CARA - HALSA - GREMLIN Contacts

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CARA - Carbamoyl-phosphate synthase small chain

UniProt:	Q9HP42	Sequences: MSDAYLALETGDVVEATARAPGMARGELVFTTAYTGYEESLTDPSYEAQVLTFAYPLIGNYGVRPERTESDRVHPSAVVARELTDDVADWLRTEGVPAVDGIDTRDLVLDIRDGGAMQVGIAAGPDASPATARAQLADCPRLSARTEIGAHVSVDTAETHGNGDTTVALVDCGAKRSIIDAFVARGATVHRLPYDATPADIAAVDPDLLFISNGPGDPANFDAAEHLVDEYIGTVPIAGICLGQQIVARALGGDTEKMDFGHRGVNQPVLDHDSGRVVMTTQNHGYTVADPGDLTVTQVNVNDGTPEALDSAPLDVLTRQYHPEANPGPHDTRGFFDDVLAMADASYTPATAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	353 (339)
Sequences:	4029 (1977)
Seq/√Len:	107.4

ECOLI - CARA
BACSU - CARA CARX
HALSA - CARA
SULSO - CARA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
166_T	188_T	4.114	1.00
228_V	246_I	3.985	1.00
85_D	93_T	3.979	1.00
185_R	337_D	3.942	1.00
168_A	192_L	3.483	1.00
28_L	119_V	3.434	1.00
50_V	79_V	3.082	1.00
53_F	78_V	2.959	1.00
295_T	310_D	2.915	1.00
219_A	254_D	2.909	1.00
167_V	343_A	2.756	1.00
255_T	288_V	2.682	1.00
248_A	288_V	2.659	1.00
153_S	194_Y	2.657	1.00
166_T	190_H	2.490	1.00
20_A	95_G	2.476	1.00
9_E	118_Q	2.394	1.00
10_T	110_D	2.309	1.00
295_T	312_A	2.297	1.00
256_E	287_T	2.261	1.00
31_T	46_Y	2.245	1.00
290_D	299_V	2.229	1.00
158_E	191_R	2.197	1.00
256_E	289_A	2.171	1.00
88_A	92_R	2.147	1.00
169_L	210_F	2.125	1.00
177_S	180_D	2.124	1.00
197_T	200_D	2.123	1.00
22_G	97_P	2.120	1.00
33_A	265_V	2.117	1.00
263_R	285_G	2.110	1.00
23_M	135_Q	2.105	1.00
238_A	335_F	2.075	1.00
159_T	188_T	2.052	1.00
247_V	318_T	2.000	1.00
293_D	313_P	1.979	1.00
154_V	158_E	1.975	1.00
187_A	340_L	1.968	1.00
248_A	309_L	1.944	1.00
293_D	312_A	1.911	1.00
134_A	138_D	1.910	1.00
296_V	306_P	1.907	1.00
40_S	51_L	1.901	1.00
113_D	260_F	1.888	1.00
170_V	192_L	1.863	1.00
247_V	316_V	1.856	1.00
192_L	196_A	1.840	1.00
133_R	137_A	1.812	1.00
165_T	344_D	1.805	1.00
309_L	318_T	1.787	1.00
199_A	230_E	1.781	1.00
172_C	224_A	1.777	1.00
254_D	289_A	1.763	1.00
169_L	174_A	1.741	1.00
14_V	110_D	1.733	1.00
202_A	235_V	1.705	1.00
7_A	133_R	1.691	1.00
270_L	275_G	1.679	1.00
12_D	110_D	1.678	1.00
232_I	316_V	1.674	1.00
311_S	315_D	1.651	1.00
68_T	90_W	1.645	1.00
170_V	227_L	1.640	1.00
165_T	343_A	1.634	1.00
209_L	235_V	1.631	1.00
17_T	101_G	1.617	1.00
73_V	94_E	1.616	1.00
168_A	204_V	1.610	1.00
79_V	99_V	1.607	1.00
54_A	108_V	1.604	1.00
234_T	314_L	1.599	1.00
226_H	229_D	1.597	1.00
102_I	107_L	1.585	1.00
50_V	119_V	1.575	1.00
51_L	75_P	1.575	1.00
181_A	333_R	1.561	1.00
147_E	150_A	1.557	1.00
310_D	338_D	1.548	1.00
294_L	311_S	1.545	1.00
198_P	202_A	1.533	1.00
