPIRIGQGVEFDYCTVHAVRALREAGIDAHVVNNNPETVSTDYDTSDGLFFEPITAEEVADVVEATNADGVMVQFGGQTSVDVGAPLEAELERRGLDCEIMGTDVDAMDLAEDRDRFNRLLDERDISQPDGGSATSVAGALELAAEVGYPVLVRPSYVLGGRAMEIVHDDDELRRYVEEAVRVSPEKPVLVDEFLADAVELDVDAVSDGEDVLVGGVMEHIESAGVHSGDSACVIPPRGLGDDILARVREVTTEIARALDTVGLLNVQLAVQDGEVYVLEANPRSSRTVPFVSKATGVPIAKLAAKVMAGESLADLDASEGVPEQYSVKEVVLPFDRLPGSDPRLGPEMKSTGEVMGTASDPGMAYWKAQVAASNAPVPGSTAVVDLLVEGLGERFEVVTVKDVPAAIRRGEVEFLVSDDRDALTAAVEAEIPYVSTVAAAEAMREGIAAADGAREAMPVADRPVNDETWG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	1042 (1009)
Sequences:	2808 (1134)
Seq/√Len:	35.7

ECOLI - CARB
BACSU - CARB CARY
HALSA - CARB
SULSO - CARB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
371_T	408_S	7.333	1.00
476_Q	480_A	5.512	1.00
239_D	286_R	4.921	1.00
7_T	41_R	4.751	1.00
7_T	43_V	4.706	1.00
67_I	96_V	4.400	1.00
567_V	603_V	4.384	1.00
80_D	109_H	4.323	1.00
102_E	122_Y	4.298	1.00
301_R	307_G	4.260	1.00
716_A	741_D	4.234	1.00
877_K	882_E	4.219	1.00
694_E	829_A	4.200	1.00
677_D	687_R	4.174	1.00
161_G	205_V	3.670	1.00
205_V	217_V	3.662	1.00
956_V	970_V	3.649	1.00
450_E	454_R	3.548	1.00
627_A	631_A	3.536	1.00
231_Y	246_N	3.519	1.00
301_R	309_E	3.491	1.00
414_R	629_E	3.463	1.00
8_I	40_A	3.423	1.00
136_D	287_E	3.394	1.00
930_A	935_M	3.393	1.00
564_H	640_D	3.379	1.00
555_S	636_A	3.335	1.00
809_R	897_Y	3.292	1.00
821_E	825_E	3.177	1.00
448_V	461_V	3.165	1.00
250_I	475_F	3.138	1.00
277_M	310_Y	3.134	1.00
73_A	108_E	3.125	1.00
76_I	109_H	3.120	1.00
246_N	266_S	3.076	1.00
452_F	472_L	3.067	1.00
781_E	883_S	3.050	1.00
77_E	109_H	3.033	1.00
603_V	633_V	3.012	1.00
722_V	762_V	3.010	1.00
953_T	976_P	3.009	1.00
883_S	886_D	3.005	1.00
143_A	221_E	2.955	1.00
40_A	343_L	2.910	1.00
481_A	496_L	2.893	1.00
73_A	77_E	2.860	1.00
519_A	635_E	2.848	1.00
163_L	202_V	2.819	1.00
41_R	61_A	2.775	1.00
172_E	198_F	2.773	1.00
776_A	823_T	2.758	1.00
459_G	469_E	2.705	1.00
777_V	878_V	2.694	1.00
882_E	886_D	2.693	1.00
452_F	458_V	2.690	1.00
712_L	745_R	2.690	1.00
73_A	109_H	2.672	1.00
901_E	940_A	2.583	1.00
409_L	445_P	2.577	1.00
813_D	817_A	2.574	1.00
128_D	132_Q	2.570	1.00
147_I	170_A	2.568	1.00
567_V	634_V	2.567	1.00
960_V	963_L	2.562	1.00
986_F	990_D	2.558	1.00
171_V	177_L	2.557	1.00
8_I	343_L	2.549	1.00
406_E	474_R	2.547	1.00
720_Y	741_D	2.488	1.00
703_G	717_E	2.484	1.00
402_G	407_E	2.482	1.00
434_A	460_D	2.480	1.00
198_F	202_V	2.460	1.00
984_V	994_A	2.454	1.00
563_A	599_D	2.450	1.00
72_I	96_V	2.424	1.00
698_S	822_V	2.417	1.00
45_V	75_V	2.371	1.00
491_A	495_A	2.363	1.00
429_D	432_L	2.337	0.99
285_I	296_I	2.332	0.99
157_D	160_E	2.306	0.99
967_F	986_F	2.303	0.99
883_S	887_L	2.288	0.99
73_A	103_Q	2.280	0.99
740_D	743_E	2.272	0.99
634_V	667_L	2.264	0.99
69_P	99_A	2.264	0.99
595_E	873_K	2.262	0.99
489_D	493_P	2.240	0.99
484_A	492_T	2.230	0.99
139_Q	283_A	2.218	0.99
703_G	714_L	2.212	0.99
231_Y	266_S	2.207	0.99
678_A	831_D	2.183	0.99
751_A	755_S	2.178	0.99
37_E	340_K	2.173	0.99
824_T	828_R	2.172	0.99
456_F	460_D	2.171	0.99
515_V	631_A	2.157	0.99
221_E	309_E	2.153	0.99
567_V	633_V	2.152	0.99
818_R	821_E	2.132	0.99
786_G	871_I	2.132	0.99
140_P	309_E	2.131	0.99
452_F	461_V	2.129	0.99
156_T	216_E	2.127	0.99
697_I	822_V	2.125	0.99
391_A	908_R	2.105	0.99
177_L	198_F	2.099	0.99
561_R	599_D	2.099	0.99
874_L	887_L	2.095	0.99
510_G	513_V	2.090	0.99
74_E	77_E	2.088	0.99
410_L	498_Y	2.082	0.99
255_I	440_P	2.078	0.99
953_T	978_A	2.065	0.99
967_F	990_D	2.063	0.99
772_L	811_L	2.050	0.99
284_V	312_V	2.044	0.99
98_A	118_L	2.027	0.98
406_E	477_N	2.021	0.98
69_P	103_Q	2.014	0.98
458_V	472_L	2.013	0.98
386_F	442_P	2.006	0.98
712_L	741_D	1.975	0.98
430_D	454_R	1.967	0.98
177_L	197_D	1.967	0.98
184_T	216_E	1.965	0.98
782_D	885_A	1.959	0.98
139_Q	280_A	1.957	0.98
680_D	687_R	1.953	0.98
680_D	728_Y	1.950	0.98
64_I	927_M	1.928	0.98
195_V	204_R	1.927	0.98
976_P	995_L	1.926	0.98
741_D	745_R	1.919	0.98
621_F	637_T	1.918	0.98
2_T	112_D	1.905	0.98
38_E	340_K	1.899	0.98
145_T	173_A	1.897	0.98
751_A	760_V	1.892	0.98
197_D	200_A	1.888	0.98
663_E	677_D	1.882	0.98
595_E	877_K	1.882	0.98
517_D	521_T	1.878	0.97
77_E	108_E	1.874	0.97
512_D	664_R	1.873	0.97
73_A	105_V	1.870	0.97
266_S	274_H	1.868	0.97
707_S	710_G	1.858	0.97
300_W	310_Y	1.851	0.97
519_A	524_E	1.849	0.97
814_D	845_G	1.843	0.97
171_V	179_V	1.833	0.97
45_V	72_I	1.825	0.97
449_F	453_E	1.813	0.97
774_V	823_T	1.812	0.97
76_I	111_V	1.807	0.97
7_T	61_A	1.804	0.97
500_N	518_V	1.797	0.97
448_V	467_F	1.791	0.97
701_D	717_E	1.788	0.97
157_D	215_A	1.774	0.96
1004_P	1008_T	1.771	0.96
101_A	118_L	1.771	0.96
596_A	877_K	1.770	0.96
984_V	996_T	1.765	0.96
