GREMLIN Database
Q9HP38 - Alcohol dehydrogenase
UniProt: Q9HP38 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (306)
Sequences: 52830 (36065)
Seq/√Len: 2061.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
321_E324_R2.9301.00
35_R141_W2.8351.00
33_D70_S2.7731.00
35_R68_V2.7041.00
7_D18_R2.7011.00
31_L70_S2.6121.00
30_V132_L2.5681.00
188_A213_D2.5101.00
169_S193_E2.5071.00
140_D143_T2.4921.00
84_R135_V2.3741.00
83_D134_A2.3671.00
317_L328_L2.3501.00
80_E83_D2.3361.00
205_Q209_E2.2721.00
226_E229_A2.2711.00
65_A120_V2.2601.00
33_D68_V2.2281.00
142_E316_V2.1701.00
22_E124_R2.1651.00
175_A196_A2.1571.00
33_D124_R2.1421.00
193_E214_H2.1371.00
165_S168_E2.0921.00
315_D328_L2.0771.00
204_L208_A2.0701.00
78_R129_A2.0601.00
170_V187_A2.0501.00
302_E306_D2.0461.00
5_T18_R2.0231.00
7_D16_D2.0211.00
28_D75_S1.9941.00
318_P321_E1.9871.00
27_A74_A1.9761.00
159_N190_A1.9671.00
26_G29_D1.9551.00
316_V341_K1.9471.00
184_V212_A1.9451.00
65_A87_V1.9331.00
138_H305_W1.9061.00
84_R141_W1.8831.00
27_A75_S1.8781.00
66_A141_W1.8651.00
327_E331_N1.8351.00
168_E260_R1.8251.00
24_D71_A1.7921.00
151_F182_A1.7811.00
171_L197_T1.7651.00
171_L236_V1.7561.00
31_L126_A1.7511.00
201_E205_Q1.7411.00
205_Q208_A1.7391.00
70_S124_R1.7271.00
324_R327_E1.7221.00
48_R330_E1.7131.00
159_N299_A1.6931.00
317_L325_A1.6851.00
195_F236_V1.6701.00
237_D256_A1.6601.00
204_L215_V1.6391.00
189_H308_T1.6381.00
135_V141_W1.6301.00
198_A204_L1.6261.00
324_R328_L1.6151.00
328_L333_E1.6151.00
260_R285_D1.6151.00
255_L261_L1.6051.00
73_G76_V1.6001.00
135_V144_A1.5921.00
173_L251_S1.5591.00
221_T226_E1.5451.00
79_F134_A1.5311.00
201_E217_N1.5221.00
217_N220_E1.5211.00
25_L126_A1.5151.00
214_H230_R1.5131.00
4_V322_T1.5121.00
255_L284_L1.5111.00
162_A238_V1.5081.00
260_R287_L1.4961.00
193_E213_D1.4911.00
206_Y209_E1.4901.00
222_N225_D1.4871.00
29_D128_P1.4871.00
142_E341_K1.4841.00
72_V81_P1.4821.00
201_E220_E1.4641.00
71_A81_P1.4471.00
31_L124_R1.4451.00
79_F83_D1.4361.00
121_H326_H1.4311.00
84_R137_E1.4281.00
34_V65_A1.4231.00
255_L259_G1.4041.00
199_S218_Y1.3801.00
68_V84_R1.3721.00
25_L31_L1.3701.00
28_D128_P1.3621.00
29_D126_A1.3491.00
184_V196_A1.3461.00
239_V251_S1.3411.00
69_V79_F1.3301.00
323_A327_E1.3181.00
47_R326_H1.3131.00
36_A341_K1.3101.00
239_V255_L1.3031.00
36_A142_E1.2891.00
30_V79_F1.2871.00
225_D229_A1.2731.00
314_R328_L1.2641.00
31_L71_A1.2601.00
169_S195_F1.2571.00
68_V141_W1.2381.00
