GREMLIN Database
CARA - Carbamoyl-phosphate synthase small chain
UniProt: Q9HP42 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (339)
Sequences: 4029 (1977)
Seq/√Len: 107.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_T188_T4.1141.00
228_V246_I3.9851.00
85_D93_T3.9791.00
185_R337_D3.9421.00
168_A192_L3.4831.00
28_L119_V3.4341.00
50_V79_V3.0821.00
53_F78_V2.9591.00
295_T310_D2.9151.00
219_A254_D2.9091.00
167_V343_A2.7561.00
255_T288_V2.6821.00
248_A288_V2.6591.00
153_S194_Y2.6571.00
166_T190_H2.4901.00
20_A95_G2.4761.00
9_E118_Q2.3941.00
10_T110_D2.3091.00
295_T312_A2.2971.00
256_E287_T2.2611.00
31_T46_Y2.2451.00
290_D299_V2.2291.00
158_E191_R2.1971.00
256_E289_A2.1711.00
88_A92_R2.1471.00
169_L210_F2.1251.00
177_S180_D2.1241.00
197_T200_D2.1231.00
22_G97_P2.1201.00
33_A265_V2.1171.00
263_R285_G2.1101.00
23_M135_Q2.1051.00
238_A335_F2.0751.00
159_T188_T2.0521.00
247_V318_T2.0001.00
293_D313_P1.9791.00
154_V158_E1.9751.00
187_A340_L1.9681.00
248_A309_L1.9441.00
293_D312_A1.9111.00
134_A138_D1.9101.00
296_V306_P1.9071.00
40_S51_L1.9011.00
113_D260_F1.8881.00
170_V192_L1.8631.00
247_V316_V1.8561.00
192_L196_A1.8401.00
133_R137_A1.8121.00
165_T344_D1.8051.00
309_L318_T1.7871.00
199_A230_E1.7811.00
172_C224_A1.7771.00
254_D289_A1.7631.00
169_L174_A1.7411.00
14_V110_D1.7331.00
202_A235_V1.7051.00
7_A133_R1.6911.00
270_L275_G1.6791.00
12_D110_D1.6781.00
232_I316_V1.6741.00
311_S315_D1.6511.00
68_T90_W1.6451.00
170_V227_L1.6401.00
165_T343_A1.6341.00
209_L235_V1.6311.00
17_T101_G1.6171.00
73_V94_E1.6161.00
168_A204_V1.6101.00
79_V99_V1.6071.00
54_A108_V1.6041.00
234_T314_L1.5991.00
226_H229_D1.5971.00
102_I107_L1.5851.00
50_V119_V1.5751.00
51_L75_P1.5751.00
181_A333_R1.5611.00
147_E150_A1.5571.00
310_D338_D1.5481.00
294_L311_S1.5451.00
198_P202_A1.5331.00
311_S314_L1.5271.00
192_L204_V1.5161.00
80_A83_L1.4991.00
273_D295_T1.4881.00
195_D223_A1.4581.00
86_D89_D1.4581.00
50_V77_A1.4481.00
17_T100_D1.4471.00
251_L311_S1.4431.00
168_A206_P1.4381.00
31_T40_S1.4361.00
134_A137_A1.4341.00
244_Q318_T1.4261.00
227_L230_E1.4231.00
209_L231_Y1.4211.00
272_H299_V1.4171.00
170_V201_I1.4151.00
196_A200_D1.4111.00
172_C211_I1.4101.00
47_E74_H1.3971.00
271_D338_D1.3921.00
77_A121_I1.3911.00
278_V334_G1.3891.00
198_P230_E1.3741.00
251_L294_L1.3601.00
4_A99_V1.3511.00
41_L75_P1.3160.99
169_L189_V1.3020.99
64_R67_R1.2930.99
187_A343_A1.2870.99
273_D310_D1.2830.99
164_D344_D1.2730.99
85_D89_D1.2680.99
149_G242_L1.2650.99
225_E249_R1.2640.99
131_T134_A1.2580.99
200_D203_A1.2570.99
12_D106_D1.2550.99
278_V332_T1.2550.99
210_F238_A1.2400.99
232_I251_L1.2370.99
169_L179_I1.2350.99
167_V187_A1.2340.99
256_E305_T1.2180.99