156_T	160_E	1.762	0.96
145_T	170_A	1.758	0.96
437_L	451_A	1.738	0.96
713_E	717_E	1.737	0.96
705_A	714_L	1.736	0.96
778_S	828_R	1.734	0.96
181_A	217_V	1.731	0.96
746_R	750_E	1.730	0.96
656_A	664_R	1.724	0.96
772_L	842_V	1.724	0.96
752_V	760_V	1.722	0.96
483_A	486_S	1.716	0.96
133_R	287_E	1.716	0.96
524_E	635_E	1.709	0.96
691_L	826_I	1.705	0.96
452_F	475_F	1.704	0.96
818_R	822_V	1.701	0.95
181_A	219_V	1.699	0.95
457_T	460_D	1.697	0.95
209_L	215_A	1.692	0.95
449_F	475_F	1.691	0.95
566_V	672_M	1.686	0.95
698_S	846_E	1.681	0.95
462_N	472_L	1.672	0.95
404_T	549_S	1.668	0.95
1018_G	1038_D	1.667	0.95
772_L	819_V	1.662	0.95
122_Y	129_L	1.656	0.95
776_A	836_L	1.653	0.95
288_L	315_V	1.653	0.95
177_L	201_L	1.651	0.95
147_I	160_E	1.642	0.95
691_L	829_A	1.632	0.94
962_G	1021_A	1.629	0.94
812_G	845_G	1.626	0.94
596_A	880_A	1.619	0.94
514_A	517_D	1.619	0.94
516_D	520_A	1.611	0.94
71_A	75_V	1.607	0.94
539_A	542_P	1.606	0.94
701_D	764_E	1.601	0.94
978_A	1015_M	1.598	0.94
84_V	111_V	1.594	0.94
812_G	815_I	1.592	0.94
231_Y	281_A	1.578	0.93
564_H	598_I	1.575	0.93
196_H	200_A	1.573	0.93
627_A	657_P	1.569	0.93
131_R	135_A	1.568	0.93
181_A	201_L	1.568	0.93
734_A	751_A	1.566	0.93
998_A	1030_P	1.563	0.93
815_I	847_V	1.560	0.93
398_A	415_S	1.558	0.93
123_A	287_E	1.554	0.93
698_S	818_R	1.550	0.93
842_V	847_V	1.550	0.93
101_A	107_D	1.547	0.93
689_N	699_Q	1.543	0.92
69_P	72_I	1.541	0.92
413_L	445_P	1.541	0.92
772_L	847_V	1.538	0.92
808_P	816_L	1.534	0.92
642_V	667_L	1.532	0.92
932_D	935_M	1.526	0.92
593_L	600_A	1.525	0.92
503_V	507_A	1.522	0.92
237_A	346_R	1.521	0.92
640_D	670_E	1.514	0.92
517_D	520_A	1.509	0.92
593_L	880_A	1.504	0.91
751_A	754_V	1.500	0.91
643_M	876_A	1.494	0.91
777_V	871_I	1.488	0.91
803_A	901_E	1.486	0.91
481_A	493_P	1.485	0.91
405_F	470_W	1.485	0.91
529_Q	544_Y	1.481	0.91
477_N	496_L	1.480	0.91
456_F	461_V	1.477	0.91
69_P	96_V	1.476	0.91
511_G	515_V	1.473	0.91
478_V	498_Y	1.471	0.90
273_G	308_G	1.466	0.90
818_R	847_V	1.462	0.90
490_V	517_D	1.460	0.90
958_L	966_R	1.457	0.90
105_V	109_H	1.454	0.90
238_G	346_R	1.448	0.90
876_A	880_A	1.446	0.90
509_D	514_A	1.444	0.90
627_A	665_R	1.441	0.90
882_E	887_L	1.439	0.89
250_I	261_T	1.436	0.89
434_A	464_H	1.430	0.89
817_A	820_R	1.427	0.89
654_V	658_L	1.422	0.89
687_R	728_Y	1.420	0.89
86_A	97_T	1.419	0.89
815_I	845_G	1.419	0.89
434_A	456_F	1.415	0.89
485_A	493_P	1.408	0.88
778_S	783_V	1.405	0.88
433_A	461_V	1.397	0.88
132_Q	136_D	1.390	0.88
99_A	102_E	1.387	0.88
561_R	565_S	1.386	0.88
979_I	994_A	1.385	0.88
692_L	849_V	1.384	0.88
822_V	847_V	1.380	0.87
783_V	828_R	1.378	0.87
142_P	311_R	1.377	0.87
337_V	353_E	1.373	0.87
678_A	681_L	1.372	0.87
519_A	632_D	1.371	0.87
67_I	72_I	1.369	0.87
766_L	843_Q	1.365	0.87
566_V	593_L	1.364	0.87
462_N	466_G	1.362	0.87
421_S	505_A	1.358	0.87
430_D	460_D	1.355	0.86
147_I	161_G	1.352	0.86
997_A	1005_Y	1.351	0.86
681_L	829_A	1.347	0.86
501_S	511_G	1.347	0.86
557_V	636_A	1.344	0.86
600_A	880_A	1.343	0.86
963_L	982_G	1.342	0.86
697_I	847_V	1.341	0.86
250_I	448_V	1.341	0.86
566_V	880_A	1.336	0.86
565_S	599_D	1.331	0.85
452_F	476_Q	1.324	0.85
171_V	201_L	1.314	0.85
988_V	996_T	1.314	0.85
823_T	840_L	1.310	0.84
815_I	842_V	1.309	0.84
234_M	337_V	1.309	0.84
1022_A	1028_A	1.309	0.84
478_V	496_L	1.302	0.84
970_V	977_A	1.301	0.84
124_T	296_I	1.301	0.84
158_I	201_L	1.291	0.84
485_A	506_L	1.289	0.83
715_A	720_Y	1.284	0.83
38_E	345_K	1.279	0.83
453_E	482_S	1.274	0.83
524_E	632_D	1.269	0.83
784_L	889_A	1.268	0.82
276_E	300_W	1.267	0.82
270_P	273_G	1.266	0.82
818_R	846_E	1.262	0.82
357_Q	540_S	1.261	0.82
98_A	129_L	1.261	0.82
68_E	71_A	1.260	0.82
303_D	307_G	1.255	0.82
421_S	501_S	1.253	0.82
689_N	702_G	1.250	0.82
409_L	475_F	1.249	0.81
481_A	489_D	1.242	0.81
474_R	477_N	1.238	0.81
9_L	84_V	1.234	0.81
643_M	879_M	1.232	0.81
515_V	665_R	1.232	0.81
826_I	838_V	1.224	0.80
748_V	752_V	1.220	0.80
985_E	989_S	1.217	0.80
250_I	263_V	1.216	0.80
752_V	755_S	1.211	0.79
1032_A	1036_V	1.205	0.79
631_A	665_R	1.205	0.79
420_P	446_Y	1.205	0.79
998_A	1034_R	1.204	0.79
158_I	163_L	1.203	0.79
805_V	933_P	1.197	0.79
456_F	464_H	1.193	0.78
410_L	478_V	1.190	0.78
84_V	106_L	1.187	0.78
655_G	658_L	1.186	0.78
690_R	694_E	1.185	0.78
816_L	820_R	1.183	0.78
4_D	112_D	1.180	0.78
161_G	219_V	1.176	0.77
988_V	994_A	1.176	0.77
470_W	474_R	1.169	0.77
449_F	479_A	1.168	0.77
183_T	192_S	1.167	0.77
484_A	489_D	1.163	0.77
144_S	220_T	1.157	0.76
619_G	637_T	1.156	0.76
509_D	513_V	1.154	0.76
169_D	172_E	1.154	0.76
485_A	503_V	1.151	0.76
345_K	350_I	1.150	0.76
878_V	887_L	1.149	0.76