311_S	314_L	1.527	1.00
192_L	204_V	1.516	1.00
80_A	83_L	1.499	1.00
273_D	295_T	1.488	1.00
195_D	223_A	1.458	1.00
86_D	89_D	1.458	1.00
50_V	77_A	1.448	1.00
17_T	100_D	1.447	1.00
251_L	311_S	1.443	1.00
168_A	206_P	1.438	1.00
31_T	40_S	1.436	1.00
134_A	137_A	1.434	1.00
244_Q	318_T	1.426	1.00
227_L	230_E	1.423	1.00
209_L	231_Y	1.421	1.00
272_H	299_V	1.417	1.00
170_V	201_I	1.415	1.00
196_A	200_D	1.411	1.00
172_C	211_I	1.410	1.00
47_E	74_H	1.397	1.00
271_D	338_D	1.392	1.00
77_A	121_I	1.391	1.00
278_V	334_G	1.389	1.00
198_P	230_E	1.374	1.00
251_L	294_L	1.360	1.00
4_A	99_V	1.351	1.00
41_L	75_P	1.316	0.99
169_L	189_V	1.302	0.99
64_R	67_R	1.293	0.99
187_A	343_A	1.287	0.99
273_D	310_D	1.283	0.99
164_D	344_D	1.273	0.99
85_D	89_D	1.268	0.99
149_G	242_L	1.265	0.99
225_E	249_R	1.264	0.99
131_T	134_A	1.258	0.99
200_D	203_A	1.257	0.99
12_D	106_D	1.255	0.99
278_V	332_T	1.255	0.99
210_F	238_A	1.240	0.99
232_I	251_L	1.237	0.99
169_L	179_I	1.235	0.99
167_V	187_A	1.234	0.99
256_E	305_T	1.218	0.99
208_L	343_A	1.215	0.99
273_D	338_D	1.213	0.99
294_L	309_L	1.195	0.99
174_A	179_I	1.192	0.99
4_A	18_A	1.190	0.99
270_L	299_V	1.190	0.99
170_V	196_A	1.184	0.99
41_L	78_V	1.176	0.99
341_A	344_D	1.172	0.99
47_E	151_H	1.167	0.99
71_D	74_H	1.164	0.99
219_A	255_T	1.162	0.99
211_I	228_V	1.158	0.99
219_A	249_R	1.157	0.99
7_A	13_V	1.153	0.98
298_Q	321_Y	1.149	0.98
9_E	117_M	1.142	0.98
21_P	92_R	1.140	0.98
183_V	189_V	1.136	0.98
22_G	95_G	1.123	0.98
271_D	278_V	1.119	0.98
166_T	204_V	1.117	0.98
231_Y	237_I	1.114	0.98
238_A	317_L	1.110	0.98
290_D	296_V	1.107	0.98
202_A	234_T	1.100	0.98
19_R	98_A	1.098	0.98
24_A	77_A	1.093	0.98
226_H	230_E	1.081	0.98
7_A	136_L	1.078	0.98
149_G	221_F	1.073	0.98
6_L	99_V	1.065	0.97
28_L	111_I	1.057	0.97
83_L	88_A	1.054	0.97
154_V	157_A	1.054	0.97
65_P	85_D	1.041	0.97
270_L	301_V	1.029	0.97
247_V	309_L	1.027	0.97
63_V	85_D	1.023	0.97
341_A	345_A	1.015	0.97
167_V	340_L	1.011	0.97
4_A	123_A	1.008	0.96
73_V	96_V	1.003	0.96
230_E	233_G	1.002	0.96
153_S	195_D	1.000	0.96
190_H	204_V	0.996	0.96
170_V	197_T	0.995	0.96
33_A	40_S	0.988	0.96
131_T	135_Q	0.986	0.96
106_D	110_D	0.976	0.96
228_V	237_I	0.973	0.96
181_A	184_A	0.971	0.96
40_S	53_F	0.969	0.96
5_Y	15_E	0.967	0.96
237_I	247_V	0.966	0.95
111_I	119_V	0.964	0.95
265_V	281_T	0.958	0.95
69_E	180_D	0.954	0.95
122_A	132_A	0.952	0.95
317_L	335_F	0.952	0.95
227_L	231_Y	0.948	0.95
293_D	311_S	0.942	0.95
23_M	124_G	0.940	0.95
159_T	190_H	0.935	0.95
205_D	235_V	0.931	0.94
182_F	187_A	0.925	0.94
14_V	106_D	0.919	0.94
271_D	276_R	0.918	0.94
143_S	219_A	0.917	0.94
