GREMLIN Database
Q9HP36 - Uncharacterized protein
UniProt: Q9HP36 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (229)
Sequences: 386 (255)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_E199_D6.4831.00
50_W74_A4.2401.00
196_V201_T3.8011.00
175_E200_R3.6521.00
138_D200_R3.6501.00
49_V203_T3.6281.00
59_N64_Q3.5841.00
67_V130_V3.4721.00
64_Q172_T3.2490.99
13_D28_H3.1640.99
71_A78_L2.9250.98
58_A81_A2.4020.94
175_E198_P2.2820.93
56_V71_A2.2420.92
26_P33_N2.1470.90
44_L170_V2.1410.90
70_A74_A2.1100.89
219_L223_R2.0920.89
195_V202_I2.0690.88
107_T110_G2.0680.88
92_L115_G2.0660.88
5_Y9_E2.0230.87
173_V178_V1.9770.86
8_R12_W1.8950.83
21_A24_P1.8890.83
48_D52_R1.8770.83
19_G27_P1.8750.82
45_T70_A1.8650.82
47_T194_Y1.8390.81
5_Y149_Y1.8190.80
41_A59_N1.7630.78
91_F96_P1.7370.77
131_S190_V1.6360.73
91_F118_V1.6310.73
16_E21_A1.6150.72
33_N63_P1.6140.72
41_A53_A1.5990.71
69_R73_R1.5570.69
225_A231_D1.5470.68
30_R33_N1.5450.68
106_T110_G1.5370.68
20_V176_R1.4860.65
4_K8_R1.4750.65
80_A111_I1.4560.63
202_I224_L1.4560.63
39_E42_A1.4480.63
46_E49_V1.4060.61
179_V182_A1.4060.61
170_V194_Y1.4060.61
67_V196_V1.3620.58
36_G135_A1.3540.58
78_L94_L1.3340.57
99_I102_I1.3280.56
31_I145_K1.2960.54
51_Q126_I1.2920.54
77_T93_R1.2800.53
9_E13_D1.2780.53
144_G148_G1.2770.53
56_V214_I1.2680.53
59_N84_R1.2680.53
154_F158_R1.2610.52
43_R201_T1.2570.52
61_D132_G1.2440.51
42_A121_G1.2330.51
87_D221_E1.2240.50
56_V126_I1.2230.50
62_A108_V1.2220.50
14_D18_S1.2200.50
142_R189_D1.2150.50
41_A67_V1.2140.49
47_T170_V1.2130.49
169_T210_T1.2040.49
52_R56_V1.1820.48
41_A66_P1.1810.47
154_F169_T1.1780.47
16_E26_P1.1680.47
142_R153_E1.1670.47
40_A171_T1.1660.47
47_T201_T1.1590.46
63_P147_E1.1550.46
21_A26_P1.1540.46
137_T141_E1.1480.46
21_A27_P1.1480.46
145_K153_E1.1450.45
154_F209_D1.1320.45
88_E232_R1.1150.44
60_P68_R1.1130.43
49_V201_T1.0840.42
16_E110_G1.0830.42
48_D215_D1.0820.42
84_R147_E1.0810.42
170_V201_T1.0750.41
88_E150_S1.0740.41
141_E185_T1.0580.40
24_P33_N1.0550.40
97_T121_G1.0530.40
44_L130_V1.0510.40
57_K129_I1.0470.40
54_E180_D1.0450.40
14_D176_R1.0450.40
222_Q226_E1.0410.39
23_F169_T1.0380.39
31_I142_R1.0360.39
26_P63_P1.0270.39
30_R62_A1.0270.39
107_T113_E1.0260.38
129_I176_R1.0170.38
3_D199_D1.0090.38
38_D73_R0.9960.37
27_P171_T0.9910.37
58_A192_M0.9840.36
50_W80_A0.9730.36
223_R227_I0.9720.35
156_L195_V0.9710.35
194_Y203_T0.9680.35
56_V78_L0.9630.35
43_R198_P0.9600.35
187_A215_D0.9590.35