822_V	840_L	1.147	0.76
263_V	371_T	1.146	0.76
528_K	554_G	1.140	0.75
280_A	310_Y	1.140	0.75
560_D	619_G	1.133	0.75
123_A	133_R	1.132	0.75
590_V	617_S	1.131	0.75
221_E	311_R	1.129	0.74
461_V	475_F	1.128	0.74
123_A	136_D	1.126	0.74
207_T	211_L	1.125	0.74
462_N	469_E	1.121	0.74
32_C	58_M	1.114	0.73
631_A	667_L	1.113	0.73
124_T	734_A	1.113	0.73
356_G	540_S	1.112	0.73
978_A	995_L	1.110	0.73
406_E	496_L	1.106	0.73
234_M	285_I	1.105	0.73
437_L	465_T	1.104	0.73
69_P	73_A	1.102	0.73
591_R	616_T	1.102	0.73
788_V	820_R	1.101	0.73
404_T	496_L	1.101	0.73
97_T	113_V	1.100	0.72
629_E	632_D	1.100	0.72
139_Q	312_V	1.099	0.72
69_P	105_V	1.097	0.72
45_V	100_L	1.092	0.72
738_V	760_V	1.090	0.72
122_Y	185_Y	1.088	0.72
98_A	122_Y	1.086	0.71
240_S	361_A	1.085	0.71
877_K	887_L	1.085	0.71
231_Y	241_C	1.083	0.71
754_V	760_V	1.080	0.71
862_F	927_M	1.080	0.71
337_V	350_I	1.079	0.71
596_A	882_E	1.078	0.71
131_R	220_T	1.077	0.71
981_R	996_T	1.076	0.71
490_V	523_P	1.072	0.70
525_R	548_R	1.072	0.70
135_A	141_V	1.072	0.70
17_Q	190_S	1.069	0.70
436_Y	447_A	1.068	0.70
129_L	132_Q	1.068	0.70
205_V	219_V	1.065	0.70
430_D	434_A	1.063	0.70
504_A	510_G	1.062	0.70
1010_A	1034_R	1.062	0.70
450_E	453_E	1.062	0.70
241_C	282_V	1.061	0.70
999_V	1007_S	1.059	0.70
1003_I	1008_T	1.059	0.70
461_V	472_L	1.056	0.69
201_L	219_V	1.055	0.69
11_I	93_G	1.054	0.69
1010_A	1037_N	1.053	0.69
11_I	72_I	1.052	0.69
436_Y	441_S	1.052	0.69
788_V	816_L	1.049	0.69
275_Q	278_R	1.049	0.69
140_P	221_E	1.048	0.69
227_V	468_R	1.048	0.69
11_I	67_I	1.046	0.69
823_T	838_V	1.046	0.69
220_T	223_I	1.040	0.68
161_G	181_A	1.039	0.68
632_D	635_E	1.038	0.68
204_R	208_G	1.037	0.68
240_S	346_R	1.037	0.68
271_D	275_Q	1.037	0.68
569_V	630_V	1.032	0.68
139_Q	296_I	1.030	0.67
272_D	308_G	1.027	0.67
119_D	129_L	1.027	0.67
99_A	103_Q	1.026	0.67
241_C	286_R	1.025	0.67
451_A	456_F	1.020	0.67
745_R	749_E	1.019	0.67
898_S	929_T	1.019	0.67
398_A	412_A	1.017	0.66
697_I	818_R	1.015	0.66
963_L	983_E	1.015	0.66
83_G	86_A	1.013	0.66
590_V	600_A	1.013	0.66
528_K	549_S	1.008	0.66
197_D	1003_I	1.008	0.66
998_A	1002_E	1.006	0.65
404_T	408_S	1.006	0.65
954_A	1019_I	1.003	0.65
34_A	350_I	1.003	0.65
241_C	285_I	1.000	0.65
181_A	205_V	0.999	0.65
433_A	454_R	0.999	0.65
131_R	146_T	0.998	0.65
263_V	405_F	0.996	0.65
177_L	202_V	0.995	0.65
728_Y	758_K	0.992	0.64
233_V	243_I	0.991	0.64
888_D	893_V	0.991	0.64
437_L	447_A	0.991	0.64
475_F	479_A	0.984	0.64
33_R	615_D	0.983	0.64
826_I	849_V	0.982	0.64
430_D	456_F	0.980	0.63
279_N	283_A	0.978	0.63
473_Q	476_Q	0.978	0.63
36_Q	58_M	0.978	0.63
803_A	902_V	0.977	0.63
828_R	831_D	0.977	0.63
247_M	262_V	0.973	0.63
956_V	987_L	0.973	0.63
284_V	639_A	0.972	0.63
896_Q	929_T	0.972	0.63
734_A	752_V	0.971	0.63
625_I	654_V	0.970	0.63
303_D	466_G	0.966	0.62
403_R	528_K	0.961	0.62
806_I	863_V	0.959	0.62
820_R	893_V	0.958	0.62
627_A	654_V	0.956	0.61
504_A	514_A	0.956	0.61
706_T	710_G	0.955	0.61
238_G	348_H	0.951	0.61
177_L	639_A	0.951	0.61
119_D	123_A	0.950	0.61
373_V	376_W	0.949	0.61
866_A	898_S	0.948	0.61
955_V	980_R	0.947	0.61
275_Q	536_E	0.946	0.61
163_L	177_L	0.945	0.61
266_S	366_I	0.945	0.61
275_Q	537_F	0.943	0.60
43_V	75_V	0.941	0.60
9_L	76_I	0.941	0.60
403_R	549_S	0.938	0.60
163_L	181_A	0.937	0.60
458_V	476_Q	0.935	0.60
352_N	355_T	0.933	0.60
369_V	408_S	0.932	0.59
980_R	983_E	0.930	0.59
234_M	242_I	0.930	0.59
22_A	574_I	0.929	0.59
197_D	1012_A	0.924	0.59
599_D	619_G	0.921	0.59
769_A	841_A	0.920	0.58
410_L	470_W	0.918	0.58
711_A	748_V	0.917	0.58
977_A	994_A	0.917	0.58
748_V	751_A	0.917	0.58
998_A	1001_A	0.915	0.58
226_W	311_R	0.914	0.58
774_V	819_V	0.914	0.58
231_Y	274_H	0.914	0.58
458_V	473_Q	0.912	0.58
1001_A	1005_Y	0.909	0.58
808_P	811_L	0.906	0.57
833_V	878_V	0.906	0.57
202_V	206_R	0.906	0.57
358_T	362_F	0.906	0.57
395_T	574_I	0.903	0.57
6_R	41_R	0.894	0.56
353_E	614_Y	0.894	0.56
748_V	760_V	0.890	0.56
646_F	875_A	0.886	0.56
126_D	216_E	0.885	0.56
481_A	484_A	0.884	0.55
979_I	983_E	0.883	0.55
280_A	284_V	0.883	0.55
171_V	205_V	0.883	0.55
708_V	745_R	0.882	0.55
1030_P	1034_R	0.882	0.55
997_A	1004_P	0.881	0.55
790_E	810_G	0.881	0.55
142_P	223_I	0.881	0.55
410_L	502_A	0.880	0.55
163_L	198_F	0.880	0.55
72_I	75_V	0.880	0.55
362_F	541_T	0.879	0.55
525_R	632_D	0.879	0.55
589_A	643_M	0.878	0.55
275_Q	362_F	0.877	0.55
271_D	537_F	0.876	0.55
587_V	1032_A	0.875	0.55
460_D	463_D	0.875	0.55
484_A	488_G	0.874	0.55
281_A	298_F	0.874	0.55
490_V	514_A	0.873	0.54
231_Y	267_Q	0.873	0.54
247_M	315_V	0.872	0.54
180_I	194_V	0.871	0.54
105_V	108_E	0.871	0.54
223_I	253_M	0.870	0.54
490_V	518_V	0.870	0.54