48_A	76_S	0.916	0.94
38_E	64_R	0.916	0.94
221_F	224_A	0.915	0.94
198_P	227_L	0.913	0.94
177_S	181_A	0.913	0.94
165_T	187_A	0.908	0.94
24_A	121_I	0.902	0.94
338_D	341_A	0.901	0.93
120_G	132_A	0.891	0.93
80_A	100_D	0.888	0.93
174_A	210_F	0.882	0.93
89_D	92_R	0.882	0.93
241_C	322_H	0.880	0.93
127_A	131_T	0.878	0.93
197_T	227_L	0.877	0.93
10_T	114_G	0.875	0.92
147_E	224_A	0.872	0.92
321_Y	332_T	0.868	0.92
57_L	82_E	0.866	0.92
72_R	94_E	0.861	0.92
165_T	340_L	0.860	0.92
233_G	314_L	0.857	0.92
297_T	310_D	0.856	0.92
79_V	102_I	0.854	0.92
299_V	304_G	0.851	0.91
232_I	247_V	0.849	0.91
196_A	204_V	0.849	0.91
139_C	142_L	0.848	0.91
150_A	195_D	0.844	0.91
199_A	203_A	0.842	0.91
181_A	185_R	0.842	0.91
118_Q	141_R	0.837	0.91
71_D	176_R	0.835	0.91
26_G	50_V	0.834	0.91
340_L	343_A	0.834	0.91
222_D	226_H	0.833	0.90
5_Y	13_V	0.833	0.90
189_V	210_F	0.830	0.90
5_Y	125_P	0.830	0.90
269_V	307_E	0.828	0.90
169_L	212_S	0.827	0.90
63_V	68_T	0.823	0.90
91_L	96_V	0.823	0.90
160_H	163_G	0.816	0.90
45_S	241_C	0.814	0.89
24_A	76_S	0.812	0.89
147_E	223_A	0.809	0.89
28_L	52_T	0.808	0.89
122_A	127_A	0.807	0.89
185_R	340_L	0.803	0.89
154_V	191_R	0.801	0.89
133_R	136_L	0.797	0.88
79_V	119_V	0.796	0.88
263_R	267_Q	0.787	0.88
251_L	316_V	0.785	0.88
7_A	122_A	0.781	0.87
125_P	131_T	0.779	0.87
48_A	151_H	0.778	0.87
176_R	180_D	0.777	0.87
41_L	87_V	0.776	0.87
172_C	246_I	0.776	0.87
91_L	98_A	0.771	0.87
242_L	249_R	0.770	0.87
184_A	333_R	0.767	0.86
18_A	123_A	0.766	0.86
201_I	206_P	0.763	0.86
213_N	241_C	0.762	0.86
42_T	68_T	0.761	0.86
88_A	98_A	0.757	0.86
124_G	127_A	0.756	0.86
110_D	114_G	0.753	0.85
229_D	233_G	0.753	0.85
19_R	88_A	0.752	0.85
271_D	274_S	0.752	0.85
70_S	74_H	0.752	0.85
211_I	237_I	0.752	0.85
167_V	208_L	0.751	0.85
25_R	120_G	0.750	0.85
337_D	340_L	0.749	0.85
41_L	91_L	0.742	0.85
311_S	316_V	0.738	0.84
253_G	294_L	0.737	0.84
196_A	201_I	0.731	0.84
158_E	179_I	0.727	0.83
290_D	306_P	0.726	0.83
265_V	300_N	0.726	0.83
267_Q	302_N	0.722	0.83
89_D	93_T	0.717	0.83
130_A	134_A	0.716	0.83
23_M	122_A	0.714	0.82
122_A	126_D	0.713	0.82
47_E	76_S	0.713	0.82
187_A	208_L	0.710	0.82
194_Y	223_A	0.709	0.82
47_E	72_R	0.709	0.82
298_Q	334_G	0.708	0.82
163_G	188_T	0.707	0.82
321_Y	334_G	0.703	0.81
163_G	183_V	0.702	0.81
31_T	53_F	0.701	0.81
201_I	227_L	0.700	0.81
164_D	188_T	0.698	0.81
8_L	107_L	0.697	0.81
157_A	192_L	0.697	0.81
226_H	233_G	0.697	0.81
251_L	314_L	0.692	0.80
90_W	94_E	0.691	0.80
208_L	339_V	0.690	0.80
178_I	325_A	0.690	0.80
120_G	136_L	0.686	0.80
118_Q	142_L	0.683	0.79
135_Q	138_D	0.683	0.79
