GREMLIN Database
Q9HP37 - Molybdenum cofactor biosynthesis protein
UniProt: Q9HP37 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (162)
Sequences: 1631 (1225)
Seq/√Len: 96.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_R135_E5.0351.00
141_E144_R3.9041.00
57_S121_D3.8421.00
51_A107_V2.9601.00
73_A185_D2.8621.00
128_A172_C2.8441.00
111_I173_L2.6951.00
118_V136_L2.6711.00
53_V101_L2.5131.00
132_F163_G2.4581.00
146_R150_D2.4161.00
74_V79_H2.3331.00
50_V74_V2.3181.00
55_V94_V2.1981.00
70_V184_T2.0591.00
65_P177_E2.0331.00
55_V87_V2.0031.00
91_Y95_Q1.8801.00
71_V75_E1.8291.00
59_R62_S1.8191.00
91_Y130_P1.8101.00
132_F161_T1.7941.00
95_Q99_D1.7471.00
49_G108_A1.7411.00
66_A113_T1.7401.00
58_S62_S1.6821.00
49_G80_E1.6561.00
71_V84_R1.6491.00
68_D84_R1.6061.00
97_A101_L1.5931.00
90_R93_R1.5901.00
91_Y127_A1.5771.00
95_Q130_P1.5741.00
171_F188_I1.5641.00
95_Q127_A1.5521.00
88_T93_R1.5431.00
72_A76_A1.5251.00
70_V173_L1.4981.00
109_A192_L1.4871.00
178_H182_L1.4821.00
85_E100_N1.4771.00
51_A101_L1.4351.00
90_R94_V1.4301.00
112_T172_C1.4281.00
69_A180_A1.4171.00
85_E97_A1.4090.99
164_V199_A1.3860.99
70_V180_A1.3850.99
143_F183_G1.3780.99
110_V170_V1.3210.99
70_V113_T1.3000.99
53_V97_A1.2940.99
133_D166_G1.2760.99
103_G165_V1.2580.99
153_T191_E1.2520.99
92_D96_G1.2390.99
138_G144_R1.2370.99
108_A200_G1.2260.99
52_V71_V1.1940.98
115_G124_T1.1920.98
98_L112_T1.1830.98
152_G179_A1.1800.98
89_D175_G1.1790.98
132_F135_E1.1720.98
98_L128_A1.1710.98
96_G100_N1.1490.98
102_T168_T1.1270.97
69_A181_T1.1090.97
148_A186_E1.0970.97
66_A180_A1.0830.97
54_T113_T1.0810.97
112_T170_V1.0710.97
72_A96_G1.0530.96
74_V184_T1.0370.96
171_F191_E1.0300.96
101_L107_V0.9940.95
55_V58_S0.9770.94
73_A184_T0.9770.94
70_V111_I0.9770.94
69_A72_A0.9680.94
142_E145_R0.9660.94
97_A100_N0.9640.94
143_F188_I0.9640.94
165_V170_V0.9590.94
60_S63_D0.9580.94
136_L139_F0.9530.93
77_A189_L0.9500.93
135_E140_G0.9450.93
112_T173_L0.9370.93
52_V74_V0.9250.92
173_L183_G0.9160.92
94_V123_V0.9130.92
48_V79_H0.9050.92
148_A187_I0.9020.91
184_T188_I0.8940.91
142_E156_I0.8840.91
109_A169_L0.8690.90
69_A73_A0.8660.90
184_T189_L0.8630.90
111_I184_T0.8610.89
146_R187_I0.8610.89
140_G144_R0.8420.88
116_T120_P0.8350.88
136_L140_G0.8330.88
153_T156_I0.8290.88
128_A132_F0.8280.88
55_V112_T0.8200.87
79_H193_A0.8180.87
108_A112_T0.8140.87
100_N105_D0.8130.87
100_N106_D0.8080.86
155_I158_S0.8040.86
89_D113_T0.7980.86
102_T165_V0.7960.85
47_Q80_E0.7940.85
129_R161_T0.7940.85
75_E80_E0.7930.85
144_R155_I0.7830.84
94_V127_A0.7820.84
188_I191_E0.7790.84
60_S88_T0.7660.83
112_T128_A0.7640.83
198_L201_H0.7630.83
116_T121_D0.7610.83
69_A177_E0.7570.82
169_L195_L0.7510.82
89_D115_G0.7450.81
102_T110_V0.7450.81
61_L71_V0.7410.81