143_A	309_E	0.870	0.54
193_G	204_R	0.870	0.54
700_P	730_L	0.870	0.54
299_A	311_R	0.868	0.54
957_D	983_E	0.867	0.54
1022_A	1031_V	0.867	0.54
395_T	605_N	0.865	0.54
418_Y	446_Y	0.864	0.54
1020_A	1034_R	0.863	0.54
740_D	762_V	0.863	0.54
179_V	201_L	0.863	0.54
730_L	862_F	0.863	0.54
1023_D	1029_M	0.862	0.54
949_V	952_S	0.860	0.53
462_N	467_F	0.860	0.53
699_Q	734_A	0.859	0.53
387_E	439_R	0.858	0.53
373_V	412_A	0.857	0.53
179_V	219_V	0.856	0.53
1036_V	1039_E	0.856	0.53
336_R	353_E	0.856	0.53
385_D	442_P	0.855	0.53
526_T	549_S	0.855	0.53
247_M	310_Y	0.855	0.53
261_T	445_P	0.853	0.53
259_E	388_L	0.853	0.53
481_A	492_T	0.852	0.53
294_C	315_V	0.849	0.52
953_T	1016_R	0.849	0.52
2_T	8_I	0.849	0.52
692_L	696_D	0.849	0.52
819_V	823_T	0.849	0.52
978_A	1009_V	0.848	0.52
523_P	548_R	0.848	0.52
243_I	354_I	0.848	0.52
755_S	760_V	0.847	0.52
954_A	958_L	0.847	0.52
585_C	872_A	0.847	0.52
45_V	67_I	0.844	0.52
158_I	171_V	0.843	0.52
278_R	362_F	0.841	0.52
477_N	481_A	0.840	0.52
956_V	966_R	0.840	0.52
778_S	836_L	0.840	0.52
239_D	243_I	0.839	0.52
352_N	531_D	0.839	0.52
226_W	615_D	0.839	0.52
143_A	173_A	0.838	0.51
362_F	536_E	0.836	0.51
513_V	516_D	0.835	0.51
383_E	921_K	0.834	0.51
399_M	622_F	0.833	0.51
773_D	786_G	0.833	0.51
407_E	497_G	0.833	0.51
169_D	173_A	0.832	0.51
370_V	401_I	0.832	0.51
1018_G	1034_R	0.830	0.51
278_R	531_D	0.829	0.51
1023_D	1031_V	0.826	0.50
190_S	908_R	0.825	0.50
784_L	890_S	0.825	0.50
147_I	217_V	0.822	0.50
956_V	977_A	0.822	0.50
752_V	758_K	0.821	0.50
247_M	395_T	0.821	0.50
819_V	842_V	0.821	0.50
803_A	941_Q	0.821	0.50
139_Q	310_Y	0.818	0.50
574_I	605_N	0.818	0.50
901_E	941_Q	0.818	0.50
219_V	277_M	0.817	0.50
3_E	40_A	0.817	0.50
566_V	598_I	0.817	0.50
433_A	451_A	0.816	0.50
158_I	161_G	0.815	0.49
231_Y	285_I	0.815	0.49
816_L	823_T	0.814	0.49
214_N	539_A	0.812	0.49
691_L	830_L	0.811	0.49
843_Q	846_E	0.811	0.49
864_S	871_I	0.810	0.49
777_V	889_A	0.808	0.49
1006_V	1034_R	0.808	0.49
640_D	672_M	0.807	0.49
1000_E	1005_Y	0.806	0.49
278_R	363_E	0.805	0.49
984_V	988_V	0.803	0.48
160_E	169_D	0.803	0.48
100_L	106_L	0.802	0.48
352_N	541_T	0.801	0.48
174_V	180_I	0.801	0.48
587_V	591_R	0.801	0.48
2_T	40_A	0.800	0.48
977_A	992_R	0.799	0.48
819_V	847_V	0.799	0.48
600_A	876_A	0.799	0.48
686_D	706_T	0.798	0.48
966_R	987_L	0.797	0.48
792_I	805_V	0.796	0.48
275_Q	533_C	0.794	0.48
362_F	537_F	0.793	0.48
820_R	892_G	0.793	0.48
658_L	667_L	0.792	0.47
92_T	187_L	0.791	0.47
181_A	204_R	0.791	0.47
190_S	930_A	0.790	0.47
724_V	823_T	0.790	0.47
131_R	218_L	0.790	0.47
954_A	970_V	0.789	0.47
826_I	836_L	0.788	0.47
83_G	114_M	0.788	0.47
159_D	169_D	0.787	0.47
181_A	208_G	0.787	0.47
958_L	970_V	0.786	0.47
255_I	387_E	0.786	0.47
220_T	625_I	0.785	0.47
792_I	850_L	0.785	0.47
231_Y	242_I	0.782	0.47
533_C	537_F	0.782	0.47
953_T	995_L	0.780	0.46
255_I	439_R	0.778	0.46
190_S	391_A	0.777	0.46
742_D	745_R	0.777	0.46
262_V	310_Y	0.776	0.46
950_P	975_V	0.775	0.46
29_A	53_M	0.774	0.46
748_V	755_S	0.773	0.46
656_A	663_E	0.772	0.46
373_V	445_P	0.772	0.46
773_D	905_P	0.772	0.46
242_I	605_N	0.771	0.46
3_E	8_I	0.771	0.46
494_A	628_E	0.771	0.46
58_M	62_V	0.770	0.46
234_M	339_A	0.770	0.46
502_A	505_A	0.770	0.46
415_S	624_P	0.770	0.46
709_A	713_E	0.768	0.45
780_G	783_V	0.768	0.45
733_R	752_V	0.767	0.45
995_L	1014_A	0.767	0.45
565_S	640_D	0.766	0.45
290_I	569_V	0.766	0.45
902_V	940_A	0.765	0.45
589_A	876_A	0.765	0.45
234_M	244_V	0.765	0.45
681_L	691_L	0.765	0.45
55_D	584_Y	0.764	0.45
692_L	756_P	0.764	0.45
402_G	497_G	0.762	0.45
463_D	466_G	0.762	0.45
262_V	315_V	0.761	0.45
147_I	850_L	0.758	0.45
964_G	968_E	0.758	0.45
825_E	829_A	0.758	0.45
174_V	975_V	0.758	0.45
783_V	824_T	0.757	0.44
84_V	992_R	0.757	0.44
246_N	274_H	0.757	0.44
196_H	224_T	0.756	0.44
832_T	836_L	0.755	0.44
713_E	716_A	0.754	0.44
226_W	309_E	0.753	0.44
772_L	904_L	0.753	0.44
362_F	531_D	0.753	0.44
377_P	395_T	0.753	0.44
361_A	589_A	0.752	0.44
376_W	418_Y	0.752	0.44
146_T	184_T	0.751	0.44
686_D	704_S	0.750	0.44
980_R	1034_R	0.749	0.44
271_D	278_R	0.748	0.44
953_T	1009_V	0.747	0.44
976_P	993_D	0.747	0.44
689_N	723_L	0.746	0.44
27_S	93_G	0.746	0.44
163_L	171_V	0.746	0.44
592_A	873_K	0.744	0.43
538_A	542_P	0.744	0.43
53_M	259_E	0.744	0.43
255_I	445_P	0.744	0.43
842_V	845_G	0.743	0.43
433_A	447_A	0.743	0.43
88_L	223_I	0.742	0.43
159_D	199_E	0.741	0.43
117_P	237_A	0.741	0.43
964_G	986_F	0.741	0.43
714_L	751_A	0.741	0.43
5_S	954_A	0.741	0.43
140_P	143_A	0.739	0.43
56_P	868_G	0.739	0.43
512_D	665_R	0.739	0.43
591_R	595_E	0.738	0.43
747_Y	752_V	0.736	0.43
171_V	181_A	0.735	0.43
502_A	506_L	0.735	0.43
