Q9HP36 - HALSA - GREMLIN Contacts

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Q9HP36 - Uncharacterized protein

UniProt:	Q9HP36	Sequences: MTDKYRLRERVWDDLEDSGVARFPFPPHGRIPNYAGADEAAARLTETDVWQRAETVKANPDAPQLPVRRAALRAGKTLYAAVPRLRDEECFLRLDPTTIDDIDAATTVSGIEEYGDPVGPGDVDPIDLIVSGSVAVTDRGERVGKGEGYSDLEFALLRAFGRVDDDTATVTTVHERQVVDDAVPTAAHDVPMEYVVTPDRTITTTHEDDTPSGIDWDALDEQRLAEIPVLDRRSP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	235 (229)
Sequences:	386 (255)
Seq/√Len:	16.8

HALSA - Q9HP36
SULSO - Q97ZW6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
175_E	199_D	6.483	1.00
50_W	74_A	4.240	1.00
196_V	201_T	3.801	1.00
175_E	200_R	3.652	1.00
138_D	200_R	3.650	1.00
49_V	203_T	3.628	1.00
59_N	64_Q	3.584	1.00
67_V	130_V	3.472	1.00
64_Q	172_T	3.249	0.99
13_D	28_H	3.164	0.99
71_A	78_L	2.925	0.98
58_A	81_A	2.402	0.94
175_E	198_P	2.282	0.93
56_V	71_A	2.242	0.92
26_P	33_N	2.147	0.90
44_L	170_V	2.141	0.90
70_A	74_A	2.110	0.89
219_L	223_R	2.092	0.89
195_V	202_I	2.069	0.88
107_T	110_G	2.068	0.88
92_L	115_G	2.066	0.88
5_Y	9_E	2.023	0.87
173_V	178_V	1.977	0.86
8_R	12_W	1.895	0.83
21_A	24_P	1.889	0.83
48_D	52_R	1.877	0.83
19_G	27_P	1.875	0.82
45_T	70_A	1.865	0.82
47_T	194_Y	1.839	0.81
5_Y	149_Y	1.819	0.80
41_A	59_N	1.763	0.78
91_F	96_P	1.737	0.77
131_S	190_V	1.636	0.73
91_F	118_V	1.631	0.73
16_E	21_A	1.615	0.72
33_N	63_P	1.614	0.72
41_A	53_A	1.599	0.71
69_R	73_R	1.557	0.69
225_A	231_D	1.547	0.68
30_R	33_N	1.545	0.68
106_T	110_G	1.537	0.68
20_V	176_R	1.486	0.65
4_K	8_R	1.475	0.65
80_A	111_I	1.456	0.63
202_I	224_L	1.456	0.63
39_E	42_A	1.448	0.63
46_E	49_V	1.406	0.61
179_V	182_A	1.406	0.61
170_V	194_Y	1.406	0.61
67_V	196_V	1.362	0.58
36_G	135_A	1.354	0.58
78_L	94_L	1.334	0.57
99_I	102_I	1.328	0.56
31_I	145_K	1.296	0.54
51_Q	126_I	1.292	0.54
77_T	93_R	1.280	0.53
9_E	13_D	1.278	0.53
144_G	148_G	1.277	0.53
56_V	214_I	1.268	0.53
59_N	84_R	1.268	0.53
154_F	158_R	1.261	0.52
43_R	201_T	1.257	0.52
61_D	132_G	1.244	0.51
42_A	121_G	1.233	0.51
87_D	221_E	1.224	0.50
56_V	126_I	1.223	0.50
62_A	108_V	1.222	0.50
14_D	18_S	1.220	0.50
142_R	189_D	1.215	0.50
41_A	67_V	1.214	0.49
47_T	170_V	1.213	0.49
169_T	210_T	1.204	0.49
52_R	56_V	1.182	0.48
41_A	66_P	1.181	0.47
154_F	169_T	1.178	0.47
16_E	26_P	1.168	0.47
142_R	153_E	1.167	0.47
40_A	171_T	1.166	0.47
47_T	201_T	1.159	0.46
63_P	147_E	1.155	0.46
21_A	26_P	1.154	0.46
137_T	141_E	1.148	0.46
21_A	27_P	1.148	0.46
145_K	153_E	1.145	0.45
154_F	209_D	1.132	0.45
88_E	232_R	1.115	0.44
60_P	68_R	1.113	0.43
49_V	201_T	1.084	0.42
16_E	110_G	1.083	0.42
48_D	215_D	1.082	0.42
84_R	147_E	1.081	0.42
170_V	201_T	1.075	0.41
88_E	150_S	1.074	0.41
141_E	185_T	1.058	0.40
24_P	33_N	1.055	0.40
97_T	121_G	1.053	0.40
44_L	130_V	1.051	0.40
57_K	129_I	1.047	0.40
54_E	180_D	1.045	0.40
14_D	176_R	1.045	0.40
222_Q	226_E	1.041	0.39
23_F	169_T	1.038	0.39
31_I	142_R	1.036	0.39
26_P	63_P	1.027	0.39
30_R	62_A	1.027	0.39
107_T	113_E	1.026	0.38