208_L343_A1.2150.99
273_D338_D1.2130.99
294_L309_L1.1950.99
174_A179_I1.1920.99
4_A18_A1.1900.99
270_L299_V1.1900.99
170_V196_A1.1840.99
41_L78_V1.1760.99
341_A344_D1.1720.99
47_E151_H1.1670.99
71_D74_H1.1640.99
219_A255_T1.1620.99
211_I228_V1.1580.99
219_A249_R1.1570.99
7_A13_V1.1530.98
298_Q321_Y1.1490.98
9_E117_M1.1420.98
21_P92_R1.1400.98
183_V189_V1.1360.98
22_G95_G1.1230.98
271_D278_V1.1190.98
166_T204_V1.1170.98
231_Y237_I1.1140.98
238_A317_L1.1100.98
290_D296_V1.1070.98
202_A234_T1.1000.98
19_R98_A1.0980.98
24_A77_A1.0930.98
226_H230_E1.0810.98
7_A136_L1.0780.98
149_G221_F1.0730.98
6_L99_V1.0650.97
28_L111_I1.0570.97
83_L88_A1.0540.97
154_V157_A1.0540.97
65_P85_D1.0410.97
270_L301_V1.0290.97
247_V309_L1.0270.97
63_V85_D1.0230.97
341_A345_A1.0150.97
167_V340_L1.0110.97
4_A123_A1.0080.96
73_V96_V1.0030.96
230_E233_G1.0020.96
153_S195_D1.0000.96
190_H204_V0.9960.96
170_V197_T0.9950.96
33_A40_S0.9880.96
131_T135_Q0.9860.96
106_D110_D0.9760.96
228_V237_I0.9730.96
181_A184_A0.9710.96
40_S53_F0.9690.96
5_Y15_E0.9670.96
237_I247_V0.9660.95
111_I119_V0.9640.95
265_V281_T0.9580.95
69_E180_D0.9540.95
122_A132_A0.9520.95
317_L335_F0.9520.95
227_L231_Y0.9480.95
293_D311_S0.9420.95
23_M124_G0.9400.95
159_T190_H0.9350.95
205_D235_V0.9310.94
182_F187_A0.9250.94
14_V106_D0.9190.94
271_D276_R0.9180.94
143_S219_A0.9170.94
48_A76_S0.9160.94
38_E64_R0.9160.94
221_F224_A0.9150.94
198_P227_L0.9130.94
177_S181_A0.9130.94
165_T187_A0.9080.94
24_A121_I0.9020.94
338_D341_A0.9010.93
120_G132_A0.8910.93
80_A100_D0.8880.93
174_A210_F0.8820.93
89_D92_R0.8820.93
241_C322_H0.8800.93
127_A131_T0.8780.93
197_T227_L0.8770.93
10_T114_G0.8750.92
147_E224_A0.8720.92
321_Y332_T0.8680.92
57_L82_E0.8660.92
72_R94_E0.8610.92
165_T340_L0.8600.92
233_G314_L0.8570.92
297_T310_D0.8560.92
79_V102_I0.8540.92
299_V304_G0.8510.91
232_I247_V0.8490.91
196_A204_V0.8490.91
139_C142_L0.8480.91
150_A195_D0.8440.91
199_A203_A0.8420.91
181_A185_R0.8420.91
118_Q141_R0.8370.91
71_D176_R0.8350.91
26_G50_V0.8340.91
340_L343_A0.8340.91
222_D226_H0.8330.90
5_Y13_V0.8330.90
189_V210_F0.8300.90
5_Y125_P0.8300.90
269_V307_E0.8280.90
169_L212_S0.8270.90
63_V68_T0.8230.90
91_L96_V0.8230.90
160_H163_G0.8160.90
45_S241_C0.8140.89
24_A76_S0.8120.89
147_E223_A0.8090.89
28_L52_T0.8080.89
122_A127_A0.8070.89
185_R340_L0.8030.89
154_V191_R0.8010.89
133_R136_L0.7970.88
79_V119_V0.7960.88
263_R267_Q0.7870.88
251_L316_V0.7850.88
7_A122_A0.7810.87
125_P131_T0.7790.87
48_A151_H0.7780.87
176_R180_D0.7770.87
41_L87_V0.7760.87
172_C246_I0.7760.87
91_L98_A0.7710.87
242_L249_R0.7700.87
184_A333_R0.7670.86
18_A123_A0.7660.86
201_I206_P0.7630.86
213_N241_C0.7620.86
42_T68_T0.7610.86