666_G	780_G	0.734	0.43
29_A	58_M	0.734	0.43
1005_Y	1008_T	0.733	0.42
490_V	521_T	0.733	0.42
405_F	474_R	0.732	0.42
452_F	456_F	0.730	0.42
422_V	425_A	0.730	0.42
407_E	547_A	0.728	0.42
45_V	105_V	0.728	0.42
197_D	1011_A	0.728	0.42
246_N	267_Q	0.727	0.42
514_A	522_A	0.727	0.42
179_V	205_V	0.726	0.42
193_G	208_G	0.722	0.42
315_V	395_T	0.721	0.41
561_R	619_G	0.720	0.41
567_V	667_L	0.719	0.41
352_N	363_E	0.718	0.41
10_L	42_V	0.717	0.41
247_M	574_I	0.717	0.41
784_L	869_V	0.717	0.41
301_R	311_R	0.716	0.41
413_L	417_E	0.715	0.41
766_L	827_A	0.715	0.41
353_E	615_D	0.715	0.41
514_A	521_T	0.713	0.41
76_I	105_V	0.712	0.41
1009_V	1014_A	0.712	0.41
770_V	815_I	0.712	0.41
507_A	514_A	0.712	0.41
748_V	754_V	0.712	0.41
522_A	886_D	0.712	0.41
562_D	565_S	0.709	0.40
460_D	535_G	0.709	0.40
141_V	144_S	0.708	0.40
351_D	359_T	0.708	0.40
139_Q	315_V	0.708	0.40
179_V	195_V	0.707	0.40
988_V	993_D	0.706	0.40
244_V	266_S	0.706	0.40
675_D	831_D	0.704	0.40
738_V	751_A	0.704	0.40
271_D	352_N	0.703	0.40
795_A	841_A	0.703	0.40
716_A	720_Y	0.703	0.40
460_D	464_H	0.703	0.40
363_E	531_D	0.703	0.40
850_L	1025_A	0.703	0.40
158_I	181_A	0.703	0.40
177_L	181_A	0.703	0.40
957_D	980_R	0.702	0.40
959_L	1031_V	0.702	0.40
967_F	987_L	0.702	0.40
132_Q	135_A	0.702	0.40
158_I	205_V	0.701	0.40
708_V	749_E	0.701	0.40
867_T	889_A	0.700	0.40
841_A	905_P	0.699	0.40
274_H	362_F	0.699	0.40
734_A	754_V	0.698	0.40
263_V	832_T	0.698	0.40
878_V	883_S	0.698	0.40
586_T	872_A	0.697	0.39
459_G	463_D	0.696	0.39
184_T	765_F	0.696	0.39
706_T	752_V	0.696	0.39
770_V	810_G	0.694	0.39
158_I	206_R	0.694	0.39
122_Y	415_S	0.694	0.39
500_N	515_V	0.694	0.39
129_L	185_Y	0.693	0.39
790_E	809_R	0.693	0.39
64_I	580_V	0.693	0.39
816_L	847_V	0.693	0.39
814_D	818_R	0.692	0.39
244_V	597_G	0.691	0.39
247_M	341_V	0.691	0.39
430_D	450_E	0.691	0.39
5_S	619_G	0.690	0.39
10_L	32_C	0.690	0.39
568_I	600_A	0.690	0.39
355_T	531_D	0.690	0.39
271_D	363_E	0.689	0.39
836_L	852_A	0.688	0.39
902_V	905_P	0.688	0.39
75_V	341_V	0.687	0.39
569_V	644_V	0.687	0.39
986_F	989_S	0.686	0.39
291_Q	587_V	0.685	0.38
717_E	825_E	0.685	0.38
262_V	395_T	0.684	0.38
515_V	632_D	0.684	0.38
690_R	696_D	0.684	0.38
22_A	395_T	0.683	0.38
709_A	745_R	0.683	0.38
77_E	80_D	0.681	0.38
1013_E	1018_G	0.681	0.38
980_R	1030_P	0.681	0.38
766_L	842_V	0.680	0.38
437_L	464_H	0.680	0.38
284_V	296_I	0.679	0.38
705_A	755_S	0.679	0.38
147_I	219_V	0.679	0.38
823_T	836_L	0.679	0.38
274_H	468_R	0.678	0.38
428_S	432_L	0.678	0.38
835_L	872_A	0.677	0.38
574_I	909_L	0.676	0.38
357_Q	539_A	0.676	0.38
8_I	872_A	0.675	0.38
434_A	461_V	0.675	0.38
339_A	626_T	0.675	0.38
129_L	277_M	0.675	0.38
645_Q	850_L	0.675	0.38
186_T	212_S	0.674	0.38
711_A	715_A	0.674	0.38
1007_S	1037_N	0.674	0.38
894_P	898_S	0.673	0.37
303_D	469_E	0.672	0.37
738_V	744_L	0.672	0.37
262_V	294_C	0.672	0.37
555_S	558_R	0.672	0.37
781_E	828_R	0.672	0.37
869_V	874_L	0.672	0.37
355_T	541_T	0.671	0.37
5_S	9_L	0.671	0.37
693_D	699_Q	0.671	0.37
744_L	751_A	0.671	0.37
784_L	874_L	0.670	0.37
377_P	921_K	0.670	0.37
644_V	671_I	0.670	0.37
281_A	351_D	0.669	0.37
183_T	186_T	0.669	0.37
998_A	1008_T	0.669	0.37
186_T	192_S	0.669	0.37
76_I	100_L	0.668	0.37
806_I	937_Y	0.668	0.37
401_I	530_V	0.668	0.37
654_V	788_V	0.668	0.37
190_S	211_L	0.668	0.37
6_R	476_Q	0.667	0.37
569_V	625_I	0.666	0.37
484_A	932_D	0.666	0.37
872_A	876_A	0.666	0.37
704_S	748_V	0.666	0.37
161_G	218_L	0.665	0.37
40_A	83_G	0.665	0.37
452_F	478_V	0.665	0.37
633_V	636_A	0.664	0.37
956_V	1019_I	0.664	0.37
220_T	840_L	0.664	0.37
17_Q	255_I	0.664	0.37
332_Y	909_L	0.663	0.37
84_V	105_V	0.663	0.37
93_G	522_A	0.663	0.37
133_R	136_D	0.663	0.37
866_A	871_I	0.663	0.37
958_L	962_G	0.662	0.37
568_I	593_L	0.662	0.37
199_E	484_A	0.662	0.37
271_D	355_T	0.661	0.36
527_F	546_S	0.660	0.36
603_V	634_V	0.659	0.36
850_L	1032_A	0.659	0.36
1004_P	1030_P	0.656	0.36
102_E	524_E	0.656	0.36
781_E	886_D	0.655	0.36
663_E	676_V	0.655	0.36
45_V	69_P	0.655	0.36
708_V	748_V	0.655	0.36
262_V	574_I	0.655	0.36
536_E	541_T	0.655	0.36
262_V	909_L	0.655	0.36
698_S	847_V	0.655	0.36
826_I	830_L	0.655	0.36
247_M	288_L	0.654	0.36
544_Y	605_N	0.654	0.36
882_E	885_A	0.652	0.36
128_D	146_T	0.652	0.36
1002_E	1005_Y	0.652	0.36
403_R	554_G	0.651	0.36
231_Y	262_V	0.650	0.36
566_V	641_G	0.650	0.36
926_V	943_A	0.650	0.36
957_D	1034_R	0.649	0.36
71_A	942_V	0.647	0.35
601_H	621_F	0.647	0.35
92_T	402_G	0.646	0.35
493_P	523_P	0.646	0.35
180_I	195_V	0.645	0.35
47_S	64_I	0.644	0.35
278_R	536_E	0.644	0.35
487_E	709_A	0.643	0.35
1007_S	1010_A	0.643	0.35
739_H	961_E	0.642	0.35
944_A	948_P	0.642	0.35