129_I	176_R	1.017	0.38
3_D	199_D	1.009	0.38
38_D	73_R	0.996	0.37
27_P	171_T	0.991	0.37
58_A	192_M	0.984	0.36
50_W	80_A	0.973	0.36
223_R	227_I	0.972	0.35
156_L	195_V	0.971	0.35
194_Y	203_T	0.968	0.35
56_V	78_L	0.963	0.35
43_R	198_P	0.960	0.35
187_A	215_D	0.959	0.35
82_V	99_I	0.956	0.35
194_Y	201_T	0.955	0.35
66_P	69_R	0.953	0.34
33_N	37_A	0.953	0.34
41_A	172_T	0.947	0.34
110_G	115_G	0.944	0.34
170_V	204_T	0.944	0.34
42_A	156_L	0.941	0.34
43_R	200_R	0.940	0.34
105_A	115_G	0.939	0.34
33_N	154_F	0.937	0.34
59_N	66_P	0.935	0.33
63_P	84_R	0.935	0.33
31_I	153_E	0.934	0.33
50_W	70_A	0.934	0.33
137_T	183_V	0.933	0.33
135_A	145_K	0.933	0.33
30_R	63_P	0.929	0.33
129_I	195_V	0.925	0.33
41_A	44_L	0.920	0.33
7_L	47_T	0.919	0.33
37_A	59_N	0.912	0.32
141_E	219_L	0.908	0.32
55_T	126_I	0.902	0.32
229_V	233_R	0.901	0.32
96_P	155_A	0.895	0.31
11_V	203_T	0.886	0.31
50_W	81_A	0.883	0.31
146_G	151_D	0.882	0.31
79_Y	82_V	0.880	0.31
221_E	231_D	0.878	0.31
35_A	168_A	0.877	0.30
152_L	219_L	0.864	0.30
146_G	219_L	0.861	0.30
14_D	178_V	0.859	0.30
153_E	188_H	0.859	0.30
33_N	62_A	0.853	0.29
43_R	46_E	0.852	0.29
56_V	225_A	0.841	0.29
115_G	126_I	0.841	0.29
158_R	210_T	0.839	0.29
55_T	64_Q	0.837	0.29
137_T	179_V	0.834	0.28
87_D	122_D	0.832	0.28
178_V	215_D	0.831	0.28
164_D	168_A	0.830	0.28
41_A	64_Q	0.824	0.28
137_T	217_D	0.823	0.28
209_D	224_L	0.820	0.28
16_E	24_P	0.817	0.28
214_I	219_L	0.808	0.27
59_N	62_A	0.808	0.27
20_V	125_P	0.806	0.27
41_A	146_G	0.805	0.27
53_A	168_A	0.804	0.27
86_R	162_R	0.800	0.27
59_N	172_T	0.795	0.27
55_T	69_R	0.795	0.27
151_D	216_W	0.791	0.26
82_V	232_R	0.786	0.26
15_L	29_G	0.785	0.26
145_K	149_Y	0.784	0.26
219_L	224_L	0.776	0.26
130_V	231_D	0.776	0.26
180_D	194_Y	0.775	0.26
156_L	160_F	0.773	0.26
144_G	151_D	0.773	0.26
52_R	122_D	0.772	0.25
38_D	66_P	0.771	0.25
212_S	217_D	0.770	0.25
179_V	183_V	0.770	0.25
57_K	161_G	0.768	0.25
87_D	117_P	0.756	0.25
39_E	52_R	0.754	0.25
141_E	183_V	0.753	0.25
86_R	224_L	0.752	0.25
25_F	151_D	0.749	0.24
153_E	189_D	0.749	0.24
59_N	63_P	0.738	0.24
57_K	147_E	0.735	0.24
133_S	147_E	0.733	0.24
15_L	48_D	0.732	0.24
136_V	171_T	0.730	0.24
69_R	110_G	0.730	0.24
105_A	157_L	0.729	0.24
16_E	25_F	0.728	0.24
65_L	69_R	0.727	0.23
43_R	202_I	0.724	0.23
201_T	212_S	0.717	0.23
138_D	180_D	0.717	0.23
20_V	35_A	0.717	0.23
37_A	64_Q	0.710	0.23
142_R	151_D	0.707	0.23
51_Q	116_D	0.704	0.23
11_V	70_A	0.703	0.22
14_D	20_V	0.702	0.22
71_A	76_K	0.702	0.22
154_F	191_P	0.700	0.22
92_L	112_E	0.699	0.22
185_T	191_P	0.696	0.22
131_S	143_V	0.693	0.22
48_D	217_D	0.692	0.22
45_T	74_A	0.691	0.22
19_G	103_D	0.689	0.22
23_F	30_R	0.685	0.22
16_E	27_P	0.681	0.22
151_D	189_D	0.681	0.22
154_F	190_V	0.681	0.22
57_K	149_Y	0.681	0.22
125_P	164_D	0.675	0.21
69_R	103_D	0.674	0.21
49_V	194_Y	0.674	0.21
100_D	181_D	0.671	0.21
50_W	194_Y	0.670	0.21
11_V	179_V	0.664	0.21
79_Y	156_L	0.663	0.21
54_E	163_V	0.660	0.21
11_V	14_D	0.658	0.21
