Q9HP41 - HALSA - GREMLIN Contacts

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Q9HP41 - Transcription regulator

UniProt:	Q9HP41	Sequences: MDDIDQQILDTLRRDARTPYTEIADDIGVSEGTIRNRVDQLVDDGVIERFTVSTSTGNVKAMIEIGVAMDADTHVVGDRMVEWDAVDFVWQVSGEDDIVLIVDAADTSGVNDLMRRAREQDVVVSTRTRLILDEKLG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	137 (132)
Sequences:	12968 (8364)
Seq/√Len:	728.0

ECOLI - LRP YBAO ASNC
BACSU - AZLB YWRC YUGG LRPC LRPB LRPA YEZC
HALSA - Q9HP41 Q9HQ33 Q9HNI1 Q9HQ13 Q9HQB6 Q9HQG1 Q9HNW8 Q9HP70 Q9HQ80
SULSO - LYSM Q7LXS6 Q97W90 Q7LX67 Q97XP7 Q97X78 Q97VN7 Q97VH3 Q980P3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_V	50_F	2.898	1.00
11_T	26_D	2.862	1.00
95_E	127_R	2.567	1.00
88_F	101_I	2.480	1.00
66_G	125_S	2.433	1.00
105_A	109_G	2.370	1.00
20_Y	38_V	2.256	1.00
57_G	108_S	2.128	1.00
11_T	18_T	2.083	1.00
48_E	55_S	2.017	1.00
40_Q	44_D	2.016	1.00
83_W	116_R	1.976	1.00
68_A	124_V	1.959	1.00
87_D	103_D	1.836	1.00
48_E	53_S	1.785	1.00
5_D	37_R	1.756	1.00
83_W	113_L	1.720	1.00
62_M	90_W	1.708	1.00
60_K	101_I	1.704	1.00
72_D	75_V	1.687	1.00
39_D	43_D	1.685	1.00
18_T	26_D	1.666	1.00
11_T	14_R	1.644	1.00
4_I	29_V	1.636	1.00
21_T	25_D	1.618	1.00
29_V	33_T	1.595	1.00
64_E	129_R	1.545	1.00
106_D	109_G	1.541	1.00
79_R	120_Q	1.510	1.00
109_G	112_D	1.508	1.00
29_V	34_I	1.503	1.00
22_E	25_D	1.460	1.00
79_R	82_E	1.437	1.00
27_I	34_I	1.432	1.00
111_N	133_D	1.416	1.00
76_V	80_M	1.412	1.00
20_Y	35_R	1.410	1.00
85_A	109_G	1.408	1.00
17_R	50_F	1.407	1.00
8_I	23_I	1.407	1.00
77_G	81_V	1.394	1.00
21_T	31_E	1.373	1.00
18_T	23_I	1.352	1.00
112_D	115_R	1.297	1.00
77_G	133_D	1.291	1.00
3_D	7_Q	1.283	1.00
30_S	33_T	1.275	1.00
74_H	78_D	1.271	1.00
66_G	95_E	1.255	1.00
12_L	38_V	1.237	1.00
65_I	100_L	1.229	1.00
64_E	96_D	1.222	1.00
22_E	26_D	1.204	1.00
14_R	26_D	1.203	1.00
63_I	102_V	1.189	1.00
11_T	23_I	1.186	1.00
49_R	53_S	1.184	1.00
66_G	124_V	1.178	1.00
4_I	7_Q	1.176	1.00
15_D	26_D	1.168	1.00
39_D	42_V	1.155	1.00
19_P	22_E	1.142	1.00
85_A	116_R	1.116	1.00
64_E	127_R	1.098	1.00
86_V	102_V	1.075	1.00
59_V	107_T	1.074	1.00
20_Y	24_A	1.071	1.00
67_V	76_V	1.055	1.00
60_K	103_D	1.054	1.00
4_I	27_I	1.053	1.00
77_G	98_I	1.047	1.00
104_A	109_G	1.013	1.00
18_T	22_E	1.013	1.00
10_D	14_R	1.010	1.00
7_Q	11_T	1.004	1.00
7_Q	10_D	0.986	1.00
16_A	50_F	0.972	1.00
24_A	34_I	0.971	1.00
75_V	79_R	0.968	1.00
7_Q	27_I	0.963	1.00
17_R	42_V	0.962	1.00
20_Y	31_E	0.943	1.00
35_R	39_D	0.938	1.00
90_W	101_I	0.935	1.00
102_V	113_L	0.928	1.00
89_V	100_L	0.925	1.00
78_D	81_V	0.914	1.00
104_A	113_L	0.900	1.00
92_V	99_V	0.897	1.00
31_E	35_R	0.892	1.00
1_M	6_Q	0.877	1.00
95_E	125_S	0.863	1.00
104_A	110_V	0.863	1.00
79_R	83_W	0.863	1.00
41_L	46_V	0.861	1.00
2_D	37_R	0.858	1.00