302_E305_W1.2321.00
183_A240_V1.2241.00
155_W159_N1.2201.00
173_L197_T1.2201.00
4_V17_Y1.2011.00
3_A20_V1.1921.00
164_V192_A1.1821.00
189_H303_H1.1781.00
79_F132_L1.1631.00
204_L217_N1.1611.00
22_E31_L1.1511.00
35_R84_R1.1461.00
169_S237_D1.1371.00
208_A215_V1.1301.00
25_L29_D1.1041.00
196_A212_A1.0931.00
28_D129_A1.0801.00
299_A302_E1.0731.00
32_V67_G1.0721.00
34_V125_A1.0721.00
70_S81_P1.0711.00
127_V132_L1.0701.00
185_Q310_D1.0681.00
168_E237_D1.0601.00
226_E230_R1.0551.00
143_T310_D1.0531.00
162_A262_V1.0501.00
4_V319_M1.0401.00
39_L325_A1.0391.00
322_T340_V1.0311.00
253_R278_R1.0251.00
17_Y320_R1.0221.00
47_R330_E1.0141.00
201_E204_L1.0081.00
154_A186_I1.0071.00
222_N226_E1.0061.00
208_A214_H1.0061.00
303_H308_T1.0051.00
32_V85_V1.0041.00
199_S219_T1.0021.00
206_Y335_F1.0021.00
35_R66_A1.0001.00
318_P341_K0.9911.00
243_V247_T0.9901.00
298_D302_E0.9891.00
36_A141_W0.9881.00
37_G121_H0.9881.00
220_E226_E0.9861.00
161_R285_D0.9841.00
200_T217_N0.9741.00
154_A183_A0.9701.00
164_V168_E0.9631.00
5_T20_V0.9631.00
195_F214_H0.9621.00
40_N64_D0.9581.00
199_S204_L0.9561.00
40_N63_S0.9561.00
37_G120_V0.9531.00
121_H322_T0.9521.00
157_M264_C0.9461.00
328_L338_V0.9461.00
187_A192_A0.9431.00
11_G14_V0.9411.00
147_A304_V0.9401.00
224_A253_R0.9351.00
175_A198_A0.9311.00
5_T60_V0.9291.00
241_D244_G0.9201.00
22_E71_A0.9191.00
72_V76_V0.9161.00
172_V183_A0.9151.00
36_A339_V0.9111.00
231_T235_G0.9091.00
151_F300_A0.9061.00
76_V129_A0.9021.00
139_V144_A0.9021.00
184_V194_V0.9021.00
197_T218_Y0.8881.00
3_A60_V0.8881.00
249_D253_R0.8871.00
186_I300_A0.8861.00
327_E330_E0.8861.00
44_V329_L0.8831.00
33_D123_E0.8831.00
159_N296_E0.8791.00
80_E134_A0.8771.00
173_L239_V0.8761.00
172_V187_A0.8741.00
59_H118_P0.8661.00
155_W299_A0.8661.00
28_D73_G0.8661.00
4_V15_I0.8651.00
227_I236_V0.8631.00
198_A215_V0.8621.00
38_A64_D0.8621.00
224_A250_D0.8611.00
175_A207_A0.8601.00
181_H206_Y0.8581.00
250_D253_R0.8581.00
20_V118_P0.8571.00
24_D31_L0.8551.00
121_H340_V0.8551.00
143_T312_R0.8531.00
77_T129_A0.8511.00
171_L254_S0.8481.00
202_Q205_Q0.8471.00
22_E70_S0.8461.00
175_A184_V0.8461.00
195_F216_V0.8451.00
157_M240_V0.8321.00
169_S236_V0.8271.00
278_R282_N0.8251.00
65_A125_A0.8251.00
203_K335_F0.8241.00
279_V286_I0.8171.00
329_L338_V0.8151.00
168_E238_V0.8121.00
196_A207_A0.8081.00
224_A228_R0.8031.00
299_A303_H0.7981.00
86_A301_L0.7971.00
258_G283_Q0.7971.00
7_D14_V0.7951.00
26_G126_A0.7951.00