83_G	402_G	0.642	0.35
653_D	733_R	0.642	0.35
32_C	36_Q	0.641	0.35
98_A	102_E	0.641	0.35
568_I	737_I	0.640	0.35
108_E	951_G	0.640	0.35
630_V	654_V	0.639	0.35
888_D	892_G	0.639	0.35
850_L	934_G	0.639	0.35
493_P	758_K	0.639	0.35
116_T	262_V	0.639	0.35
80_D	105_V	0.638	0.35
567_V	600_A	0.638	0.35
714_L	762_V	0.638	0.35
274_H	535_G	0.638	0.35
773_D	840_L	0.638	0.35
459_G	643_M	0.638	0.35
949_V	1017_E	0.637	0.35
822_V	825_E	0.636	0.34
811_L	816_L	0.635	0.34
417_E	573_P	0.635	0.34
998_A	1004_P	0.635	0.34
494_A	548_R	0.633	0.34
584_Y	588_H	0.633	0.34
1001_A	1008_T	0.633	0.34
137_L	762_V	0.633	0.34
966_R	986_F	0.632	0.34
981_R	985_E	0.632	0.34
544_Y	557_V	0.631	0.34
242_I	337_V	0.631	0.34
555_S	560_D	0.631	0.34
565_S	601_H	0.631	0.34
724_V	744_L	0.631	0.34
6_R	82_D	0.631	0.34
243_I	286_R	0.630	0.34
504_A	511_G	0.630	0.34
820_R	824_T	0.630	0.34
711_A	751_A	0.629	0.34
172_E	177_L	0.629	0.34
4_D	40_A	0.629	0.34
677_D	680_D	0.629	0.34
369_V	404_T	0.628	0.34
954_A	957_D	0.628	0.34
601_H	619_G	0.628	0.34
13_S	67_I	0.627	0.34
174_V	179_V	0.627	0.34
275_Q	531_D	0.626	0.34
733_R	751_A	0.626	0.34
792_I	966_R	0.626	0.34
425_A	447_A	0.625	0.34
437_L	940_A	0.625	0.34
365_A	534_A	0.625	0.34
278_R	352_N	0.625	0.34
428_S	433_A	0.623	0.33
525_R	629_E	0.620	0.33
787_G	863_V	0.620	0.33
226_W	585_C	0.620	0.33
713_E	742_D	0.620	0.33
1020_A	1030_P	0.620	0.33
365_A	535_G	0.620	0.33
869_V	878_V	0.619	0.33
296_I	419_D	0.619	0.33
206_R	883_S	0.617	0.33
354_I	614_Y	0.617	0.33
686_D	690_R	0.617	0.33
452_F	477_N	0.615	0.33
827_A	836_L	0.615	0.33
568_I	929_T	0.615	0.33
237_A	291_Q	0.615	0.33
185_Y	826_I	0.615	0.33
428_S	436_Y	0.614	0.33
22_A	262_V	0.614	0.33
214_N	339_A	0.614	0.33
126_D	129_L	0.614	0.33
528_K	547_A	0.614	0.33
394_S	769_A	0.613	0.33
979_I	987_L	0.613	0.33
310_Y	909_L	0.613	0.33
734_A	1022_A	0.611	0.33
844_D	991_D	0.611	0.33
460_D	977_A	0.611	0.33
515_V	548_R	0.610	0.32
737_I	748_V	0.609	0.32
158_I	194_V	0.608	0.32
207_T	724_V	0.608	0.32
45_V	78_Q	0.608	0.32
253_M	394_S	0.607	0.32
675_D	678_A	0.607	0.32
45_V	76_I	0.607	0.32
1010_A	1018_G	0.607	0.32
129_L	133_R	0.606	0.32
985_E	988_V	0.606	0.32
112_D	117_P	0.605	0.32
216_E	296_I	0.605	0.32
1003_I	1012_A	0.605	0.32
644_V	679_M	0.605	0.32
33_R	616_T	0.605	0.32
681_L	694_E	0.605	0.32
603_V	1016_R	0.604	0.32
788_V	808_P	0.604	0.32
312_V	962_G	0.604	0.32
117_P	289_G	0.604	0.32
465_T	621_F	0.604	0.32
738_V	930_A	0.604	0.32
714_L	717_E	0.604	0.32
987_L	990_D	0.603	0.32
461_V	465_T	0.603	0.32
131_R	144_S	0.602	0.32
2_T	343_L	0.602	0.32
377_P	574_I	0.602	0.32
979_I	984_V	0.602	0.32
414_R	499_T	0.601	0.32
159_D	487_E	0.600	0.32
437_L	461_V	0.600	0.32
310_Y	315_V	0.600	0.32
280_A	283_A	0.599	0.32
449_F	605_N	0.599	0.32
240_S	278_R	0.598	0.32
250_I	405_F	0.598	0.32
998_A	1005_Y	0.597	0.32
531_D	534_A	0.597	0.32
247_M	909_L	0.597	0.32
274_H	278_R	0.597	0.32
830_L	945_S	0.597	0.32
6_R	486_S	0.597	0.32
434_A	567_V	0.596	0.31
573_P	605_N	0.596	0.31
465_T	598_I	0.596	0.31
889_A	893_V	0.595	0.31
131_R	790_E	0.595	0.31
959_L	962_G	0.595	0.31
269_I	338_T	0.595	0.31
453_E	502_A	0.594	0.31
819_V	880_A	0.594	0.31
515_V	635_E	0.594	0.31
417_E	575_R	0.593	0.31
247_M	294_C	0.593	0.31
5_S	339_A	0.593	0.31
518_V	548_R	0.593	0.31
234_M	319_V	0.593	0.31
395_T	651_S	0.593	0.31
41_R	267_Q	0.592	0.31
77_E	972_V	0.592	0.31
261_T	475_F	0.592	0.31
142_P	681_L	0.592	0.31
598_I	640_D	0.591	0.31
417_E	482_S	0.590	0.31
352_N	362_F	0.590	0.31
1024_G	1027_E	0.590	0.31
22_A	377_P	0.590	0.31
338_T	400_A	0.590	0.31
905_P	909_L	0.590	0.31
441_S	672_M	0.589	0.31
756_P	840_L	0.589	0.31
252_P	466_G	0.589	0.31
821_E	824_T	0.589	0.31
131_R	223_I	0.589	0.31
113_V	131_R	0.588	0.31
718_V	722_V	0.588	0.31
278_R	355_T	0.588	0.31
395_T	909_L	0.588	0.31
76_I	108_E	0.587	0.31
377_P	587_V	0.587	0.31
1002_E	1008_T	0.587	0.31
914_P	1036_V	0.587	0.31
404_T	547_A	0.587	0.31
184_T	193_G	0.586	0.31
196_H	1003_I	0.586	0.31
96_V	105_V	0.586	0.31
1007_S	1034_R	0.585	0.31
315_V	574_I	0.585	0.31
533_C	541_T	0.584	0.31
216_E	277_M	0.584	0.31
271_D	354_I	0.584	0.31
547_A	788_V	0.584	0.31
599_D	777_V	0.584	0.31
138_G	141_V	0.584	0.31
128_D	220_T	0.583	0.30
1004_P	1012_A	0.583	0.30
1023_D	1028_A	0.583	0.30
672_M	879_M	0.583	0.30
1007_S	1011_A	0.582	0.30
515_V	518_V	0.582	0.30
720_Y	956_V	0.582	0.30
435_D	439_R	0.582	0.30
789_M	802_S	0.582	0.30
997_A	1002_E	0.582	0.30
797_V	988_V	0.581	0.30
663_E	687_R	0.581	0.30
267_Q	369_V	0.581	0.30
34_A	81_P	0.580	0.30
65_E	76_I	0.579	0.30
410_L	571_G	0.579	0.30
518_V	523_P	0.577	0.30
782_D	824_T	0.576	0.30
139_Q	395_T	0.576	0.30