142_L	148_I	0.682	0.79
167_V	182_F	0.679	0.79
198_P	231_Y	0.675	0.79
46_Y	49_Q	0.675	0.79
223_A	226_H	0.673	0.78
25_R	139_C	0.672	0.78
168_A	190_H	0.670	0.78
202_A	230_E	0.669	0.78
223_A	227_L	0.668	0.78
58_I	80_A	0.667	0.78
258_M	287_T	0.665	0.78
201_I	209_L	0.665	0.78
148_I	286_Y	0.665	0.78
44_P	324_E	0.665	0.78
97_P	121_I	0.664	0.78
222_D	225_E	0.663	0.77
22_G	123_A	0.663	0.77
149_G	220_N	0.660	0.77
168_A	201_I	0.659	0.77
224_A	227_L	0.659	0.77
75_P	78_V	0.658	0.77
61_Y	64_R	0.657	0.77
208_L	238_A	0.656	0.77
42_T	90_W	0.656	0.77
61_Y	302_N	0.654	0.76
278_V	321_Y	0.654	0.76
201_I	231_Y	0.653	0.76
111_I	116_A	0.648	0.76
237_I	316_V	0.647	0.76
312_A	315_D	0.647	0.76
178_I	240_I	0.645	0.75
83_L	100_D	0.643	0.75
160_H	183_V	0.642	0.75
20_A	92_R	0.642	0.75
140_P	144_A	0.641	0.75
282_Q	307_E	0.640	0.75
53_F	58_I	0.639	0.75
170_V	224_A	0.639	0.75
150_A	223_A	0.638	0.75
202_A	231_Y	0.638	0.75
166_T	207_D	0.637	0.75
6_L	102_I	0.635	0.74
249_R	254_D	0.634	0.74
253_G	309_L	0.634	0.74
33_A	281_T	0.633	0.74
99_V	102_I	0.632	0.74
263_R	321_Y	0.631	0.74
209_L	237_I	0.631	0.74
52_T	108_V	0.630	0.74
241_C	329_P	0.628	0.74
40_S	46_Y	0.626	0.73
292_G	312_A	0.626	0.73
170_V	211_I	0.626	0.73
220_N	286_Y	0.623	0.73
289_A	306_P	0.621	0.73
31_T	267_Q	0.620	0.73
195_D	200_D	0.618	0.72
107_L	119_V	0.618	0.72
47_E	148_I	0.617	0.72
149_G	172_C	0.617	0.72
29_V	263_R	0.616	0.72
25_R	136_L	0.614	0.72
108_V	300_N	0.613	0.72
5_Y	128_S	0.612	0.72
225_E	229_D	0.612	0.72
34_Y	61_Y	0.609	0.71
9_E	114_G	0.609	0.71
38_E	298_Q	0.608	0.71
75_P	96_V	0.607	0.71
113_D	259_D	0.606	0.71
178_I	241_C	0.605	0.71
165_T	186_G	0.603	0.71
144_A	220_N	0.603	0.71
144_A	217_D	0.602	0.70
78_V	91_L	0.602	0.70
182_F	189_V	0.602	0.70
21_P	97_P	0.599	0.70
23_M	131_T	0.598	0.70
199_A	202_A	0.598	0.70
326_N	330_H	0.598	0.70
241_C	260_F	0.596	0.70
169_L	238_A	0.594	0.69
315_D	342_M	0.593	0.69
80_A	98_A	0.593	0.69
185_R	333_R	0.592	0.69
7_A	132_A	0.590	0.69
282_Q	300_N	0.588	0.69
263_R	307_E	0.587	0.68
248_A	253_G	0.586	0.68
76_S	151_H	0.586	0.68
242_L	246_I	0.585	0.68
118_Q	140_P	0.585	0.68
57_L	61_Y	0.585	0.68
18_A	98_A	0.585	0.68
116_A	286_Y	0.583	0.68
158_E	183_V	0.583	0.68
179_I	191_R	0.583	0.68
177_S	333_R	0.582	0.68
265_V	326_N	0.579	0.67
319_R	335_F	0.578	0.67
337_D	341_A	0.578	0.67
217_D	255_T	0.577	0.67
165_T	207_D	0.577	0.67
322_H	329_P	0.576	0.67
157_A	204_V	0.575	0.67
136_L	139_C	0.575	0.67
47_E	152_V	0.570	0.66
270_L	304_G	0.570	0.66
241_C	261_G	0.568	0.66
29_V	260_F	0.567	0.66
19_R	97_P	0.567	0.66
130_A	133_R	0.564	0.65
73_V	90_W	0.564	0.65