161_R287_L0.7911.00
28_D74_A0.7881.00
39_L329_L0.7831.00
158_L187_A0.7821.00
207_A212_A0.7801.00
137_E305_W0.7751.00
225_D228_R0.7671.00
40_N43_D0.7661.00
154_A179_V0.7651.00
156_R296_E0.7641.00
200_T203_K0.7621.00
154_A182_A0.7591.00
223_F250_D0.7581.00
25_L71_A0.7551.00
186_I303_H0.7531.00
275_N278_R0.7531.00
317_L321_E0.7531.00
159_N186_I0.7521.00
157_M183_A0.7511.00
4_V323_A0.7501.00
170_V192_A0.7451.00
195_F227_I0.7421.00
239_V261_L0.7391.00
39_L121_H0.7391.00
87_V127_V0.7381.00
251_S261_L0.7371.00
169_S234_R0.7371.00
222_N250_D0.7351.00
17_Y319_M0.7331.00
25_L73_G0.7331.00
187_A194_V0.7331.00
224_A254_S0.7321.00
85_V132_L0.7321.00
164_V238_V0.7311.00
20_V60_V0.7271.00
156_R283_Q0.7251.00
303_H306_D0.7241.00
190_A299_A0.7241.00
139_V304_V0.7221.00
64_D149_L0.7211.00
42_L63_S0.7201.00
72_V80_E0.7171.00
173_L247_T0.7161.00
279_V284_L0.7161.00
194_V213_D0.7151.00
195_F230_R0.7131.00
317_L340_V0.7131.00
40_N149_L0.7101.00
328_L331_N0.7091.00
133_I298_D0.7081.00
163_D260_R0.7041.00
303_H307_G0.7031.00
136_P305_W0.7011.00
246_A250_D0.7011.00
172_V196_A0.7001.00
242_H264_C0.6981.00
236_V239_V0.6971.00
30_V129_A0.6971.00
279_V288_G0.6961.00
6_F14_V0.6951.00
315_D324_R0.6911.00
154_A158_L0.6901.00
297_A301_L0.6861.00
84_R138_H0.6851.00
198_A207_A0.6851.00
334_G338_V0.6841.00
313_I316_V0.6821.00
86_A135_V0.6821.00
238_V262_V0.6721.00
66_A145_A0.6711.00
301_L305_W0.6691.00
163_D287_L0.6681.00
315_D338_V0.6671.00
133_I297_A0.6671.00
155_W300_A0.6661.00
317_L338_V0.6661.00
13_G327_E0.6651.00
263_T286_I0.6641.00
227_I254_S0.6611.00
234_R256_A0.6611.00
204_L207_A0.6571.00
248_W261_L0.6531.00
192_A238_V0.6521.00
78_R134_A0.6511.00
63_S149_L0.6511.00
209_E310_D0.6501.00
150_V178_G0.6471.00
30_V69_V0.6461.00
66_A135_V0.6441.00
231_T234_R0.6421.00
41_H45_W0.6411.00
133_I301_L0.6401.00
40_N150_V0.6401.00
149_L153_T0.6381.00
32_V87_V0.6381.00
120_V125_A0.6361.00
153_T179_V0.6361.00
155_W303_H0.6341.00
228_R231_T0.6341.00
23_P126_A0.6331.00
257_K282_N0.6311.00
83_D137_E0.6311.00
198_A218_Y0.6271.00
66_A84_R0.6271.00
188_A194_V0.6261.00
228_R235_G0.6241.00
28_D130_D0.6221.00
241_D261_L0.6211.00
36_A66_A0.6211.00
78_R81_P0.6191.00
185_Q210_L0.6191.00
206_Y210_L0.6181.00
326_H330_E0.6161.00
184_V210_L0.6151.00
36_A316_V0.6131.00
35_R341_K0.6131.00
42_L46_T0.6121.00
186_I190_A0.6121.00
163_D285_D0.6071.00
236_V254_S0.6051.00
204_L218_Y0.6041.00
249_D278_R0.6041.00
295_G299_A0.5981.00
86_A148_P0.5971.00