58_N	106_D	0.849	1.00
62_M	99_V	0.849	1.00
24_A	29_V	0.838	1.00
86_V	89_V	0.827	1.00
86_V	100_L	0.826	1.00
78_D	82_E	0.826	1.00
62_M	101_I	0.821	1.00
23_I	38_V	0.812	1.00
64_E	99_V	0.787	1.00
56_T	103_D	0.785	1.00
6_Q	10_D	0.782	1.00
62_M	131_I	0.779	1.00
21_T	35_R	0.777	1.00
23_I	34_I	0.764	1.00
80_M	89_V	0.763	1.00
93_S	130_L	0.761	1.00
75_V	78_D	0.750	1.00
76_V	98_I	0.750	1.00
69_M	72_D	0.741	1.00
5_D	40_Q	0.740	1.00
15_D	18_T	0.737	1.00
112_D	116_R	0.731	1.00
90_W	131_I	0.725	1.00
74_H	77_G	0.724	1.00
118_R	126_T	0.711	1.00
8_I	18_T	0.708	1.00
68_A	72_D	0.707	1.00
73_T	98_I	0.707	1.00
32_G	36_N	0.703	1.00
16_A	52_V	0.702	1.00
114_M	128_T	0.698	1.00
85_A	105_A	0.696	1.00
75_V	122_V	0.695	1.00
96_D	127_R	0.693	1.00
68_A	122_V	0.679	1.00
64_E	95_E	0.678	1.00
11_T	15_D	0.673	1.00
3_D	6_Q	0.670	1.00
8_I	38_V	0.669	1.00
16_A	22_E	0.667	1.00
66_G	96_D	0.660	1.00
107_T	130_L	0.656	1.00
61_A	130_L	0.656	1.00
32_G	35_R	0.655	1.00
8_I	37_R	0.655	1.00
85_A	113_L	0.641	1.00
80_M	100_L	0.640	1.00
108_S	112_D	0.640	1.00
16_A	49_R	0.639	1.00
60_K	131_I	0.638	1.00
92_V	96_D	0.637	1.00
36_N	40_Q	0.636	1.00
65_I	123_V	0.633	1.00
1_M	46_V	0.632	1.00
5_D	41_L	0.628	1.00
91_Q	98_I	0.627	1.00
8_I	11_T	0.621	1.00
114_M	126_T	0.613	1.00
36_N	39_D	0.603	1.00
58_N	103_D	0.598	1.00
20_Y	34_I	0.595	1.00
45_G	48_E	0.595	1.00
75_V	121_D	0.592	1.00
108_S	111_N	0.590	1.00
8_I	34_I	0.580	1.00
108_S	133_D	0.576	1.00
91_Q	111_N	0.576	1.00
13_R	51_T	0.574	1.00
73_T	118_R	0.574	1.00
9_L	41_L	0.571	1.00
79_R	122_V	0.569	1.00
107_T	132_L	0.568	1.00
109_G	113_L	0.562	1.00
72_D	122_V	0.559	1.00
8_I	41_L	0.548	1.00
92_V	131_I	0.548	1.00
63_I	126_T	0.547	1.00
61_A	110_V	0.545	1.00
58_N	105_A	0.543	1.00
15_D	22_E	0.543	1.00
74_H	119_E	0.541	1.00
66_G	127_R	0.539	1.00
91_Q	132_L	0.539	1.00
47_I	50_F	0.536	1.00
83_W	120_Q	0.536	1.00
113_L	117_A	0.534	1.00
37_R	41_L	0.532	1.00
114_M	132_L	0.530	1.00
21_T	24_A	0.528	1.00
69_M	118_R	0.524	1.00
118_R	125_S	0.523	1.00
65_I	76_V	0.520	1.00
53_S	56_T	0.516	1.00
69_M	124_V	0.508	1.00
10_D	13_R	0.507	1.00
24_A	31_E	0.506	1.00
63_I	100_L	0.506	1.00
14_R	18_T	0.503	0.99
79_R	121_D	0.503	0.99
40_Q	43_D	0.503	0.99
72_D	121_D	0.500	0.99
87_D	101_I	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ch7A	1	0.9708	100	0.157	Contact Map
4un1B	1	0.9927	100	0.192	Contact Map
4un1A	1	0.9854	100	0.199	Contact Map
2e1cA	1	0.9927	99.9	0.211	Contact Map
4pcqA	2	1	99.9	0.213	Contact Map
2p5vA	5	1	99.9	0.218	Contact Map
2ia0A	2	0.9635	99.9	0.222	Contact Map
2cg4A	6	1	99.9	0.226	Contact Map
3i4pA	5	0.9927	99.9	0.247	Contact Map
2pn6A	5	0.9927	99.9	0.248	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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