39_E	203_T	0.656	0.21
127_D	136_V	0.652	0.20
62_A	65_L	0.649	0.20
63_P	154_F	0.647	0.20
3_D	137_T	0.645	0.20
141_E	223_R	0.642	0.20
93_R	116_D	0.641	0.20
195_V	220_D	0.640	0.20
73_R	103_D	0.637	0.20
87_D	229_V	0.632	0.20
132_G	174_H	0.631	0.20
104_A	113_E	0.629	0.20
185_T	208_D	0.629	0.20
79_Y	120_P	0.626	0.19
4_K	12_W	0.625	0.19
130_V	170_V	0.624	0.19
31_I	189_D	0.624	0.19
32_P	136_V	0.624	0.19
61_D	174_H	0.623	0.19
63_P	204_T	0.622	0.19
83_P	145_K	0.618	0.19
170_V	221_E	0.618	0.19
44_L	67_V	0.618	0.19
8_R	144_G	0.616	0.19
57_K	145_K	0.616	0.19
67_V	146_G	0.614	0.19
138_D	178_V	0.614	0.19
22_R	149_Y	0.609	0.19
138_D	181_D	0.607	0.19
7_L	35_A	0.606	0.19
48_D	138_D	0.605	0.19
81_A	210_T	0.603	0.19
58_A	82_V	0.603	0.19
178_V	182_A	0.600	0.19
50_W	86_R	0.599	0.18
48_D	51_Q	0.598	0.18
106_T	115_G	0.598	0.18
120_P	232_R	0.595	0.18
113_E	137_T	0.595	0.18
6_R	143_V	0.594	0.18
108_V	112_E	0.591	0.18
143_V	187_A	0.589	0.18
126_I	179_V	0.589	0.18
81_A	219_L	0.587	0.18
78_L	182_A	0.586	0.18
186_A	218_A	0.585	0.18
111_I	176_R	0.584	0.18
33_N	171_T	0.583	0.18
43_R	71_A	0.582	0.18
131_S	154_F	0.579	0.18
130_V	200_R	0.575	0.18
91_F	94_L	0.574	0.18
22_R	69_R	0.574	0.18
50_W	58_A	0.568	0.17
66_P	172_T	0.568	0.17
101_D	200_R	0.566	0.17
113_E	157_L	0.560	0.17
199_D	215_D	0.559	0.17
151_D	223_R	0.559	0.17
10_R	14_D	0.558	0.17
63_P	83_P	0.555	0.17
131_S	150_S	0.555	0.17
61_D	149_Y	0.555	0.17
47_T	130_V	0.551	0.17
150_S	178_V	0.551	0.17
204_T	224_L	0.550	0.17
122_D	217_D	0.549	0.17
151_D	228_P	0.549	0.17
8_R	142_R	0.547	0.17
3_D	6_R	0.547	0.17
15_L	20_V	0.542	0.17
73_R	201_T	0.539	0.16
134_V	171_T	0.539	0.16
137_T	182_A	0.538	0.16
159_A	228_P	0.538	0.16
6_R	53_A	0.536	0.16
207_E	217_D	0.535	0.16
31_I	57_K	0.533	0.16
81_A	162_R	0.530	0.16
82_V	168_A	0.529	0.16
148_G	151_D	0.529	0.16
42_A	51_Q	0.528	0.16
216_W	229_V	0.527	0.16
42_A	139_R	0.526	0.16
35_A	128_L	0.523	0.16
5_Y	233_R	0.523	0.16
142_R	145_K	0.519	0.16
29_G	80_A	0.519	0.16
111_I	184_P	0.517	0.16
61_D	145_K	0.515	0.16
176_R	184_P	0.515	0.16
212_S	231_D	0.514	0.16
144_G	189_D	0.514	0.16
12_W	144_G	0.514	0.16
57_K	64_Q	0.514	0.16
40_A	172_T	0.512	0.16
178_V	195_V	0.511	0.16
82_V	88_E	0.511	0.16
74_A	113_E	0.510	0.15
85_L	107_T	0.506	0.15
168_A	210_T	0.506	0.15
55_T	59_N	0.506	0.15
81_A	85_L	0.504	0.15
169_T	190_V	0.504	0.15
74_A	105_A	0.503	0.15
99_I	162_R	0.502	0.15
94_L	149_Y	0.500	0.15
46_E	118_V	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wkcA	1	0.7021	100	0.679	Contact Map
1ydmA	3	0.7404	100	0.702	Contact Map
3hy3A	2	0.7617	100	0.706	Contact Map
1souA	1	0.8	100	0.706	Contact Map
2jcbA	1	0.7617	100	0.713	Contact Map
1sbqA	1	0.6553	99.9	0.741	Contact Map
3gdeA	1	0.7617	12.1	0.972	Contact Map
1ei5A	2	0.5021	11.6	0.972	Contact Map
1poiB	1	0.817	10.9	0.973	Contact Map
2hivA	1	0.8255	10.3	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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