82_V99_I0.9560.35
194_Y201_T0.9550.35
66_P69_R0.9530.34
33_N37_A0.9530.34
41_A172_T0.9470.34
110_G115_G0.9440.34
170_V204_T0.9440.34
42_A156_L0.9410.34
43_R200_R0.9400.34
105_A115_G0.9390.34
33_N154_F0.9370.34
59_N66_P0.9350.33
63_P84_R0.9350.33
31_I153_E0.9340.33
50_W70_A0.9340.33
137_T183_V0.9330.33
135_A145_K0.9330.33
30_R63_P0.9290.33
129_I195_V0.9250.33
41_A44_L0.9200.33
7_L47_T0.9190.33
37_A59_N0.9120.32
141_E219_L0.9080.32
55_T126_I0.9020.32
229_V233_R0.9010.32
96_P155_A0.8950.31
11_V203_T0.8860.31
50_W81_A0.8830.31
146_G151_D0.8820.31
79_Y82_V0.8800.31
221_E231_D0.8780.31
35_A168_A0.8770.30
152_L219_L0.8640.30
146_G219_L0.8610.30
14_D178_V0.8590.30
153_E188_H0.8590.30
33_N62_A0.8530.29
43_R46_E0.8520.29
56_V225_A0.8410.29
115_G126_I0.8410.29
158_R210_T0.8390.29
55_T64_Q0.8370.29
137_T179_V0.8340.28
87_D122_D0.8320.28
178_V215_D0.8310.28
164_D168_A0.8300.28
41_A64_Q0.8240.28
137_T217_D0.8230.28
209_D224_L0.8200.28
16_E24_P0.8170.28
214_I219_L0.8080.27
59_N62_A0.8080.27
20_V125_P0.8060.27
41_A146_G0.8050.27
53_A168_A0.8040.27
86_R162_R0.8000.27
59_N172_T0.7950.27
55_T69_R0.7950.27
151_D216_W0.7910.26
82_V232_R0.7860.26
15_L29_G0.7850.26
145_K149_Y0.7840.26
219_L224_L0.7760.26
130_V231_D0.7760.26
180_D194_Y0.7750.26
156_L160_F0.7730.26
144_G151_D0.7730.26
52_R122_D0.7720.25
38_D66_P0.7710.25
212_S217_D0.7700.25
179_V183_V0.7700.25
57_K161_G0.7680.25
87_D117_P0.7560.25
39_E52_R0.7540.25
141_E183_V0.7530.25
86_R224_L0.7520.25
25_F151_D0.7490.24
153_E189_D0.7490.24
59_N63_P0.7380.24
57_K147_E0.7350.24
133_S147_E0.7330.24
15_L48_D0.7320.24
136_V171_T0.7300.24
69_R110_G0.7300.24
105_A157_L0.7290.24
16_E25_F0.7280.24
65_L69_R0.7270.23
43_R202_I0.7240.23
201_T212_S0.7170.23
138_D180_D0.7170.23
20_V35_A0.7170.23
37_A64_Q0.7100.23
142_R151_D0.7070.23
51_Q116_D0.7040.23
11_V70_A0.7030.22
14_D20_V0.7020.22
71_A76_K0.7020.22
154_F191_P0.7000.22
92_L112_E0.6990.22
185_T191_P0.6960.22
131_S143_V0.6930.22
48_D217_D0.6920.22
45_T74_A0.6910.22
19_G103_D0.6890.22
23_F30_R0.6850.22
16_E27_P0.6810.22
151_D189_D0.6810.22
154_F190_V0.6810.22
57_K149_Y0.6810.22
125_P164_D0.6750.21
69_R103_D0.6740.21
49_V194_Y0.6740.21
100_D181_D0.6710.21
50_W194_Y0.6700.21
11_V179_V0.6640.21
79_Y156_L0.6630.21
54_E163_V0.6600.21
11_V14_D0.6580.21
39_E203_T0.6560.21
127_D136_V0.6520.20
62_A65_L0.6490.20
63_P154_F0.6470.20
3_D137_T0.6450.20
141_E223_R0.6420.20
93_R116_D0.6410.20
195_V220_D0.6400.20