504_A	509_D	0.575	0.30
478_V	667_L	0.575	0.30
231_Y	247_M	0.575	0.30
356_G	478_V	0.574	0.30
275_Q	541_T	0.574	0.30
766_L	836_L	0.574	0.30
88_L	805_V	0.574	0.30
147_I	205_V	0.573	0.30
141_V	223_I	0.573	0.30
296_I	636_A	0.573	0.30
229_L	300_W	0.573	0.30
275_Q	279_N	0.573	0.30
751_A	756_P	0.573	0.30
407_E	872_A	0.571	0.30
960_V	1018_G	0.571	0.30
1011_A	1015_M	0.570	0.30
15_P	20_Q	0.570	0.30
708_V	712_L	0.570	0.30
956_V	959_L	0.570	0.30
352_N	536_E	0.570	0.30
1018_G	1037_N	0.570	0.30
803_A	937_Y	0.569	0.29
982_G	1020_A	0.569	0.29
186_T	208_G	0.569	0.29
560_D	601_H	0.569	0.29
395_T	769_A	0.569	0.29
425_A	428_S	0.567	0.29
98_A	850_L	0.567	0.29
214_N	376_W	0.567	0.29
52_I	692_L	0.567	0.29
207_T	391_A	0.567	0.29
590_V	701_D	0.566	0.29
438_Q	464_H	0.566	0.29
671_I	676_V	0.566	0.29
565_S	637_T	0.566	0.29
1001_A	1004_P	0.566	0.29
312_V	615_D	0.566	0.29
139_Q	247_M	0.565	0.29
441_S	447_A	0.565	0.29
239_D	403_R	0.565	0.29
291_Q	341_V	0.565	0.29
309_E	413_L	0.564	0.29
682_A	776_A	0.564	0.29
596_A	876_A	0.563	0.29
362_F	533_C	0.563	0.29
84_V	97_T	0.562	0.29
179_V	605_N	0.562	0.29
285_I	315_V	0.562	0.29
769_A	786_G	0.562	0.29
118_L	345_K	0.562	0.29
963_L	1020_A	0.562	0.29
278_R	537_F	0.561	0.29
158_I	202_V	0.561	0.29
531_D	541_T	0.561	0.29
579_G	624_P	0.561	0.29
760_V	943_A	0.560	0.29
226_W	353_E	0.560	0.29
481_A	485_A	0.560	0.29
246_N	294_C	0.559	0.29
43_V	657_P	0.559	0.29
134_M	180_I	0.559	0.29
682_A	700_P	0.559	0.29
33_R	949_V	0.559	0.29
789_M	806_I	0.558	0.29
432_L	436_Y	0.558	0.29
387_E	762_V	0.558	0.29
968_E	971_T	0.558	0.29
452_F	986_F	0.558	0.29
1031_V	1035_P	0.556	0.29
358_T	363_E	0.556	0.29
711_A	762_V	0.556	0.29
634_V	639_A	0.556	0.29
184_T	192_S	0.556	0.29
73_A	114_M	0.556	0.29
769_A	905_P	0.556	0.29
377_P	914_P	0.555	0.28
782_D	828_R	0.555	0.28
586_T	615_D	0.555	0.28
500_N	548_R	0.555	0.28
982_G	998_A	0.555	0.28
531_D	535_G	0.555	0.28
310_Y	574_I	0.554	0.28
226_W	301_R	0.554	0.28
88_L	493_P	0.553	0.28
137_L	226_W	0.553	0.28
784_L	842_V	0.553	0.28
592_A	684_D	0.552	0.28
706_T	755_S	0.552	0.28
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789_M	804_C	0.552	0.28
730_L	906_F	0.552	0.28
515_V	522_A	0.552	0.28
7_T	81_P	0.552	0.28
458_V	462_N	0.552	0.28
363_E	536_E	0.552	0.28
141_V	691_L	0.552	0.28
566_V	876_A	0.551	0.28
987_L	994_A	0.551	0.28
432_L	435_D	0.550	0.28
825_E	856_S	0.550	0.28
269_I	468_R	0.550	0.28
285_I	542_P	0.550	0.28
355_T	363_E	0.550	0.28
784_L	867_T	0.550	0.28
1011_A	1037_N	0.550	0.28
229_L	262_V	0.550	0.28
34_A	339_A	0.550	0.28
692_L	697_I	0.550	0.28
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953_T	956_V	0.549	0.28
480_A	483_A	0.549	0.28
656_A	676_V	0.549	0.28
250_I	445_P	0.548	0.28
180_I	280_A	0.548	0.28
941_Q	1017_E	0.547	0.28
890_S	893_V	0.546	0.28
83_G	279_N	0.546	0.28
1000_E	1031_V	0.546	0.28
337_V	667_L	0.546	0.28
55_D	65_E	0.546	0.28
734_A	755_S	0.546	0.28
226_W	470_W	0.545	0.28
948_P	1017_E	0.545	0.28
774_V	847_V	0.545	0.28
345_K	955_V	0.545	0.28
434_A	438_Q	0.545	0.28
818_R	845_G	0.545	0.28
108_E	237_A	0.545	0.28
963_L	998_A	0.545	0.28
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515_V	519_A	0.544	0.28
223_I	312_V	0.544	0.28
720_Y	785_V	0.544	0.28
126_D	277_M	0.544	0.28
969_V	986_F	0.543	0.28
219_V	461_V	0.543	0.28
872_A	935_M	0.543	0.28
504_A	523_P	0.543	0.28
96_V	722_V	0.543	0.28
238_G	818_R	0.543	0.28
240_S	362_F	0.543	0.28
459_G	473_Q	0.542	0.28
352_N	535_G	0.542	0.28
769_A	804_C	0.542	0.28
424_W	428_S	0.542	0.28
271_D	536_E	0.541	0.27
850_L	876_A	0.541	0.27
404_T	717_E	0.541	0.27
131_R	493_P	0.541	0.27
1022_A	1026_R	0.541	0.27
242_I	296_I	0.541	0.27
267_Q	391_A	0.540	0.27
523_P	886_D	0.540	0.27
274_H	366_I	0.540	0.27
195_V	217_V	0.540	0.27
205_V	209_L	0.540	0.27
355_T	537_F	0.539	0.27
999_V	1033_D	0.539	0.27
332_Y	359_T	0.539	0.27
394_S	786_G	0.539	0.27
17_Q	742_D	0.539	0.27
742_D	882_E	0.539	0.27
43_V	61_A	0.538	0.27
71_A	943_A	0.538	0.27
812_G	847_V	0.538	0.27
484_A	633_V	0.538	0.27
192_S	216_E	0.538	0.27
781_E	833_V	0.538	0.27
954_A	959_L	0.538	0.27
85_I	97_T	0.538	0.27
267_Q	446_Y	0.537	0.27
375_R	784_L	0.537	0.27
362_F	539_A	0.537	0.27
819_V	914_P	0.537	0.27
88_L	530_V	0.537	0.27
539_A	898_S	0.537	0.27
240_S	352_N	0.536	0.27
625_I	629_E	0.536	0.27
250_I	267_Q	0.536	0.27
142_P	177_L	0.535	0.27
426_T	514_A	0.535	0.27
769_A	937_Y	0.535	0.27
110_D	270_P	0.535	0.27
55_D	378_N	0.535	0.27
1005_Y	1022_A	0.534	0.27
433_A	896_Q	0.534	0.27
242_I	285_I	0.534	0.27
310_Y	395_T	0.534	0.27
483_A	487_E	0.534	0.27
616_T	850_L	0.533	0.27
765_F	934_G	0.533	0.27