52_T	79_V	0.564	0.65
41_L	53_F	0.562	0.65
144_A	286_Y	0.562	0.65
155_D	229_D	0.561	0.65
45_S	322_H	0.559	0.65
225_E	250_A	0.559	0.65
160_H	188_T	0.558	0.65
179_I	210_F	0.558	0.65
300_N	307_E	0.558	0.65
177_S	326_N	0.557	0.64
111_I	117_M	0.554	0.64
69_E	177_S	0.554	0.64
271_D	334_G	0.552	0.64
148_I	258_M	0.550	0.63
210_F	318_T	0.548	0.63
181_A	263_R	0.547	0.63
68_T	94_E	0.546	0.63
33_A	263_R	0.546	0.63
29_V	259_D	0.546	0.63
271_D	297_T	0.545	0.63
271_D	298_Q	0.543	0.63
52_T	111_I	0.543	0.63
288_V	309_L	0.542	0.62
31_T	178_I	0.542	0.62
46_Y	241_C	0.541	0.62
195_D	224_A	0.541	0.62
18_A	21_P	0.541	0.62
26_G	51_L	0.541	0.62
143_S	220_N	0.541	0.62
25_R	135_Q	0.539	0.62
121_I	293_D	0.538	0.62
234_T	315_D	0.537	0.62
142_L	147_E	0.535	0.61
307_E	321_Y	0.535	0.61
253_G	288_V	0.534	0.61
244_Q	288_V	0.534	0.61
126_D	135_Q	0.530	0.61
213_N	322_H	0.530	0.61
64_R	298_Q	0.529	0.61
40_S	267_Q	0.529	0.61
50_V	75_P	0.529	0.61
8_L	110_D	0.528	0.60
160_H	179_I	0.524	0.60
206_P	209_L	0.522	0.60
248_A	294_L	0.522	0.60
221_F	242_L	0.521	0.59
251_L	291_P	0.521	0.59
82_E	101_G	0.520	0.59
31_T	52_T	0.520	0.59
194_Y	224_A	0.519	0.59
241_C	245_Q	0.519	0.59
59_G	62_G	0.518	0.59
57_L	307_E	0.518	0.59
322_H	328_G	0.518	0.59
55_Y	61_Y	0.518	0.59
278_V	298_Q	0.518	0.59
45_S	213_N	0.517	0.59
147_E	220_N	0.517	0.59
65_P	68_T	0.517	0.59
176_R	179_I	0.516	0.59
258_M	285_G	0.516	0.59
317_L	342_M	0.516	0.59
6_L	28_L	0.516	0.59
224_A	246_I	0.515	0.58
287_T	306_P	0.515	0.58
77_A	81_R	0.515	0.58
116_A	285_G	0.515	0.58
18_A	83_L	0.513	0.58
40_S	263_R	0.512	0.58
172_C	227_L	0.512	0.58
232_I	237_I	0.512	0.58
142_L	286_Y	0.512	0.58
5_Y	122_A	0.512	0.58
338_D	342_M	0.511	0.58
197_T	231_Y	0.511	0.58
61_Y	241_C	0.511	0.58
279_M	324_E	0.511	0.58
267_Q	327_P	0.511	0.58
83_L	98_A	0.509	0.58
253_G	289_A	0.508	0.57
170_V	231_Y	0.508	0.57
8_L	119_V	0.506	0.57
245_Q	322_H	0.505	0.57
5_Y	126_D	0.505	0.57
82_E	327_P	0.504	0.57
161_G	188_T	0.504	0.57
89_D	95_G	0.503	0.57
221_F	258_M	0.502	0.57
35_T	265_V	0.502	0.57
233_G	315_D	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a9xB	1	0.9858	100	0.222	Contact Map
1vcoA	4	0.9178	100	0.656	Contact Map
1s1mA	4	0.9235	100	0.671	Contact Map
3nvaA	2	0.9065	100	0.697	Contact Map
4zdjA	4	0.9122	100	0.714	Contact Map
2vxoA	2	0.5212	100	0.78	Contact Map
1qdlB	2	0.5042	100	0.789	Contact Map
3tqiA	3	0.4958	100	0.79	Contact Map
1i1qB	1	0.4901	100	0.791	Contact Map
2vpiA	1	0.4986	100	0.792	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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