GREMLIN Database
Q9HP41 - Transcription regulator
UniProt: Q9HP41 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (132)
Sequences: 12968 (8364)
Seq/√Len: 728.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_V50_F2.8981.00
11_T26_D2.8621.00
95_E127_R2.5671.00
88_F101_I2.4801.00
66_G125_S2.4331.00
105_A109_G2.3701.00
20_Y38_V2.2561.00
57_G108_S2.1281.00
11_T18_T2.0831.00
48_E55_S2.0171.00
40_Q44_D2.0161.00
83_W116_R1.9761.00
68_A124_V1.9591.00
87_D103_D1.8361.00
48_E53_S1.7851.00
5_D37_R1.7561.00
83_W113_L1.7201.00
62_M90_W1.7081.00
60_K101_I1.7041.00
72_D75_V1.6871.00
39_D43_D1.6851.00
18_T26_D1.6661.00
11_T14_R1.6441.00
4_I29_V1.6361.00
21_T25_D1.6181.00
29_V33_T1.5951.00
64_E129_R1.5451.00
106_D109_G1.5411.00
79_R120_Q1.5101.00
109_G112_D1.5081.00
29_V34_I1.5031.00
22_E25_D1.4601.00
79_R82_E1.4371.00
27_I34_I1.4321.00
111_N133_D1.4161.00
76_V80_M1.4121.00
20_Y35_R1.4101.00
85_A109_G1.4081.00
17_R50_F1.4071.00
8_I23_I1.4071.00
77_G81_V1.3941.00
21_T31_E1.3731.00
18_T23_I1.3521.00
112_D115_R1.2971.00
77_G133_D1.2911.00
3_D7_Q1.2831.00
30_S33_T1.2751.00
74_H78_D1.2711.00
66_G95_E1.2551.00
12_L38_V1.2371.00
65_I100_L1.2291.00
64_E96_D1.2221.00
22_E26_D1.2041.00
14_R26_D1.2031.00
63_I102_V1.1891.00
11_T23_I1.1861.00
49_R53_S1.1841.00
66_G124_V1.1781.00
4_I7_Q1.1761.00
15_D26_D1.1681.00
39_D42_V1.1551.00
19_P22_E1.1421.00
85_A116_R1.1161.00
64_E127_R1.0981.00
86_V102_V1.0751.00
59_V107_T1.0741.00
20_Y24_A1.0711.00
67_V76_V1.0551.00
60_K103_D1.0541.00
4_I27_I1.0531.00
77_G98_I1.0471.00
104_A109_G1.0131.00
18_T22_E1.0131.00
10_D14_R1.0101.00
7_Q11_T1.0041.00
7_Q10_D0.9861.00
16_A50_F0.9721.00
24_A34_I0.9711.00
75_V79_R0.9681.00
7_Q27_I0.9631.00
17_R42_V0.9621.00
20_Y31_E0.9431.00
35_R39_D0.9381.00
90_W101_I0.9351.00
102_V113_L0.9281.00
89_V100_L0.9251.00
78_D81_V0.9141.00
104_A113_L0.9001.00
92_V99_V0.8971.00
31_E35_R0.8921.00
1_M6_Q0.8771.00
95_E125_S0.8631.00
104_A110_V0.8631.00
79_R83_W0.8631.00
41_L46_V0.8611.00
2_D37_R0.8581.00
58_N106_D0.8491.00
62_M99_V0.8491.00
24_A29_V0.8381.00
86_V89_V0.8271.00
86_V100_L0.8261.00
78_D82_E0.8261.00
62_M101_I0.8211.00
23_I38_V0.8121.00
64_E99_V0.7871.00
56_T103_D0.7851.00
6_Q10_D0.7821.00
62_M131_I0.7791.00
21_T35_R0.7771.00
23_I34_I0.7641.00
80_M89_V0.7631.00
93_S130_L0.7611.00
75_V78_D0.7501.00
76_V98_I0.7501.00
69_M72_D0.7411.00
5_D40_Q0.7401.00
15_D18_T0.7371.00
112_D116_R0.7311.00
90_W131_I0.7251.00
74_H77_G0.7241.00
118_R126_T0.7111.00
8_I18_T0.7081.00
68_A72_D0.7071.00
73_T98_I0.7071.00
32_G36_N0.7031.00
16_A52_V0.7021.00
114_M128_T0.6981.00
85_A105_A0.6961.00
75_V122_V0.6951.00
96_D127_R0.6931.00
68_A122_V0.6791.00
64_E95_E0.6781.00
11_T15_D0.6731.00
3_D6_Q0.6701.00
8_I38_V0.6691.00
16_A22_E0.6671.00
66_G96_D0.6601.00
107_T130_L0.6561.00
61_A130_L0.6561.00
32_G35_R0.6551.00
8_I37_R0.6551.00
85_A113_L0.6411.00
80_M100_L0.6401.00
108_S112_D0.6401.00
16_A49_R0.6391.00
60_K131_I0.6381.00
92_V96_D0.6371.00
36_N40_Q0.6361.00
65_I123_V0.6331.00
1_M46_V0.6321.00
5_D41_L0.6281.00
91_Q98_I0.6271.00
8_I11_T0.6211.00
114_M126_T0.6131.00
36_N39_D0.6031.00
58_N103_D0.5981.00
20_Y34_I0.5951.00
45_G48_E0.5951.00
75_V121_D0.5921.00
108_S111_N0.5901.00
8_I34_I0.5801.00
108_S133_D0.5761.00
91_Q111_N0.5761.00
13_R51_T0.5741.00
73_T118_R0.5741.00
9_L41_L0.5711.00
79_R122_V0.5691.00
107_T132_L0.5681.00
109_G113_L0.5621.00
72_D122_V0.5591.00
8_I41_L0.5481.00
92_V131_I0.5481.00
63_I126_T0.5471.00
61_A110_V0.5451.00
58_N105_A0.5431.00
15_D22_E0.5431.00
74_H119_E0.5411.00
66_G127_R0.5391.00
91_Q132_L0.5391.00
47_I50_F0.5361.00
83_W120_Q0.5361.00
113_L117_A0.5341.00
37_R41_L0.5321.00
114_M132_L0.5301.00
21_T24_A0.5281.00
69_M118_R0.5241.00
118_R125_S0.5231.00
65_I76_V0.5201.00
53_S56_T0.5161.00
69_M124_V0.5081.00
10_D13_R0.5071.00
24_A31_E0.5061.00
63_I100_L0.5061.00
14_R18_T0.5030.99
79_R121_D0.5030.99
40_Q43_D0.5030.99
72_D121_D0.5000.99
87_D101_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9708 100 0.157 Contact Map
4un1B 1 0.9927 100 0.192 Contact Map
4un1A 1 0.9854 100 0.199 Contact Map
2e1cA 1 0.9927 99.9 0.211 Contact Map
4pcqA 2 1 99.9 0.213 Contact Map
2p5vA 5 1 99.9 0.218 Contact Map
2ia0A 2 0.9635 99.9 0.222 Contact Map
2cg4A 6 1 99.9 0.226 Contact Map
3i4pA 5 0.9927 99.9 0.247 Contact Map
2pn6A 5 0.9927 99.9 0.248 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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