778_S	782_D	0.532	0.27
710_G	713_E	0.532	0.27
57_E	595_E	0.532	0.27
5_S	492_T	0.532	0.27
202_V	696_D	0.532	0.27
293_G	319_V	0.531	0.27
899_V	936_A	0.531	0.27
194_V	224_T	0.531	0.27
1025_A	1029_M	0.531	0.27
737_I	766_L	0.531	0.27
849_V	948_P	0.531	0.27
97_T	601_H	0.530	0.27
489_D	523_P	0.530	0.27
592_A	596_A	0.530	0.27
694_E	781_E	0.530	0.27
345_K	349_E	0.530	0.27
653_D	836_L	0.530	0.27
452_F	462_N	0.529	0.27
274_H	371_T	0.529	0.27
682_A	730_L	0.529	0.27
458_V	469_E	0.528	0.27
499_T	523_P	0.528	0.27
93_G	586_T	0.528	0.27
717_E	968_E	0.527	0.27
330_T	795_A	0.527	0.27
562_D	845_G	0.527	0.27
873_K	877_K	0.527	0.27
904_L	921_K	0.527	0.27
730_L	856_S	0.526	0.26
65_E	939_K	0.526	0.26
738_V	752_V	0.526	0.26
505_A	664_R	0.526	0.26
217_V	441_S	0.525	0.26
781_E	885_A	0.525	0.26
814_D	823_T	0.525	0.26
204_R	958_L	0.525	0.26
15_P	47_S	0.525	0.26
80_D	817_A	0.524	0.26
544_Y	805_V	0.524	0.26
631_A	642_V	0.524	0.26
593_L	643_M	0.524	0.26
354_I	363_E	0.524	0.26
963_L	979_I	0.523	0.26
987_L	992_R	0.523	0.26
653_D	657_P	0.523	0.26
62_V	290_I	0.522	0.26
8_I	277_M	0.522	0.26
158_I	219_V	0.522	0.26
414_R	625_I	0.522	0.26
783_V	821_E	0.521	0.26
377_P	442_P	0.521	0.26
239_D	285_I	0.521	0.26
772_L	788_V	0.521	0.26
161_G	201_L	0.521	0.26
88_L	544_Y	0.521	0.26
247_M	377_P	0.521	0.26
999_V	1005_Y	0.520	0.26
567_V	639_A	0.520	0.26
766_L	841_A	0.520	0.26
407_E	808_P	0.520	0.26
560_D	636_A	0.520	0.26
286_R	403_R	0.520	0.26
5_S	40_A	0.520	0.26
159_D	163_L	0.520	0.26
102_E	272_D	0.520	0.26
9_L	113_V	0.519	0.26
453_E	479_A	0.519	0.26
670_E	879_M	0.519	0.26
512_D	516_D	0.519	0.26
13_S	1022_A	0.519	0.26
956_V	971_T	0.518	0.26
957_D	982_G	0.518	0.26
271_D	541_T	0.518	0.26
676_V	863_V	0.518	0.26
678_A	829_A	0.518	0.26
36_Q	740_D	0.518	0.26
477_N	692_L	0.517	0.26
140_P	310_Y	0.517	0.26
261_T	400_A	0.517	0.26
163_L	172_E	0.517	0.26
526_T	632_D	0.517	0.26
234_M	357_Q	0.516	0.26
240_S	535_G	0.516	0.26
587_V	921_K	0.516	0.26
708_V	757_E	0.515	0.26
491_A	717_E	0.515	0.26
87_G	271_D	0.515	0.26
720_Y	723_L	0.515	0.26
385_D	738_V	0.515	0.26
449_F	502_A	0.515	0.26
957_D	963_L	0.515	0.26
734_A	945_S	0.514	0.26
979_I	982_G	0.514	0.26
602_V	651_S	0.514	0.26
699_Q	702_G	0.514	0.26
508_S	684_D	0.514	0.26
240_S	531_D	0.514	0.26
81_P	850_L	0.513	0.26
383_E	697_I	0.513	0.26
533_C	542_P	0.513	0.26
57_E	870_P	0.513	0.26
354_I	542_P	0.513	0.26
371_T	405_F	0.513	0.26
73_A	84_V	0.512	0.26
773_D	866_A	0.512	0.26
634_V	877_K	0.512	0.26
391_A	940_A	0.512	0.26
5_S	345_K	0.512	0.26
491_A	519_A	0.512	0.26
817_A	824_T	0.511	0.25
42_V	530_V	0.511	0.25
199_E	463_D	0.511	0.25
140_P	386_F	0.511	0.25
436_Y	882_E	0.511	0.25
192_S	391_A	0.511	0.25
393_K	755_S	0.511	0.25
64_I	929_T	0.510	0.25
724_V	734_A	0.510	0.25
59_A	720_Y	0.510	0.25
239_D	296_I	0.510	0.25
227_V	532_T	0.510	0.25
945_S	1036_V	0.509	0.25
65_E	106_L	0.509	0.25
102_E	213_R	0.509	0.25
22_A	605_N	0.509	0.25
113_V	118_L	0.509	0.25
356_G	993_D	0.509	0.25
224_T	253_M	0.508	0.25
334_I	579_G	0.508	0.25
826_I	914_P	0.508	0.25
967_F	992_R	0.508	0.25
754_V	758_K	0.508	0.25
398_A	416_S	0.508	0.25
667_L	864_S	0.508	0.25
141_V	285_I	0.508	0.25
408_S	412_A	0.508	0.25
169_D	215_A	0.507	0.25
340_K	345_K	0.507	0.25
713_E	988_V	0.507	0.25
433_A	513_V	0.507	0.25
525_R	842_V	0.506	0.25
981_R	997_A	0.506	0.25
603_V	667_L	0.506	0.25
431_E	999_V	0.506	0.25
124_T	678_A	0.506	0.25
433_A	816_L	0.505	0.25
80_D	677_D	0.505	0.25
42_V	259_E	0.505	0.25
963_L	980_R	0.504	0.25
312_V	739_H	0.504	0.25
27_S	856_S	0.504	0.25
544_Y	914_P	0.504	0.25
108_E	458_V	0.504	0.25
820_R	891_E	0.503	0.25
574_I	702_G	0.503	0.25
1019_I	1034_R	0.503	0.25
36_Q	627_A	0.503	0.25
276_E	310_Y	0.503	0.25
119_D	122_Y	0.503	0.25
118_L	122_Y	0.503	0.25
217_V	224_T	0.503	0.25
33_R	226_W	0.503	0.25
561_R	967_F	0.502	0.25
434_A	437_L	0.502	0.25
863_V	871_I	0.502	0.25
373_V	413_L	0.501	0.25
557_V	560_D	0.501	0.25
143_A	311_R	0.501	0.25
158_I	177_L	0.501	0.25
337_V	356_G	0.501	0.25
271_D	533_C	0.501	0.25
352_N	539_A	0.501	0.25
274_H	536_E	0.501	0.25
433_A	813_D	0.500	0.25
213_R	218_L	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a9xA	3	0.9587	100	0.421	Contact Map
3jrxA	1	0.3964	100	0.894	Contact Map
3glkA	1	0.3781	100	0.894	Contact Map
3orqA	2	0.3445	100	0.899	Contact Map
2vpqA	2	0.3983	100	0.901	Contact Map
1ulzA	2	0.404	100	0.901	Contact Map
3q2oA	2	0.3474	100	0.903	Contact Map
2dzdA	2	0.3973	100	0.904	Contact Map
1w96A	1	0.406	100	0.905	Contact Map
2dwcA	4	0.356	100	0.908	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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