88_A98_A0.7570.86
124_G127_A0.7560.86
110_D114_G0.7530.85
229_D233_G0.7530.85
19_R88_A0.7520.85
271_D274_S0.7520.85
70_S74_H0.7520.85
211_I237_I0.7520.85
167_V208_L0.7510.85
25_R120_G0.7500.85
337_D340_L0.7490.85
41_L91_L0.7420.85
311_S316_V0.7380.84
253_G294_L0.7370.84
196_A201_I0.7310.84
158_E179_I0.7270.83
290_D306_P0.7260.83
265_V300_N0.7260.83
267_Q302_N0.7220.83
89_D93_T0.7170.83
130_A134_A0.7160.83
23_M122_A0.7140.82
122_A126_D0.7130.82
47_E76_S0.7130.82
187_A208_L0.7100.82
194_Y223_A0.7090.82
47_E72_R0.7090.82
298_Q334_G0.7080.82
163_G188_T0.7070.82
321_Y334_G0.7030.81
163_G183_V0.7020.81
31_T53_F0.7010.81
201_I227_L0.7000.81
164_D188_T0.6980.81
8_L107_L0.6970.81
157_A192_L0.6970.81
226_H233_G0.6970.81
251_L314_L0.6920.80
90_W94_E0.6910.80
208_L339_V0.6900.80
178_I325_A0.6900.80
120_G136_L0.6860.80
118_Q142_L0.6830.79
135_Q138_D0.6830.79
142_L148_I0.6820.79
167_V182_F0.6790.79
198_P231_Y0.6750.79
46_Y49_Q0.6750.79
223_A226_H0.6730.78
25_R139_C0.6720.78
168_A190_H0.6700.78
202_A230_E0.6690.78
223_A227_L0.6680.78
58_I80_A0.6670.78
258_M287_T0.6650.78
201_I209_L0.6650.78
148_I286_Y0.6650.78
44_P324_E0.6650.78
97_P121_I0.6640.78
222_D225_E0.6630.77
22_G123_A0.6630.77
149_G220_N0.6600.77
168_A201_I0.6590.77
224_A227_L0.6590.77
75_P78_V0.6580.77
61_Y64_R0.6570.77
208_L238_A0.6560.77
42_T90_W0.6560.77
61_Y302_N0.6540.76
278_V321_Y0.6540.76
201_I231_Y0.6530.76
111_I116_A0.6480.76
237_I316_V0.6470.76
312_A315_D0.6470.76
178_I240_I0.6450.75
83_L100_D0.6430.75
160_H183_V0.6420.75
20_A92_R0.6420.75
140_P144_A0.6410.75
282_Q307_E0.6400.75
53_F58_I0.6390.75
170_V224_A0.6390.75
150_A223_A0.6380.75
202_A231_Y0.6380.75
166_T207_D0.6370.75
6_L102_I0.6350.74
249_R254_D0.6340.74
253_G309_L0.6340.74
33_A281_T0.6330.74
99_V102_I0.6320.74
263_R321_Y0.6310.74
209_L237_I0.6310.74
52_T108_V0.6300.74
241_C329_P0.6280.74
40_S46_Y0.6260.73
292_G312_A0.6260.73
170_V211_I0.6260.73
220_N286_Y0.6230.73
289_A306_P0.6210.73
31_T267_Q0.6200.73
195_D200_D0.6180.72
107_L119_V0.6180.72
47_E148_I0.6170.72
149_G172_C0.6170.72
29_V263_R0.6160.72
25_R136_L0.6140.72
108_V300_N0.6130.72
5_Y128_S0.6120.72
225_E229_D0.6120.72
34_Y61_Y0.6090.71
9_E114_G0.6090.71
38_E298_Q0.6080.71
75_P96_V0.6070.71
113_D259_D0.6060.71
178_I241_C0.6050.71
165_T186_G0.6030.71
144_A220_N0.6030.71
144_A217_D0.6020.70
78_V91_L0.6020.70
182_F189_V0.6020.70
21_P97_P0.5990.70
23_M131_T0.5980.70
199_A202_A0.5980.70
326_N330_H0.5980.70
241_C260_F0.5960.70
169_L238_A0.5940.69
315_D342_M0.5930.69
80_A98_A0.5930.69
185_R333_R0.5920.69
7_A132_A0.5900.69
282_Q300_N0.5880.69
263_R307_E0.5870.68
248_A253_G0.5860.68
76_S151_H0.5860.68
242_L246_I0.5850.68
118_Q140_P0.5850.68