73_R103_D0.6370.20
87_D229_V0.6320.20
132_G174_H0.6310.20
104_A113_E0.6290.20
185_T208_D0.6290.20
79_Y120_P0.6260.19
4_K12_W0.6250.19
130_V170_V0.6240.19
31_I189_D0.6240.19
32_P136_V0.6240.19
61_D174_H0.6230.19
63_P204_T0.6220.19
83_P145_K0.6180.19
170_V221_E0.6180.19
44_L67_V0.6180.19
8_R144_G0.6160.19
57_K145_K0.6160.19
67_V146_G0.6140.19
138_D178_V0.6140.19
22_R149_Y0.6090.19
138_D181_D0.6070.19
7_L35_A0.6060.19
48_D138_D0.6050.19
81_A210_T0.6030.19
58_A82_V0.6030.19
178_V182_A0.6000.19
50_W86_R0.5990.18
48_D51_Q0.5980.18
106_T115_G0.5980.18
120_P232_R0.5950.18
113_E137_T0.5950.18
6_R143_V0.5940.18
108_V112_E0.5910.18
143_V187_A0.5890.18
126_I179_V0.5890.18
81_A219_L0.5870.18
78_L182_A0.5860.18
186_A218_A0.5850.18
111_I176_R0.5840.18
33_N171_T0.5830.18
43_R71_A0.5820.18
131_S154_F0.5790.18
130_V200_R0.5750.18
91_F94_L0.5740.18
22_R69_R0.5740.18
50_W58_A0.5680.17
66_P172_T0.5680.17
101_D200_R0.5660.17
113_E157_L0.5600.17
199_D215_D0.5590.17
151_D223_R0.5590.17
10_R14_D0.5580.17
63_P83_P0.5550.17
131_S150_S0.5550.17
61_D149_Y0.5550.17
47_T130_V0.5510.17
150_S178_V0.5510.17
204_T224_L0.5500.17
122_D217_D0.5490.17
151_D228_P0.5490.17
8_R142_R0.5470.17
3_D6_R0.5470.17
15_L20_V0.5420.17
73_R201_T0.5390.16
134_V171_T0.5390.16
137_T182_A0.5380.16
159_A228_P0.5380.16
6_R53_A0.5360.16
207_E217_D0.5350.16
31_I57_K0.5330.16
81_A162_R0.5300.16
82_V168_A0.5290.16
148_G151_D0.5290.16
42_A51_Q0.5280.16
216_W229_V0.5270.16
42_A139_R0.5260.16
35_A128_L0.5230.16
5_Y233_R0.5230.16
142_R145_K0.5190.16
29_G80_A0.5190.16
111_I184_P0.5170.16
61_D145_K0.5150.16
176_R184_P0.5150.16
212_S231_D0.5140.16
144_G189_D0.5140.16
12_W144_G0.5140.16
57_K64_Q0.5140.16
40_A172_T0.5120.16
178_V195_V0.5110.16
82_V88_E0.5110.16
74_A113_E0.5100.15
85_L107_T0.5060.15
168_A210_T0.5060.15
55_T59_N0.5060.15
81_A85_L0.5040.15
169_T190_V0.5040.15
74_A105_A0.5030.15
99_I162_R0.5020.15
94_L149_Y0.5000.15
46_E118_V0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wkcA 1 0.7021 100 0.679 Contact Map
1ydmA 3 0.7404 100 0.702 Contact Map
3hy3A 2 0.7617 100 0.706 Contact Map
1souA 1 0.8 100 0.706 Contact Map
2jcbA 1 0.7617 100 0.713 Contact Map
1sbqA 1 0.6553 99.9 0.741 Contact Map
3gdeA 1 0.7617 12.1 0.972 Contact Map
1ei5A 2 0.5021 11.6 0.972 Contact Map
1poiB 1 0.817 10.9 0.973 Contact Map
2hivA 1 0.8255 10.3 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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