34_V37_G0.5971.00
238_V260_R0.5961.00
197_T216_V0.5951.00
162_A260_R0.5951.00
170_V238_V0.5941.00
181_H312_R0.5931.00
153_T264_C0.5891.00
21_P24_D0.5881.00
198_A217_N0.5881.00
23_P31_L0.5871.00
45_W50_M0.5861.00
295_G298_D0.5861.00
206_Y312_R0.5861.00
247_T251_S0.5831.00
25_L75_S0.5831.00
88_L133_I0.5831.00
183_A264_C0.5821.00
239_V254_S0.5821.00
214_H226_E0.5811.00
23_P124_R0.5811.00
129_A132_L0.5811.00
223_F227_I0.5771.00
87_V132_L0.5761.00
249_D271_R0.5711.00
150_V182_A0.5661.00
41_H177_G0.5661.00
241_D265_G0.5661.00
157_M289_S0.5621.00
77_T80_E0.5611.00
44_V330_E0.5601.00
146_A311_V0.5591.00
304_V311_V0.5581.00
146_A339_V0.5581.00
22_E126_A0.5581.00
42_L45_W0.5571.00
64_D337_K0.5571.00
32_V132_L0.5561.00
198_A203_K0.5551.00
169_S231_T0.5541.00
79_F129_A0.5541.00
216_V221_T0.5531.00
171_L239_V0.5531.00
159_N162_A0.5511.00
304_V309_F0.5511.00
283_Q293_T0.5501.00
40_N337_K0.5491.00
158_L186_I0.5491.00
22_E25_L0.5471.00
62_G121_H0.5471.00
55_L59_H0.5441.00
72_V83_D0.5431.00
212_A215_V0.5431.00
25_L28_D0.5421.00
12_T327_E0.5421.00
328_L334_G0.5421.00
66_A144_A0.5391.00
46_T51_P0.5371.00
184_V207_A0.5341.00
166_P191_G0.5341.00
246_A249_D0.5341.00
166_P190_A0.5311.00
140_D316_V0.5301.00
152_Q296_E0.5281.00
23_P29_D0.5261.00
34_V87_V0.5251.00
182_A186_I0.5251.00
307_G310_D0.5251.00
140_D144_A0.5241.00
249_D273_E0.5241.00
167_G192_A0.5241.00
37_G340_V0.5211.00
15_I326_H0.5211.00
32_V65_A0.5191.00
14_V47_R0.5191.00
207_A215_V0.5161.00
262_V289_S0.5161.00
155_W190_A0.5151.00
44_V48_R0.5151.00
216_V230_R0.5131.00
188_A212_A0.5131.00
208_A212_A0.5131.00
56_S59_H0.5121.00
29_D117_V0.5111.00
271_R275_N0.5111.00
60_V119_G0.5101.00
216_V226_E0.5101.00
87_V120_V0.5101.00
181_H210_L0.5101.00
216_V223_F0.5091.00
173_L223_F0.5091.00
17_Y322_T0.5091.00
54_D57_M0.5051.00
135_V139_V0.5041.00
199_S217_N0.5041.00
14_V323_A0.5031.00
30_V76_V0.5021.00
182_A185_Q0.5021.00
317_L324_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gi2A 2 1 100 0.144 Contact Map
2eihA 4 0.9885 100 0.144 Contact Map
1rjwA 4 0.9741 100 0.156 Contact Map
1h2bA 4 0.9654 100 0.159 Contact Map
4gkvA 4 0.9625 100 0.165 Contact Map
3jv7A 4 0.9654 100 0.165 Contact Map
3ip1A 4 0.9798 100 0.165 Contact Map
1vj0A 4 0.9712 100 0.168 Contact Map
4oh1A 4 0.9625 100 0.171 Contact Map
2dq4A 4 0.9654 100 0.172 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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