57_L61_Y0.5850.68
18_A98_A0.5850.68
116_A286_Y0.5830.68
158_E183_V0.5830.68
179_I191_R0.5830.68
177_S333_R0.5820.68
265_V326_N0.5790.67
319_R335_F0.5780.67
337_D341_A0.5780.67
217_D255_T0.5770.67
165_T207_D0.5770.67
322_H329_P0.5760.67
157_A204_V0.5750.67
136_L139_C0.5750.67
47_E152_V0.5700.66
270_L304_G0.5700.66
241_C261_G0.5680.66
29_V260_F0.5670.66
19_R97_P0.5670.66
130_A133_R0.5640.65
73_V90_W0.5640.65
52_T79_V0.5640.65
41_L53_F0.5620.65
144_A286_Y0.5620.65
155_D229_D0.5610.65
45_S322_H0.5590.65
225_E250_A0.5590.65
160_H188_T0.5580.65
179_I210_F0.5580.65
300_N307_E0.5580.65
177_S326_N0.5570.64
111_I117_M0.5540.64
69_E177_S0.5540.64
271_D334_G0.5520.64
148_I258_M0.5500.63
210_F318_T0.5480.63
181_A263_R0.5470.63
68_T94_E0.5460.63
33_A263_R0.5460.63
29_V259_D0.5460.63
271_D297_T0.5450.63
271_D298_Q0.5430.63
52_T111_I0.5430.63
288_V309_L0.5420.62
31_T178_I0.5420.62
46_Y241_C0.5410.62
195_D224_A0.5410.62
18_A21_P0.5410.62
26_G51_L0.5410.62
143_S220_N0.5410.62
25_R135_Q0.5390.62
121_I293_D0.5380.62
234_T315_D0.5370.62
142_L147_E0.5350.61
307_E321_Y0.5350.61
253_G288_V0.5340.61
244_Q288_V0.5340.61
126_D135_Q0.5300.61
213_N322_H0.5300.61
64_R298_Q0.5290.61
40_S267_Q0.5290.61
50_V75_P0.5290.61
8_L110_D0.5280.60
160_H179_I0.5240.60
206_P209_L0.5220.60
248_A294_L0.5220.60
221_F242_L0.5210.59
251_L291_P0.5210.59
82_E101_G0.5200.59
31_T52_T0.5200.59
194_Y224_A0.5190.59
241_C245_Q0.5190.59
59_G62_G0.5180.59
57_L307_E0.5180.59
322_H328_G0.5180.59
55_Y61_Y0.5180.59
278_V298_Q0.5180.59
45_S213_N0.5170.59
147_E220_N0.5170.59
65_P68_T0.5170.59
176_R179_I0.5160.59
258_M285_G0.5160.59
317_L342_M0.5160.59
6_L28_L0.5160.59
224_A246_I0.5150.58
287_T306_P0.5150.58
77_A81_R0.5150.58
116_A285_G0.5150.58
18_A83_L0.5130.58
40_S263_R0.5120.58
172_C227_L0.5120.58
232_I237_I0.5120.58
142_L286_Y0.5120.58
5_Y122_A0.5120.58
338_D342_M0.5110.58
197_T231_Y0.5110.58
61_Y241_C0.5110.58
279_M324_E0.5110.58
267_Q327_P0.5110.58
83_L98_A0.5090.58
253_G289_A0.5080.57
170_V231_Y0.5080.57
8_L119_V0.5060.57
245_Q322_H0.5050.57
5_Y126_D0.5050.57
82_E327_P0.5040.57
161_G188_T0.5040.57
89_D95_G0.5030.57
221_F258_M0.5020.57
35_T265_V0.5020.57
233_G315_D0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a9xB 1 0.9858 100 0.222 Contact Map
1vcoA 4 0.9178 100 0.656 Contact Map
1s1mA 4 0.9235 100 0.671 Contact Map
3nvaA 2 0.9065 100 0.697 Contact Map
4zdjA 4 0.9122 100 0.714 Contact Map
2vxoA 2 0.5212 100 0.78 Contact Map
1qdlB 2 0.5042 100 0.789 Contact Map
3tqiA 3 0.4958 100 0.79 Contact Map
1i1qB 1 0.4901 100 0.791 Contact Map
2vpiA 1 0.4986 100 0.792 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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