176_S194_H0.7290.80
99_D102_T0.7270.80
119_T151_I0.7210.79
91_Y123_V0.7160.79
143_F171_F0.7120.78
181_T185_D0.7100.78
157_G195_L0.7080.78
156_I187_I0.7080.78
48_V196_A0.7060.78
54_T67_G0.7040.78
146_R151_I0.6970.77
140_G160_A0.6930.77
94_V98_L0.6920.76
53_V85_E0.6900.76
89_D122_D0.6820.75
39_A42_D0.6760.75
98_L131_L0.6720.74
118_V157_G0.6710.74
100_N103_G0.6700.74
92_D95_Q0.6700.74
113_T173_L0.6680.74
74_V81_V0.6680.74
82_A106_D0.6670.74
122_D152_G0.6610.73
82_A107_V0.6600.73
118_V199_A0.6600.73
150_D178_H0.6530.72
54_T57_S0.6520.72
109_A171_F0.6520.72
190_P193_A0.6440.71
54_T66_A0.6430.71
150_D177_E0.6400.71
87_V93_R0.6390.71
83_T100_N0.6380.70
93_R97_A0.6370.70
99_D103_G0.6360.70
56_S116_T0.6270.69
125_V172_C0.6240.69
116_T176_S0.6240.69
152_G182_L0.6230.69
49_G82_A0.6210.68
101_L110_V0.6190.68
139_F156_I0.6160.68
53_V98_L0.6160.68
103_G106_D0.6140.68
145_R148_A0.6120.67
96_G99_D0.6110.67
72_A105_D0.6100.67
56_S89_D0.6100.67
154_K183_G0.6100.67
109_A196_A0.6070.67
106_D167_G0.6060.67
191_E195_L0.6020.66
51_A83_T0.6000.66
118_V164_V0.5970.65
53_V94_V0.5960.65
55_V124_T0.5940.65
90_R121_D0.5870.64
192_L200_G0.5870.64
151_I178_H0.5860.64
148_A183_G0.5860.64
56_S59_R0.5860.64
70_V189_L0.5850.64
110_V168_T0.5840.64
99_D131_L0.5800.63
91_Y128_A0.5770.63
107_V168_T0.5760.63
50_V79_H0.5740.62
125_V182_L0.5730.62
75_E129_R0.5720.62
182_L190_P0.5680.62
83_T86_L0.5680.62
58_S65_P0.5670.61
142_E148_A0.5650.61
40_H44_D0.5650.61
118_V152_G0.5640.61
153_T187_I0.5630.61
107_V110_V0.5620.61
48_V197_G0.5570.60
64_D174_P0.5570.60
147_S160_A0.5560.60
153_T175_G0.5560.60
46_S100_N0.5550.60
75_E78_G0.5500.59
140_G162_G0.5490.59
76_A185_D0.5480.59
51_A122_D0.5470.59
183_G187_I0.5470.59
154_K191_E0.5450.58
53_V112_T0.5440.58
73_A180_A0.5380.57
156_I171_F0.5360.57
93_R99_D0.5340.57
139_F171_F0.5330.57
127_A130_P0.5320.57
117_G176_S0.5280.56
87_V101_L0.5260.56
125_V128_A0.5260.56
132_F170_V0.5260.56
45_V196_A0.5250.56
120_P167_G0.5200.55
147_S151_I0.5200.55
141_E150_D0.5190.55
90_R123_V0.5190.55
113_T177_E0.5190.55
136_L141_E0.5160.54
65_P150_D0.5150.54
118_V195_L0.5090.53
52_V67_G0.5070.53
167_G200_G0.5060.53
156_I191_E0.5050.53
125_V136_L0.5030.53
64_D67_G0.5030.53
154_K188_I0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rfqA 5 0.761 100 0.352 Contact Map
4lhbA 4 0.7512 100 0.355 Contact Map
1di6A 3 0.7512 100 0.363 Contact Map
1y5eA 4 0.7756 100 0.365 Contact Map
1jljA 3 0.761 100 0.372 Contact Map
4pd0A 2 0.9561 100 0.374 Contact Map
3iwtA 4 0.761 100 0.379 Contact Map
2pbqA 3 0.7707 100 0.382 Contact Map
4xcwA 3 0.7854 100 0.382 Contact Map
1mkzA 2 0.8049 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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